Microstructural alteration of the anterior cingulum is associated with apathy in Alzheimer disease
Abstract
Objectives To identify regional alterations of white matter integrity associated with apathy in Alzheimer disease (AD).Design Cross-sectional study.Setting University Dementia Clinic.Participants Fifty-one very mild or mild probable AD subjects.Intervention Volumetric magnetic resonance imaging with diffusion tensor imaging.Measurements Volume of interest analyses were performed to compare regional fractional anisotropy (FA) between apathy and apathy-free group, and to test linear relationship between regional FA and apathy severity. Apathy was assessed by the Neuropsychiatric Inventory.Results Apathy group showed significantly lower FA values than apathy-free group in the left anterior cingulum (A-C), regardless of concomitant depression and psychotropic medications. Left A-C FA values also had significant linear relationship with apathy-composite scores as a measure of apathy severity, even after controlling gray matter density of the ipsilateral anterior cingulate cortex.Conclusions Our findings support that communication failure between the anterior cingulate cortex and other brain structures via the A-C contributes to the development and aggravation of apathy in AD, additionally supporting the general notion of disconnection syndrome for clinical manifestation of AD.
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Apathy in Alzheimer's disease is associated with decreased anterior cingulate cortex white matter integrity by diffusion tensor imaging.
“Similarly apathy is associated with decreased perfusion in ACC (Benoit et al., 2004; Lanctôt et al., 2007; Robert et al., 2006), decreased ACC white matter integrity by DTI (Hahn et al., 2013; Kim et al., 2011; Ota et al., 2012) and increased amyloid burden in right ACC (Mori et al., 2014).”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Kim et al., 2011
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- Authors
- Kim, J. W., Lee, D. Y., Choo, I. H., Seo, E. H., Kim, S. G., Park, S. Y., & Woo, J. I.
- Affiliations
- Seoul National University (KR)
- Seoul National University Hospital (KR)
- Soonchunhyang University Hospital Bucheon (KR)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Corresponding author
- Lee, Dong Young
- Venue
- The American Journal of Geriatric Psychiatry
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 19
- Issue
- 7
- Pages
- 644-653
- ISSN
- 1064-7481 (ISSN-L)
- OpenAlex
- W2153044647
- Cited by
- 79
- References
- 44
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 7 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 8 · 2016: 10 · 2015: 6 · 2014: 7 · 2013: 8 · 2012: 2
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- apathy, Alzheimer's disease, anterior cingulum, white matter integrity, fractional anisotropy, anterior cingulate cortex, disconnection syndrome, neuropsychiatric symptoms, diffusion tensor imaging, mild dementia
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Female, Gyrus Cinguli, Humans, Male, Middle Aged, Neuropsychological Tests, Prefrontal Cortex, Diffusion Tensor Imaging, Leukoencephalopathies, Apathy
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