CoChat
Sign Up
Cited by 190Pituitary Gland Disorders and TreatmentsPancreatic function and diabetesAdrenal Hormones and Disorders

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Pathophysiology of Diabetes Mellitus in Cushing’s Syndrome

Pivonello, Rosario, De Leo, Monica, Vitale, Pasquale, Cozzolino, Alessia, Simeoli, Chiara, De Martino, Maria Cristina, Lombardi, Gaetano, Colao, Annamaria·2010·Neuroendocrinology
DOI 10.1159/000314319
Open this paper in CoChat — free account

Abstract

Cushing’s syndrome is commonly complicated with an impairment of glucose metabolism, which is often clinically manifested as diabetes mellitus. The development of diabetes mellitus in Cushing’s syndrome is both a direct and indirect consequence of glucocorticoid excess. Indeed, glucocorticoid excess induces a stimulation of gluconeogenesis in the liver as well as an inhibition of insulin sensitivity both in the liver and in the skeletal muscles, which represent the most important sites responsible for glucose metabolism. In particular, glucocorticoid excess stimulates the expression of several key enzymes involved in the process of gluconeogenesis, with a consequent increase of glucose production, and induces an impairment of insulin sensitivity either directly by interfering with the insulin receptor signaling pathway or indirectly, through the stimulation of lipolysis and proteolysis and the consequent increase of fatty acids and amino acids, which contribute to the development of insulin resistance. Moreover, the peculiar distribution of adipose tissue throughout the body, with the predominance of visceral adipose tissue, significantly contributes to the worsening of insulin resistance and the development of a metabolic syndrome, which participates in the occurrence and maintenance of the impairment of glucose tolerance. Finally, glucocorticoid excess is able to impair insulin secretion as well as act at the level of the pancreatic beta cells, where it inhibits different steps of the insulin secretion process. This phenomenon is probably responsible for the passage from an impairment of glucose tolerance to an overt diabetes mellitus in susceptible patients with Cushing’s syndrome.

Overview

Integrity signals

Registry

Crossref · 10.1159/000314319

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 24 references

Research works printed but not linked: 5

  1. 10.1042%2FCS19980388 · DOI
  2. 10.1210%2Fjc.77.5.1180 · DOI · Paper page
  3. 10.1007%2Fs00125-003-1190-9 · DOI · Paper page
  4. 10.1074%2Fjbc.272.48.30261 · DOI
  5. 10.1210%2Fjc.81.7.2621 · DOI

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Pivonello, R., De Leo, M., Vitale, P., Cozzolino, A., Simeoli, C., De Martino, M. C., Lombardi, G., & Colao, A.
Affiliations
Federico II University Hospital (IT)
ORCID
Venue
Neuroendocrinology
Publisher
S. Karger AG
Published
2010
Volume
92
Issue
Suppl. 1
Pages
77-81
ISSN
  • 0028-3835 (ISSN-L)
  • 1423-0194
DOI
10.1159/000314319
OpenAlex
W2100232797
Cited by
190
References
24
Citations by year
2026: 6 · 2025: 10 · 2024: 14 · 2023: 13 · 2022: 8 · 2021: 15 · 2020: 14 · 2019: 13 · 2018: 13 · 2017: 11 · 2016: 10 · 2015: 17 · 2014: 13 · 2013: 16 · 2012: 14
FWCI
7.99
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
Cushing's syndrome, diabetes mellitus, glucocorticoid excess, insulin resistance, insulin secretion, gluconeogenesis, glucose tolerance, visceral adipose tissue, metabolic syndrome, pancreatic beta cells, lipolysis
MeSH terms
Insulin Secretion, Cushing Syndrome, Diabetes Mellitus, Glucose, Humans, Insulin, Insulin Resistance, Insulin-Secreting Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review