NUCLEAR RECEPTORS IN MACROPHAGE BIOLOGY: At the Crossroads of Lipid Metabolism and Inflammation

Castrillo, Antonio; Tontonoz, Peter

doi:10.1146/annurev.cellbio.20.012103.134432

Cited by 260

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

NUCLEAR RECEPTORS IN MACROPHAGE BIOLOGY: At the Crossroads of Lipid Metabolism and Inflammation

Castrillo, Antonio, Tontonoz, Peter·2004·Annual Review of Cell and Developmental Biology

DOI 10.1146/annurev.cellbio.20.012103.134432

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Abstract

▪ Abstract Macrophages are essential modulators of lipid metabolism and the innate immune system. Lipid and inflammatory pathways induced in activated macrophages are central to the pathogenesis of human diseases including atherosclerosis. Recent work has shown that expression of genes involved in lipid uptake and cholesterol efflux in macrophages is controlled by peroxisome proliferator-activated receptors (PPARs) and liver X receptors (LXRs). Other studies have implicated these same receptors in the modulation of macrophage inflammatory gene expression. Together, these observations position PPARs and LXRs at the crossroads of lipid metabolism and inflammation and suggest that these receptors may serve to integrate these pathways in the control of macrophage gene expression. In this review, we summarize recent work that has advanced our understanding of the roles of PPARs and LXRs in macrophage biology and discuss the implication of these results for cardiovascular physiology and disease.

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There are two LXR receptors, LXRα and LXRβ, that share a high degree of functional overlap.
“There are two LXR receptors, LXRα and LXRβ, that share a high degree of functional overlap (Castrillo and Tontonoz, 2004).”
From Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP (2017) · cites this paper as Castrillo and Tontonoz, 2004

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Authors: Castrillo, A., & Tontonoz, P.
Affiliations: Howard Hughes Medical Institute, and Department of Pathology and Laboratory Medicine, University of California, Los Angeles, California 90095;
Venue: Annual Review of Cell and Developmental Biology
Publisher: Annual Reviews
Published: 2004-11-01
Volume: 20
Issue: 1
Pages: 455-480
ISSN: 1081-0706
1530-8995
DOI: 10.1146/annurev.cellbio.20.012103.134432
Cited by: 260
References: 12
Language: en

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NUCLEAR RECEPTORS IN MACROPHAGE BIOLOGY: At the Crossroads of Lipid Metabolism and Inflammation

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