CoChat
Sign Up
Cited by 67Systemic Lupus Erythematosus ResearchBlood Coagulation and Thrombosis MechanismsHeparin-Induced Thrombocytopenia and Thrombosis

Prevalence of antibodies to prothrombin in solid phase (aPT) and to phosphatidylserine-prothrombin complex (aPS/PT) in patients with and without lupus anticoagulant

Sciascia, Savino, Murru, Veronica, Garcia-Fernandez, Cesar, Sanna, Giovanni, Khamashta, Munther, Bertolaccini, Maria Laura·2013·Thrombosis and Haemostasis
DOI 10.1160/th12-07-0527
Open this paper in CoChat — free account

Abstract

Summary: Antibodies to prothrombin in solid phase (aPT) and those to phosphatidiyserine- prothrombin complex (aPS/PT) have been suggested to strongly correlate with the presence of lupus anticoagulant (LA). As their clinical diagnostic value and true relationship with the LA remains elusive, we designed this study to evaluate the prevalence and significance of aPT and aPS/PT in a large cohort of patients with and without LA. Samples from 257 patients were included. aPT and aPS/PT were tested by ELISA. LA was tested as per the current criteria from the ISTH Subcommittee on LA-Phospholipid-dependent antibodies. aPS/PT and aPT were found in 51% and 32% of LA-positive (LA+ve) patients and in 22% and 28% of LA-negative (LA-ve) patients, respectively. Thrombosis, particularly venous thrombosis was associated with IgG aPT in the LA+ve group (p=0.0006) and in the LA-ve group (p=0.017). Antibodies to phosphatidylserine-prothrombin, either IgG and IgM were associated with thrombosis in general (p=0.0003) in particularly with venous thrombosis in the LA+ve group (p<0.0001 for IgG and p=0.025 for IgM; respectively) and the LA-ve group (p=0.028, 0.02 and 0.001, respectively). Further multivariate logistic regression analysis showed that LA and of IgG and/or IgM aPS/PT were independent risk factors for thrombosis and pregnancy loss. In conclusion, aPS/PT, but not aPT, are more frequently found in patients with LA. Their association with thrombosis seems to be independent of the presence of LA.

Integrity signals

Registry

Crossref · 10.1160/th12-07-0527

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Among non-canonical aPL-associated antibodies, such as antibodies against protein Z or prothrombin, only a weak association was observed between higher IgM-isotype antibodies against protein Z and a higher risk of anamnestic thrombosis.

    “Among non-canonical aPL-associated antibodies [11], such as antibodies against protein Z or prothrombin, we only observed a weak association between higher IgM-isotype antibodies against protein Z and a higher risk of anamnestic thrombosis.”

    From Cardiovascular risk factors are major determinants of thrombotic risk in patients with the lupus anticoagulant (2017) · cites this paper as [11]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Sciascia, S., Murru, V., Garcia-Fernandez, C., Sanna, G., Khamashta, M., & Bertolaccini, M. L.
Affiliations
  • St Thomas' Hospital (GB)
  • King's College London (GB)
  • Guy's Hospital (GB)
ORCID
Venue
Thrombosis and Haemostasis
Publisher
Georg Thieme Verlag KG
Published
2013
Volume
109
Issue
02
Pages
207-213
ISSN
  • 0340-6245 (ISSN-L)
  • 2567-689X
DOI
10.1160/th12-07-0527
OpenAlex
W2039668401
Cited by
67
References
27
Citations by year
2026: 2 · 2025: 2 · 2024: 6 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 11 · 2018: 5 · 2017: 8 · 2016: 5 · 2015: 6 · 2014: 4 · 2013: 4
FWCI
3.44
Type
journal article
Language
en
Open access
closed
Locations
  • Thrombosis and Haemostasis (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
Louise Gergel Fellowship
Topics
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
  • Health Sciences › Medicine › Surgery › Heparin-Induced Thrombocytopenia and Thrombosis
Keywords
lupus anticoagulant, venous thrombosis, thrombosis risk factors, miscarriage, autoantibodies, IgM and IgG antibodies, prevalence
MeSH terms
Abortion, Spontaneous, Adult, Enzyme-Linked Immunosorbent Assay, Female, United Kingdom, Humans, Immunoglobulin G, Immunoglobulin M, Male, Middle Aged, Phosphatidylserines, Pregnancy, Prothrombin, Risk Factors, Biomarkers, Multivariate Analysis, Logistic Models, Odds Ratio, Seroepidemiologic Studies, Lupus Coagulation Inhibitor, Antiphospholipid Syndrome, Risk Assessment, Venous Thrombosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review