Risk of developing ovarian cancer among women with ovarian endometrioma: A cohort study in Shizuoka, Japan
Open accessAbstract
Although some studies have indicated that endometriosis may increase the risk of developing ovarian cancer, there are no data from epidemiologic studies in Japan. We prospectively analyzed all cases of ovarian endometrioma enrolled in the prefecture-wide Shizuoka Cohort Study on Endometriosis and Ovarian Cancer Programme, which was initiated in 1985. To evaluate the risk of ovarian cancer by time periods subsequent to ovarian endometrioma diagnosis, a cohort of 6,398 women with a clinically documented ovarian endometrioma in Shizuoka between 1985 and 1995 was identified from the Shizuoka Cancer Registry (SCR), with follow-up through 2002. Ovarian cancer incidence among cohort members was ascertained by linkage to the SCR using a unique person-identification number. Standardized incidence ratios (SIR) and their 95% confidence intervals (CI) were computed by a use of prefecture-wide rates of ovarian cancer, adjusted for age and calendar year. During follow-up of up to 17 years of the ovarian endometrioma cohort, 46 incident ovarian cancers were identified, yielding that the ovarian cancer risk was elevated significantly among patients with ovarian endometrioma (SIR = 8.95, 95% CI = 4.12-15.3). The SIR did not increase with increasing follow-up duration. The risk increased with increasing age at ovarian endometrioma diagnosis, with a SIR equal to 13.2 (95% CI = 6.90-20.9) in women above 50 years of age. Our findings for the first time support the hypothesis that ovarian endometrioma increases the subsequent risk of developing ovarian cancer in Shizuoka, Japan.
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Kobayashi et al. conducted a prospective cohort study of 6398 cases of ovarian endometriosis, which resulted in 46 cases (0.72%) being diagnosed with ovarian carcinoma.
“Kobayashi et al. conducted a prospective cohort study of 6398 cases of ovarian endometriosis, which resulted in 46 cases (0.72%) being diagnosed with ovarian carcinoma [8].”
From Malignancies Associated with Extraovarian Endometriosis: A Literature Review (2021) · cites this paper as [8]
Malignant transformation of ovarian endometriosis has been well documented.
“Malignant transformation of ovarian endometriosis has been well documented.”
From Malignancies Associated with Extraovarian Endometriosis: A Literature Review (2021) · cites this paper as [8]
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- Authors
- Kobayashi, H., Sumimoto, K., Moniwa, N., Imai, M., Takakura, K., Kuromaki, T., Morioka, E., Arisawa, K., & Terao, T.
- Affiliations
- Nara Medical University (JP)
- Hamamatsu University (JP)
- Shizuoka Cancer Center (JP)
- Corresponding author
- Kobayashi, H.
- ORCID
- Kobayashi, H.
- Venue
- International Journal of Gynecological Cancer
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 17
- Issue
- 1
- Pages
- 37-43
- ISSN
- 1048-891X (ISSN-L)
- OpenAlex
- W2099581897
- Cited by
- 305
- References
- 33
- Citations by year
- 2026: 11 · 2025: 7 · 2024: 12 · 2023: 13 · 2022: 12 · 2021: 18 · 2020: 24 · 2019: 16 · 2018: 22 · 2017: 19 · 2016: 24 · 2015: 19 · 2014: 25 · 2013: 16 · 2012: 17
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- International Journal of Gynecological Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Keywords
- endometrioma, ovarian cancer risk, endometriosis, ovarian cancer incidence, age at diagnosis, standardized incidence ratio
- MeSH terms
- Adult, Endometriosis, Female, Humans, Japan, Middle Aged, Ovarian Neoplasms, Prospective Studies, Registries, Risk Factors, Cohort Studies
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