Cited by 76Nutritional Studies and DietDiabetes, Cardiovascular Risks, and LipoproteinsNitric Oxide and Endothelin Effects

Effect of L-Arginine and Selenium Added to a Hypocaloric Diet Enriched with Legumes on Cardiovascular Disease Risk Factors in Women with Central Obesity: A Randomized, Double-Blind, Placebo-Controlled Trial

Alizadeh, Mohammad, Safaeiyan, Abdolrasoul, Ostadrahimi, Alireza, Estakhri, Rassul, Daneghian, Sevana, Ghaffari, Aida, Gargari, Bahram Pourghassem·2012·Annals of Nutrition and Metabolism

Abstract

Background/aims We aimed to discover if L-arginine and selenium alone or together can increase the effect of a hypocaloric diet enriched in legumes (HDEL) on central obesity and cardiovascular risk factors in women with central obesity. Methods This randomized, double-blind, placebo-controlled trial was undertaken in 84 premenopausal women with central obesity. After a 2-week run-in period on an isocaloric diet, participants were randomly assigned to a control diet (HDEL), L-arginine (5 g/day) and HDEL, selenium (200 μg/day) and HDEL or L-arginine, selenium and HDEL for 6 weeks. Cardiovascular risk factors were assessed before intervention and 3 and 6 weeks afterwards. Results After 6 weeks, L-arginine had significantly reduced waist circumference (WC); selenium had significantly lowered fasting concentrations of serum insulin and the homeostasis model assessment of insulin resistance index; the interaction between L-arginine and selenium significantly reduced the fasting concentration of nitric oxides (NO(x)), and HDEL lowered triglycerides (TG) and WC and significantly increased the fasting concentration of NO(x). HDEL reduced high-sensitivity C-reactive protein levels in the first half of the study and returned them to basal levels in the second half. Conclusion These data indicate the beneficial effects of L-arginine on central obesity, selenium on insulin resistance and HDEL on serum concentrations of NO(x) and TG.

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Crossref · 10.1159/000335470

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  • Human studies have repeatedly shown that L-arginine supplementation has favorable effects on body composition and insulin sensitivity.

    “However, human studies have repeatedly shown that L-arginine supplementation has favorable effects on body composition and insulin sensitivity [271-277].”

    From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [273]

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Authors
Alizadeh, M., Safaeiyan, A., Ostadrahimi, A., Estakhri, R., Daneghian, S., Ghaffari, A., & Gargari, B. P.
Affiliations
  • Urmia University of Medical Sciences (IR)
  • Tabriz University of Medical Sciences (IR)
Venue
Annals of Nutrition and Metabolism
Publisher
S. Karger AG
Published
2012
Volume
60
Issue
2
Pages
157-168
ISSN
  • 0250-6807 (ISSN-L)
  • 1421-9697
OpenAlex
W2083743440
Cited by
76
References
71
Citations by year
2026: 2 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 3 · 2020: 6 · 2019: 8 · 2018: 6 · 2017: 3 · 2016: 9 · 2015: 5 · 2014: 9 · 2013: 6 · 2012: 2
FWCI
6.79
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of Nutrition and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
University of Tabriz
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
L-arginine, selenium, hypocaloric diet, Fabaceae, abdominal obesity, cardiovascular risk factors, premenopausal women, insulin resistance, nitric oxide, C-reactive protein, triglycerides, waist circumference, weight loss
MeSH terms
Adult, Arginine, Cardiovascular Diseases, Diet, Reducing, Double-Blind Method, Female, Humans, Insulin Resistance, Iran, Fabaceae, Middle Aged, Nitric Oxide, Risk Factors, Seeds, Selenium, Hypertriglyceridemia, Weight Loss, Dietary Supplements, Waist Circumference, Obesity, Abdominal

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