Predictive Value of Mild Cognitive Impairment for Dementia
Abstract
Background/Aims: In population studies, different mild cognitive impairment (MCI) definitions have been used to predict dementia at a later stage. This study compared predictive values of different MCI definitions for dementia, and the effect of age on the predictive values was investigated. Methods: This study was conducted as part of an ongoing longitudinal study into the determinants of cognitive aging, the Maastricht Aging Study. Results: MCI best predicted dementia when multiple cognitive domains were considered and subjective complaints were not (sensitivity: 0.66, specificity: 0.78). Age had a strong influence on the sensitivity of MCI for dementia (age 60–70 years: sensitivity = 0.56; age 70–85 years: sensitivity = 0.70). Conclusion: The inclusion of multiple cognitive domains and participants aged 70 years and older leads to the best prediction of dementia, regardless of subjective complaints.
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Most works support the hypothesis that amnestic subtype of MCI is more likely to subsequently convert to AD, although this is still debated.
“Most of works support the hypothesis that amnestic subtype of MCI is more likely to subsequently convert to AD [43], although this is still a debated issue [44].”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [44]
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- Authors
- Baars, M. A. E., van Boxtel, M. P. J., Dijkstra, J. B., Visser, P. J., van den Akker, M., Verhey, F. R. J., & Jolles, J.
- Affiliations
- Maastricht University (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2009
- Volume
- 27
- Issue
- 2
- Pages
- 173-181
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- OpenAlex
- W2396577992
- Cited by
- 87
- References
- 35
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 6 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 1 · 2013: 7 · 2012: 5
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- VU Research Portal (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- mild cognitive impairment, dementia prediction, cognitive domain, subjective complaints, age effects, sensitivity and specificity, cognitive aging
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Aging, Cognition Disorders, Dementia, Female, Follow-Up Studies, Humans, Learning, Longitudinal Studies, Male, Middle Aged, Netherlands, Neuropsychological Tests, Predictive Value of Tests, ROC Curve, Disease Progression, Area Under Curve
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