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HPA and Immune Axes in Stress: Involvement of the Serotonergic System
Abstract
Chronic stress, by initiating changes in the hypothalamic-pituitary-adrenal axis and the immune system, acts as a trigger for anxiety and depression. There is experimental and clinical evidence that the rise in the concentration of pro-inflammatory cytokines and glucocorticoids, which occurs in a chronically stressful situation and also in depression, contributes to the behavioural changes associated with depression. A defect in serotonergic function is associated with these hormonal and immune changes. Neurodegenerative changes in the hippocampus, prefrontal cortex and amygdalae are the frequent outcomes of the changes in the hypothalamic-pituitary-adrenal axis and the immune system. Such changes may provide evidence for the link between chronic depression and dementia in later life.
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“Cytokines affect two biological systems that are most associated with the pathophysiology of depression: The hypothalamic-pituitary-adrenal axis and the catecholamine/sympathetic nervous system.”
From Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness? (2016) · cites this paper as [2]
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Cites
Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162
A Syndrome produced by Diverse Nocuous Agents
Selye, H. (1936) · Nature · doi:10.1038/138032a0 · Cited by 3,967
The Concepts of Stress and Stress System Disorders: Overview of Physical and Behavioral Homeostasis
Chrousos, G. P. (1992) · JAMA · doi:10.1001/jama.1992.03480090092034 · Cited by 2,689
A molecular and cellular theory of depression
Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129
Glial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525
Rajkowska, G., Miguel-Hidalgo, J. J., Wei, J., Dilley, G., Pittman, S. D., Meltzer, H. Y., Overholser, J. C., Roth, B. L., & Stockmeier, C. A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00041-4 · Cited by 1,477
Sheline, Y. I., Sanghavi, M., Mintun, M. A., & Gado, M. H. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-12-05034.1999 · Cited by 1,382 · cited 1×
“The microglia are known to produce both 3-hydroxyanthranilic acid and quinolinic acid in depression, while the astrocytes produce mainly kynurenic acid. Astrocytes also metabolise quinolinic acid and thereby reduce the neurotoxic impact of microglia activation [”
BackgroundThe role of corticotropin-releasing factor in depression and anxiety disorders
Arborelius, L., Owens, M., Plotsky, P., & Nemeroff, C. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600001 · Cited by 1,378
Chalmers, D., Lovenberg, T. W., & Souza, E. D. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-10-06340.1995 · Cited by 925
A review of psychoendocrine research on the pituitary–adrenal cortical system
MASON, J. W. (1968) · Psychosomatic Medicine · doi:10.1097/00006842-196809000-00020 · Cited by 874
Research works printed but not linked: 3
- 10.1001%2Farchinte.153.18.2093 · DOI · Paper page
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Oxenkrug, G. F. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05356.x · Cited by 223
Watt, D. F., & Panksepp, J. (2009) · Neuropsychoanalysis · doi:10.1080/15294145.2009.10773593 · Cited by 216
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Weersing, V. R., Rozenman, M. S., Maher-Bridge, M., & Campo, J. V. (2011) · Cognitive and Behavioral Practice · doi:10.1016/j.cbpra.2011.06.002 · Cited by 122
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Sansores‐España, L. D., Melgar‐Rodríguez, S., Sagredo-Olivares, K., Cafferata, E. A., Martínez-Aguilar, V. M., Vernal, R., Paula-Lima, A. C., & Díaz‐Zúñiga, J. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.781582 · Cited by 110
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Lee, M.-K., Ryu, Y. H., Cho, W. G., Kang, Y. W., Lee, S. J., Jeon, T. J., Lyoo, C. H., Kim, C. H., Kim, D. G., Lee, K., et al. (2015) · Synapse · doi:10.1002/syn.21834 · Cited by 30
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Merrick, J., & Sher, L. (2013) · De Gruyter eBooks · doi:10.1515/9783110316612 · Cited by 29
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Zhou, X. P., Xu, X., Lu, D., Chen, K., Wu, Y., Yang, X., Xiong, W., Chen, X., Lan, L., Li, W., et al. (2022) · British Journal of Anaesthesia · doi:10.1016/j.bja.2022.06.039 · Cited by 24
Kumar, A., Kaur, G., & Rinwa, P. (2014) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(14)60089-3 · Cited by 23
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Haavik, H., Niazi, I. K., Kumari, N., Amjad, I., Duehr, J., & Holt, K. R. (2021) · Medicina · doi:10.3390/medicina57060536 · Cited by 19
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Tsormpatzoudi, S.-O., Μoraitou, D., Papaliagkas, V. T., Pezirkianidis, C., & Tsolaki, M. (2023) · Behavioral Sciences · doi:10.3390/bs13100792 · Cited by 15
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Maia, G. H., Soares, J. I., Andrade, P., Leite, J. F., Luz, L. L., Andrade, J. P., & Lukoyanov, N. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.10.010 · Cited by 13
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Ruiz-Mar, M. G., Heckel, G., Solana‐Arellano, E., Schramm, Y., García‐Aguilar, M. C., & Arteaga, M. C. (2022) · PLoS ONE · doi:10.1371/journal.pone.0270129 · Cited by 12
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Jiao, W., Liu, L., Zeng, Z., Li, L., & Chen, J. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1053925 · Cited by 12
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Scott, K. A., Tamashiro, K. L., & Sakai, R. R. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-375097-6.10023-x · Cited by 12
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Baeken, C., Bossuyt, A. M., & Raedt, R. D. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2013.12.005 · Cited by 10
Metadata
- Authors
- Leonard, B. E.
- Affiliations
- Ollscoil na Gaillimhe – University of Galway (IE)
- Corresponding author
- Leonard, Brian E.
- Venue
- Neuroimmunomodulation
- Publisher
- S. Karger AG
- Published
- 2006
- Volume
- 13
- Issue
- 5-6
- Pages
- 268-276
- ISSN
- 1021-7401 (ISSN-L)
- 1423-0216
- OpenAlex
- W2025883568
- Cited by
- 169
- References
- 69
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 7 · 2023: 7 · 2022: 8 · 2021: 8 · 2020: 3 · 2019: 10 · 2018: 5 · 2017: 8 · 2016: 12 · 2015: 12 · 2014: 8 · 2013: 10 · 2012: 13
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImmunoModulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- chronic stress, hypothalamic-pituitary-adrenal axis, immune system, serotonergic system, inflammatory cytokines, glucocorticoids, depression, anxiety, hippocampus, prefrontal cortex, amygdala, neurodegeneration, dementia
- MeSH terms
- Animals, Anxiety, Brain, Chronic Disease, Depression, Glucocorticoids, Humans, Hypothalamo-Hypophyseal System, Nerve Degeneration, Pituitary-Adrenal System, Serotonin, Stress, Psychological, Cytokines
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