Cited by 390Cholesterol and Lipid MetabolismAtherosclerosis and Cardiovascular DiseasesLipoproteins and Cardiovascular Health

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Increased Atherosclerosis in Hyperlipidemic Mice With Inactivation of ABCA1 in Macrophages

Open access

Aiello, Robert J., Brees, Dominique, Bourassa, Patricia-Ann, Royer, Lori, Lindsey, Saralyn, Coskran, Timothy, Haghpassand, Mehrdad, Francone, Omar L.·2002·Arteriosclerosis, Thrombosis, and Vascular Biology

DOI 10.1161/01.atv.0000014804.35824.da

Open this paper in CoChat — free account Open PDF

Abstract

The ATP-binding cassette transporter A1 (ABCA1) encodes a membrane protein that promotes cholesterol and phospholipid efflux from cells. Mutations in ABCA1 lead to HDL deficiency and tissue accumulation of macrophages in patients with homozygous Tangier disease. In this study, we examined whether the complete absence of ABCA1 or selected inactivation in macrophages is accompanied by an increase in atherosclerotic lesion progression in hypercholesterolemic apolipoprotein E–deficient (apoE −/− ) mice and LDLR receptor–deficient (LDLr −/− ) mice. The absence of ABCA1 led to reduced plasma cholesterol levels in both the apoE −/− and LDLr −/− mice, along with severe skin xanthomatosis characterized by marked foamy macrophages and cholesterol ester accumulation. However, the complete absence of ABCA1 did not affect the development, progression, or composition of atherosclerotic lesions in either the LDLr −/− or the apoE −/− mice fed a chow or atherogenic diet. In contrast, bone marrow transplantation studies demonstrated that the selective inactivation of ABCA1 in macrophages markedly increased atherosclerosis and foam cell accumulation in apoE −/− . Taken together, these findings demonstrate that the complete absence of ABCA1 has a major impact on plasma lipoprotein homeostasis, and the proposed antiatherogenic effect resulting from ABCA1 deficiency is compensated by a less atherogenic profile. ABCA1 deficiency in macrophages, however, demonstrates the antiatherogenic properties of ABCA1 independent of plasma lipids and HDL levels.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/01.atv.0000014804.35824.da

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189
Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
Springer, T. A. (1994) · Cell · doi:10.1016/0092-8674(94)90337-9 · Cited by 7,009
High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies.
Gordon, D. J., Probstfield, J. L., Garrison, R. J., Neaton, J. D., Castelli, W. P., Knoke, J. D., Jacobs, D. R., Bangdiwala, S., & Tyroler, H. A. (1989) · Circulation · doi:10.1161/01.cir.79.1.8 · Cited by 3,162
The Human ATP-Binding Cassette (ABC) Transporter SuperfamilyPreprint
Dean, M. C., Rzhetsky, A., & Allikmets, R. L. (2001) · Genome Research · doi:10.1101/gr.184901 · Cited by 1,820
Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
Brooks-Wilson, A., Marcil, M., Clee, S. M., Zhang, L.-H., Roomp, K., van Dam, M., Yu, L., Brewer, C., Collins, J. A., Molhuizen, H. O. F., et al. (1999) · Nature Genetics · doi:10.1038/11905 · Cited by 1,687
The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
Bodzioch, M., Orsó, E., Klucken, J., Langmann, T., Böttcher, A., Diederich, W., Drobnik, W., Barlage, S., Büchler, C., Porsch-Özcürümez, M., et al. (1999) · Nature Genetics · doi:10.1038/11914 · Cited by 1,512
Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1
Rust, S., Rosier, M., Funke, H., Real, J., Amoura, Z., Piette, J.-C., Deleuze, J.-F., Brewer, H. B., Duverger, N., Denèfle, P., et al. (1999) · Nature Genetics · doi:10.1038/11921 · Cited by 1,433
A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis
Chawla, A., Boisvert, W. A., Lee, C.-H., Laffitte, B. A., Barak, Y., Joseph, S. B., Liao, D., Nagy, L., Edwards, P. A., Curtiss, L. K., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00164-2 · Cited by 1,347
Regulation of Absorption and ABC1-Mediated Efflux of Cholesterol by RXR Heterodimers
Repa, J. J., Turley, S. D., Lobaccaro, J. A., Medina, J. C., Li, L., Lustig, K. D., Shan, B., Heyman, R. A., Dietschy, J. M., & Mangelsdorf, D. J. (2000) · Science · doi:10.1126/science.289.5484.1524 · Cited by 1,317
The human ATP-binding cassette (ABC) transporter superfamily
Dean, M., Hamon, Y., & Chimini, G. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31588-1 · Cited by 1,302

Show all 38 references

Research works printed but not linked: 9

10.1161/atvb.20.6.1565 · DOI
10.1161/atv91.14.12.7981195 · DOI
10.1161/circ.103.2.e13 · DOI
10.1161/circ.79.1.2642759 · DOI
10.1161/atv91.12.5.1576121 · DOI
10.1172/JCI200112517 · DOI
10.1161/circ.103.7.1000 · DOI
10.1161/atv91.12.2.1543690 · DOI
10.1161/atvb.18.12.1983 · DOI

Sorted by citations

Apoptotic cell clearance: basic biology and therapeutic potential
Poon, I. K. H., Lucas, C. D., Rossi, A. G., & Ravichandran, K. S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3607 · Cited by 1,223
New Insights Into the Regulation of HDL Metabolism and Reverse Cholesterol Transport
Lewis, G. F., & Rader, D. J. (2005) · Circulation Research · doi:10.1161/01.res.0000170946.56981.5c · Cited by 1,104
Liver X receptors as integrators of metabolic and inflammatory signaling
Zelcer, N. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27883 · Cited by 978
Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease
Zheng, L., Nukuna, B. N., Brennan, M., Sun, M., Goormastic, M., Settle, M., Schmitt, D., Fu, X., Thomson, L., Fox, P. L., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21109 · Cited by 735
The macrophage foam cell as a target for therapeutic intervention
Li, A. C., & Glass, C. K. (2002) · Nature Medicine · doi:10.1038/nm1102-1235 · Cited by 700
Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis
Rayner, K. J., Sheedy, F. J., Esau, C. C., Hussain, F. N., Temel, R. E., Parathath, S., van Gils, J. M., Rayner, A. J., Chang, A. N., Suarez, Y., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57275 · Cited by 690
Role of HDL, ABCA1, and ABCG1 Transporters in Cholesterol Efflux and Immune Responses
Yvan‐Charvet, L., Wang, N., & Tall, A. R. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.179283 · Cited by 683
Liver X Receptor Signaling Pathways in Cardiovascular Disease
Tontonoz, P., & Mangelsdorf, D. J. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0061 · Cited by 639
HDL Cholesterol and Protective Factors in Atherosclerosis
Assmann, G., & Gotto, A. M. (2004) · Circulation · doi:10.1161/01.cir.0000131512.50667.46 · Cited by 637
HDL, ABC transporters, and cholesterol efflux: implications for the treatment of atherosclerosis
Tall, A. R., Yvan-Charvet, L., Terasaka, N., Pagler, T., & Wang, N. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.03.001 · Cited by 540
Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice
Yvan-Charvet, L., Ranalletta, M., Wang, N., Han, S., Terasaka, N., Li, R., Welch, C., & Tall, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci33372 · Cited by 536
Macrophage Reverse Cholesterol Transport
Cuchel, M., & Rader, D. J. (2006) · Circulation · doi:10.1161/circulationaha.104.475715 · Cited by 536
ATP-Binding Cassette Transporter A1: A Cell Cholesterol Exporter That Protects Against Cardiovascular Disease
Oram, J. F., & Heinecke, J. W. (2005) · Physiological Reviews · doi:10.1152/physrev.00005.2005 · Cited by 531
Importance of Different Pathways of Cellular Cholesterol Efflux
Yancey, P. G., Bortnick, A. E., Kellner-Weibel, G., de la Llera-Moya, M., Phillips, M. C., & Rothblat, G. H. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000057572.97137.dd · Cited by 516
Atherosclerosis in the Apolipoprotein E–Deficient Mouse
Meir, K. S., & Leitersdorf, E. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000128849.12617.f4 · Cited by 498
HDL as a target in the treatment of atherosclerotic cardiovascular disease
Linsel‐Nitschke, P., & Tall, A. R. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1658 · Cited by 489
Association of Loss-of-Function Mutations in the <emph type="ital">ABCA1</emph> Gene With High-Density Lipoprotein Cholesterol Levels and Risk of Ischemic Heart Disease
Frikke-Schmidt, R. (2008) · JAMA · doi:10.1001/jama.299.21.2524 · Cited by 464
Molecular Biology of Atherosclerosis
Hopkins, P. N. (2013) · Physiological Reviews · doi:10.1152/physrev.00004.2012 · Cited by 469
Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I
Timmins, J. M., Lee, J.-Y., Boudyguina, E., Kluckman, K. D., Brunham, L. R., Mulya, A., Gebre, A. K., Coutinho, J. M., Colvin, P. L., Smith, T. L., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23915 · Cited by 447
Identification of macrophage liver X receptors as inhibitors of atherosclerosis
Tangirala, R. K., Bischoff, E. D., Joseph, S. B., Wagner, B. L., Walczak, R., Laffitte, B. A., Daige, C. L., Thomas, D., Heyman, R. A., Mangelsdorf, D. J., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182199799 · Cited by 444
Cholesterol efflux pathways and other potential mechanisms involved in the athero‐protective effect of high density lipoproteins
Tall, A. R. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01898.x · Cited by 436
ATP-Binding Cassette Cholesterol Transporters and Cardiovascular Disease
Oram, J. F., & Vaughan, A. M. (2006) · Circulation Research · doi:10.1161/01.res.0000250171.54048.5c · Cited by 411
Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL
Zannis, V. I., Chroni, A., & Krieger, M. (2006) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0030-4 · Cited by 404
The liver X receptor gene team: Potential new players in atherosclerosis
Repa, J. J., & Mangelsdorf, D. J. (2002) · Nature Medicine · doi:10.1038/nm1102-1243 · Cited by 389
Increased Cellular Free Cholesterol in Macrophage-specific Abca1 Knock-out Mice Enhances Pro-inflammatory Response of Macrophages
Zhu, X., Lee, J., Timmins, J. M., Brown, J. M., Boudyguina, E. Y., Mulya, A., Gebre, A. K., Willingham, M. C., Hiltbold, E. M., Mishra, N., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801408200 · Cited by 356
Atheroprotective Effects of High-Density Lipoproteins
Assmann, G., & Nofer, J. (2003) · Annual Review of Medicine · doi:10.1146/annurev.med.54.101601.152409 · Cited by 345
Human Immunodeficiency Virus Impairs Reverse Cholesterol Transport from Macrophages
Mujawar, Z., Rose, H. M., Morrow, M. P., Pushkarsky, T., Dubrovsky, L., Mukhamedova, N., Fu, Y., Dart, A. M., Orenstein, J. M., Bobryshev, Y. V., et al. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040365 · Cited by 335
Reverse cholesterol transport and cholesterol efflux in atherosclerosis
Ohashi, R., Mu, H. H., Wang, X., Yao, Q., & Chen, C. (2005) · QJM · doi:10.1093/qjmed/hci136 · Cited by 336
Nuclear receptors in macrophage biology: at the crossroads of lipid metabolism and inflammation
Castrillo, A., & Tontonoz, P. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.012103.134432 · Cited by 260
The Macrophage Cholesterol Exporter ABCA1 Functions as an Anti-inflammatory Receptor
Tang, C., Liu, Y., Kessler, P. S., Vaughan, A. M., & Oram, J. F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.047472 · Cited by 284
ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL
Vaughan, A. M., & Oram, J. F. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600218-jlr200 · Cited by 291
Regulation and Mechanisms of ATP-Binding Cassette Transporter A1-Mediated Cellular Cholesterol Efflux
Wang, N., & Tall, A. R. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000075912.83860.26 · Cited by 261
ATP-Binding Cassette Transporters, Atherosclerosis, and Inflammation
Westerterp, M., Bochem, A. E., Yvan‐Charvet, L., Murphy, A. J., Wang, N., & Tall, A. R. (2014) · Circulation Research · doi:10.1161/circresaha.114.300738 · Cited by 261
Increased ABCA1 activity protects against atherosclerosis
Singaraja, R. R., Fievet, C., Castro, G., James, E. R., Hennuyer, N., Clee, S. M., Bissada, N., Choy, J. C., Fruchart, J.-C., McManus, B. M., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15748 · Cited by 250
Efflux and Atherosclerosis
Singaraja, R. R., Brunham, L. R., Visscher, H., Kastelein, J. J. P., & Hayden, M. R. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000078520.89539.77 · Cited by 248
High density lipoproteins (HDLs) and atherosclerosis; the unanswered questions
Barter, P. J., Kastelein, J. J. P., Nunn, A. V. W., & Hobbs, R. F. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00006-6 · Cited by 242
Lipid efflux by the ATP-binding cassette transporters ABCA1 and ABCG1
Cavelier, C., Lorenzi, I., Rohrer, L., & von Eckardstein, A. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.04.012 · Cited by 237
The HDL hypothesis: does high-density lipoprotein protect from atherosclerosis?
Vergeer, M., Holleboom, A. G., Kastelein, J. J. P., & Kuivenhoven, J. A. (2010) · Journal of Lipid Research · doi:10.1194/jlr.r001610 · Cited by 222
Scavenger Receptor Class B Type I–Mediated Protection Against Atherosclerosis in LDL Receptor–Negative Mice Involves Its Expression in Bone Marrow–Derived Cells
Covey, S. D., Krieger, M., Wang, W., Penman, M., & Trigatti, B. L. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000083343.19940.a0 · Cited by 221
MicroRNA‐33 Deficiency Reduces the Progression of Atherosclerotic Plaque in ApoE −/− Mice
Horie, T., Baba, O., Kuwabara, Y., Chujo, Y., Watanabe, S., Kinoshita, M., Horiguchi, M., Nakamura, T., Chonabayashi, K., Hishizawa, M., et al. (2012) · Journal of the American Heart Association · doi:10.1161/jaha.112.003376 · Cited by 220
Molecular mechanisms of vascular effects of High‐density lipoprotein: alterations in cardiovascular disease
Besler, C., Lüscher, T. F., & Landmesser, U. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200224 · Cited by 226
Regulation and mechanisms of macrophage cholesterol efflux
Tall, A. R., Costet, P., & Wang, N. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16391 · Cited by 235
Macrophage ABCG1 Deletion Disrupts Lipid Homeostasis in Alveolar Macrophages and Moderately Influences Atherosclerotic Lesion Development in LDL Receptor-Deficient Mice
Out, R., Hoekstra, M., Hildebrand, R. B., Kruit, J. K., Meurs, I., Li, Z., Kuipers, F., van Berkel, T. J. C., & Eck, M. V. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000237629.29842.4c · Cited by 204
ABCA1 redistributes membrane cholesterol independent of apolipoprotein interactions
Vaughan, A. M., & Oram, J. F. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300078-jlr200 · Cited by 203
Combined Deletion of Macrophage ABCA1 and ABCG1 Leads to Massive Lipid Accumulation in Tissue Macrophages and Distinct Atherosclerosis at Relatively Low Plasma Cholesterol Levels
Out, R., Hoekstra, M., Habets, K. L. L., Meurs, I., de Waard, V., Hildebrand, R. B., Wang, Y., Chimini, G., Kuiper, J., van Berkel, T. J. C., et al. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.156935 · Cited by 199
Do not let death do us part: ‘find-me’ signals in communication between dying cells and the phagocytes
Medina, C. B., & Ravichandran, K. S. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.13 · Cited by 199
The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse
Chisholm, J. W., Hong, J., Mills, S. A., & Lawn, R. M. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300135-jlr200 · Cited by 198
ABC transporters, atherosclerosis and inflammation
Fitzgerald, M. L., Mujawar, Z., & Tamehiro, N. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.01.011 · Cited by 196
Phosphorylation of a Pest Sequence in ABCA1 Promotes Calpain Degradation and Is Reversed by ApoA-I
Martinez, L. O., Agerholm-Larsen, B., Wang, N., Chen, W., & Tall, A. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307161200 · Cited by 186
ABC A-subfamily transporters: Structure, function and disease
Kaminski, W. E., Piehler, A. P., & Wenzel, J. J. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.01.011 · Cited by 183
Scavenger receptor BI and ATP-binding cassette transporter A1 in reverse cholesterol transport and atherosclerosis
Eck, M. V., Pennings, M., Hoekstra, M., Out, R., & van Berkel, T. J. C. (2005) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000169351.28019.04 · Cited by 181
Myeloperoxidase Targets Apolipoprotein A-I, the Major High Density Lipoprotein Protein, for Site-Specific Oxidation in Human Atherosclerotic Lesions
Shao, B., Pennathur, S., & Heinecke, J. W. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.337345 · Cited by 170
Macrophage ATP-Binding Cassette Transporter A1 Overexpression Inhibits Atherosclerotic Lesion Progression in Low-Density Lipoprotein Receptor Knockout Mice
Eck, M. V., Singaraja, R. R., Ye, D., Hildebrand, R. B., James, E. R., Hayden, M. R., & van Berkel, T. J. C. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000208364.22732.16 · Cited by 170
Impaired Development of Atherosclerosis in Hyperlipidemic Ldlr −/− and ApoE −/− Mice Transplanted With Abcg1 −/− Bone Marrow
Baldán, Á., Pei, L., Lee, R. G., Tarr, P. T., Tangirala, R. K., Weinstein, M. M., Frank, J. S., Li, A. C., Tontonoz, P., & Edwards, P. A. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000240051.22944.dc · Cited by 164
Atherosclerosis
Lu, H. S., & Daugherty, A. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305380 · Cited by 171
Emerging roles of the intestine in control of cholesterol metabolism
Kruit, J. K. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i40.6429 · Cited by 165
HDL: The Metabolism, Function, and Therapeutic Importance
Wang, M., & Briggs, M. R. (2003) · Chemical Reviews · doi:10.1021/cr020466v · Cited by 159
ATP-Binding Membrane Cassette Transporter A1 (ABCA1): A Possible Link between Inflammation and Reverse Cholesterol Transport
Yin, K., Liao, D., & Tang, C. (2010) · Molecular Medicine · doi:10.2119/molmed.2010.00004 · Cited by 158
ABCA1 and nascent HDL biogenesis
Wang, S., & Smith, J. D. (2014) · BioFactors · doi:10.1002/biof.1187 · Cited by 161
Different roles of liver X receptor α and β in lipid metabolism: Effects of an α-selective and a dual agonist in mice deficient in each subtype
Lund, E. G., Peterson, L. B., Adams, A. D., Lam, M.-H. N., Burton, C. A., Chin, J., Guo, Q., Huang, S., Latham, M., Lopez, J. C., et al. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.11.004 · Cited by 148
HDL and atherosclerotic cardiovascular disease: genetic insights into complex biology
Rosenson, R. S., Brewer, H. B., Barter, P. J., Björkegren, J., Chapman, M. J., Gaudet, D., Kim, D. S., Niesor, E. J., Rye, K., Sacks, F. M., et al. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.115 · Cited by 149
ABCA1-Deficient Mice
Aiello, R. J., Brees, D., & Francone, O. L. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000054661.21499.fb · Cited by 146
Self-citation
Mechanisms of Disease: macrophage-derived foam cells emerging as therapeutic targets in atherosclerosis
Choudhury, R. P., Lee, J., & Greaves, D. R. (2005) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0195 · Cited by 146
Interleukin‐10 overexpression in macrophages suppresses atherosclerosis in hyperlipidemic mice
Han, X., Kitamoto, S., Wang, H., & Boisvert, W. A. (2010) · The FASEB Journal · doi:10.1096/fj.09-148155 · Cited by 145
Variations on a Gene: Rare and Common Variants in ABCA1 and Their Impact on HDL Cholesterol Levels and Atherosclerosis
Brunham, L. R., Singaraja, R. R., & Hayden, M. R. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.26.061505.111214 · Cited by 148
ABCA1-mediated Cholesterol Efflux Is Defective in Free Cholesterol-loaded Macrophages
Feng, B., & Tabas, I. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207532200 · Cited by 143
Apolipoprotein A-I Modulates Regulatory T Cells in Autoimmune LDLr−/−, ApoA-I−/− Mice
Wilhelm, A. J., Zabalawi, M., Owen, J. S., Shah, D., Grayson, J. M., Major, A. S., Bhat, S., Gibbs, D. P., Thomas, M. J., & Sorci‐Thomas, M. G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.134130 · Cited by 145
Liver X receptors as regulators of macrophage inflammatory and metabolic pathways
A-González, N., & Castrillo, A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.12.015 · Cited by 139
Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor
Quinet, E. M., Savio, D. A., Halpern, A. R., Chen, L., Miller, C. P., & Nambi, P. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400257-jlr200 · Cited by 144
OSBP-related Protein 8 (ORP8) Suppresses ABCA1 Expression and Cholesterol Efflux from Macrophages
Yan, D., Mäyränpää, M. I., Wong, J., Perttilä, J., Lehto, M. J., Jauhiainen, M., Kovanen, P. T., Ehnholm, C., Brown, A. J., & Olkkonen, V. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705313200 · Cited by 138
Liver X receptors at the intersection of lipid metabolism and atherogenesis
Lee, S. D., & Tontonoz, P. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.06.042 · Cited by 135
Stearoyl-CoA Desaturase Inhibits ATP-binding Cassette Transporter A1-mediated Cholesterol Efflux and Modulates Membrane Domain Structure
Sun, Y., Hao, M., Luo, Y., Liang, C.-P., Silver, D. L., Cheng, C., Maxfield, F. R., & Tall, A. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208687200 · Cited by 134
Genetic Variation in ABCA1 Predicts Ischemic Heart Disease in the General Population
Frikke‐Schmidt, R., Nordestgaard, B. G., Jensen, G. B., Steffensen, R., & Tybjærg‐Hansen, A. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.153858 · Cited by 134
Inhibitory effect of PCSK9 on Abca1 protein expression and cholesterol efflux in macrophages
Adorni, M. P., Cipollari, E., Favari, E., Zanotti, I., Zimetti, F., Corsini, A., Ricci, C., Bernini, F., & Ferri, N. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.11.019 · Cited by 130
Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking
Zhang, J. R., Coleman, T., Langmade, S. J., Scherrer, D. E., Lane, L. M., Lanier, M. H., Chu, F., Sands, M. S., Schaffer, J. E., Semenkovich, C. F., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32561 · Cited by 127
Regulation of cholesterol homeostasis in macrophages and consequences for atherosclerotic lesion development
Pennings, M., Meurs, I., Ye, D., Out, R., Hoekstra, M., van Berkel, T. J. C., & Eck, M. V. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.08.022 · Cited by 126
ABCA1 Is Essential for Efficient Basolateral Cholesterol Efflux during the Absorption of Dietary Cholesterol in Chickens
Mulligan, J. D., Flowers, M. T., Oler, A. T., BITGOOD, J. J., Wellington, C. L., Hayden, M. R., & Attie, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212377200 · Cited by 125
Interferon-γ and atherosclerosis: Pro- or anti-atherogenic?
Harvey, E. J., & Ramji, D. P. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.04.019 · Cited by 126
Apolipoprotein A-I and Its Role in Lymphocyte Cholesterol Homeostasis and Autoimmunity
Wilhelm, A. J., Zabalawi, M., Grayson, J. M., Weant, A. E., Major, A. S., Owen, J., Bharadwaj, M. S., Walzem, R. L., Chan, L., Oka, K., et al. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.183442 · Cited by 124
Pulmonary abnormalities due to ABCA1 deficiency in mice
Bates, S. R., Tao, J., Collins, H. L., Francone, O. L., & Rothblat, G. H. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00234.2005 · Cited by 123
Self-citation
Coffee Consumption Enhances High-Density Lipoprotein-Mediated Cholesterol Efflux in Macrophages
Uto‐Kondo, H., Ayaori, M., Ogura, M., Nakaya, K., Ito, M., Suzuki, A., Takiguchi, S., Yakushiji, E., Terao, Y., Ozasa, H., et al. (2010) · Circulation Research · doi:10.1161/circresaha.109.206615 · Cited by 119
High-density lipoproteins and atherosclerosis
Rader, D. J. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02635-8 · Cited by 116
The cell cholesterol exporter ABCA1 as a protector from cardiovascular disease and diabetes
Tang, C., & Oram, J. F. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.03.011 · Cited by 115
High Density Lipoprotein Biogenesis, Cholesterol Efflux, and Immune Cell Function
Sorci‐Thomas, M. G., & Thomas, M. J. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300135 · Cited by 116
Study of ABCA1 function in transgenic mice.
Joyce, C. W., Freeman, L., Brewer, H., & Santamarina-Fojo, S. (2003) · Arteriosclerosis, Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000055194.85073.ff · Cited by 118
Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1
Fond, A. M., Lee, C. S., Schulman, I. G., Kiss, R. S., & Ravichandran, K. S. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80300 · Cited by 114
Hypercholesterolemia and reduced HDL-C promote hematopoietic stem cell proliferation and monocytosis: Studies in mice and FH children
Tolani, S., Pagler, T. A., Murphy, A. J., Bochem, A. E., Abramowicz, S., Welch, C. L., Nagareddy, P. R., Holleran, S., Hovingh, G. K., Kuivenhoven, J. A., et al. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.03.031 · Cited by 119
HDL Biogenesis, Remodeling, and Catabolism
Zannis, V. I., Fotakis, P., Κούκος, Γ., Kardassis, D., Ehnholm, C., Jauhiainen, M., & Chroni, A. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-09665-0_2 · Cited by 123
Intramural Plasminogen Activator Inhibitor Type-1 and Coronary Atherosclerosis
Sobel, B. E., Taatjes, D. J., & Schneider, D. J. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000091250.53231.4d · Cited by 112
Dysfunctional HDL in diabetes mellitus and its role in the pathogenesis of cardiovascular disease
Srivastava, R. A. K. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-3165-z · Cited by 113
The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility
Selva, D. M., Hirsch‐Reinshagen, V., Burgess, B. L., Zhou, S., Chan, J. Y., McIsaac, S. A., Hayden, M. R., Hammond, G. L., Vogl, A. W., & Wellington, C. L. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400007-jlr200 · Cited by 109
Synthetic High-Density Lipoprotein-Mediated Targeted Delivery of Liver X Receptors Agonist Promotes Atherosclerosis Regression
Guo, Y., Yuan, W., Yu, B., Kuai, R., Hu, W., Morin, E. E., Garcia-Barrio, M. T., Zhang, J., Moon, J. J., Schwendeman, A. A., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.12.021 · Cited by 107
LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis
Xian, X., Ding, Y., Dieckmann, M., Zhou, L., Plattner, F., Liu, M., Parks, J. S., Hammer, R. E., Boucher, P., Tsai, S. X., et al. (2017) · eLife · doi:10.7554/elife.29292 · Cited by 102
Tissue-Specific Roles of ABCA1 Influence Susceptibility to Atherosclerosis
Brunham, L. R., Singaraja, R. R., Duong, M., Timmins, J. M., Fievet, C., Bissada, N., Kang, M. H., Samra, A., Fruchart, J.-C., McManus, B., et al. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.182303 · Cited by 102
Development of mannose functionalized dendrimeric nanoparticles for targeted delivery to macrophages: use of this platform to modulate atherosclerosis
He, H., Yuan, Q., Bie, J., Wallace, R. L., Yannie, P. J., Wang, J., Lancina, M. G., Zolotarskaya, O. Y., Korzun, W. J., Yang, H., et al. (2017) · Translational research · doi:10.1016/j.trsl.2017.10.008 · Cited by 103
Genetic Basis of Atherosclerosis: Insights From Mice and Humans
Stylianou, I. M., Bauer, R. C., Reilly, M. P., & Rader, D. J. (2012) · Circulation Research · doi:10.1161/circresaha.110.230854 · Cited by 99
LXRs: new therapeutic targets in atherosclerosis?
Joseph, S. B. (2003) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(03)00009-2 · Cited by 102
A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome
Albrecht, C., McVey, J. H., Elliott, J. I., Sardini, A., Kasza, I., Mumford, A. D., Naoumova, R. P., Tuddenham, E. G. D., Szabó, K., & Higgins, C. F. (2005) · Blood · doi:10.1182/blood-2004-05-2056 · Cited by 97
Increased Cholesterol Deposition, Expression of Scavenger Receptors, and Response to Chemotactic Factors in Abca1 -Deficient Macrophages
Francone, O. L., Royer, L. J., Boucher, G., Haghpassand, M., Freeman, A., Brees, D., & Aiello, R. J. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000166522.69552.99 · Cited by 97
Self-citation
ABCA1 and atherosclerosis
Soumian, S., Albrecht, C., Davies, A. H., & Gibbs, R. (2005) · Vascular Medicine · doi:10.1191/1358863x05vm593ra · Cited by 100

Authors: Aiello, R. J., Brees, D., Bourassa, P.-A., Royer, L., Lindsey, S., Coskran, T., Haghpassand, M., & Francone, O. L.
Affiliations: Pfizer (United States) (US)
ORCID: Aiello, Robert J.
Brees, Dominique
Venue: Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2002-04
Volume: 22
Issue: 4
Pages: 630-637
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/01.atv.0000014804.35824.da
OpenAlex: W2128738849
Cited by: 390
References: 38
Citations by year: 2026: 3 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 10 · 2021: 11 · 2020: 8 · 2019: 6 · 2018: 9 · 2017: 14 · 2016: 11 · 2015: 19 · 2014: 22 · 2013: 17 · 2012: 20
FWCI: 30.15
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords: ABCA1, atherosclerosis, macrophages, hyperlipidemia, Tangier disease, HDL deficiency, ApoE-deficient mice, LDL receptor-deficient mice, foam cells, xanthomatosis, cholesterol efflux, bone marrow transplantation, atherogenic diet
MeSH terms: Animals, Apolipoproteins E, Arteriosclerosis, Cholesterol, Crosses, Genetic, Female, Hyperlipidemias, Lipids, Lipoproteins, Macrophages, Male, Mice, Inbred C57BL, Mice, Inbred DBA, Receptors, LDL, Xanthomatosis, Bone Marrow Transplantation, ATP-Binding Cassette Transporters, Mice, ATP Binding Cassette Transporter 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Increased Atherosclerosis in Hyperlipidemic Mice With Inactivation of ABCA1 in Macrophages

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks