Cited by 338Sleep and Wakefulness ResearchCircadian rhythm and melatoninSleep and Work-Related Fatigue

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

IL-6 and Its Circadian Secretion in Humans

Vgontzas, A.N., Bixler, E.O., Lin, H.-M., Prolo, P., Trakada, G., Chrousos, G.P.·2005·Neuroimmunomodulation

Open this paper in CoChat — free account

Abstract

Interleukin-6 (IL-6) is a pleiotropic cytokine produced by numerous types of immune and nonimmune cells and is involved in many pathophysiologic mechanisms in humans. Many studies suggest that IL-6 is a putative ‘sleep factor’ and its circadian secretion correlates with sleep/sleepiness. IL-6 is elevated in disorders of excessive daytime sleepiness such as narcolepsy and obstructive sleep apnea. It correlates positively with body mass index and may be a mediator of sleepiness in obesity. Also the secretion of this cytokine is stimulated by total acute or partial short-term sleep loss reflecting the increased sleepiness experienced by sleep-deprived individuals. Studies that evaluated the 24-hour secretory pattern of IL-6 in healthy young adults suggest that IL-6 is secreted in a biphasic circadian pattern with two nadirs at about 08.00 and 21.00, and two zeniths at about 19.00 and 05.00 h. In contrast, following sleep deprivation or in disorders of sleep disturbance, e.g., insomnia, IL-6 peaks during the day and, based on the level of stress system activity, i.e., cortisol secretion, contributes to either sleepiness and deep sleep (low cortisol) or feelings of tiredness and fatigue and poor sleep (high cortisol). In order to address concerns about the potential impact of differences of IL-6 levels between the beginning and the end of the 24-hour blood-drawing experiment, we proceeded with a cosinor analysis of ‘detrended’ data in young and old healthy individuals. This new analysis did not affect the biphasic circadian pattern of IL-6 secretion in young adults, while it augmented the flattened circadian pattern in old individuals in whom the difference was greater. Finally, IL-6 appears to be somnogenic in rats and exhibits a diurnal rhythm that follows the sleep/wake cycle in these animals. We conclude that IL-6 is a mediator of sleepiness and its circadian pattern reflects the homeostatic drive for sleep.

Integrity signals

Registry

Crossref · 10.1159/000084844

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1
Mohamed‐Ali, V., Goodrick, S., Rawesh, A., Katz, D. R., Miles, J. M., Yudkin, J. S., Klein, S., & Coppack, S. W. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4450 · Cited by 2,032
Bone Marrow, Cytokines, and Bone Remodeling — Emerging Insights into the Pathophysiology of Osteoporosis
Manolagas, S. C., & Jilka, R. L. (1995) · New England Journal of Medicine · doi:10.1056/nejm199502023320506 · Cited by 1,670
Sleep Apnea and Daytime Sleepiness and Fatigue: Relation to Visceral Obesity, Insulin Resistance, and Hypercytokinemia
Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Hopper, K. D., Lotsikas, A. J., LIN, H., Kales, A., & Chrousos, G. P. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.3.6484 · Cited by 1,209
Self-citation
The Pathophysiologic Roles of Interleukin-6 in Human Disease
Papanicolaou, D. A., Wilder, R. L., Manolagas, S. C., & Chrousos, G. P. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-128-2-199801150-00009 · Cited by 1,146
Self-citation
Adverse Effects of Modest Sleep Restriction on Sleepiness, Performance, and Inflammatory Cytokines
Vgontzas, A. N., Zoumakis, E., Bixler, E. O., Lin, H.-M., Follett, H., Kales, A., & Chrousos, G. P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031562 · Cited by 1,050
Self-citation
Elevation of Plasma Cytokines in Disorders of Excessive Daytime Sleepiness: Role of Sleep Disturbance and Obesity
Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Kales, A., Tyson, K., & Chrousos, G. P. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.5.3950 · Cited by 974
Self-citation
Chronic insomnia is associated with nyctohemeral activation of the hypothalamic-pituitary-adrenal axis: clinical implications
Vgontzas, A. N., Bixler, E. O., Lin, H.-M., Prolo, P., Mastorakos, G., Vela-Bueno, A., Kales, A., & Chrousos, G. P. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.8.7778 · Cited by 884
Self-citation
17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens.
Girasole, G., Jilka, R. L., Passeri, G., Boswell, S. H., Boder, G. B., Williams, D. C., & Manolagas, S. C. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115668 · Cited by 677
Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans.
Mastorakos, G., Chrousos, G. P., & Weber, J. S. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.6.8263159 · Cited by 591
Self-citation
Circadian Interleukin-6 Secretion and Quantity and Depth of Sleep
Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Lotsikas, A., Zachman, K., Kales, A., Prolo, P., Wong, M.-L., Licinio, J., Gold, P. W., et al. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.8.5894 · Cited by 516
Self-citation

Show all 47 references

Research works printed but not linked: 11

10.1210%2Fjc.77.6.1690 · DOI · Paper page
10.1210%2Fjc.81.6.2303 · DOI
10.1210%2Fjc.82.5.1313 · DOI · Paper page
10.1210%2Fjc.85.3.1331 · DOI
10.1210%2Fjc.82.12.4196 · DOI · Paper page
10.1210%2Fjc.84.6.2126 · DOI
10.1210%2Fen.137.12.5250 · DOI · Paper page
10.1210%2Fjc.85.3.1151 · DOI
10.1210%2Fjc.84.8.2603 · DOI · Paper page
10.1210%2Fjc.86.8.3787 · DOI · Paper page
10.1210%2Fjc.85.10.3597 · DOI

Sorted by citations

The effects of acute psychological stress on circulating inflammatory factors in humans: a review and meta-analysis
Steptoe, A., Hamer, M., & Chida, Y. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.03.011 · Cited by 1,278
Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies
Manna, P., & Jain, S. K. (2015) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2015.0095 · Cited by 1,211
Effect of compassion meditation on neuroendocrine, innate immune and behavioral responses to psychosocial stress
Pace, T. W. W., Negi, L. T., Adame, D. D., Cole, S. P., Sivilli, T. I., Brown, T. D., Issa, M. J., & Raison, C. L. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.08.011 · Cited by 748
“Because cortisol and IL-6 demonstrate circadian variability (Posener et al., 1996; Vgontzas et al., 2005), we also included time of stressor initiation as a covariate in all analyses of these variables.”
Background
Interleukin-6 in Aging and Chronic Disease: A Magnificent Pathway
Maggio, M. G., Guralnik, J. M., Longo, D. L., & Ferrucci, L. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.6.575 · Cited by 696
Gut microbiome diversity is associated with sleep physiology in humans
Smith, R. P., Easson, C., Lyle, S. M., Kapoor, R., Donnelly, C. P., Davidson, E. J., Parikh, E., Lopez, J. V., & Tartar, J. L. (2019) · PLOS ONE · doi:10.1371/journal.pone.0222394 · Cited by 390
Stress, Visceral Obesity, and Metabolic Complications
Kyrou, I., Chrousos, G. P., & Tsigos, C. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1367.008 · Cited by 392
Self-citation
Metabolic, Endocrine, and Immune Consequences of Sleep Deprivation
AlDabal, L. M. J. A., & BaHammam, A. S. (2011) · The Open Respiratory Medicine Journal · doi:10.2174/1874306401105010031 · Cited by 371
Absorption, Metabolism, and Antioxidant Effects of Pomegranate (Punica granatum L.) Polyphenols after Ingestion of a Standardized Extract in Healthy Human Volunteers
Mertens‐Talcott, S. U., Jilma‐Stohlawetz, P., Rios, J., Hingorani, L., & Derendorf, H. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf061674h · Cited by 353
Broad spectrum of cytokine abnormalities in panic disorder and posttraumatic stress disorder
Hoge, E. A., Brandstetter, K., Moshier, S., Pollack, M. H., Wong, K. K., & Simon, N. M. (2009) · Depression and Anxiety · doi:10.1002/da.20564 · Cited by 343
Conceptual and methodological issues relevant to cytokine and inflammatory marker measurements in clinical research
Zhou, X., Fragala, M. S., McElhaney, J. E., & Kuchel, G. A. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32833cf3bc · Cited by 329
Role of interleukin-6 in stress, sleep, and fatigue
Rohleder, N., Aringer, M., & Boentert, M. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06634.x · Cited by 289
Role of IL-6 in the regulation of neuronal development, survival and function
Kummer, K. K., Zeidler, M., Kalpachidou, T., & Kress, M. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155582 · Cited by 281
The chronobiology, etiology and pathophysiology of obesity
Garaulet, M., Ordovás, J. M., & Madrid, J. A. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.118 · Cited by 292
Subjective and Objective Sleep Quality and Aging in the Sleep Heart Health Study
Unruh, M. L., Redline, S. S., An, M., Buysse, D. J., Nieto, F. J., Yeh, J.-L., & Newman, A. B. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.01755.x · Cited by 271
Effect of acute sleep deprivation on vascular function in healthy subjects
Sauvet, F., Leftheriotis, G., Gomez-Merino, D., Langrume, C., Drogou, C., Van Beers, P., Bourrilhon, C., Florence, G., & Chennaoui, M. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00851.2009 · Cited by 268
Circadian rhythms in rheumatoid arthritis: Implications for pathophysiology and therapeutic management
Straub, R. H., & Cutolo, M. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22368 · Cited by 265
Systematic review of the association between circulating interleukin-6 (IL-6) and cancer
Heikkilä, K., Ebrahim, S., & Lawlor, D. A. (2008) · European Journal of Cancer · doi:10.1016/j.ejca.2008.02.047 · Cited by 232
Obesity‐Related Sleepiness and Fatigue
Vgontzas, A. N., Bixler, E. O., & Chrousos, G. P. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1367.023 · Cited by 240
Self-citation
Inflammation and the dimensions of depression: A review
Majd, M., Saunders, E. F. H., & Engeland, C. G. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100800 · Cited by 229
The role of cytokines in the pathophysiology of suicidal behavior
Ganança, L., Oquendo, M. A., Tyrka, A. R., Cisneros-Trujillo, S., Mann, J. J., & Sublette, M. E. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.10.008 · Cited by 217
Sleep and sleep disturbances: biological basis and clinical implications
Zisapel, N. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6529-9 · Cited by 216
Daytime napping after a night of sleep loss decreases sleepiness, improves performance, and causes beneficial changes in cortisol and interleukin-6 secretion
Vgontzas, A. N., Pejovic, S., Zoumakis, E., Lin, H. M., Bixler, E. O., Basta, M., Fang, J., Sarrigiannidis, A., & Chrousos, G. P. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00651.2005 · Cited by 205
Self-citation
Does obesity play a major role in the pathogenesis of sleep apnoea and its associated manifestations via inflammation, visceral adiposity, and insulin resistance?
Vgontzas, A. N. (2008) · Archives of Physiology and Biochemistry · doi:10.1080/13813450802364627 · Cited by 195
Self-citation
The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation.
Dooley, L. N., Kuhlman, K. R., Robles, T. F., Eisenberger, N. I., Craske, M. G., & Bower, J. E. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.006 · Cited by 176
CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids
Garaulet, M., Lee, Y.-C., Shen, J., Parnell, L. D., Arnett, D. K., Tsai, M. Y., Lai, C.-Q., & Ordovas, J. M. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27536 · Cited by 172
Diurnal Variation of Circulating Interleukin-6 in Humans: A Meta-Analysis
Nilsonne, G., Lekander, M., Åkerstedt, T., Axelsson, J., & Ingre, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165799 · Cited by 171
Effects of recovery sleep after one work week of mild sleep restriction on interleukin-6 and cortisol secretion and daytime sleepiness and performance
Pejovic, S., Basta, M., Vgontzas, A. N., Kritikou, I., Shaffer, M. L., Tsaoussoglou, M., Stiffler, D., Stefanakis, Z., Bixler, E. O., & Chrousos, G. P. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00301.2013 · Cited by 166
Self-citation
Systematic Review of Proinflammatory Cytokines in Obsessive-Compulsive Disorder
Gray, S. M., & Bloch, M. H. (2012) · Current Psychiatry Reports · doi:10.1007/s11920-012-0272-0 · Cited by 167
Increased central microglial activation associated with peripheral cytokine levels in premanifest Huntington's disease gene carriers
Politis, M., Lahiri, N., Niccolini, F., Su, P., Wu, K., Giannetti, P., Scahill, R. I., Turkheimer, F., Tabrizi, S. J., & Piccini, P. P. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.08.011 · Cited by 156
Insomnia symptoms with objective short sleep duration are associated with systemic inflammation in adolescents
Fernandez-Mendoza, J., Baker, J. H., Vgontzas, A. N., Gaines, J., Liao, D., & Bixler, E. O. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.12.026 · Cited by 155
Self-citation
Effects of Ramadan fasting on physical performance and metabolic, hormonal, and inflammatory parameters in middle-distance runners
Chennaoui, M., Desgorces, F.-D., Drogou, C., Boudjemaa, B., Tomaszewski, A., Depiesse, F., Burnat, P., Chalabi, H., & Gomez-Mérino, D. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-014 · Cited by 154
Sleep deprivation worsens inflammation and delays recovery in a mouse model of colitis
Tang, Y., Preuss, F., Turek, F. W., Jakate, S. M., & Keshavarzian, A. (2009) · Sleep Medicine · doi:10.1016/j.sleep.2008.12.009 · Cited by 152
Bidirectional Communication between the Brain and the Immune System: Implications for Physiological Sleep and Disorders with Disrupted Sleep
Lorton, D., Lubahn, C. L., Estus, C., Millar, B. A., Carter, J. L., Wood, C. A., & Bellinger, D. L. (2006) · NeuroImmunoModulation · doi:10.1159/000104864 · Cited by 147
Biomarkers of Psychological Stress in Health Disparities Research
Djurić, Z., Bird, C. E., Furumoto-Dawson, A., Rauscher, G. H., Ruffin, M. T., Stowe, R. P., Tucker, K. L., & Masi, C. M. (2008) · The Open Biomarkers Journal · doi:10.2174/1875318300801010007 · Cited by 150
Differences in cytokines between non-suicidal patients and suicidal patients in major depression
Kim, Y.-K., Lee, S.-W., Kim, S.-H., Shim, S.-H., Han, S.-W., Choi, S.-H., & Lee, B.-H. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.08.041 · Cited by 140
Circadian Timing in the Lung; A Specific Role for Bronchiolar Epithelial Cells
Gibbs, J. E., Beesley, S., Plumb, J., Singh, D., Farrow, S. N., Ray, D. W., & Loudon, A. S. I. (2008) · Endocrinology · doi:10.1210/en.2008-0638 · Cited by 137
Soluble urokinase plasminogen activator receptor is a marker of dysmetabolism in HIV‐infected patients receiving highly active antiretroviral therapy
Andersen, O., Eugen‐Olsen, J., Kofoed, K., Iversen, J., & Haugaard, S. B. (2007) · Journal of Medical Virology · doi:10.1002/jmv.21114 · Cited by 132
Cortisol and inflammatory processes in ovarian cancer patients following primary treatment: Relationships with depression, fatigue, and disability
Schrepf, A., Clevenger, L., Christensen, D., DeGeest, K., Bender, D., Ahmed, A. I., Goodheart, M. J., Dahmoush, L., Penedo, F. J., Lucci, J. A., et al. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.07.022 · Cited by 131
Hypothalamic-Pituitary-Adrenal Axis Activity in Obese Men with and without Sleep Apnea: Effects of Continuous Positive Airway Pressure Therapy
Vgontzas, A. N., Pejovic, S., Zoumakis, E., Lin, H. ‐., Bentley, C. M., Bixler, E. O., Sarrigiannidis, A., Basta, M., & Chrousos, G. P. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0774 · Cited by 129
Self-citation
Effect of time of day and partial sleep deprivation on plasma concentrations of IL-6 during a short-term maximal performance
Abedelmalek, S., Chtourou, H., Aloui, A., Aouichaoui, C., Souissi, N., & Tabka, Z. (2013) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2432-7 · Cited by 128
Sleep Loss as a Factor to Induce Cellular and Molecular Inflammatory Variations
Hurtado‐Alvarado, G., Pavón, L., Castillo-García, S. A., Hernández, M. E., Domı́nguez-Salazar, E., Velázquez‐Moctezuma, J., & Gómez‐González, B. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/801341 · Cited by 130
Impaired Objective Daytime Vigilance in Obesity-Hypoventilation Syndrome
Chouri-Pontarollo, N., Borel, J., Tamisier, R., Wuyam, B., Levy, P. A., & Pépin, J. (2007) · CHEST Journal · doi:10.1378/chest.06-1159 · Cited by 125
Neuroendocrine and neurophysiological effects of interleukin 6 in rheumatoid arthritis
Choy, E., & Calabrese, L. H. (2017) · Rheumatology · doi:10.1093/rheumatology/kex391 · Cited by 126
Short Communication: The Circadian Gene mPer2 Regulates the Daily Rhythm of IFN- γ
Arjona, A., & Sarkar, D. K. (2006) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2006.26.645 · Cited by 121
Selective effects of CPAP on sleep apnoea‐associated manifestations
Vgontzas, A. N., Zoumakis, E., Bixler, E. O., Lin, H., Collins, B., Basta, M., Pejovic, S., & Chrousos, G. P. (2008) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2008.01984.x · Cited by 118
Self-citation
Disturbed sleep is associated with increased C-reactive protein in young women
Okun, M. L., Coussons‐Read, M. E., & Hall, M. H. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.10.008 · Cited by 117
Sleep enhances IL‐6 trans‐signaling in humans
Dimitrov, S., Lange, T., Benedict, C., Nowell, M. A., Jones, S. A., Scheller, J., Rose‐John, S., Born, J., Dimitrov, S., Lange, T., et al. (2006) · The FASEB Journal · doi:10.1096/fj.06-5754fje · Cited by 115
Sleep Disturbances Increase Interleukin-6 Production During Pregnancy: Implications for Pregnancy Complications
Okun, M. L., Hall, M. H., & Coussons‐Read, M. E. (2007) · Reproductive Sciences · doi:10.1177/1933719107307647 · Cited by 116
Measuring salivary markers of inflammation in health research: A review of methodological considerations and best practices
Szabo, Y. Z., & Slavish, D. C. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.105069 · Cited by 98
Sleep and Physiological Dysregulation: A Closer Look at Sleep Intraindividual Variability
Bei, B., Seeman, T. E., Carroll, J., & Wiley, J. F. (2017) · SLEEP · doi:10.1093/sleep/zsx109 · Cited by 118
Etiology and site of temporal lobe epilepsy influence postictal cytokine release
Bauer, S., Cepok, S., Todorova-Rudolph, A., Nowak, M., Köller, M., Lorenz, R., Oertel, W. H., Rosenow, F., Hemmer, B., & Hamer, H. M. (2009) · Epilepsy Research · doi:10.1016/j.eplepsyres.2009.05.009 · Cited by 113
OSA and Cardiovascular Risk in Pediatrics
Smith, D. F., & Amin, R. S. (2019) · CHEST Journal · doi:10.1016/j.chest.2019.02.011 · Cited by 114
Menstrual cycle symptoms are associated with changes in low‐grade inflammation
Puder, J. J., Blum, C. A., Müeller, B., Geyter, C. D., Dye, L., & Keller, U. B. (2005) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2006.01591.x · Cited by 110
Normative variation in self-reported sleep quality and sleep debt is associated with stimulated pro-inflammatory cytokine production
Prather, A. A., Marsland, A. L., Hall, M., Neumann, S. A., Muldoon, M. F., & Manuck, S. B. (2009) · Biological Psychology · doi:10.1016/j.biopsycho.2009.04.008 · Cited by 106
The hypothalamic clock and its control of glucose homeostasis
Kalsbeek, A., Yi, C., la Fleur, S. E., & Fliers, E. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.02.005 · Cited by 112
Human skeletal myotubes display a cell-autonomous circadian clock implicated in basal myokine secretion
Perrin, L., Loizides‐Mangold, U., Skarupelova, S., Pulimeno, P., Chanon, S., Robert, M., Bouzakri, K., Modoux, C., Roux‐Lombard, P., Vidal, H., et al. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.07.009 · Cited by 107
Inflammation and Sleep in Healthy Individuals
Mills, P. J., von Känel, R., Norman, D., Natarajan, L., Ziegler, M. G., & Dimsdale, J. E. (2007) · SLEEP · doi:10.1093/sleep/30.6.729 · Cited by 105
Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors in overweight subjects (GOLDN population)
Garaulet, M., Lee, Y.-C., Shen, J., Parnell, L. D., Arnett, D. K., Tsai, M. Y., Lai, C.-Q., & Ordovas, J. M. (2010) · European Journal of Human Genetics · doi:10.1038/ejhg.2009.176 · Cited by 101
Sleep Dysfunction and Gastrointestinal Diseases.
Khanijow, V., Prakash, P., Emsellem, H. A., Borum, M. L., & Doman, D. B. (2015) · PubMed Central · Cited by 100
ISSLS PRIZE IN CLINICAL SCIENCE 2018: longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode—the good, the bad, and the ugly
Klyne, D. M., Barbe, M. F., van den Hoorn, W., & Hodges, P. W. (2018) · European Spine Journal · doi:10.1007/s00586-018-5490-7 · Cited by 101
Obstructive sleep apnea syndrome is a systemic disease. Current evidence
Zamarrón, C., García-Paz, V., & Riveiro, A. (2008) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2007.12.006 · Cited by 100
Sleep disturbance, cytokines, and fatigue in women with ovarian cancer
Clevenger, L., Schrepf, A., Christensen, D., DeGeest, K., Bender, D., Ahmed, A. I., Goodheart, M. J., Penedo, F. J., Lubaroff, D. M., Sood, A. K., et al. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.04.003 · Cited by 99
Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain
Klyne, D. M., Barbe, M. F., & Hodges, P. W. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.10.003 · Cited by 99
Disturbed Sleep and Inflammatory Cytokines in Depressed and Nondepressed Pregnant Women: An Exploratory Analysis of Pregnancy Outcomes
Okun, M. L., Luther, J. F., Wisniewski, S. R., & Wisner, K. L. (2013) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31829cc3e7 · Cited by 94
Cortisol awakening rise in middle-aged women in relation to psychological stress.
O'Connor, D. B., Hendrickx, H., Dadd, T., Elliman, T. D., Willis, T. A., Talbot, D., Mayes, A., Thethi, K., Powell, J., & Dye, L. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.002 · Cited by 100
The factors associated with pain severity in patients with knee osteoarthritis vary according to the radiographic disease severity: a cross-sectional study
Shimura, Y., Kurosawa, H., Sugawara, Y., Tsuchiya, M., Sawa, M., Kaneko, H., Futami, I., Liu, L., SADATSUKI, R., HADA, S., et al. (2013) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2013.05.014 · Cited by 91
Interleukin-6 and melanoma
Hoejberg, L., Bastholt, L., & Schmidt, H. (2012) · Melanoma research · doi:10.1097/cmr.0b013e3283543d72 · Cited by 87
Effects of Partial Sleep Deprivation on Proinflammatory Cytokines, Growth Hormone, and Steroid Hormone Concentrations During Repeated Brief Sprint Interval Exercise
Abedelmalek, S., Souissi, N., Chtourou, H., Denguezli, M., Aouichaoui, C., Ajina, M. Z., Aloui, A., Dogui, M., Haddouk, S., & Tabka, Z. (2013) · Chronobiology International · doi:10.3109/07420528.2012.742102 · Cited by 90
Sleep and energy balance: interactive homeostatic systems
VanItallie, T. B. (2006) · Metabolism · doi:10.1016/j.metabol.2006.07.010 · Cited by 89
Circadian control of pain and neuroinflammation
Segal, J. P., Tresidder, K. A., Bhatt, C., Gilron, I., & Ghasemlou, N. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24150 · Cited by 97
Systemic effects of IL-6 blockade in rheumatoid arthritis beyond the joints
Jarlborg, M., & Gabay, C. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155742 · Cited by 90
Acute effects of exposure to vapours of acetic acid in humans
Ernstgård, L., Iregren, A., Sjögren, B., & Johanson, G. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.01.010 · Cited by 87
The Efficacy of Hypericum perforatum (St Johnʼs Wort) for the Treatment of Premenstrual Syndrome
Canning, S. E., Waterman, M. G., Orsi, N. M., Ayres, J., Simpson, N., & Dye, L. (2010) · CNS Drugs · doi:10.2165/11530120-000000000-00000 · Cited by 89
Pre-analytical and biological variability in circulating interleukin 6 in healthy subjects and patients with rheumatoid arthritis
Knudsen, L. S., Christensen, I. J., Lottenburger, T., Svendsen, M. N., Nielsen, H. J., Nielsen, L., Hørslev‐Petersen, K., Jensen, J. B., Kollerup, G., & Johansen, J. S. (2008) · Biomarkers · doi:10.1080/13547500701615017 · Cited by 86
Enhancing influence of intranasal interleukin‐6 on slowwave activity and memory consolidation during sleep
Benedict, C., Scheller, J., Rose‐John, S., Jan Born, A., & Marshall, L. (2009) · The FASEB Journal · doi:10.1096/fj.08-122853 · Cited by 88
Population differences in proinflammatory biology: Japanese have healthier profiles than Americans
Coe, C. L., Love, G. D., Karasawa, M., Kawakami, N., Kitayama, S., Markus, H. R., Tracy, R. P., & Ryff, C. D. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.11.013 · Cited by 83
Obesity and sleep disturbances: Meaningful sub-typing of obesity
Vgontzas, A. N., Bixler, E. O., Chrousos, G. P., & Pejovic, S. (2008) · Archives of Physiology and Biochemistry · doi:10.1080/13813450802521507 · Cited by 82
Self-citation
Sustained Elevation of Serum Interleukin-6 and Relative Insensitivity to Hydrocortisone Differentiates Posttraumatic Stress Disorder with and Without Depression
Gill, J., Luckenbaugh, D., Charney, D., & Vythilingam, M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.033 · Cited by 80
Neuroinflammation and Non-motor Symptoms: The Dark Passenger of Parkinson’s Disease?
Barnum, C. J., & Tansey, M. G. (2012) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-012-0283-6 · Cited by 82
Evidence of NI‐0101 pharmacological activity, an anti‐TLR4 antibody, in a randomized phase I dose escalation study in healthy volunteers receiving LPS
Monnet, E., Lapeyre, G., van Poelgeest, E. P., Jacqmin, P., de Graaf, K., Reijers, J. A. A., Moerland, M., Burggraaf, J., & de Min, C. (2016) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.522 · Cited by 79
Circadian disruption of ICU patients: A review of pathways, expression, and interventions
Korompeli, A., Muurlink, O. T., Kavrochorianou, N., Katsoulas, T. A., Fildissis, G., & Baltopoulos, G. J. (2016) · Journal of Critical Care · doi:10.1016/j.jcrc.2016.12.006 · Cited by 81
Inflammation mediates the association between visceral adiposity and obstructive sleep apnea in adolescents
Gaines, J., Vgontzas, A. N., Fernández‐Mendoza, J., Calhoun, S. L., He, F., Liao, D., Sawyer, M. D., & Bixler, E. O. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00249.2016 · Cited by 78
Self-citation
Applications of artificial intelligence−machine learning for detection of stress: a critical overview
Mentis, A.-F. A., Lee, D., & Roussos, P. (2024) · Molecular Psychiatry · doi:10.1038/s41380-023-02047-6 · Cited by 75
Acute hyperinsulinemia raises plasma interleukin-6 in both nondiabetic and type 2 diabetes mellitus subjects, and this effect is inversely associated with body mass index
Ruge, T., Lockton, J. A., Renström, F., Lystig, T., Sukonina, V., Svensson, M. K. E., & Eriksson, J. W. (2009) · Metabolism · doi:10.1016/j.metabol.2009.02.010 · Cited by 76
Sleep disruption induces activation of inflammation and heightens risk for infectious disease: Role of impairments in thermoregulation and elevated ambient temperature
Irwin, M. R. (2022) · Temperature · doi:10.1080/23328940.2022.2109932 · Cited by 80
Minocycline and aspirin in the treatment of bipolar depression: a protocol for a proof-of-concept, randomised, double-blind, placebo-controlled, 2×2 clinical trial
Savitz, J. B., Preskorn, S., Teague, T. K., Drevets, D. A., Yates, W. R., & Drevets, W. (2012) · BMJ Open · doi:10.1136/bmjopen-2011-000643 · Cited by 73
Obstructive Sleep Apnea and Risk of Osteoporosis: A Population-Based Cohort Study in Taiwan
Chen, Y., Weng, S., Shen, Y., Chou, C., Yang, C.-Y., Wang, J., & Tien, K. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1718 · Cited by 70
Fatigue, Tiredness, Lack of Energy, and Sleepiness in Multiple Sclerosis Patients Referred for Clinical Polysomnography
Braley, T. J., Chervin, R. D., & Segal, B. M. (2012) · Multiple Sclerosis International · doi:10.1155/2012/673936 · Cited by 68
Il-6 Involvement in pain, fatigue and mood disorders in rheumatoid arthritis and the effects of Il-6 inhibitor sarilumab
Atzeni, F., Nucera, V., Masala, I. F., Sarzi‐Puttini, P., & Bonitta, G. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104402 · Cited by 66
Oscillations in the immune system
Stark, J., Chan, C. C. W., & George, A. J. T. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00501.x · Cited by 66
Daily Step Count Is Associated With Plasma C-Reactive Protein and IL-6 in a US Cohort With COPD
Moy, M. L., Teylan, M., Weston, N. A., GAGNON, D. R., Danilack, V. A., & Garshick, E. (2013) · CHEST Journal · doi:10.1378/chest.13-1052 · Cited by 66
Racial discrimination predicts greater systemic inflammation in pregnant African American women
Giurgescu, C., Engeland, C. G., Templin, T., Zenk, S. N., Koenig, M. D., & Garfield, L. (2016) · Applied Nursing Research · doi:10.1016/j.apnr.2016.06.008 · Cited by 65
Anxiety, not anger, induces inflammatory activity: An avoidance/approach model of immune system activation.
Moons, W. G., & Shields, G. S. (2015) · Emotion · doi:10.1037/emo0000055 · Cited by 64
Circadian rhythmicity, variability and correlation of interleukin-6 levels in plasma and cerebrospinal fluid of healthy men
Agorastos, A., Hauger, R. L., Barkauskas, D. A., Moeller‐Bertram, T., Clopton, P., Haji, U., Lohr, J. B., Geracioti, T. D., Patel, P. M., Chrousos, G. P., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.02.020 · Cited by 65
Self-citation
Sleep Apnea and its Association with the Stress System, Inflammation, Insulin Resistance and Visceral Obesity
Trakada, G., Chrousos, G. P., Pejovic, S., & Vgontzas, A. N. (2007) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2007.04.003 · Cited by 67
Self-citation
Moderate blast exposure results in increased IL-6 and TNFα in peripheral blood
Gill, J., Motamedi, V., Osier, N. D., Dell, K. C., Arcurio, L. R., Carr, W. S., Walker, P., Ahlers, S. T., LoPresti, M. L., & Yarnell, A. M. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.02.015 · Cited by 63
The role of interleukins in preeclampsia: A comprehensive review
Bellos, I., Karageorgiou, V., Kapnias, D., Karamanli, K., & Siristatidis, C. S. (2018) · American Journal of Reproductive Immunology · doi:10.1111/aji.13055 · Cited by 64
Anti-inflammatory effect of naringin and sericin combination on human peripheral blood mononuclear cells (hPBMCs) from patient with psoriasis
Deenonpoe, R., Prayong, P., Thippamom, N., Meephansan, J., & Na‐Bangchang, K. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2535-3 · Cited by 62
Determinants of sleepiness in obstructive sleep apnea
Prasad, B., Steffen, A. D., Dongen, H. P. A. V., Pack, F. M., Strakovsky, I., Staley, B. A., Dinges, D. F., Maislin, G., Pack, A. I., & Weaver, T. E. (2018) · SLEEP · doi:10.1093/sleep/zsx199 · Cited by 65
Endogenous cortisol determines the circadian rhythm of lipopolysaccharide‐ but not lipoteichoic acid‐inducible cytokine release
Hermann, C., von Aulock, S., Dehus, O., Keller, M., Okigami, H., Gantner, F., Wendel, A., & Härtung, T. (2006) · European Journal of Immunology · doi:10.1002/eji.200535470 · Cited by 63

Authors: Vgontzas, A. N., Bixler, E. O., Lin, H.-M., Prolo, P., Trakada, G., & Chrousos, G. P.
Affiliations: Pennsylvania State University (US)
University of California, Los Angeles (US)
National Institutes of Health (US)
ORCID: Lin, H.-M.
Trakada, G.
Chrousos, G.P.
Venue: Neuroimmunomodulation
Publisher: S. Karger AG
Published: 2005
Volume: 12
Issue: 3
Pages: 131-140
ISSN: 1021-7401 (ISSN-L)
1423-0216
DOI: 10.1159/000084844
OpenAlex: W1970138464
Cited by: 338
References: 47
Citations by year: 2026: 9 · 2025: 18 · 2024: 10 · 2023: 20 · 2022: 14 · 2021: 7 · 2020: 19 · 2019: 22 · 2018: 12 · 2017: 19 · 2016: 16 · 2015: 14 · 2014: 10 · 2013: 17 · 2012: 20
FWCI: 1.96
Type: journal article
Language: en
Open access: closed
Licence: www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)
Locations: NeuroImmunoModulation (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: interleukin-6, circadian rhythm, sleepiness, sleep deprivation, narcolepsy, obstructive sleep apnea, obesity, insomnia, cortisol, aging, cosinor analysis, sleep homeostasis, rats
MeSH terms: Aging, Animals, Circadian Rhythm, Homeostasis, Humans, Hydrocortisone, Sleep, Sleep Wake Disorders, Species Specificity, Interleukin-6, Up-Regulation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

IL-6 and Its Circadian Secretion in Humans

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks