Heterogeneity of atherosclerotic plaque macrophage origin, phenotype and functions: Implications for treatment
Open accessAbstract
Macrophages are key players in atherosclerotic lesions, regulating the local inflammatory milieu and plaque stability by the secretion of many inflammatory molecules, growth factors and cytokines. Monocytes have long been considered to be the main source of plaque macrophages. However, recent findings provide evidence for proliferation of local macrophages or transdifferentiation from other vascular cells as alternative sources. Recent years of research focused on the further identification and characterisation of macrophage phenotypes and functions. In this review we describe the advances in our understanding of monocyte and macrophage heterogeneity and its implications for specific therapeutic interventions, aiming to reduce the ever growing significant risk of cardiovascular events without any detrimental side effects on the patient's immune response.
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Local macrophage proliferation and transdifferentiation of intimal smooth muscle cells into macrophage-like cells are further sources of lesional macrophages.
“Local proliferation of macrophages and transdifferentiation of intimal smooth muscle cells into macrophage-like cells are two additional sources of macrophages in the lesions141.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [141]
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The Role of Macrophages in Atherosclerosis Development
Bezsonov, E. E., Gavrilova, D., Grebenshchikov, E. S., Grinev, A., Puchinova, E., Kuzmin, V., Oganesyan, A., Bogomolov, D., Degtyarevskaya, T., Lazareva, Y. B., et al. (2026) · Gene Expression · doi:10.14218/ge.2025.00080
- Authors
- Nagenborg, J., Goossens, P., Biessen, E. A. L., & Donners, M. M. P. C.
- Affiliations
- Maastricht University (NL)
- Corresponding author
- Donners, Marjo M.P.C.
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 816
- Pages
- 14-24
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2762391541
- Cited by
- 50
- References
- 192
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 9 · 2023: 8 · 2022: 5 · 2021: 10 · 2020: 5 · 2019: 5 · 2018: 1 · 2017: 1
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- European Journal of Pharmacology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, cc-by-nc-nd)
- RWTH Publications (RWTH Aachen) (submittedVersion, cc-by-nc-nd)
- Research Publications (Maastricht University) (submittedVersion, cc-by-nc-nd)
- RWTH Publications (RWTH Aachen)
- Funders
- Marie Sklodowska-Curie (675111)
- EU Horizon2020-MSCA-IF (661099)
- Heart Foundation (2012T079)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- atherosclerosis, plaque macrophages, macrophage heterogeneity, monocyte origin, macrophage phenotype, plaque stability, inflammation, cytokines
- MeSH terms
- Animals, Humans, Macrophages, Monocytes, Phenotype, Plaque, Atherosclerotic, Molecular Targeted Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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