Cited by 56Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid MetabolismImmune cells in cancer

Heterogeneity of atherosclerotic plaque macrophage origin, phenotype and functions: Implications for treatment

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Nagenborg, Jan, Goossens, Pieter, Biessen, Erik A.L., Donners, Marjo M.P.C.·2017·European Journal of Pharmacology

Abstract

Macrophages are key players in atherosclerotic lesions, regulating the local inflammatory milieu and plaque stability by the secretion of many inflammatory molecules, growth factors and cytokines. Monocytes have long been considered to be the main source of plaque macrophages. However, recent findings provide evidence for proliferation of local macrophages or transdifferentiation from other vascular cells as alternative sources. Recent years of research focused on the further identification and characterisation of macrophage phenotypes and functions. In this review we describe the advances in our understanding of monocyte and macrophage heterogeneity and its implications for specific therapeutic interventions, aiming to reduce the ever growing significant risk of cardiovascular events without any detrimental side effects on the patient's immune response.

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Crossref · 10.1016/j.ejphar.2017.10.005

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  • Local macrophage proliferation and transdifferentiation of intimal smooth muscle cells into macrophage-like cells are further sources of lesional macrophages.

    “Local proliferation of macrophages and transdifferentiation of intimal smooth muscle cells into macrophage-like cells are two additional sources of macrophages in the lesions141.”

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  3. Zawada, A.M., Rogacev, K.S., Winter, P., Marell, R.-R., Fliser, D., Heine, G.H., 2011. SuperSAGE evidence for CD14. Blood 118, 50-62. http://dx.doi.org/10.1182/blood- 2011-01-326827. · DOI
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Authors
Nagenborg, J., Goossens, P., Biessen, E. A. L., & Donners, M. M. P. C.
Affiliations
Maastricht University (NL)
Corresponding author
Donners, Marjo M.P.C.
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
2017-12
Volume
816
Pages
14-24
ISSN
0014-2999 (ISSN-L)
OpenAlex
W2762391541
Cited by
50
References
192
Citations by year
2026: 3 · 2025: 3 · 2024: 9 · 2023: 8 · 2022: 5 · 2021: 10 · 2020: 5 · 2019: 5 · 2018: 1 · 2017: 1
FWCI
1.48
Type
journal article
Language
en
Open access
Locations
  • European Journal of Pharmacology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (publishedVersion, cc-by-nc-nd)
  • RWTH Publications (RWTH Aachen) (submittedVersion, cc-by-nc-nd)
  • Research Publications (Maastricht University) (submittedVersion, cc-by-nc-nd)
  • RWTH Publications (RWTH Aachen)
Funders
  • Marie Sklodowska-Curie (675111)
  • EU Horizon2020-MSCA-IF (661099)
  • Heart Foundation (2012T079)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords
atherosclerosis, plaque macrophages, macrophage heterogeneity, monocyte origin, macrophage phenotype, plaque stability, inflammation, cytokines
MeSH terms
Animals, Humans, Macrophages, Monocytes, Phenotype, Plaque, Atherosclerotic, Molecular Targeted Therapy

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