Suppression of the HPA axis during cholestasis can be attributed to hypothalamic bile acid signaling

The Continuing Importance of Bile Acids in Liver and Intestinal Disease

Hofmann, A. F. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.22.2647 · Cited by 972 · see citing works

Glucocorticoids and the circadian clock

Dickmeis, T. (2009) · Journal of Endocrinology · doi:10.1677/joe-08-0415 · Cited by 494 · see citing works

Cloning and molecular characterization of the ontogeny of a rat ileal sodium-dependent bile acid transporter.

Shneider, B. L., Dawson, P. A., Christie, D. M., Hardikar, W., Wong, M. H., & Suchy, F. J. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117722 · Cited by 307 · see citing works

Adrenal insufficiency in patients with cirrhosis and septic shock: Effect of treatment with hydrocortisone on survival

Fernández, J., Escorsell, À., Zabalza, M., Felipe, V., Navasa, M., Mas, A., Lacy, A. M., Ginès, P., & Arroyo, V. (2006) · Hepatology · doi:10.1002/hep.21352 · Cited by 292 · see citing works

Adrenal insufficiency in patients with cirrhosis, severe sepsis and septic shock†

Tsai, M., Peng, Y., Chen, Y., Liu, N.-J., Ho, Y., Fang, J., Lien, J., Yang, C., Chen, P., & Wu, C. (2006) · Hepatology · doi:10.1002/hep.21101 · Cited by 288 · see citing works

Bile acids are nutrient signaling hormones

Zhou, H., & Hylemon, P. B. (2014) · Steroids · doi:10.1016/j.steroids.2014.04.016 · Cited by 285 · see citing works

Mechanism of Cholestasis

Greim, H. A., Trulzsch, D. V., Roboz, J., Dressler, K. P., Czygan, P., Hutterer, F., Schaffner, F., & Pópper, H. (1972) · Gastroenterology · doi:10.1016/s0016-5085(19)33225-1 · Cited by 273 · see citing works

Bile acids permeabilize the blood brain barrier after bile duct ligation in rats via Rac1-dependent mechanisms

Quinn, M., McMillin, M., Galindo, C., Frampton, G., Pae, H. Y., & DeMorrow, S. (2014) · Digestive and Liver Disease · doi:10.1016/j.dld.2014.01.159 · Cited by 259 · see citing works

Hypothalamic-pituitary-adrenocortical axis regulation

Jacobson, L. (2005) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2005.01.003 · Cited by 248 · see citing works

Role of the Intestinal Bile Acid Transporters in Bile Acid and Drug Disposition

Dawson, P. A. (2010) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-14541-4_4 · Cited by 227 · see citing works

The clinical importance of adrenal insufficiency in acute hepatic dysfunction

Harry, R., Auzinger, G. M., & Wendon, J. A. (2002) · Hepatology · doi:10.1053/jhep.2002.34514 · Cited by 226 · see citing works

The hypothalamus and the regulation of energy homeostasis: lifting the lid on a black box

Williams, G., Harrold, J. A., & Cutler, D. J. (2000) · Proceedings of The Nutrition Society · doi:10.1017/s0029665100000434 · Cited by 216 · see citing works

Mechanism of Cholestasis

Greim, H. A., Trulzsch, D. V., Czygan, P., Rudick, J., Hutterer, F., Schaffner, F., & Pópper, H. (1972) · Gastroenterology · doi:10.1016/s0016-5085(19)33226-3 · Cited by 206 · see citing works

Transport of Bile Acids in Hepatic and Non-Hepatic Tissues

St–Pierre, M. V., Kullak-Ublick, G. A., Hagenbuch, B., & Meier, P. J. (2001) · Journal of Experimental Biology · doi:10.1242/jeb.204.10.1673 · Cited by 186 · see citing works

HPA and Immune Axes in Stress: Involvement of the Serotonergic System

Leonard, B. E. (2006) · Neuroimmunomodulation · doi:10.1159/000104854 · Cited by 169 · see citing works

Functional Modulation of the Glucocorticoid Receptor and Suppression of NF-κB-dependent Transcription by Ursodeoxycholic Acid

Miura, T., Ouchida, R., Yoshikawa, N., Okamoto, K., Makino, Y., Nakamura, T., Morimoto, C., Makino, I., & Tanaka, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107098200 · Cited by 137 · see citing works

TGR 5 signaling reduces neuroinflammation during hepatic encephalopathy

McMillin, M., Frampton, G. A., Tobin, R. P., Dusio, G. F., Smith, J., Shin, H. D., Newell‐Rogers, K., Grant, S. M., & DeMorrow, S. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13243 · Cited by 129 · see citing works

DYNAMICS AND MECHANICS OF CORTICOSTEROID FEEDBACK AT THE HYPOTHALAMUS AND ANTERIOR PITUITARY GLAND

Jones, M. T., Hillhouse, E. W., & Burden, J. (1977) · Journal of Endocrinology · doi:10.1677/joe.0.0730405 · Cited by 129 · see citing works

The Effect of Hypotension in Obstructive Jaundice

Williams, R. D. (1960) · Archives of Surgery · doi:10.1001/archsurg.1960.01300020162022 · Cited by 111 · see citing works

Opposing Actions of Endocannabinoids on Cholangiocarcinoma Growth

DeMorrow, S., Glaser, S. S., Francis, H., Venter, J. K., Vaculin, B. T., Vaculin, S., & Alpini, G. D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608238200 · Cited by 96 · see citing works

Effects of altered cardiac membrane fluidity on β-adrenergic receptor signalling in rats with cirrhotic cardiomyopathy

Ma, Z., Lee, S. S., & Meddings, J. B. (1997) · Journal of Hepatology · doi:10.1016/s0168-8278(97)80259-0 · Cited by 93 · see citing works

Hepatic Transport Mechanisms of Cholyl-l-Lysyl-Fluorescein

de Waart, D. R., Häusler, S., Vlaming, M. L. H., Kunne, C., Hänggi, E., Gruss, H.-J., Elferink, R. P. J. O., & Stieger, B. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.166991 · Cited by 92 · see citing works

Suppression of hypothalamic-pituitary-adrenal axis responsiveness to stress in a rat model of acute cholestasis.

Swain, M. G., Patchev, V. K., Vergalla, J., Chrousos, G. P., & Jones, E. A. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116408 · Cited by 91 · see citing works

Bile acids modulate glucocorticoid metabolism and the hypothalamic–pituitary–adrenal axis in obstructive jaundice

McNeilly, A. D., Macfarlane, D. P., O’Flaherty, E., Livingstone, D. E. W., Mitić, T., McConnell, K. M. M., MacKenzie, S. M., Davies, E., Reynolds, R. M., Thiesson, H. C., et al. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2009.10.037 · Cited by 90 · see citing works

Defective corticotropin-releasing hormone mediated neuroendocrine and behavioral responses in cholestatic rats: Implications for cholestatic liver disease-related sickness behaviors

Swain, M. G., & Maric, M. (1995) · Hepatology · doi:10.1002/hep.1840220532 · Cited by 75 · see citing works

The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway

DeMorrow, S., Francis, H., Gaudio, E., Venter, J. K., Franchitto, A., Kopriva, S. E., Onori, P., Mancinelli, R., Frampton, G. A., Coufal, M., et al. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90455.2008 · Cited by 72 · see citing works

The Course of Neonatal Cholestasis in Congenital Combined Pituitary Hormone Deficiency

Binder, G., Martin, D. D., Kanther, I., Schwarze, C. P., & Ranke, M. (2007) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2007.20.6.695 · Cited by 69 · see citing works

POMC‐Derived Peptides and Their Biological Action

Solomon, S. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08663.x · Cited by 68 · see citing works

Surgical aspects of jaundice.

Rm, Z., & Rd, W. (1956) · PubMed · Cited by 55 · see citing works

Anandamide inhibits cholangiocyte hyperplastic proliferation via activation of thioredoxin 1/redox factor 1 and AP-1 activation

DeMorrow, S., Francis, H., Gaudio, E., Ueno, Y., Venter, J. K., Onori, P., Franchitto, A., Vaculin, B. T., Vaculin, S., & Alpini, G. D. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00304.2007 · Cited by 53 · see citing works

Anterior pituitary hormone effects on hepatic functions in infants with congenital hypopituitarism

Karnsakul, W. W., Sawathiparnich, P., Nimkarn, S., Likitmaskul, S., Santiprabhob, J., & Aanpreung, P. (2007) · Annals of Hepatology · doi:10.1016/s1665-2681(19)31939-8 · Cited by 51 · see citing works

Bile acids as endogenous vasodilators?

Bomzon, A., & Ljubuncic, P. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)00428-o · Cited by 50 · see citing works

Cholyl-lysylfluorescein: synthesis, biliary excretion in vivo and during single-pass perfusion of isolated perfused rat liver

Mills, C. O., Rahman, K., COLEMAN, R., & Elias, E. (1991) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(91)90024-b · Cited by 44 · see citing works

Pruritus of chronic cholestasis

Raiford, D. S. (1995) · QJM · doi:10.1093/oxfordjournals.qjmed.a069108 · Cited by 36 · see citing works

Suppression of the HPA axis during extrahepatic biliary obstruction induces cholangiocyte proliferation in the rat

Quinn, M. A., Ueno, Y., Pae, H. Y., Huang, L., Frampton, G. A., Galindo, C., Francis, H., Horvat, D., McMillin, M., & DeMorrow, S. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00205.2011 · Cited by 33 · see citing works

Gli1 activation and protection against hepatic encephalopathy is suppressed by circulating transforming growth factor β1 in mice

McMillin, M., Galindo, C., Pae, H. Y., Frampton, G. A., Patre, P. L. D., Quinn, M. A., Whittington, E., & DeMorrow, S. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.07.015 · Cited by 30 · see citing works

The Role of the Enterohepatic Circulation of Bile Salts and Nuclear Hormone Receptors in the Regulation of Cholesterol Homeostasis: Bile Salts as Ligands for Nuclear Hormone Receptors

Redinger, R. N. (2003) · Canadian Journal of Gastroenterology · doi:10.1155/2003/190784 · Cited by 27 · see citing works

Cholestatic hepatitis as a result of severe cortisol deficiency in early infancy: report of two cases and review of literature

Gonc, E. N., Kandemir, N., Andıran, N., Özön, A., & Yordam, N. (2006) · The Turkish Journal of Pediatrics · doi:10.24953/turkjpediatr.2006.2665 · Cited by 27 · see citing works

Defective interleukin-1-induced ACTH release in cholestatic rats: impaired hypothalamic PGE2 release

Swain, M. G., Maric, M., & Carter, L. (1995) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1995.268.3.g404 · Cited by 20 · see citing works

Intrathecal bombesin-induced inhibition of gastrointestinal transit: requirement for an intact pituitary-adrenal axis

Koslo, R. J., Gmerek, D. E., Cowan, A., & Porreca, F. (1986) · Regulatory Peptides · doi:10.1016/0167-0115(86)90006-6 · Cited by 14 · see citing works

Dose-Response Studies of Interferon-α 2b on Liver Fibrosis and Cholestasis Induced by Biliary Obstruction in Rats

Muriel, P., & Castro, V. (2008) · Pharmacology · doi:10.1159/000139485 · Cited by 13 · see citing works

Surgical aspects of jaundice

Howard, M. A. (1956) · The American Journal of Surgery · doi:10.1016/s0002-9610(56)80083-4 · Cited by 13 · see citing works

479 Elevated Serum Bile Acids Contribute to the Neurological Impairment Following Acute Liver Failure

Ashfaq, S., McMillin, M., Galindo, C., Frampton, G. A., & DeMorrow, S. (2014) · Gastroenterology · doi:10.1016/s0016-5085(14)63324-2 · Cited by 1 · see citing works

From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways

Rogers, G. B., Keating, D. J., Young, R. L., Wong, M.-L., Licinio, J., & Wesselingh, S. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.50 · Cited by 969 · see citing works

Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis

Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works

Bile acid signaling pathways from the enterohepatic circulation to the central nervous system

Mertens, K. L., Kalsbeek, A., Soeters, M. R., & Eggink, H. M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00617 · Cited by 287 · see citing works

Sex differences in gut microbiota in patients with major depressive disorder

Chen, J.-J., Zheng, P., Liu, Y.-Y., Zhong, X.-G., Wang, H.-Y., Guo, Y.-J., & Xie, P. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s159322 · Cited by 272 · see citing works

The biosynthesis, signaling, and neurological functions of bile acids

Kiriyama, Y., & Nochi, H. (2019) · Biomolecules · doi:10.3390/biom9060232 · Cited by 204 · see citing works

Effects of bile acids on neurological function and disease

McMillin, M., & DeMorrow, S. (2016) · The FASEB Journal · doi:10.1096/fj.201600275r · Cited by 192 · see citing works

Bile acid signaling in neurodegenerative and neurological disorders

Grant, S. M., & DeMorrow, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21175982 · Cited by 185 · see citing works

Adrenal function and dysfunction in critically ill patients

Téblick, A., Peeters, B., Langouche, L., & den Berghe, G. V. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0185-7 · Cited by 156 · see citing works

Bile acids: a communication channel in the gut-brain axis

Monteiro-Cardoso, V. F., Corlianò, M., & Singaraja, R. R. (2021) · NeuroMolecular Medicine · doi:10.1007/s12017-020-08625-z · Cited by 145 · see citing works

Roles of bile acids signaling in neuromodulation under physiological and pathological conditions

Chen, X., Huang, X., Wang, D., Yu, D., Hou, S., Cui, H., & Song, L. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01053-z · Cited by 120 · see citing works

Bile acids as key modulators of the brain-Gut-Microbiota axis in alzheimer’s disease

Mulak, A. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210608 · Cited by 114 · see citing works

The Adrenal Cortex, an Underestimated Site of SARS-CoV-2 Infection

Mao, Y., Xu, B., Guan, W., Xu, D., Li, F., Ren, R., Zhu, X., Gao, Y., & Jiang, L. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.593179 · Cited by 100 · see citing works

Nutritional Modulation of Immune and Central Nervous System Homeostasis: The Role of Diet in Development of Neuroinflammation and Neurological Disease

Estrada, J. A., & Contreras, I. (2019) · Nutrients · doi:10.3390/nu11051076 · Cited by 65 · see citing works

ACTH and cortisol responses to CRH in acute, subacute, and prolonged critical illness: a randomized, double-blind, placebo-controlled, crossover cohort study

Peeters, B., Meersseman, P., Perre, S. V., Wouters, P. J., Debaveye, Y. A., Langouche, L., & den Berghe, G. V. (2018) · Intensive Care Medicine · doi:10.1007/s00134-018-5427-y · Cited by 66 · see citing works

Gut microbiota and its metabolites: Bridge of dietary nutrients and obesity-related diseases

Zhou, M., Johnston, L. J., Wu, C., & Ma, X. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1986466 · Cited by 65 · see citing works

Neurohormonal Changes in the Gut–Brain Axis and Underlying Neuroendocrine Mechanisms following Bariatric Surgery

Martinou, E., Stefanova, I., Iosif, E., & Angelidi, A. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063339 · Cited by 61 · see citing works

Gut-Brain Axis a Key Player to Control Gut Dysbiosis in Neurological Diseases

Pan, I., Issac, P. K., Rahman, M. M., Guru, A., & Arockiaraj, J. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03691-3 · Cited by 60 · see citing works

FXR in the dorsal vagal complex is sufficient and necessary for upper small intestinal microbiome-mediated changes of TCDCA to alter insulin action in rats

Zhang, S., Li, R. J. W., Lim, Y.-M., Batchuluun, B., Liu, H., Waise, T. M. Z., & Lam, T. K. T. (2020) · Gut · doi:10.1136/gutjnl-2020-321757 · Cited by 58 · see citing works

Hepatic alterations are accompanied by changes to bile acid transporter-expressing neurons in the hypothalamus after traumatic brain injury

Nizamutdinov, D., DeMorrow, S., McMillin, M., Kain, J., Mukherjee, S., Zeitouni, S., Frampton, G. A., Bricker, P. C. S., Hurst, J., & Shapiro, L. A. (2017) · Scientific Reports · doi:10.1038/srep40112 · Cited by 54 · see citing works

Coordinate regulation of long non-coding RNAs and protein-coding genes in germ-free mice

Dempsey, J. L., Zhang, A. Y., & Cui, J. Y. (2018) · BMC Genomics · doi:10.1186/s12864-018-5235-3 · Cited by 54 · see citing works

Anterior pituitary function in critical illness

Téblick, A., Langouche, L., & Van den Berghe, G. (2019) · Endocrine Connections · doi:10.1530/ec-19-0318 · Cited by 52 · see citing works

Diet-induced obesity and weight loss alter bile acid concentrations and bile acid–sensitive gene expression in insulin target tissues of C57BL/6J mice

Frano, M. R. L., Hernandez, A. M., Weber, N., Borkowski, K., Pedersen, T. L., Osborn, O., & Newman, J. W. I. (2017) · Nutrition Research · doi:10.1016/j.nutres.2017.07.006 · Cited by 51 · see citing works

Emerging Roles of Bile Acids and TGR5 in the Central Nervous System: Molecular Functions and Therapeutic Implications

Romero‐Ramírez, L., & Mey, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179279 · Cited by 49 · see citing works

Bile Acids in Hepatic Encephalopathy

DeMorrow, S. (2018) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2018.04.011 · Cited by 47 · see citing works

The clinical and mechanistic roles of bile acids in depression, Alzheimer's disease, and stroke

Wu, L., Zhao, M., Li, M., Guo, Q., Zhenxing, R., Xiaojiao, Z., & Chen, T. (2022) · PROTEOMICS · doi:10.1002/pmic.202100324 · Cited by 47 · see citing works

Asynchronous rhythms of circulating conjugated and unconjugated bile acids in the modulation of human metabolism

Al-Khaifi, A., Straniero, S., Voronova, V., Chernikova, D., Sokolov, V. V., Kumar, C., Angelin, B., & Rudling, M. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12811 · Cited by 40 · see citing works

Molecular mechanism and therapeutic strategy of bile acids in Alzheimer’s disease from the emerging perspective of the microbiota–gut–brain axis

Wu, M., Cheng, Y., Zhang, R., Han, W., Jiang, H., Bi, C., Zhang, Z., Ye, M., Lin, X., & Liu, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117228 · Cited by 38 · see citing works

FXR-Mediated Cortical Cholesterol Accumulation Contributes to the Pathogenesis of Type A Hepatic Encephalopathy

McMillin, M., Grant, S. M., Frampton, G. A., Petrescu, A. D., Kain, J., Williams, E., Haines, R., Canady, L., & DeMorrow, S. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.02.008 · Cited by 38 · see citing works

Hypothalamus-Pituitary-Adrenal Dysfunction in Cholestatic Liver Disease

Petrescu, A. D., Kain, J., Liere, V., Heavener, T. E., & DeMorrow, S. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00660 · Cited by 37 · see citing works

The Pathological Effects of Circulating Hydrophobic Bile Acids in Alzheimer’s Disease

Ehtezazi, T., Rahman, K., Davies, R., & Leach, A. G. (2023) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-220071 · Cited by 35 · see citing works

Metabolic Diffusion in Neuropathologies: The Relevance of Brain-Liver Axis

Vegas‐Suárez, S., Simón, J., Martínez‐Chantar, M. L., & Moratalla, R. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.864263 · Cited by 33 · see citing works

Gut–Brain Axis and Bile Acid Signaling: Linking Microbial Metabolism to Brain Function and Metabolic Regulation

Stanimirov, B., Đanić, M., Pavlović, N., Zaklan, D., Lazarević, S., Mikov, M., & Stankov, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262412167 · Cited by 37 · see citing works

Linking Nonalcoholic Fatty Liver Disease and Brain Disease: Focusing on Bile Acid Signaling

Ren, Z., Li, C.-X., Ma, C., Chen, D., Chen, J., Xu, W., Chen, C.-A., Cheng, F., & Wang, X. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113045 · Cited by 32 · see citing works

Bile acids and glucocorticoid metabolism in health and disease

Theiler-Schwetz, V., Zaufel, A., Schlager, H., Obermayer-Pietsch, B., Fickert, P., & Zollner, G. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.08.001 · Cited by 31 · see citing works

Bile acids, bioactive signalling molecules in interoceptive gut‐to‐brain communication

Joyce, S. A., & O'Malley, D. (2022) · The Journal of Physiology · doi:10.1113/jp281727 · Cited by 31 · see citing works

A critical review of bile acids and their receptors in hepatic encephalopathy

Williams, E., Chu, C. S., & DeMorrow, S. (2021) · Analytical Biochemistry · doi:10.1016/j.ab.2021.114436 · Cited by 31 · see citing works

Mechanistic insights into the liver–brain axis during chronic liver disease

Siddle, M. R., Durán, R. G., Goel, D., Renquist, B. J., Holt, M. K., & Hadjihambi, A. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01142-z · Cited by 33 · see citing works

Gut feelings: the microbiota-gut-brain axis on steroids

So, S. Y., & Savidge, T. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00294.2021 · Cited by 29 · see citing works

Bile acids increase steroidogenesis in cholemic mice and induce cortisol secretion in adrenocortical H295R cells via S1 PR 2, ERK and SF ‐1

Liu, L., Panzitt, K., Racedo, S., Wagner, M., Platzer, W., Zaufel, A., Theiler‐Schwetz, V., Obermayer-Pietsch, B. M., Müller, H., Höfler, G., et al. (2019) · Liver International · doi:10.1111/liv.14052 · Cited by 26 · see citing works

The fibroblast growth factor system in cognitive disorders and dementia

Zhai, W., Zhang, T., Jin, Y., Huang, S., Xu, M., & Pan, J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1136266 · Cited by 25 · see citing works

Ageing sensitized by iPLA 2 β deficiency induces liver fibrosis and intestinal atrophy involving suppression of homeostatic genes and alteration of intestinal lipids and bile acids

Li, J., Gan‐Schreier, H., Zhu, X., Wang, W., Tuma‐Kellner, S., Liebisch, G., Stremmel, W., & Chamulitrat, W. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.09.001 · Cited by 23 · see citing works

Aberrant Gut-To-Brain Signaling in Irritable Bowel Syndrome - The Role of Bile Acids

Dhonnabháín, R. N., Xiao, Q., & O’Malley, D. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.745190 · Cited by 22 · see citing works

Functional recovery outcomes following acute stroke is associated with abundance of gut microbiota related to inflammation, butyrate and secondary bile acid

Hammond, T. C., Powell, E. S., Green, S. J., Chlipala, G. E., Frank, J. A., Yackzan, A. T., Yanckello, L. M., Chang, Y., Xing, X., Heil, S. D., et al. (2022) · Frontiers in Rehabilitation Sciences · doi:10.3389/fresc.2022.1017180 · Cited by 23 · see citing works

Melatonin inhibits hypothalamic gonadotropin-releasing hormone release and reduces biliary hyperplasia and fibrosis in cholestatic rats

McMillin, M., DeMorrow, S., Glaser, S. S., Venter, J. K., Kyritsi, K., Zhou, T., Grant, S. M., Giang, T., Greene, J. F., Wu, N., et al. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00421.2016 · Cited by 20 · see citing works

Dynamics and prognostic value of the hypothalamus–pituitary–adrenal axis responses to pediatric critical illness and association with corticosteroid treatment: a prospective observational study

Jacobs, A., Derese, I., Perre, S. V., Wouters, P. J., Verbruggen, S. C. A. T., Billen, J., Vermeersch, P., Guerra, G. G., Joosten, K. F. M., Vanhorebeek, I., et al. (2019) · Intensive Care Medicine · doi:10.1007/s00134-019-05854-0 · Cited by 20 · see citing works

GPCR-mediated effects of fatty acids and bile acids on glucose homeostasis

Oteng, A., & Liu, L. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1206063 · Cited by 19 · see citing works

Glucocorticoids Cause Gender-Dependent Reversal of Hepatic Fibrosis in the MDR2-Knockout Mouse Model

Petrescu, A. D., Grant, S. M., Frampton, G. A., Kain, J., Hadidi, K., Williams, E., McMillin, M., & DeMorrow, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112389 · Cited by 18 · see citing works

Apple Polyphenol Extracts Attenuated Depressive-Like Behaviors of High-Sucrose Diet Feeding Mice by Farnesoid X Receptor-Mediated Modulation of Bile Acid Circulation within the Liver–Gut–Brain Axis

Xie, Y., Shang, S., Luan, W., Ma, J., Yang, H., Qian, Q., Wu, Z., & Li, X. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c07035 · Cited by 17 · see citing works

An impaired pituitary–adrenal signalling axis in stable cirrhosis is linked to worse prognosis

Hartl, L., Simbrunner, B., Jachs, M., Wolf, P. S., Bauer, D. J. M., Scheiner, B., Balcar, L., Semmler, G., Schwarz, M., Marculescu, R., et al. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100789 · Cited by 17 · see citing works

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Duarte‐Silva, S., Silva, J. D. D., Monteiro‐Fernandes, D., Costa, M. D., Neves‐Carvalho, A., Raposo, M., Soares‐Cunha, C., Correia, J. S., Nogueira-Goncalves, G., Fernandes, H. S., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci162246 · Cited by 17 · see citing works

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Huete-Acevedo, J., Mas‐Bargues, C., Arnal-Forné, M., Atencia-Rabadán, S., Sanz‐Ros, J., & Borrás, C. (2024) · Antioxidants · doi:10.3390/antiox13121493 · Cited by 15 · see citing works

Duodenal bile acids as determinants of intestinal mucosal homeostasis and disease

Keely, S., & Talley, N. J. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13854 · Cited by 15 · see citing works

Neuroprotection vs. Neurotoxicity: The Dual Impact of Brain Lipids in Depression

Yan, Y., Zhang, Y., Liu, M., Li, L., & Zheng, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062722 · Cited by 14 · see citing works

Grape Polyphenols May Prevent High-Fat Diet–Induced Dampening of the Hypothalamic–Pituitary–Adrenal Axis in Male Mice

Mezhibovsky, E., Tveter, K. M., Villa-Rodríguez, J. A., Bacalia, K. M. A., Kshatriya, D., Desai, N., Cabales, A., Wu, Y., Sui, K., Duran, R. M., et al. (2023) · Journal of the Endocrine Society · doi:10.1210/jendso/bvad095 · Cited by 12 · see citing works

Neurosteroids as positive and negative allosteric modulators of ligand-gated ion channels: P2X receptor perspective

Sivcev, S., Kudová, E., & Zemkova, H. W. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109542 · Cited by 13 · see citing works

Coordinated Targeting of Galanin Receptors on Cholangiocytes and Hepatic Stellate Cells Ameliorates Liver Fibrosis in Multidrug Resistance Protein 2 Knockout Mice

Petrescu, A. D., Grant, S. M., Williams, E., Frampton, G. A., Parks, N., Blaney, H. L., Davies, M., John, R., Reinhart, E. H., McMillin, M., et al. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2019.10.023 · Cited by 12 · see citing works

Bile acid interactions with neurotransmitter transporters

Romanazzi, T., Zanella, D., Bhatt, M., Iacovo, A. D., Galli, A., & Bossi, E. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1161930 · Cited by 11 · see citing works

Further evidence for blood-to-brain influx of unconjugated bile acids by passive diffusion: Determination of their brain-to-serum concentration ratios in rats by LC/MS/MS

Shibuya, T., Sato, A., Nishimoto‐Kusunose, S., Yoshizawa, K., & Higashi, T. (2024) · Steroids · doi:10.1016/j.steroids.2024.109397 · Cited by 11 · see citing works

Bile Acid Permeation Enhancement for Inner Ear Cochlear Drug Pharmacological Uptake: Bio-Nanotechnologies in Chemotherapy-Induced Hearing Loss

Carey, L., Walker, D., Jones, M., Ionescu, C. M., Wagle, S. R., Kovačević, B., Brown, D. J., Mikov, M., Mooranian, A., & Al‐Salami, H. (2021) · Therapeutic Delivery · doi:10.4155/tde-2021-0048 · Cited by 11 · see citing works

Dynamic expression of corticotropin-releasing hormone and urocortin in estrogen induced-cholestasis pregnant rat

Zhou, F., Gao, B., Deng, C., Huang, G., Xu, T., & Wang, X. (2016) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.07.019 · Cited by 11 · see citing works

Gut–brain communication mediates the impact of dietary lipids on cognitive capacity

Fan, C., Xu, J., Tong, H., Fang, Y., Chen, Y., Lin, Y., Chen, R., Chen, F., & Wu, G. (2024) · Food & Function · doi:10.1039/d3fo05288e · Cited by 10 · see citing works

Bile acids regulate SF-1 to alter cholesterol balance in adrenocortical cells via S1PR2

Liu, L., Zhou, S., Zaufel, A., Xie, Z., Racedo, S., Wagner, M., Zollner, G., Fickert, P., & Zhang, Q. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149342 · Cited by 8 · see citing works

The Role of Hypothalamic Neuropeptides in Regulation of Liver Functions in Health and Disease

Petrescu, A. D., An, S. Y., Venter, J., McMillin, M., & DeMorrow, S. (2023) · Endocrines · doi:10.3390/endocrines4020034 · Cited by 6 · see citing works

Exercise training ameliorates carbon tetrachloride-induced liver fibrosis and anxiety-like behaviors

Tomiga, Y., Tanaka, K., Kusuyama, J., Takano, A., Higaki, Y., Anzai, K., & Takahashi, K. (2024) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00161.2024 · Cited by 7 · see citing works

Microbiota–gut–brain axis and related therapeutics in Alzheimer’s disease: prospects for multitherapy and inflammation control

Li, J., Zhang, F., Zhao, L., & Dong, C. (2023) · Reviews in the Neurosciences · doi:10.1515/revneuro-2023-0006 · Cited by 6 · see citing works

Adrenal High‐Expressional CYP27A1 Mediates Bile Acid Increase and Functional Impairment in Adult Male Offspring by Prenatal Dexamethasone Exposure

Cao, J., Hu, W., Chen, Y., Ailikaiti, A., Zhang, Z., Li, R., Yu, H., & Wang, H. (2025) · Advanced Science · doi:10.1002/advs.202413299 · Cited by 4 · see citing works

Pathologic and therapeutic insights into cholestatic liver disease-associated depressive disorder

Li, X., Wang, H., Li, Y., Huang, M., Li, X., Yu, Z., Li, P., & Liu, R. (2025) · Acta Materia Medica · doi:10.15212/amm-2024-0082 · Cited by 4 · see citing works

Effects of cholestasis and hyperammonemia on dendritic spine density and turnover in rat hippocampal neurons

Giovannoni, L., Pierzchała, K., Roo, M. D., Braissant, O., Bruce, S., McLin, V. A., & Vutskits, L. (2024) · Scientific Reports · doi:10.1038/s41598-024-80871-8 · Cited by 3 · see citing works

Hypothalamic Cell Models

Dalvi, P. S., Loganathan, N., McIlwraith, E. K., Tran, A., & Belsham, D. D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819801-8.00002-8 · Cited by 3 · see citing works

Increased serum total bile acid level is associated with improved prognosis of ischemic stroke

Liu, Y., Mao, X., Li, Q., Liu, Y., Wu, X., Chu, M., Niu, H., Sun, L., He, Y., Chang, X., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.03.132 · Cited by 2 · see citing works

Dexamethasone may affect the occurrence of parenteral nutrition-associated cholestasis in preterm neonates

Jiang, S., Hu, Q., & Zhang, J. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.1023798 · Cited by 2 · see citing works

An open-label, multicenter, randomized, parallel, single-dose, comparative bioavailability study of two triamcinolone hexacetonide injectable suspensions in patients with knee osteoarthritis

Anand, K., Kumar, P., Haveri, S., Acharya, S., Tripathi, A. P., Bhole, M., & Malhotra, D. (2023) · International Journal of Research in Orthopaedics · doi:10.18203/issn.2455-4510.intjresorthop20232171 · Cited by 2 · see citing works

Neurologic Consequences of Liver Disease

McMillin, M., Rhodes, K., & DeMorrow, S. (2026) · American Journal Of Pathology · doi:10.1016/j.ajpath.2026.07.014 · Cited by 1 · see citing works

Gastric Bypass Surgery Regulates Glucose Homeostasis Through the Hypothalamus

Quan, H. (2019) · Clinical Medicine Research · doi:10.11648/j.cmr.20190802.11 · Cited by 1 · see citing works

Preparation for Pediatric Liver Transplant: Medical Aspects

Rock, N. M., & McLin, V. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-63671-1.00006-9 · Cited by 1 · see citing works

Neuroinflammatory Signals during Acute and Chronic Liver Diseases

McMillin, M., & DeMorrow, S. (2017) · InTech eBooks · doi:10.5772/intechopen.68938

Hypothalamus–pituitary axis transcriptomic modification dependent on growth rate in geese (Anser anser domesticus)

Piórkowska, K., Żukowski, K., Połtowicz, K., Witarski, W., Nowak, J., Potocka, P., & Ropka‐Molik, K. (2021) · Animal Genetics · doi:10.1111/age.13140

Adrenal histological and functional changes after hepatic encephalopathy: From mice model to an integrative bioinformatics analysis

Sepehri, A., Jahromi, G. P., Shahbazi, A., Sahraei, H., Hatef, B., Meftahi, G. H., & Negah, S. S. (2022) · Acta Histochemica · doi:10.1016/j.acthis.2022.151960

Central Administration of Recombinant IGF1 Is Neuroprotective in a Rodent Model of Acute Liver Failure

Wang, Y., McMillin, M., Frampton, G. A., Rhodes, K., Williams, E., Venter, J., Tyson, J., Gupta, E., Patankar, M., Mireles, P., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27083547

The Gut-Reproduction-Oral-Immune Axis: Microbial Dysbiosis as a Shared Driver in Polycystic Ovary Syndrome and Endometriosis

Li, T., Kuang, H., Zhang, J., Meng, Y., Feng, X., Mao, X., Pan, Z., & Sun, M. (2026) · Current Microbiology · doi:10.1007/s00284-026-04918-x

Interaction of gonadotropin-releasing hormone with the gastrointestinal tract: experimental and clinical perspectives

Майбородин, И. В., Sheplev, B. V., & Chernomortseva, E. S. (2026) · Russian Journal of Evidence-Based Gastroenterology · doi:10.17116/dokgastro20261502143

Suppression of the HPA axis during extrahepatic biliary obstruction induces cholangiocyte proliferation in the rat

Quinn, M. A., Ueno, Y., Pae, H. Y., Huang, L., Frampton, G. A., Galindo, C., Francis, H., Horvat, D., McMillin, M., & DeMorrow, S. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00205.2011 · Cited by 33 · see citing works

Suppression of hypothalamic-pituitary-adrenal axis responsiveness to stress in a rat model of acute cholestasis.

Swain, M. G., Patchev, V. K., Vergalla, J., Chrousos, G. P., & Jones, E. A. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116408 · Cited by 91 · see citing works

767 Inhibition of FGF19 Signaling Decreases Proliferation and Sensitizes Cholangiocytes to Apoptosis

Mohr, A. M., Smith, M. A., Natarajan, S. K., Wehrkamp, C. J., & Mott, J. L. (2014) · Gastroenterology · doi:10.1016/s0016-5085(14)63368-0 · Cited by 1 · see citing works

766 Hypothalamic Expression of Galanin Is Dysregulated During Cholestatic Liver Injury and Contributes to Hyperplastic Cholangiocyte Proliferation

McMillin, M., Frampton, G. A., Galindo, C., & DeMorrow, S. (2014) · Gastroenterology · doi:10.1016/s0016-5085(14)63367-9

Hypothalamus-Pituitary-Adrenal Dysfunction in Cholestatic Liver Disease

Petrescu, A. D., Kain, J., Liere, V., Heavener, T. E., & DeMorrow, S. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00660 · Cited by 37 · see citing works