Role of interleukin-6 in stress, sleep, and fatigue
Abstract
Chronic low‐grade inflammation, in particular increased concentrations of proinflammatory cytokines such as interleukin (IL)‐6 in the circulation, is observed with increasing age, but it is also as a consequence of various medical and psychological conditions, as well as life‐style choices. Since molecules such as IL‐6 have pleiotropic effects, consequences are wide ranging. This short review summarizes the evidence showing how IL‐6 elevations in the context of inflammatory disease affect the organism, with a focus on sleep‐related symptoms and fatigue; and conversely, how alterations in sleep duration and quality stimulate increased concentrations of IL‐6 in the circulation. Research showing that acute as well as chronic psychological stress also increase concentrations of IL‐6 supports the notion of a close link between an organism's response to physiological and psychological perturbations. The findings summarized here further underscore the particular importance of IL‐6 as a messenger molecule that connects peripheral regulatory processes with the CNS.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Laboratory studies have shown that physiologic sleep restriction is associated with a proinflammatory state, including elevations in inflammatory cytokines such as IL-1B, IL-6, IL-17, TNF-α, and C-reactive protein.
“Laboratory studies have shown that physiologic sleep restriction is associated with a proinflamma-tory state, including elevations in inflammatory cytokines, such as interleukin 1B (IL-1B),64,65 IL-6,64,66–68 IL-17,64,69 tumor necrosis factor-α,64,68,70–72 and C-reactive protein.64,69,73–76”
From Sleep, Health, and Society (2017) · cites this paper as [67]
Cites
Acute-Phase Proteins and Other Systemic Responses to Inflammation
Gabay, C., & Kushner, I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400607 · Cited by 6,734 · see citing works
Aletaha, D., Neogi, T., Silman, A. J., Funovits, J., Felson, D. T., Bingham, C. O., Birnbaum, N. S., Burmester, G. R., Bykerk, V. P., Cohen, M. D., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.138461 · Cited by 4,959 · see citing works
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803 · see citing works
Two-Process Model of Sleep Regulation
Binder, M. D., Hirokawa, N., & Windhorst, U. (2008) · Springer eBooks · doi:10.1007/978-3-540-29678-2_6166 · Cited by 3,895 · see citing works
The anti-inflammatory effect of exercise
Petersen, A. M. W., & Pedersen, B. K. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00164.2004 · Cited by 3,100 · see citing works
Baumann, H., & Gauldie, J. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90137-6 · Cited by 2,907 · see citing works
Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650 · see citing works
Zhong, Z., Wen, Z., & Darnell, J. E. (1994) · Science · doi:10.1126/science.8140422 · Cited by 2,070 · see citing works
Xing, Z., Gauldie, J., Cox, G., Baumann, H., Jordana, M., Lei, X.-F., & Achong, M. K. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1368 · Cited by 1,578 · see citing works
Immune-neuro-endocrine interactions: facts and hypotheses.
BESEDOVSKY, H. O., & REY, A. D. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-1-64 · Cited by 1,564 · see citing works
Smolen, J. S., Beaulieu, A. D., Rubbert‐Roth, A., Ramos-Remus, C., Rovensky, J., Alecock, E., WOODWORTH, T. G., & Alten, R. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60453-5 · Cited by 1,399 · see citing works
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
Taga, T., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T., & Kishimoto, T. (1989) · Cell · doi:10.1016/0092-8674(89)90438-8 · Cited by 1,396 · see citing works
Gangwisch, J. E., Heymsfield, S. B., Boden-Albala, B., Buijs, R. M., Kreier, F., Pickering, T. G., Rundle, A. G., Zammit, G. K., & Malaspina, D. (2006) · Hypertension · doi:10.1161/01.hyp.0000217362.34748.e0 · Cited by 1,284 · see citing works
Steptoe, A., Hamer, M., & Chida, Y. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.03.011 · Cited by 1,278 · see citing works
Chronic stress and age-related increases in the proinflammatory cytokine IL-6.
Kiecolt-Glaser, J. K., Preacher, K. J., MacCallum, R. C., Atkinson, C., Malarkey, W. B., & Glaser, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1531903100 · Cited by 1,220 · see citing works
Emery, P., Keystone, E., Tony, H. P., Cantagrel, A., van Vollenhoven, R., Sanchez, A., Alecock, E., Lee, J., & Kremer, J. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.092932 · Cited by 1,104 · see citing works
Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor
Yamasaki, K., Taga, T., Hirata, Y., Yawata, H., Kawanishi, Y., Seed, B., Taniguchi, T., Hirano, T., & Kishimoto, T. (1988) · Science · doi:10.1126/science.3136546 · Cited by 1,053 · see citing works
Adverse Effects of Modest Sleep Restriction on Sleepiness, Performance, and Inflammatory Cytokines
Vgontzas, A. N., Zoumakis, E., Bixler, E. O., Lin, H.-M., Follett, H., Kales, A., & Chrousos, G. P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031562 · Cited by 1,050 · see citing works
Felson, D. T., Smolen, J. S., Wells, G. A., Zhang, B., van Tuyl, L. H. D., Funovits, J., Aletaha, D., Allaart, C. F., Bathon, J. M., Bombardieri, S., et al. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30129 · Cited by 1,025 · see citing works
Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Kales, A., Tyson, K., & Chrousos, G. P. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.5.3950 · Cited by 974 · see citing works
A mechanism converting psychosocial stress into mononuclear cell activation
Bierhaus, A., Wolf, J., Andrassy, M., Rohleder, N., Humpert, P. M., Petrov, D., Ferstl, R., von Eynatten, M., Wendt, T., Rudofsky, G., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0438019100 · Cited by 926 · see citing works
Self-citationGarlanda, C., Bottazzi, B., Bastone, A., & Mantovani, A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115756 · Cited by 885 · see citing works
Genovese, M. C., McKay, J. D., Nasonov, E. L., Mysler, E. F., da Silva, N. A., Alecock, E., Woodworth, T., & Gomez‐Reino, J. J. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23940 · Cited by 855 · see citing works
Pace, T. W. W., Mletzko, T. C., Alagbe, O., Musselman, D. L., Nemeroff, C. B., Miller, A. H., & Heim, C. M. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1630 · Cited by 810 · see citing works
Pace, T. W. W., Negi, L. T., Adame, D. D., Cole, S. P., Sivilli, T. I., Brown, T. D., Issa, M. J., & Raison, C. L. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.08.011 · Cited by 748 · see citing works
Nishimoto, N., Hashimoto, J., Miyasaka, N., Yamamoto, K., Kawai, S., Takeuchi, T., Murata, N., van der Heijde, D. M. F. M., & Kishimoto, T. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.068064 · Cited by 727 · see citing works
A Prospective Study of Sleep Duration and Mortality Risk in Women
Patel, S. R., Ayas, N. T., Malhotra, M. R., White, D. P., Schernhammer, E. S., Speizer, F. E., Stampfer, M. J., & Hu, F. B. (2004) · Sleep · doi:10.1093/sleep/27.3.440 · Cited by 663 · see citing works
Rose‐John, S., Scheller, J., Elson, G., & Jones, S. A. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1105674 · Cited by 647 · see citing works
Interleukin 6: from bench to bedside
Nishimoto, N., & Kishimoto, T. (2006) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0338 · Cited by 639 · see citing works
Sleep Duration and Biomarkers of Inflammation
Patel, S. R., Zhu, X., Storfer-Isser, A., Mehra, R., Jenny, N. S., Tracy, R., & Redline, S. (2009) · Sleep · doi:10.1093/sleep/32.2.200 · Cited by 615 · see citing works
Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action
Benveniste, E. N. (1992) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1992.263.1.c1 · Cited by 608 · see citing works
Grandner, M. A., Hale, L., Moore, M., & Patel, N. P. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.07.006 · Cited by 602 · see citing works
Sleep Duration as a Risk Factor for Diabetes Incidence in a Large US Sample
Gangwisch, J. E., Heymsfield, S. B., Boden-Albala, B., Buijs, R. M., Kreier, F., Pickering, T. G., Rundle, A. G., Zammit, G. K., & Malaspina, D. (2007) · Sleep · doi:10.1093/sleep/30.12.1667 · Cited by 573 · see citing works
IL-1 stimulates IL-6 production in endothelial cells.
Sironi, M., Breviario, F., Proserpio, P., Biondi, A., Vecchi, A., Damme, J. V., Dejana, E., & Mantovani, A. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.2.549 · Cited by 522 · see citing works
Circadian Interleukin-6 Secretion and Quantity and Depth of Sleep
Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Lotsikas, A., Zachman, K., Kales, A., Prolo, P., Wong, M.-L., Licinio, J., Gold, P. W., et al. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.8.5894 · Cited by 516 · see citing works
Zhou, D., Kusnecov, A. W., Shurin, M. R., DePaoli, M., & Rabin, B. S. (1993) · Endocrinology · doi:10.1210/endo.133.6.8243274 · Cited by 494 · see citing works
The paradigm of IL-6: from basic science to medicine.
Naka, T., Nishimoto, N., & Kishimoto, T. (2002) · Arthritis Research · doi:10.1186/ar565 · Cited by 480 · see citing works
Interleukin‐6: A Cytokine for Gerontolgists
Ershler, W. B. (1993) · Journal of The American Geriatrics Society · doi:10.1111/j.1532-5415.1993.tb02054.x · Cited by 480 · see citing works
Association between plasma IL-6 response to acute stress and early-life adversity in healthy adults
Carpenter, L. L., Gawuga, C. E., Tyrka, A. R., Lee, J. K., Anderson, G. M., & Price, L. H. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.159 · Cited by 464 · see citing works
Inflammation as a psychophysiological biomarker in chronic psychosocial stress
Hänsel, A., Hong, S., Cámara, R. J. A., & von Känel, R. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.12.012 · Cited by 458 · see citing works
Shearer, W. T., Reuben, J. M., Mullington, J. M., Price, N. J., Lee, B.-N., Smith, E. O., Szuba, M. P., Van Dongen, H. P. A., & Dinges, D. F. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.112270 · Cited by 455 · see citing works
TNF-α suppresses the expression of clock genes by interfering with E-box-mediated transcription
Cavadini, G., Petrzilka, S., Kohler, P. P., Jud, C., Tobler, I., Birchler, T., & Fontana, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701466104 · Cited by 421 · see citing works
Kremer, J. M., Blanco, R., Brzosko, M., Burgos‐Vargas, R., Halland, A.-M., Vernon, E., Ambs, P., & Fleischmann, R. (2010) · Arthritis & Rheumatism · doi:10.1002/art.30158 · Cited by 405 · see citing works
Circadian system, sleep and endocrinology
Morris, C. J., Aeschbach, D., & Scheer, F. A. J. L. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.003 · Cited by 403 · see citing works
Späth‐Schwalbe, E. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.5.1573 · Cited by 377 · see citing works
Redwine, L. S., Hauger, R. L., Gillin, J. C., & Irwin, M. R. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.10.6871 · Cited by 373 · see citing works
Effects of sleep and sleep loss on immunity and cytokines
Irwin, M. R. (2002) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(02)00003-x · Cited by 366 · see citing works
Blockade of TNF-α rapidly inhibits pain responses in the central nervous system
Heß, A., Axmann, R., Rech, J., Finzel, S., Heindl, C., Kreitz, S., Sergeeva, M., Saake, M., Garcia, M., Kollias, G. A., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011774108 · Cited by 357 · see citing works
IL-6 and its circadian secretion in humans
Vgontzas, A. N., Bixler, E. O., Lin, H.-M., Prolo, P., Trakada, G., & Chrousos, G. P. (2005) · Neuroimmunomodulation · doi:10.1159/000084844 · Cited by 338 · see citing works
Stress, Inflammation, and Yoga Practice
Kiecolt-Glaser, J. K., Christian, L., Preston, H., Houts, C. R., Malarkey, W. B., Emery, C. F., & Glaser, R. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181cb9377 · Cited by 327 · see citing works
The effects of psychological stress on plasma interleukin-6 activity in rats
LeMay, L. G., Vander, A. J., & Kluger, M. J. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90024-x · Cited by 313 · see citing works
Neuroendocrine regulation of autoimmune/inflammatory disease
Sternberg, E. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1690429 · Cited by 308 · see citing works
Life stress, mood disturbance, and elevated interleukin-6 in healthy older women
Lutgendorf, S. K., Garand, L., Buckwalter, K. C., Reimer, T. T., Hong, S.-Y., & Lubaroff, D. M. (1999) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/54.9.m434 · Cited by 305 · see citing works
Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people
BRUUNSGAARD, H., LADELUND, S., PEDERSEN, A. N., SCHROLL, M., JØRGENSEN, T., & PEDERSEN, B. K. (2003) · Clinical and Experimental Immunology · doi:10.1046/j.1365-2249.2003.02137.x · Cited by 300 · see citing works
Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130.
Narazaki, M., Witthuhn, B. A., Yoshida, K., Silvennoinen, O., Yasukawa, K., Ihle, J. N., Kishimoto, T., & Taga, T. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2285 · Cited by 299 · see citing works
Redwine, L. S. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.10.3597 · Cited by 285 · see citing works
Involvement of IL-6 signal transducer gp130 in IL-11-mediated signal transduction.
Yin, T., Taga, T., Tsang, M., Yasukawa, K., Kishimoto, T., & Yang, Y. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.5.2555 · Cited by 262 · see citing works
Psychosocial Factors and Inflammation in the Multi-Ethnic Study of Atherosclerosis
Ranjit, N. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.2.174 · Cited by 261 · see citing works
Crofford, L. J. (1997) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.4.1279 · Cited by 242 · see citing works
Interleukin 1 alters rat sleep: temporal and dose-related effects
Opp, M. R., Obal, F., & Krueger, J. M. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.260.1.r52 · Cited by 232 · see citing works
Papanicolaou, D. A., Petrides, J. S., Tsigos, C., Bina, S., Kalogeras, K. T., Wilder, R. L., Gold, P. W., Deuster, P. A., & Chrousos, G. P. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.3.e601 · Cited by 225 · see citing works
Fatigue in rheumatoid arthritis: time for a conceptual model
HEWLETT, S. E., Chalder, T., Choy, E., Cramp, F. L., Davis, B., Dures, E. K., Nicholls, C., & Kirwan, J. (2010) · Lara D. Veeken · doi:10.1093/rheumatology/keq282 · Cited by 214 · see citing works
von Känel, R., Dimsdale, J. E., Mills, P. J., Ancoli-Israel, S., Patterson, T. L., Mausbach, B. T., & Grant, I. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.9.963 · Cited by 196 · see citing works
Vgontzas, A. N., Pejovic, S., Zoumakis, E., Lin, H. M., Bixler, E. O., Basta, M., Fang, J., Sarrigiannidis, A., & Chrousos, G. P. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00651.2005 · Cited by 194 · see citing works
β-Adrenergic Regulation of IL-6 Release from Adipose Tissue:In Vivoandin VitroStudies
Mohamed‐Ali, V., Flower, L., Sethi, J. K., Hotamışlıgil, G. S., Gray, R. P., Humphries, S. E., York, D. A., & Pinkney, J. H. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8104 · Cited by 190 · see citing works
Socioeconomic status and stress-induced increases in interleukin-6
Brydon, L., Edwards, S., Mohamed‐Ali, V., & Steptoe, A. (2003) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2003.09.011 · Cited by 189 · see citing works
The relation among stress, adrenalin, interleukin 6 and acute phase proteins in the rat
Gool, J. V., van Vugt, H., Helle, M., & Aarden, L. A. (1990) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(90)90034-n · Cited by 179 · see citing works
Brydon, L., Walker, C., Wawrzyniak, A., Whitehead, D., Okamura, H., Yajima, J., Tsuda, A., & Steptoe, A. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.09.007 · Cited by 164 · see citing works
Burmester, G. R., Feist, E., Kellner, H., Braun, J., Iking‐Konert, C., & Rubbert‐Roth, A. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.139725 · Cited by 164 · see citing works
Humoral Links between Sleep and the Immune System
Krueger, J. M., & Majde, J. A. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03133.x · Cited by 163 · see citing works
Interleukin-6: The Endocrine Cytokine
Papanicolaou, D. A. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.3.6582 · Cited by 159 · see citing works
Excess mortality emerges after 10 years in an inception cohort of early rheumatoid arthritis
Radovits, B. J., Fransen, J., Shamma, S. A., et al. (2010) · Arthritis Care & Research · doi:10.1002/acr.20105 · Cited by 144 · see citing works
Ancoli‐Israel, S. (2006) · PubMed · Cited by 141 · see citing works
Induction of plasma interleukin-6 by circulating adrenaline in the rat
DeRijk, R. H., Boelen, A., Tilders, F. J. H., & BERKENBOSCH, F. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90005-1 · Cited by 139 · see citing works
Inflammatory Cytokines in Nonpathological States
Cannon, J. G. (2000) · Physiology · doi:10.1152/physiologyonline.2000.15.6.298 · Cited by 137 · see citing works
Hamer, M., & Steptoe, A. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318148c4c0 · Cited by 135 · see citing works
Negative affective responses to a speech task predict changes in interleukin (IL)-6
Carroll, J. E., Low, C. A., Prather, A. A., Cohen, S., Fury, J. M., Ross, D. C., & Marsland, A. L. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.09.024 · Cited by 128 · see citing works
Testosterone and IL-6 requirements for human C-reactive protein gene expression in transgenic mice.
Szalai, A., van Ginkel, F. V., Dalrymple, S., Murray, R., Mcghee, J., & Volanakis, J. (1998) · Journal of Immunology · doi:10.4049/jimmunol.160.11.5294 · Cited by 127 · see citing works
Tauman, R., O'Brien, L. M., & Gozal, D. (2006) · Sleep And Breathing · doi:10.1007/s11325-006-0085-7 · Cited by 121 · see citing works
Self-esteem levels and cardiovascular and inflammatory responses to acute stress.
O’Donnell, K., Brydon, L., Wright, C. E., & Steptoe, A. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.06.012 · Cited by 118 · see citing works
Disturbed sleep is associated with increased C-reactive protein in young women
Okun, M. L., Coussons‐Read, M. E., & Hall, M. H. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.10.008 · Cited by 117 · see citing works
Sleep enhances IL‐6 trans‐signaling in humans
Dimitrov, S., Lange, T., Benedict, C., Nowell, M. A., Jones, S. A., Scheller, J., Rose‐John, S., Born, J., Dimitrov, S., Lange, T., et al. (2006) · The FASEB Journal · doi:10.1096/fj.06-5754fje · Cited by 115 · see citing works
Chauffier, K., Salliot, C., Berenbaum, F., & Sellam, J. (2011) · Lara D. Veeken · doi:10.1093/rheumatology/ker162 · Cited by 114 · see citing works
Interleukin-6 alters sleep of rats
Hogan, D. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00038-9 · Cited by 112 · see citing works
Soluble Interleukin 6 Receptor
Mehra, R. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.16.1725 · Cited by 96 · see citing works
Nikolaisen, C., Figenschau, Y., & Nossent, J. C. (2008) · PubMed · Cited by 89 · see citing works
Exploring the cytokine and endocrine involvement in narcolepsy
Okun, M. L., Giese, S., Lin, L., Einen, M. A., Mignot, E. J.-M., & Coussons‐Read, M. E. (2003) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2003.11.002 · Cited by 89 · see citing works
Chronic Systemic Inflammation in Overweight and Obese Adults
Vgontzas, A. N., Bixler, E. O., Papanicolaou, D. A., & Chrousos, G. P. (2000) · JAMA · doi:10.1001/jama.283.17.2235-c · Cited by 87 · see citing works
Determinants of the NF-κB response to acute psychosocial stress in humans
Wolf, J. M., Rohleder, N., Bierhaus, A., Nawroth, P. P., & Kirschbaum, C. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.09.009 · Cited by 87 · see citing works
Self-citationTeramoto, S., Yamamoto, H., & Ouchi, Y. (2003) · Circulation · doi:10.1161/01.cir.0000053956.46188.5f · Cited by 86 · see citing works
The Role of Interleukin-6 in Certain Age-Related Diseases
Ershler, W. B., Sun, W., & Binkley, N. (1994) · Drugs & Aging · doi:10.2165/00002512-199405050-00005 · Cited by 82 · see citing works
Sleep Disturbances and Interleukin 6 Receptor Inhibition in Rheumatoid Arthritis
FRAGIADAKI, K., TEKTONIDOU, M. G., KONSTA, M., CHROUSOS, G. P., & SFIKAKIS, P. P. (2012) · The Journal of Rheumatology · doi:10.3899/jrheum.110617 · Cited by 82 · see citing works
The Human PER1 Gene is Inducible by Interleukin-6
Motzkus, D., Albrecht, U., & Maronde, E. (2002) · Journal of Molecular Neuroscience · doi:10.1385/jmn:18:1-2:105 · Cited by 71 · see citing works
-Adrenergic Regulation of IL-6 Release from Adipose Tissue: In Vivo and in Vitro Studies
Mohamed‐Ali, V. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.12.5864 · Cited by 69 · see citing works
Association of anemia and physical disability among patients with rheumatoid arthritis.
Han, C., Rahman, M. U., Doyle, M. K., Bathon, J. M., Smolen, J. S., Kavanaugh, A., Westhovens, R., Clair, E. W. S., Baker, D., & BALA, M. M. (2007) · PubMed · Cited by 66 · see citing works
Neu, D., Maîresse, O., Hoffmann, G., Valsamis, J.-B., Verbanck, P., Linkowski, P., & Bon, O. L. (2010) · Neuroepidemiology · doi:10.1159/000301714 · Cited by 60 · see citing works
Unemployment and ill health: a connection through inflammation?
Hintikka, J. J., Lehto, S. M., NISKANEN, L. K., Huotari, A., Herzig, K., Koivumaa-Honkanen, H. T., Honkalampi, K. M., Sinikallio, S., & Viinamäki, H. T. (2009) · BMC Public Health · doi:10.1186/1471-2458-9-410 · Cited by 54 · see citing works
Olivadoti, M. D., & Opp, M. R. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.008 · Cited by 53 · see citing works
Søndergaard, S. R., Ostrowski, K., Ullum, H., & Pedersen, B. K. (2000) · European Journal of Applied Physiology · doi:10.1007/s004210000257 · Cited by 52 · see citing works
Richlin, V. A., Arevalo, J. M. G., Zack, J. A., & Cole, S. W. (2003) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2003.08.001 · Cited by 49 · see citing works
Fluorescent stilbene (BADS) binding proteins in anion-transporting epithelia
Pearce, S. F. A., & Zadunaisky, J. A. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.259.3.c439 · Cited by 37 · see citing works
Cytokine Expression in the Rat Adrenal Cortex
Judd, A. (1998) · Hormone and Metabolic Research · doi:10.1055/s-2007-978905 · Cited by 36 · see citing works
Iking‐Konert, C., Aringer, M., Wollenhaupt, J., et al. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2011.152678 · Cited by 29 · see citing works
Self-citationvon Känel, R., Kudielka, B. M., Metzenthin, P., Helfricht, S., Preckel, D., Haeberli, A., Stutz, M., & Fischer, J. E. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.07.005 · Cited by 27 · see citing works
Psychosocial and Biological Indicators of Depression in the Caregiving Population
Clark, M. C., Nicholas, J., Wassira, L. N., & Gutierrez, A. P. (2011) · Biological Research For Nursing · doi:10.1177/1099800411414872 · Cited by 20 · see citing works
Teramoto, S., Yamamoto, H., & Ouchi, Y. (2004) · CHEST Journal · doi:10.1378/chest.125.5.1964 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa
Dantzer, R. (2018) · Physiological Reviews · doi:10.1152/physrev.00039.2016 · Cited by 1,073 · see citing works
Grandner, M. A. (2017) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2016.10.012 · Cited by 720 · see citing works
Periodontal therapy and cardiovascular risk
Orlandi, M., Graziani, F., & D'Aiuto, F. (2020) · Periodontology 2000 · doi:10.1111/prd.12299 · Cited by 155 · see citing works
Saber, M., Giordano, K. R., Hur, Y., Ortiz, J. B., Morrison, H., Godbout, J. P., Murphy, S. M., Lifshitz, J., & Rowe, R. K. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14611 · Cited by 46 · see citing works
Clinical Phenotype of Depression Affects Interleukin-6 Synthesis
Zadka, Ł., Dzięgiel, P., Kulus, M., & Olajossy, M. (2017) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2016.0074 · Cited by 20 · see citing works
- Authors
- Rohleder, N., Aringer, M., & Boentert, M.
- Affiliations
- Brandeis University (US)
- University Hospital Carl Gustav Carus (DE)
- University Hospital Münster (DE)
- Corresponding author
- Rohleder, Nicolas
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2012-07
- Volume
- 1261
- Issue
- 1
- Pages
- 88-96
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1779727726
- Semantic Scholar
- ef054203f05379a442c74ff23a3577ba7fddb174
- Cited by
- 289
- References
- 106
- Citations by year
- 2026: 14 · 2025: 25 · 2024: 13 · 2023: 18 · 2022: 22 · 2021: 21 · 2020: 32 · 2019: 18 · 2018: 28 · 2017: 28 · 2016: 22 · 2015: 23 · 2014: 12 · 2013: 12 · 2012: 1
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- interleukin-6, inflammatory cytokines, low-grade inflammation, psychological stress, sleep, fatigue, sleep quality, sleep duration, sleep symptoms, inflammatory diseases, central nervous system
- MeSH terms
- Interleukin-6 Inhibitors, Animals, Arthritis, Rheumatoid, Fatigue, Humans, Immune System, Sleep Wake Disorders, Stress, Physiological, Stress, Psychological, Neuroimmunomodulation, Interleukin-6, Mice, Antibodies, Monoclonal, Humanized
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
