Cited by 190Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeurobiology of Language and Bilingualism

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Structural correlates of apathy in Alzheimer's disease

Apostolova, Liana G., Akopyan, Gohar G., Partiali, Negar, Steiner, Calen A., Dutton, Rebecca A., Hayashi, Kiralee M., Dinov, Ivo D., Toga, Arthur W., Cummings, Jeffrey L., Thompson, Paul M.·2007·Dementia and Geriatric Cognitive Disorders

DOI 10.1159/000103914

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Abstract

BACKGROUND: Apathy is the most common noncognitive symptom in Alzheimer's disease (AD). The structural correlates of apathy in AD have not yet been described. METHODS: We analyzed magnetic resonance imaging data of 35 AD patients with and without apathy. RESULTS: There was a significant linear association between apathy severity and cortical gray matter atrophy in the bilateral anterior cingulate [Brodmann area (BA) 24; r = 0.39-0.42, p = 0.01] and left medial frontal cortex (BA 8 and 9; r = 0.4, p < 0.02). Left mean cingulate cortical thinning predicted the presence/absence of apathy at the trend level of significance. CONCLUSION: Our study demonstrates a strong association between apathy and the integrity of medial frontal regions in AD.

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Clinical diagnosis of Alzheimer's disease: Report of the NINCDS‐ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994) · Neurology · doi:10.1212/wnl.44.12.2308 · Cited by 7,568
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047
The spectrum of behavioral changes in Alzheimer's disease
Mega, M., Cummings, J., Fiorello, T., & Gornbein, J. (1996) · Neurology · doi:10.1212/wnl.46.1.130 · Cited by 1,124
Neuroanatomical correlates of pleasant and unpleasant emotion
Lane, R. D., Reiman, E. M., Bradley, M. M., Lang, P. J., Ahern, G. L., Davidson, R. J., & Schwartz, G. E. (1997) · Neuropsychologia · doi:10.1016/s0028-3932(97)00070-5 · Cited by 830
Neuroanatomical correlates of happiness, sadness, and disgust
Lane, R. D., Reiman, E. M., Ahern, G. L., SCHWARTZ, G. E. R., & Davidson, R. J. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.7.926 · Cited by 756
Apathy Is Not Depression
Levy, M. L., Cummings, J. L., Fairbanks, L. A., Masterman, D. L., Miller, B. L., Craig, A., Paulsen, J. S., & Litvan, I. (1998) · Journal of Neuropsychiatry · doi:10.1176/jnp.10.3.314 · Cited by 712
Neuroanatomical correlates of behavioural disorders in dementia
Rosen, H. J., Allison, S. C., Schauer, G. F., Gorno-Tempini, M. L., Weiner, M. W., & Miller, B. L. (2005) · Brain · doi:10.1093/brain/awh628 · Cited by 497
Apathy in Alzheimer's Disease
Landes, A. M., Sperry, S. D., Strauss, M. E., & Geldmacher, D. (2001) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2001.49282.x · Cited by 389
A prospective longitudinal study of depression, cognitive decline, and physical impairments in patients with Parkinson's disease.
STARKSTEIN, S. E., Mayberg, H. S., Leiguarda, R. C., Preziosi, T. J., & Robinson, R. G. (1992) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.55.5.377 · Cited by 373

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Waldemar, G., Gauthier, S. G., Jones, R. W., Wilkinson, D. G., Cummings, J. L., López, O. L., Zhang, R. H., Xu, Y., Sun, Y., Knox, S., et al. (2010) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2507 · Cited by 53
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Saggu, S., Bai, A., Aida, M., Rehman, H., Pless, A., Ware, D., Deák, F., Jiao, K., & Wang, Q. (2024) · GeroScience · doi:10.1007/s11357-024-01359-x · Cited by 48
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Hett, K., Ta, V., Oğuz, İ., Manjón, J. V., & Pierrick Coupé, A. (2020) · Medical Image Analysis · doi:10.1016/j.media.2020.101850 · Cited by 48
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van Dyck, C. H., Arnsten, A. F. T., Padala, P. R., Brawman‐Mintzer, O., Lerner, A. J., Porsteinsson, A. P., Scherer, R. W., Levey, A. I., Herrmann, N., Jamil, N., et al. (2020) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2020.04.026 · Cited by 53
Mapping cerebellar degeneration in HIV/AIDS
Klunder, A. D., Chiang, M.-C., Dutton, R. A., Lee, S. E., Toga, A. W., López, O. L., Aizenstein, H. J., Becker, J. T., & Thompson, P. M. (2008) · Neuroreport · doi:10.1097/wnr.0b013e328311d374 · Cited by 46
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Different Apathy Profile in Behavioral Variant of Frontotemporal Dementia and Alzheimer's Disease: A Preliminary Investigation
Quaranta, D., Marra, C., Rossi, C., Gainotti, G., & Masullo, C. (2012) · Current Gerontology and Geriatrics Research · doi:10.1155/2012/719250 · Cited by 47
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Siafarikas, N., Alnæs, D., Sánchez, J. M., Lund, M. J., Selbæk, G., Korsnes, M. S., Persson, K., Barca, M. L., Almdahl, I. S., Fladby, T., et al. (2021) · International Psychogeriatrics · doi:10.1017/s1041610221000934 · Cited by 42
White Matter Microstructure and Apathy Level in Amnestic Mild Cognitive Impairment
Cacciari, C., Moraschi, M., Paola, M. D., Cherubini, A., Orfei, M. D., Giove, F., Maraviglia, B., Caltagirone, C., & Spalletta, G. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1384 · Cited by 40
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Guerrier, L., Men, J. L., Gane, A., Planton, M., Salabert, A., Payoux, P., Dumas, H., Bonneville, F., Péran, P., & Pariente, J. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180324 · Cited by 39
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The neural basis of neuropsychiatric symptoms in Alzheimer’s disease
Zhang, N. K., Zhang, S. K., Zhang, L. I., Tao, H. W., & Zhang, G. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1487875 · Cited by 39
Structural correlates of apathy in Alzheimer's disease: a multimodal MRI study
Agüera-Ortíz, L., Hernandez-Tamames, J. A., Martínez‐Martín, P., Cruz, I., Pájares, G., López‐Álvarez, J., Osorio, R. S., Sanz, M. F. R., & Olazarán, J. (2016) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4548 · Cited by 33
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Authors: Apostolova, L. G., Akopyan, G. G., Partiali, N., Steiner, C. A., Dutton, R. A., Hayashi, K. M., Dinov, I. D., Toga, A. W., Cummings, J. L., & Thompson, P. M.
Affiliations: University of California, Los Angeles (US)
ORCID: Apostolova, Liana G.
Steiner, Calen A.
Dinov, Ivo D.
Toga, Arthur W.
Cummings, Jeffrey L.
Thompson, Paul M.
Venue: Dementia and Geriatric Cognitive Disorders
Publisher: S. Karger AG
Published: 2007
Volume: 24
Issue: 2
Pages: 91-97
ISSN: 1420-8008 (ISSN-L)
1421-9824
DOI: 10.1159/000103914
OpenAlex: W2165677325
Cited by: 190
References: 28
Citations by year: 2026: 1 · 2025: 7 · 2024: 5 · 2023: 9 · 2022: 7 · 2021: 13 · 2020: 10 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 12 · 2015: 15 · 2014: 12 · 2013: 14 · 2012: 12
FWCI: 8.07
Type: journal article
Language: en
Open access: closed
Licence: www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)
Locations: Dementia and Geriatric Cognitive Disorders (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (P50AG016570, K23 AG036803)
National Institute of Mental Health (R01MH071940)
National Institute of Neurological Disorders and Stroke (NS 049194)
National Institute of Biomedical Imaging and Bioengineering (EB 01651)
U.S. National Library of Medicine (LM 05639, R01LM005639)
National Center for Research Resources (P41RR013642, R21RR019771, U54RR021813, RR019771)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 050735, R01HD050735)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
Keywords: apathy, Alzheimer's disease, gray matter atrophy, anterior cingulate cortex, medial frontal cortex, cortical thinning, non-cognitive symptoms, brain structure
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Cerebral Cortex, Dominance, Cerebral, Female, Frontal Lobe, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Motivation, Reference Values, Statistics as Topic, Imaging, Three-Dimensional

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Structural correlates of apathy in Alzheimer's disease

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