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Cited by 91Stress Responses and CortisolNeural and Behavioral Psychology StudiesResilience and Mental Health

Prefrontal Plasticity and Stress Inoculation-Induced Resilience

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Katz, Maor, Liu, Chunlei, Schaer, Marie, Parker, Karen J., Ottet, Marie-Christine, Epps, Averi, Buckmaster, Christine L., Bammer, Roland +4 more·2009·Developmental Neuroscience
DOI 10.1159/000216540PMC PMC2820579
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Abstract

Coping with mild early life stress tends to make subsequent coping efforts more effective and therefore more likely to be used as a means of arousal regulation and resilience. Here we show that this developmental learning-like process of stress inoculation increases ventromedial prefrontal cortical volumes in peripubertal monkeys. Larger volumes do not reflect increased cortical thickness but instead represent surface area expansion of ventromedial prefrontal cortex. Expansion of ventromedial prefrontal cortex coincides with increased white matter myelination inferred from diffusion tensor magnetic resonance imaging. These findings suggest that the process of coping with early life stress increases prefrontal myelination and expands a region of cortex that broadly controls arousal regulation and resilience.

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  • Moderate stress exposure in nonhuman primates is associated with lower cortisol following stress and decreased anxiety, as well as increased prefrontal volume and enhanced prefrontal function.

    “Research on nonhuman primates has shown that moderate stress exposure is associated with lower cortisol following stress and decreased anxiety (Parker et al., 2004), as well as increased prefrontal volume and enhanced prefrontal function (Parker et al., 2005, Katz et al., 2009).”

    From The impact of developmental timing for stress and recovery (2015) · cites this paper as Katz et al., 2009

  • Early intermittent maternal separations that promote resilience increase cortical volume in the ventromedial prefrontal cortex, a change opposite in direction to that seen in depressed humans and stressed rodents.

    “Early intermittent maternal separations that promote resilience increase cortical volume within ventromedial PFC (VMPFC)66, changes opposite in direction to those seen in depressed humans and stressed rodents.”

    From Neurobiology of resilience (2012) · cites this paper as [66]

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Cited by

Sorted by citations

Authors
Katz, M., Liu, C., Schaer, M., Parker, K. J., Ottet, M.-C., Epps, A., Buckmaster, C. L., Bammer, R., Moseley, M. E., Schatzberg, A. F., Eliez, S., & Lyons, D. M.
Affiliations
  • Stanford Medicine (US)
  • University of Geneva (CH)
ORCID
Venue
Developmental Neuroscience
Publisher
S. Karger AG
Published
2009
Volume
31
Issue
4
Pages
293-299
ISSN
  • 0378-5866 (ISSN-L)
  • 1421-9859
DOI
10.1159/000216540
PMC
PMC2820579
OpenAlex
W2127372492
Cited by
91
References
7
Citations by year
2026: 8 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 6 · 2017: 2 · 2016: 3 · 2015: 7 · 2014: 7 · 2013: 9 · 2012: 8
FWCI
3.05
Type
journal article
Language
en
Open access
Licence
Locations
  • Developmental Neuroscience (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (publishedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders
  • National Institute of Mental Health (F32MH066537, MH-47573, MH77884, R01MH077884, R01MH047573, MH66537)
  • National Institute on Drug Abuse (R01DA016902, DA16902)
  • National Institute of Biomedical Imaging and Bioengineering (K99EB007182, R00EB007182)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
Keywords
early life stress, stress inoculation training, resilience, ventromedial prefrontal cortex, white matter myelination, arousal regulation, cortical thickness
MeSH terms
Animals, Anxiety, Separation, Female, Humans, Male, Neuronal Plasticity, Random Allocation, Saimiri, Stress, Psychological, Prefrontal Cortex

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