Ovarian endometriosis associated with ovarian carcinoma: A clinicopathological and immunohistochemical study
Abstract
Objective The purpose of this study was to demonstrate the incidence, the histopathological characteristics, and the proliferation activity of endometriosis and atypical endometriosis associated with ovarian carcinoma.Methods Microscopic slides of primary lesions from 127 patients with primary ovarian carcinoma were reviewed. The presence or absence of endometriosis and the transitions from typical endometriosis to atypical endometriosis and from atypical endometriosis to carcinoma were also histologically evaluated. Ki-67 immunoreactivity of typical and atypical endometriosis and carcinoma was examined. In addition, endometrial metaplasias were also evaluated.Results Of the 127 patients, 37 had endometriosis: 70% (30/43) had clear cell adenocarcinoma, 43% (3/7) had endometrioid adenocarcinoma, 7% (4/60) had serous adenocarcinoma, and none (0/17) had mucinous adenocarcinoma. Thirty-three cases showed typical endometriosis and 29 cases had atypical endometriosis (25 cases had both). Tufting and the stratification of the lining epithelium were observed in 25 and 23 cases, respectively. The transition from typical endometriosis to atypical endometriosis was observed in 22 cases, and the transition from atypical endometriosis to carcinoma, in 23 cases. Only one case showed a direct transition from typical endometriosis to carcinoma. The mean Ki-67 indices were as follows: ovarian carcinoma, 23.1; atypical endometriosis, 9.9; typical endometriosis, 2.7. In 18 cases with metaplasia in endometriosis, eosinophilic metaplasia and ciliated metaplasia were the most common types. Five cases had two types of metaplasia.Conclusions Ovarian carcinomas, especially clear cell and endometrioid adenocarcinomas, are highly associated with endometriosis. Atypical endometriosis shows proliferation activity intermediate to those of typical endometriosis and ovarian carcinoma, suggesting it is a precancerous status.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
14.7 to 22.8% of ovarian carcinomas coexist with atypical endometriosis.
“One of the reasons is that 14.7 to 22.8% of ovarian carcinomas coexist with atypical endometriosis [13,14].”
From Malignancies Associated with Extraovarian Endometriosis: A Literature Review (2021) · cites this paper as [14]
Cites
Gerdes, J., Schwab, U., Lemke, H., & Stein, H. (1983) · International Journal of Cancer · doi:10.1002/ijc.2910310104 · Cited by 2,788 · see citing works
ENDOMETRIAL CARCINOMA OF THE OVARY, ARISING IN ENDOMETRIAL TISSUE IN THAT ORGAN
SAMPSON, J. A. (1925) · Archives of Surgery · doi:10.1001/archsurg.1925.01120100007001 · Cited by 765 · see citing works
Malignant neoplasms arising in endometriosis
Heaps, J., Rk, N., & Berek, J. (1991) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(91)90262-4 · Cited by 396 · see citing works
Goff, B. A., de la Cuesta, R. S., Muntz, H. G., et al. (1996) · Gynecologic Oncology · doi:10.1006/gyno.1996.0065 · Cited by 357 · see citing works
<b>Ovarian atypical endometriosis: its close association with malignant epithelial tumours</b>
FUKUNAGA, M., NOMURA, K., ISHIKAWA, E., & USHIGOME, S. (1997) · Histopathology · doi:10.1046/j.1365-2559.1997.d01-592.x · Cited by 333 · see citing works
Malignant changes in endometriosis.
Rb, S. (1953) · PubMed · Cited by 290 · see citing works
MALIGNANT TUMORS ARISING IN ENDOMETRIOSIS
Mostoufi-Zadeh, M., & Scully, R. E. (1980) · Clinical Obstetrics & Gynecology · doi:10.1097/00003081-198009000-00024 · Cited by 253 · see citing works
Sugihara, K., Moriya, Y., Akasu, T., & Fujita, S. (1996) · Cancer · doi:10.1002/(sici)1097-0142(19961101)78:9 · Cited by 245 · see citing works
MALIGNANT TUMORS ARISING IN ENDOMETRIOSIS
Mostoufi-Zadeh, M., & Scully, R. E. (1980) · Clinical Obstetrics & Gynecology · doi:10.1097/00003081-198023030-00024 · Cited by 232 · see citing works
Ovarian tumors associated with atypical endometriosis
LaGrenade, A., & Silverberg, S. G. (1988) · Human Pathology · doi:10.1016/s0046-8177(88)80090-x · Cited by 194 · see citing works
Endometrial epithelial metaplasias
Hendrickson, M. R., & Richard, I. (1980) · The American Journal of Surgical Pathology · doi:10.1097/00000478-198012000-00004 · Cited by 185 · see citing works
THE DEVELOPMENT OF MALIGNANCY IN ENDOMETRIOSIS
Scully, R. E., Richardson, G. S., & Barlow, J. F. (1966) · Clinical Obstetrics & Gynecology · doi:10.1097/00003081-196606000-00008 · Cited by 184 · see citing works
Ovarian clear cell adenocarcinoma
KENNEDY, A. W., Biscotti, C. V., Hart, W. R., et al. (1989) · Gynecologic Oncology · doi:10.1016/0090-8258(89)90637-9 · Cited by 182 · see citing works
Endometriosis and ovarian cancer
Vercellini, P., Parazzini, F., Bolis, G., Carinelli, S. G., Dindelli, M., Vendola, N., Luchini, L., & Crosignani, P. G. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(93)90159-g · Cited by 172 · see citing works
Clear cell adenocarcinoma of the ovary: A clinical analysis and comparison with serous carcinoma
Jenison, E. L., MONTAG, A. G., Griffiths, C. T., Welch, W. R., Lavin, P. T., Greer, J., & KNAPP, R. C. (1989) · Gynecologic Oncology · doi:10.1016/0090-8258(89)90852-4 · Cited by 164 · see citing works
Clear cell carcinoma of the ovary: A study of 59 cases
Crozier, M., Copeland, L. J., Silva, E. G., et al. (1989) · Gynecologic Oncology · doi:10.1016/0090-8258(89)90043-7 · Cited by 151 · see citing works
Malignancy arising in extragonadal endometriosis.A case report and summary of the world literature
Brooks, J. J. S., & Wheeler, J. E. (1977) · Cancer · doi:10.1002/1097-0142(197712)40:6 · Cited by 147 · see citing works
A histologic study of ovarian endometriosis with emphasis on hyperplastic and atypical changes.
Czernobilsky, B., & Morris, W. J. (1979) · PubMed · Cited by 146 · see citing works
Hitti, I. F., Glasberg, S. S., & Lubicz, S. (1990) · Gynecologic Oncology · doi:10.1016/0090-8258(90)90259-n · Cited by 129 · see citing works
Prognostic Importance of Hyperplasia and Atypia in Endometriosis
Seidman, J. D. (1996) · International Journal of Gynecological Pathology · doi:10.1097/00004347-199601000-00001 · Cited by 126 · see citing works
Clinical features of ovarian cancer in Japanese women with germ-line mutations of BRCA1.
Aida, H., Takakuwa, K., Nagata, H., et al. (1998) · PubMed · Cited by 99 · see citing works
Informed consent in the childrens cancer group
Childrens Cancer Group, Kodish, E. D., Pentz, R. D., Noll, R. B., Ruccione, K., Buckley, J. D., & Lange, B. J. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19980615)82:12 · Cited by 91 · see citing works
Matsushima, M., Kobayashi, K., Eml, M., et al. (1995) · Human Molecular Genetics · doi:10.1093/hmg/4.10.1953 · Cited by 81 · see citing works
Ovarian carcinoma arising in endometriosis
Corner, G. W., Hu, C.-Y., & Hertig, A. T. (1950) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(50)90107-4 · Cited by 81 · see citing works
Ovarian carcinoma arising in atypical endometriosis.
Moll, U. M., Chumas, J. C., Chalas, E., & Wj, M. (1990) · PubMed · Cited by 77 · see citing works
Epithelial metaplastic changes in ovarian endometriosis.
Fukunaga, M., & Ushigome, S. (1998) · PubMed · Cited by 75 · see citing works
Ovarian Endometriotic Cysts:An Analysis of Cytologic Atypia and DNA Ploidy Patterns
Ballouk, F., Ross, J. S., & Wolf, B. C. (1994) · American Journal of Clinical Pathology · doi:10.1093/ajcp/102.4.415 · Cited by 72 · see citing works
MIB1, A PROMISING MARKER FOR THE CLASSIFICATION OF CERVICAL INTRAEPITHELIAL NEOPLASIA
Bulten, J., van der Laak, J. A. W. M., Gemmink, J. H., Pahlplatz, M. M. M., de Wilde, P. C. M., & Hanselaar, A. G. J. M. (1996) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199603)178:3 · Cited by 70 · see citing works
Clear cell (“mesonephroid”) adenocarcinoma of the vulva arising in endometriosis: A case report
Mesko, J. D., Gates, H., McDonald, T. W., Youmans, R., & Lewis, J. (1988) · Gynecologic Oncology · doi:10.1016/0090-8258(88)90241-7 · Cited by 58 · see citing works
Endometrioid and Clear Cell Carcinoma of the Ovary
Brescia, R. J., Dubin, N., & Demopoulos, R. I. (1989) · International Journal of Gynecological Pathology · doi:10.1097/00004347-198906000-00006 · Cited by 49 · see citing works
Chumas, J. C., Thanning, L., & Mann, W. J. (1986) · Gynecologic Oncology · doi:10.1016/0090-8258(86)90228-3 · Cited by 48 · see citing works
Clear cell carcinoma of the inguinal region arising from endometriosis
Ahn, G., & Scully, R. E. (1991) · Cancer · doi:10.1002/1097-0142(19910101)67:1 · Cited by 47 · see citing works
Endometrial metaplasia associated with endometrial carcinoma.
Kaku, T., Tsukamoto, N., Tsuruchi, N., et al. (1992) · PubMed · Cited by 42 · see citing works
Self-citationEndometrial metaplasia associated with endometrial adenocarcmoma
Andersen, W. A., Taylor, P. T., Fechner, R. E., et al. (1987) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(87)80013-3 · Cited by 40 · see citing works
Proliferation in the normal cervix and in preinvasive cervical lesions.
Payne, S., Kernohan, N. M., & Walker, F. (1996) · Journal of Clinical Pathology · doi:10.1136/jcp.49.8.667 · Cited by 34 · see citing works
Clear cell adenocarcinoma arising in endometriosis of the rectovaginal septum.
Goldberg, M. I., Jl, B., Ed, H., & Nordqvist, S. R. B. (1978) · PubMed · Cited by 29 · see citing works
Silvestri, F., Bussani, R., Pavletic, N., et al. (1997) · Acta Oto-Laryngologica · doi:10.3109/00016489709124034 · Cited by 23 · see citing works
Kapp, D. S., Merino, M. J., & LiVolsi, V. A. (1982) · Gynecologic Oncology · doi:10.1016/0090-8258(82)90099-3 · Cited by 22 · see citing works
Chalas, E., ChumasS, J., Barbieri, R. L., et al. (1990) · Gynecologic Oncology · doi:10.1016/0090-8258(90)90288-v · Cited by 22 · see citing works
von Numers, C. (1965) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016346509153982 · Cited by 21 · see citing works
Hyman, M. P. (1977) · American Journal of Clinical Pathology · doi:10.1093/ajcp/68.4.522 · Cited by 21 · see citing works
A series of ovarian clear cell and endometrioid carcinoma and their association with endometriosis.
Chew, S., Kf, T., & Ss, R. (1997) · PubMed · Cited by 21 · see citing works
Ioachim, E. E., Assimakopoulos, D. A., Nj, A., et al. (1999) · PubMed · Cited by 18 · see citing works
Ovarian atypical endometriosis
Seidman (1998) · Histopathology · doi:10.1046/j.1365-2559.1998.0285b.x · Cited by 9 · see citing works
[Clinicopathological study on clear cell carcinoma of the ovary].
Kaku, S., Hirai, Y., Fujimoto, I., et al. (1989) · PubMed · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Priorities for Endometriosis Research: Recommendations From an International Consensus Workshop
Rogers, P. A. W., D’Hooghe, T. M., Fazleabas, A., Gargett, C. E., Giudice, L. C., Montgomery, G. W., Rombauts, L., Salamonsen, L. A., & Zondervan, K. T. (2009) · Reproductive Sciences · doi:10.1177/1933719108330568 · Cited by 346 · see citing works
Eržen, M., Rakar, S., Klančar, B., & Syrjänen, K. (2001) · Gynecologic Oncology · doi:10.1006/gyno.2001.6382 · Cited by 160 · see citing works
Malignant extraovarian endometriosis: A review
Benoit, L., Arnould, L., Cheynel, N., Diane, B., Causeret, S., Machado, A., Collin, F., Fraisse, J., & Cuisenier, J. (2006) · European Journal of Surgical Oncology (EJSO) · doi:10.1016/j.ejso.2005.08.011 · Cited by 108 · see citing works
Impact of endometriosis on risk of ovarian, endometrial and cervical cancers: A meta-analysis
li, J., Liu, R., Tang, S., Feng, F., Liu, C., Wang, L., Zhao, W., Zhang, T., Yao, Y., Wang, X., et al. (2019) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-018-4968-1 · Cited by 56 · see citing works
Taniguchi, F., Harada, T., Kobayashi, H., Hayashi, K., Momoeda, M., & Terakawa, N. (2014) · Gynecologic and Obstetric Investigation · doi:10.1159/000357819 · Cited by 31 · see citing works
Self-citationLong-Term Follow-Up after Surgical Management for Atypical Endometriosis: A Series of Nine Cases
Tanase, Y., Kawaguchi, R., Uchiyama, T., & Kobayashi, H. (2019) · Case Reports in Oncology · doi:10.1159/000496178 · Cited by 16 · see citing works
Self-citationMalignancies Associated with Extraovarian Endometriosis: A Literature Review
Inoue, N., Hirakawa, T., Mitsushita, J., Kitahara, Y., & Iwase, A. (2021) · Endocrines · doi:10.3390/endocrines2030024 · Cited by 7 · see citing works
“8% of ovarian carcinomas coexist with atypical endometriosis [13,14].”
BackgroundSelf-citation
- Authors
- Ogawa, S., Kaku, T., Amada, S., Kobayashi, H., Hirakawa, T., Ariyoshi, K., Kamura, T., & Nakano, H.
- Affiliations
- Kyushu University (JP)
- Kurume University (JP)
- Venue
- Gynecologic Oncology
- Publisher
- Elsevier BV
- Published
- 2000-05
- Volume
- 77
- Issue
- 2
- Pages
- 298-304
- ISSN
- 0090-8258 (ISSN-L)
- OpenAlex
- W2018077886
- Cited by
- 279
- References
- 45
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 12 · 2023: 3 · 2022: 7 · 2021: 10 · 2020: 6 · 2019: 18 · 2018: 19 · 2017: 10 · 2016: 13 · 2015: 19 · 2014: 14 · 2013: 20 · 2012: 16
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gynecologic Oncology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (09671692, 11671626)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- endometrioma, ovarian carcinoma, atypical endometriosis, clear cell adenocarcinoma, endometrioid carcinoma, serous adenocarcinoma, endometrial metaplasia, Ki-67 proliferation index, precancerous lesions, tufting
- MeSH terms
- Adult, Aged, Aged, 80 and over, Cell Division, Endometriosis, Female, Humans, Immunohistochemistry, Middle Aged, Ovarian Diseases, Ovarian Neoplasms, Adenocarcinoma, Clear Cell, Cystadenoma, Serous, Ki-67 Antigen
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review