The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Structural correlates of apathy in Alzheimer's disease
Abstract
BACKGROUND: Apathy is the most common noncognitive symptom in Alzheimer's disease (AD). The structural correlates of apathy in AD have not yet been described. METHODS: We analyzed magnetic resonance imaging data of 35 AD patients with and without apathy. RESULTS: There was a significant linear association between apathy severity and cortical gray matter atrophy in the bilateral anterior cingulate [Brodmann area (BA) 24; r = 0.39-0.42, p = 0.01] and left medial frontal cortex (BA 8 and 9; r = 0.4, p < 0.02). Left mean cingulate cortical thinning predicted the presence/absence of apathy at the trend level of significance. CONCLUSION: Our study demonstrates a strong association between apathy and the integrity of medial frontal regions in AD.
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“Structural imaging studies report volume loss in ACC, including reduced gray matter volume (Apostolova et al., 2007; Bruen et al., 2008; Stanton et al., 2013) and cortical thinning (Tunnard et al., 2011).”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Apostolova et al., 2007
In the citing paper
“There are also links between apathy and volume loss and/or cortical thinning in frontal cortex (Apostolova et al., 2007; Bruen et al., 2008; Stanton et al., 2013; Tunnard et al., 2011), though there is no strict concordance on the specific regions of frontal cortex which include medial, lateral, and orbital regions.”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Apostolova et al., 2007
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Behavioral and psychological symptoms of dementia
Cerejeira, J., Lagarto, L., & Mukaetova-Ladinska, E. B. (2012) · Frontiers in Neurology · doi:10.3389/fneur.2012.00073 · Cited by 1,425
Neuropsychiatric symptoms in Alzheimer's disease
Lyketsos, C. G., Carrillo, M. C., Ryan, J. M., Khachaturian, A. S., Trzepacz, P., Amatniek, J., Cedarbaum, J., Brashear, R., & Miller, D. S. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.05.2410 · Cited by 1,139
Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease
Bruen, P. D., McGeown, W. J., Shanks, M. F., & Venneri, A. (2008) · Brain · doi:10.1093/brain/awn151 · Cited by 374
Management of behavioral problems in Alzheimer's disease
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Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits?
Rosenberg, P. B., Nowrangi, M. A., & Lyketsos, C. G. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2015.05.005 · Cited by 302
Metadata
- Authors
- Apostolova, L. G., Akopyan, G. G., Partiali, N., Steiner, C. A., Dutton, R. A., Hayashi, K. M., Dinov, I. D., Toga, A. W., Cummings, J. L., & Thompson, P. M.
- Affiliations
- University of California, Los Angeles (US)
- ORCID
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2007
- Volume
- 24
- Issue
- 2
- Pages
- 91-97
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- OpenAlex
- W2165677325
- Cited by
- 190
- References
- 28
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 5 · 2023: 9 · 2022: 7 · 2021: 13 · 2020: 10 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 12 · 2015: 15 · 2014: 12 · 2013: 14 · 2012: 12
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P50AG016570, K23 AG036803)
- National Institute of Mental Health (R01MH071940)
- National Institute of Neurological Disorders and Stroke (NS 049194)
- National Institute of Biomedical Imaging and Bioengineering (EB 01651)
- U.S. National Library of Medicine (LM 05639, R01LM005639)
- National Center for Research Resources (P41RR013642, R21RR019771, U54RR021813, RR019771)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 050735, R01HD050735)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Keywords
- apathy, Alzheimer's disease, gray matter atrophy, anterior cingulate cortex, medial frontal cortex, cortical thinning, non-cognitive symptoms, brain structure
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Cerebral Cortex, Dominance, Cerebral, Female, Frontal Lobe, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Motivation, Reference Values, Statistics as Topic, Imaging, Three-Dimensional
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