The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Neuropsychiatric Symptoms Are Associated with Progression from Mild Cognitive Impairment to Alzheimer’s Disease
Abstract
Background: Neuropsychiatric disturbances are common in mild cognitive impairment (MCI). Depression and apathy may identify a subset of MCI subjects at higher risk of progression to Alzheimer’s disease (AD). However, it remains uncertain whether a broader spectrum of psychopathology is associated with progression to AD. Methods: Fifty-one MCI subjects were assessed for neuropsychiatric symptoms using the Neuropsychiatric Inventory. Subjects were followed for an average of 2 years. Twelve subjects (23.5%) progressed from MCI to possible/probable AD and 39 subjects (76.5%) remained stable or improved. Baseline Neuropsychiatric Inventory indices were compared between groups. Results: Subjects progressing to AD had a significantly higher prevalence of psychopathology than subjects who remained stable or improved (100 vs. 59%). Depression (67 vs. 31%) and apathy (50 vs. 18%) were more common in subjects who were later diagnosed with AD. After statistical adjustments for other baseline demographic variables, these specific symptoms were less robust predictors of progression to AD than the presence of any psychopathology. Conclusions: These findings suggest that neuropsychiatric symptoms in MCI are a predictor of progression to AD. Depression and apathy appear to be most useful for identifying MCI subjects at highest risk of developing dementia.
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Cited by
Cooper, C., Sommerlad, A., Lyketsos, C. G., & Livingston, G. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14070878 · Cited by 570
Anxiety as a Predictor for Cognitive Decline and Dementia: A Systematic Review and Meta-Analysis
Gulpers, B., Ramakers, I., Hamel, R., Köhler, S., Oude Voshaar, R., & Verhey, F. (2016) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2016.05.015 · Cited by 409
The association of neuropsychiatric symptoms in MCI with incident dementia and Alzheimer disease
Rosenberg, P. B., Mielke, M. M., Appleby, B. S., Oh, E. S., Geda, Y. E., & Lyketsos, C. G. (2013) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.01.006 · Cited by 366
Structural MRI correlates of apathy symptoms in older persons without dementia: AGES-Reykjavik Study
Grool, A. M., Geerlings, M. I., Sigurdsson, S., Eiriksdottir, G., Jonsson, P. V., Garcia, M. E., Siggeirsdottir, K., Harris, T. B., Sigmundsson, T., Gudnason, V., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000378 · Cited by 73
Neuropsychiatric correlates of cerebrospinal fluid biomarkers in Alzheimer's disease
Skogseth, R., Mulugeta, E., Ballard, C., Rongve, A., Nore, S., Alves, G., & Aarsland, D. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000137671 · Cited by 71
Metadata
- Authors
- Teng, E., Lu, P. H., & Cummings, J. L.
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2007
- Volume
- 24
- Issue
- 4
- Pages
- 253-259
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- OpenAlex
- W2076917672
- Cited by
- 208
- References
- 8
- FWCI
- 6.73
- Type
- journal article
- Language
- en
- Open access
- closed
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