Clinical characteristics of patients in Japan with ovarian cancer presumably arising from ovarian endometrioma
Abstract
OBJECTIVE: To investigate the clinical features of patients in Japan with malignant transformation of ovarian endometrioma. PATIENTS: Thirty-three patients diagnosed with ovarian cancer presumably arising from endometrioma were recruited retrospectively. These patients had been followed for at least 2 years after the ovarian endometrioma diagnosis, then continued to be followed after they had been found to have malignant transformation. RESULTS: The average age of the patients was 47.7 ± 9.3 years; 75.7% were premenopausal at the time of diagnosis of ovarian cancer. Among the 33 patients, ovarian cancer developed in the ipsilateral ovary of 6 patients with endometrioma after cystectomy. Twenty-eight patients were diagnosed with stage I ovarian cancer, and major histotypes were clear cell in 23 cases and endometrioid in 8. Before surgery for cancer, mural nodules within the endometriomas were detected in 32 patients, and 1 patient had a small 3-mm nodule. In 30 patients, the diameter of the tumor doubled in size 6 months prior to the diagnosis of malignant transformation. The diameter of the endometrioma and the preoperative CA125 value did not significantly correlate. CONCLUSIONS: To detect malignant transformation of ovarian endometrioma early and precisely, the clinician should determine the existence of a mural nodule and assess the rapid growth of the endometrioma.
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Malignant transformation of ovarian endometriosis has been well documented.
“Malignant transformation of ovarian endometriosis has been well documented.”
From Malignancies Associated with Extraovarian Endometriosis: A Literature Review (2021) · cites this paper as [11]
The common histological types of ovarian endometriosis-associated cancer were clear cell carcinoma (70%) and endometrioid carcinoma (24%).
“The common histological types were clear cell carcinoma (70%) and endometrioid carcinoma (24%) [11].”
From Malignancies Associated with Extraovarian Endometriosis: A Literature Review (2021) · cites this paper as [11]
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“The common histological types were clear cell carcinoma (70%) and endometrioid carcinoma (24%) [11].”
Background
- Authors
- Taniguchi, F., Harada, T., Kobayashi, H., Hayashi, K., Momoeda, M., & Terakawa, N.
- Affiliations
- Tottori University (JP)
- Nara Medical University (JP)
- Gunma University (JP)
- St. Luke's International Hospital (JP)
- Venue
- Gynecologic and Obstetric Investigation
- Publisher
- S. Karger AG
- Published
- 2014
- Volume
- 77
- Issue
- 2
- Pages
- 104-110
- ISSN
- 0378-7346 (ISSN-L)
- 1423-002X
- OpenAlex
- W2020045892
- Cited by
- 31
- References
- 23
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2021: 1 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 3
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gynecologic and Obstetric Investigation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- endometrioma, malignant transformation, ovarian cancer, clear cell carcinoma, endometrioid carcinoma, mural nodules, tumor growth rate, CA125, cystectomy, premenopausal women, early detection
- MeSH terms
- Adult, Aged, Cell Transformation, Neoplastic, Endometriosis, Female, Follow-Up Studies, Humans, Japan, Magnetic Resonance Imaging, Membrane Proteins, Middle Aged, Neoplasm Staging, Ovarian Cysts, Ovarian Neoplasms, Retrospective Studies, Ultrasonography, Adenocarcinoma, Clear Cell, Carcinoma, Endometrioid, CA-125 Antigen
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