Cited by 697Lipoproteins and Cardiovascular HealthLipid metabolism and disordersDiabetes, Cardiovascular Risks, and Lipoproteins

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Plasma triglyceride and coronary heart disease

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Austin, M A·1991·Arteriosclerosis and Thrombosis: A Journal of Vascular Biology

DOI 10.1161/01.atv.11.1.2

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Abstract

Although the literature on epidemiological associations between plasma triglyceride and CHD is not completely consistent, trends do emerge from the studies described here. First, the majority of observational studies demonstrate a significant univariate relation, although the results of case-control and cross-sectional studies are more uniform than those from prospective study designs. In many but not all studies, triglyceride remains a significant predictor of CHD in multivariate statistical analyses after controlling for TC or LDL-C. Perhaps the least consistent result is that the triglyceride association does not persist in some analyses controlling for HDL-C, while in other studies, the association remains significant. Although most studies have been conducted in men, the studies providing data on women, normocholesterolemic subjects, and diabetic subjects have generally found triglyceride to be, at the very least, a univariate risk factor. The results of intervention trials differ considerably, but no such study to date has been specifically designed to evaluate triglyceride-lowering effects on primary prevention of CHD. Important statistical properties must be taken into consideration in evaluating triglyceride as a risk factor for CHD. The large variability of triglyceride measurements and the correlation of triglyceride values with other lipid measures appears to result in the underestimation of the association between triglyceride and disease in multivariate analyses. Finally, individual genetic susceptibility may play an important role in the relation between plasma triglyceride levels and CHD. For example, risk of CHD clearly varies among the well-established familial forms of hypertriglyceridemia. A predominance of small, dense, LDL particles (LDL subclass pattern B) also appears to be a genetic trait associated with both increased risk of MI and increases in plasma triglyceride levels.

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High density lipoprotein as a protective factor against coronary heart disease
Gordon, T., Castelli, W. P., Hjortland, M. C., Kannel, W. B., & Dawber, T. R. (1977) · The American Journal of Medicine · doi:10.1016/0002-9343(77)90874-9 · Cited by 5,059
Apolipoprotein E polymorphism and atherosclerosis.
Davignon, J., Gregg, R. E., & Sing, C. F. (1988) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.8.1.1 · Cited by 1,981
HAEMOSTATIC FUNCTION AND ISCHAEMIC HEART DISEASE: PRINCIPAL RESULTS OF THE NORTHWICK PARK HEART STUDY
Meade, T. W., Brozović, M., Chakrabarti, R., Haines, A., Imeson, J., Mellows, S., Miller, G. J., North, W. R. S., Stirling, Y., & Thompson, S. G. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90111-x · Cited by 1,937
Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin
Canner, P. L., Berge, K. G., Wenger, N. K., Stamler, J., Friedman, L., Prineas, R. J., & Friedewald, W. (1986) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(86)80293-5 · Cited by 1,824
Low-Density Lipoprotein Subclass Patterns and Risk of Myocardial Infarction
Austin, M. A. (1988) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1988.03410130125037 · Cited by 1,780
Self-citation
Morbidity and mortality in diabetics in the Framingham population. Sixteen year follow-up study
Garcia, M. J., McNamara, P. M., Gordon, T., & Kannell, W. B. (1974) · Diabetes · doi:10.2337/diab.23.2.105 · Cited by 1,608
HDL cholesterol and other lipids in coronary heart disease. The cooperative lipoprotein phenotyping study
Castelli, W. P., Doyle, J. T., Gordon, T., Hames, C. G., Hjortland, M. C., Hulley, S. B., Kagan, A., & Zukel, W. J. (1977) · Circulation · doi:10.1161/01.cir.55.5.767 · Cited by 1,492
PLASMINOGEN ACTIVATOR INHIBITOR IN PLASMA: RISK FACTOR FOR RECURRENT MYOCARDIAL INFARCTION
Hamsten, A., Walldius, G., Szamosi, A., Blombäck, M., de Faire, U., Dahlén, G. H., Landou, C., & Wiman, B. (1987) · The Lancet · doi:10.1016/s0140-6736(87)93050-9 · Cited by 1,474
Hyperlipidemia in Coronary Heart Disease II. GENETIC ANALYSIS OF LIPID LEVELS IN 176 FAMILIES AND DELINEATION OF A NEW INHERITED DISORDER, COMBINED HYPERLIPIDEMIA
Goldstein, J. L., Schrott, H. G., Hazzard, W. R., Bierman, E. L., & Motulsky, A. G. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107332 · Cited by 1,444
Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk
Austin, M. A., King, M. C., Vranizan, K. M., & Krauss, R. M. (1990) · Circulation · doi:10.1161/01.cir.82.2.495 · Cited by 1,411
Self-citation

Show all 98 references

Research works printed but not linked: 26

[2]2. National Heart, Lung, and Blood Institute Consensus Development Panel: Treatment of hypertriglyceridemia. JAMA 1984;251:1196-1200
[15]15. factors in relation to acute myocardial infarction. Arteriosclerosis 1981;1:273-279
[30]30. Cambien F, Jacqueson A, Richard JL, Warnet JM, Ducimetiere P, Claude JR: Is the level of serum triglyceride a it,, ot f oo teir olemic" subjects? The Paris Prospective Study. Am J Epidemiol 1986;124:624-632
[29]29. Carlson LA, Böttiger LÈ: Risk factors for ischaemic heart disease in men and women. Acta Med Scand 1985;218:207–211
[32]32. Criqui MH, Heiss G, Cohn R, Cowan LD, Suchindran CM, Bangiwala S: Triglycerides and coronary heart disease mortality: The Lipid Research Clinics Follow-up Study. Atheroscler Rev (in press)
[34]34. Pocock SJ, Shaper AG, Phillips AN: Concentrations of high density lipoprotein cholesterol, triglyceride and total cholesterol in ischaemic heart disease. Br Med J 1989;298:998–1002
[37]37. Wilson PF: The impact of triglycerides on coronary heart disease: The Framingham Study. Atherosclerosis Rev (in press)
[4]4. Scand Suppl 1973;549:51–59
[46]46. Salel AF, Riggs K, Mason DT, Amsterdam EA, Zelis R: The impdsie rea psie ia p psng factor in coronary artery disease. Am J Med 1974;57:897–903
[50]50. Jenkins PJ, Harper RW, Nestel PJ: Severity of coronary atherosclerosis related to lipoprotein concentration. Br Med J 1978;2:388-391
[53]53. Wieland H, Seidel D, Wiegand V, Kreuzer H: Serum lipoproteins and coronary artery disease (CAD). Atherosclerosis 1980;36:269-280
[55]55. Holmes DR Jr, Elveback LR, Frye RL, Kottke BA, Ellefson RD: Association of risk factor variables and coronary artery disease documented with angiography. Circulation 1981;63: 293-299
[58]58. Reardon MF, Nestel PJ, Craig IH, Harper RW: Lipoprotein predictors of the severity of coronary artery disease in men and women. Circulation 1985;71:881-888
[64]64. Santen RJ, Willis PW, Fajaris SS: Atherosclerosis in diabetes mellitus: Correlations with lipid levels, adiposity and serum insulin level. Arch Intern Med 1972;130:833–843
[66]66. Janka HU: Five-year incidence of major macrovascular complications in diabetes mellitus. Horm Metab Res Suppl Series 1985;15:15-19
[71]71. Lipid Research Clinics Program: The Lipid Research Clinics Coronary Primary Prevention Trial results: II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. JAMA 1984;251:365-374
[77]77. Kelsey J, Thompson WD, Evans AS: Methods in Observational Epidemiology. New York, Oxford University Press, 1986, pp 293–297
[84]84. Davis CE, Kim H: Is triglyceride an independent risk factor for CHD? Circulation 1990;81:14
[88]88. Childs B: Introduction, in Childs B, Holtzman NA, Kazazian HH, Valle DL (eds): Molecular Genetics in Medicine. Progress in Medical Genetics, New Series, Vol 7. New York, Elsevier, 1988, Pp 1-16
[93]93. Mahley RW, Innerarity TL, Rall SC Jr, Weisbraber KH: Lipoproteins of special significance in atherosclerosis: Insights provided by studies of Type III hyperlipidemia. Ann N Y Acad Sci 1986;485:209–221
[92]92. Sane T, Nikkila EA: Very low density lipoprotein triglyceride metabolism in relatives of hypertriglyceridemic probands. Arteriosclerosis 1987;8:217–226
[97]97. Shen MMS, Krauss RM, Lindgren FT, Forte TM: Heterogeneity of serum low density lipoproteins in normal subjects. J Lipid Res 1981;22:236–244
[99]99. Lindgren FT, Jensen LC, Hatch FT: The isolation and quantitative analysis of serum lipoproteins, In Nelson GJ (ed): Blood Lipids and Lipoproteins. New York, Wiley Interscience, 1972, pp 181–274
[101]101. Eisenberg S, Gavish D, Oschry Y, Fainaru M, Deckelbaum RJ: Abnormalities in very low, low, and high density lipoproteins in hypertriglyceridemia. J Clin Invest 1984;74:470–482
[102]102. Nichols AV, Krauss RM, Musliner TA: Nondenaturing polyacrylamide gradient gel electrophoresis, In Segrest JP, Albers JJ (eds): Methods in Enzymology, Plasma Lipoproteins. Part A. Preparation, Structure and Molecular Biology. Orlando, Fla, Academic Press, Inc, 1986, vol 41, pp 417–431
[110]110. Gianturco SH, Bradley WA: A cellular basis for the atherogenicity of triglyceride-risk lipoproteins. Atherosclerosis Rev (in press)

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Chong, P. H., & Seeger, J. D. (1997) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/j.1875-9114.1997.tb03081.x · Cited by 47
Effect of modified dairy fat on postprandial and fasting plasma lipids and lipoproteins in healthy young men
Tholstrup, T., Sandström, B., Hermansen, J. E., & Hølmer, G. (1998) · Lipids · doi:10.1007/s11745-998-0175-0 · Cited by 47
Mutations in thelipoprotein lipaseGene Associated With Ischemic Heart Disease in Men
Wittrup, H. H., Tybjærg‐Hansen, A., Steffensen, R., Deeb, S. S., Brunzell, J. D., Jensen, G. B., & Nordestgaard, B. G. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.6.1535 · Cited by 47
The effects of tibolone
RYMER, J. M. (1998) · Gynecological Endocrinology · doi:10.3109/09513599809015548 · Cited by 47
Comparing the efficacy and safety of atorvastatin and simvastatin in Asians with elevated low-density lipoprotein-cholesterol--a multinational, multicenter, double-blind study.
Cc, W., Sy, R., Tanphaichitr, V., At, H., Suyono, S., & Yt, L. (2002) · PubMed · Cited by 46
Diabetic dyslipidemia
Betteridge, D. J. (1994) · The American Journal of Medicine · doi:10.1016/0002-9343(94)90228-3 · Cited by 45
Subcutaneous and continuous administration of lipopolysaccharide increases serum levels of triglyceride and monocyte chemoattractant protein‐1 in rats
Uchiumi, D., Kobayashi, M., TACHIKAWA, T., & Hasegawa, K. (2004) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2004.00716.x · Cited by 44
Vitamin C and plasma cholesterol
Hemilä, H. (1992) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408399209527579 · Cited by 44
The small, dense LDL phenotype as a correlate of postprandial lipemia in men
Lemieux, I., Couillard, C., Pascot, A., Bergeron, N., Prud’homme, D., Bergeron, J., Tremblay, A., Bouchard, C., Mauriège, P., & Després, J. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(00)00424-x · Cited by 44
“The relationship of plasma lipoprotein-lipids to CHD is well established and elevated plasma LDL cholesterol, TG and apoB concentrations as well as reduced HDL cholesterol have been associated with an increased risk of CHD [27–30].”
Background
The farnesoid X receptor: a novel drug target?
Claudel, T., Sturm, E., Kuipers, F., & Staels, B. (2004) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.13.9.1135 · Cited by 44
Serum lipid changes during anticonvulsive treatment serum lipids in epileptic children.
Yilmaz, E., Doşan, Y., Gürgöze, M. K., & Güngör, S. (2001) · PubMed · Cited by 44
Triglyceride-rich Lipoproteins and Atherosclerosis, from Fast to Feast
Steiner, G. A. (1993) · Annals of Medicine · doi:10.3109/07853899309147307 · Cited by 44
Impact of Oil used by the Frying Industry on Population Fat Intake
Minihane, A. M., & Harland, J. I. (2007) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390600737821 · Cited by 44
“…of diabetes and its precursor condition, the metabolic syndrome, characterized by low HDL-C levels, high fasting, and in particular postprandial (non-fasting) TG levels and a large fraction of total circulating LDL as small atherogenic LDL-3 particles (Szapary and Rader, 2004; Austin, 1991).”
Background
Effect of cigarette smoking on liver functions: a comparative study conducted among smokers and non-smokers male in El-beida City, Libya
Salhen, K. S. A., & Abdalsalam, R. D. (2014) · International Current Pharmaceutical Journal · doi:10.3329/icpj.v3i7.19077 · Cited by 42
“…secretion of hepatic free fatty acids and hepatic triglycerides along with VLDL-cholesterol in the blood stream (b) Presence of hyperinsulinaemia in smokers leads to increased activity of lipoprotein which leads to increased levels of lipid in smokers (Austin, 1991; Rustogi and Shrivastva, 1989).”
Background
In Situ Monitoring of Nanostructure Formation during the Digestion of Mayonnaise
Salentinig, S., Amenitsch, H. W., & Yaghmur, A. (2017) · ACS Omega · doi:10.1021/acsomega.7b00153 · Cited by 42
Effects of a Frequent Apolipoprotein E Isoform, ApoE4 Freiburg (Leu28→Pro), on Lipoproteins and the Prevalence of Coronary Artery Disease in Whites
Orth, M., Weng, W., Funke, H., Steinmetz, A., Assmann, G., Nauck, M., Dierkes, J., Ambrosch, A., Weisgraber, K. H., Mahley, R. W., et al. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.5.1306 · Cited by 42
Propionyl-L-carnitine prevents the progression of atherosclerotic lesions in aged hyperlipemic rabbits
Spagnoli, L. G., Orlandi, A., Marino, B., Mauriello, A., de Angelis, C., & Ramacci, M. T. (1995) · Atherosclerosis · doi:10.1016/0021-9150(94)05460-z · Cited by 41
Triacylglycerol and coronary heart disease
Austin, M. A. (1997) · Proceedings of The Nutrition Society · doi:10.1079/pns19970066 · Cited by 41
Self-citation
Concentration of Endogenous tPA Antigen in Coronary Artery Disease
Geppert, A., Graf, S., Beckmann, R., Hornykewycz, S. J., Schuster, E., Binder, B. R., & Huber, K. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.10.1634 · Cited by 41
Effect of gemfibrozil and lovastatin on postprandial lipoprotein clearance in the hypoalphalipoproteinemia and hypertriglyceridemia syndrome
Sitno, I. E., Yakichuk, J. A., & Ooi, T. C. (1993) · Atherosclerosis · doi:10.1016/0021-9150(93)90067-5 · Cited by 41
Increased Acute Phase Reactants are Associated with Levels of Lipoproteins and Increased Carotid Plaque Volume
Grønholdt, M.-L. M., Sillesen, H. H., Wiebe, B. M., Laursen, H. B., & Nordestgaard, B. G. (2001) · European Journal of Vascular and Endovascular Surgery · doi:10.1053/ejvs.2001.1321 · Cited by 40
Triglycerides: risk factor or fellow traveler?
Forrester, J. S. (2001) · Current Opinion in Cardiology · doi:10.1097/00001573-200107000-00007 · Cited by 40
Influence of triglyceride concentration on the relationship between lipoprotein cholesterol and apolipoprotein B and A-I levels
Leroux, G., Lemieux, I., Lamarche, B., Cantin, B., Dagenais, G. R., Lupien, P. J., & Després, J. (2000) · Metabolism · doi:10.1016/s0026-0495(00)90688-7 · Cited by 39
Fenofibrate‐Induced Elevation in Serum Creatinine
Ritter, J. L., & Nabulsi, S. (2001) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.21.13.1145.34623 · Cited by 40
Interaction between obesity and genetic polymorphisms in the apolipoprotein CIII gene and lipoprotein lipase gene on the risk of hypertriglyceridemia in Chinese
Ko, Y.-L., Ko, Y.-S., Wu, S.-M., Teng, M., Chen, F.-R., Hsu, T., Chiang, C.-W., & Lee, Y. (1997) · Human Genetics · doi:10.1007/s004390050511 · Cited by 40
Mechanisms of Action of Adrenergic Receptor Blockers on Lipids During Antihypertensive Drug Treatment
Rabkin, S. W. (1993) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1993.tb03958.x · Cited by 39
The Atherogenic Significance of an Elevated Plasma Triglyceride Level
Ooi, T. C., & Ooi, D. S. (1998) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408369891234255 · Cited by 37
Serum apolipoprotein B-48 levels are correlated with carotid intima-media thickness in subjects with normal serum triglyceride levels
Nakatani, K., Sugimoto, T., Masuda, D., Okano, R., Oya, T., Monden, Y., Yamashita, T., Kawase, R., Nakaoka, H., Inagaki, M., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.05.009 · Cited by 37
“Epidemiologic studies have revealed that fasting hypertriglyceridemia is also associated with atherosclerosis, independent of other coronary risk factors such as high LDL–C level [3,4].”
Background
From interaction of lipidic vehicles with intestinal epithelial cell membranes to the formation and secretion of chylomicrons
Shen, H., Howles, P. N., & Tso, P. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00181-8 · Cited by 37
Pioglitazone plus a sulphonylurea or metformin is associated with increased lipoprotein particle size in patients with type 2 diabetes
Pérez, A., Khan, M. A., Johnson, T., & Karunaratne, M. (2004) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2004.006 · Cited by 37
GENETICS OF LIPOPROTEIN DISORDERS
Davignon, J., & Genest, J. J. (1998) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70024-4 · Cited by 37
Effects of fish oil on some parameters of fibrinolysis and lipoprotein(a) in healthy subjects
Haglund, O., Mehta, J. L., & Saldeen, T. G. P. (1994) · The American Journal of Cardiology · doi:10.1016/0002-9149(94)90100-7 · Cited by 37
Effect of green tea extract microencapsulation on hypertriglyceridemia and cardiovascular tissues in high fructose-fed rats
Jung, M. H., Seong, P. N., Kim, M. H., Myong, N., & Chang, M. (2013) · Nutrition Research and Practice · doi:10.4162/nrp.2013.7.5.366 · Cited by 36
“Because the contribution of cardiovascular disease to human morbidity and mortality is very high in the elderly, much research in this area has been directed towards determining the role of specific food components on the development, progression, and prevention of CVD [4-9].”
BackgroundInfluential
MANAGEMENT OF SELECTED LIPID ABNORMALITIES
Rader, D. J., & Rosas, S. E. (2000) · Medical Clinics of North America · doi:10.1016/s0025-7125(05)70206-6 · Cited by 36
Hypertriglyceridemia: Risks and perspectives
Gotto, A. M. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)91086-j · Cited by 37
Selective deuteration for molecular insights into the digestion of medium chain triglycerides
Salentinig, S., Yepuri, N. R., Hawley, A. M., Boyd, B. J., Gilbert, E. P., & Darwish, T. A. (2015) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2015.06.007 · Cited by 35
“…components are treated and utilized during the digestion process opens opportunities for functional food products that may help to avoid or cure health issues including obesity, vitamin malabsorption, the risk of coronary heart disease and cancer (Austin, 1991; Unger and Zhou, 2001; Katan, 2000).”
Background
Postprandial triglyceride-rich lipoprotein changes in elderly and young subjects
Cassader, M., Gambino, R., Ruiu, G., Marena, S., Bodoni, P., & Pagano, G. (1996) · Aging Clinical and Experimental Research · doi:10.1007/bf03339605 · Cited by 35
Intestinally‐derived lipoproteins: Metabolism and clinical significance
Chen, Y. I., & Reaven, G. M. (1991) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610070308 · Cited by 34
Variability of lipid measurements: relevance for the clinician
Schectman, G., & Sasse, E. A. (1993) · Clinical Chemistry · doi:10.1093/clinchem/39.7.1495 · Cited by 34
Influence of Dietary Fatty Acids on the Atherogenic Lipoprotein Phenotype
Griffin, B. A., & Zampelas, A. (1995) · Nutrition Research Reviews · doi:10.1079/nrr19950004 · Cited by 34
“The ALP is believed to develop through genetic-environmental interactions (Austin, 1991).”
Background
Life Style and Cardiovascular Risk Factors in the Japanese Population-From an Epidemiological Survey on Serum Lipid Levels in Japan 1990. Part 1: Influence of Life Style and Excess Body Weight on HDL-Cholesterol and Other Lipid Parameters in Men
Yamamoto, A., Temba, H., Horibe, H., Mabuchi, H., Saitō, Y., Matsuzawa, Y., Kita, T., & Nakamura, H. (2003) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.10.165 · Cited by 34
The fibrates in clinical practice: Focus on micronised fenofibrate
Shepherd, J. (1994) · Atherosclerosis · doi:10.1016/0021-9150(94)05380-2 · Cited by 34
A study in the relationships between leptin, insulin, and body fat in Asian subjects
Ho, S., Tai, E., Eng, P., Ramli, A., Tan, C., & Fok, A. C. K. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0800801 · Cited by 33
The insulin resistance-dyslipidemia syndrome: the most prevalent cause of coronary artery disease?
Després, J. (1993) · Europe PMC (PubMed Central) · Cited by 34
Triglyceride concentration and coronary heart disease
Garber, A. M., & Avins, A. L. (1995) · BMJ · doi:10.1136/bmj.310.6974.259c · Cited by 34
Multiple reaction monitoring (MRM)-profiling with biomarker identification by LC-QTOF to characterize coronary artery disease
Yannell, K. E., Ferreira, C. R., Tichy, S. E., & Cooks, R. G. (2018) · The Analyst · doi:10.1039/c8an01017j · Cited by 33
Alterations of high-density lipoprotein subclasses in endogenous hypertriglyceridemia
Gou, L., Fu, M., Xu, Y., Tian, Y., Yan, B., & Lu-chuan, Y. (2005) · American Heart Journal · doi:10.1016/j.ahj.2005.02.032 · Cited by 33
Comparison of the efficacy of simvastatin and standard fibrate therapy in the treatment of primary hypercholesterolemia and combined hyperlipidemia
Bruckert, É., Gennes, J. L. D., Malbecq, W., & Baigts, F. (1995) · Clinical Cardiology · doi:10.1002/clc.4960181107 · Cited by 33

Authors: Austin, M. A.
Affiliations: University of Washington (US)
Corresponding author: Austin, M A
Venue: Arteriosclerosis and Thrombosis: A Journal of Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1991-01
Volume: 11
Issue: 1
Pages: 2-14
ISSN: 1049-8834 (ISSN-L)
DOI: 10.1161/01.atv.11.1.2
OpenAlex: W2155238815
Cited by: 697
References: 98
Citations by year: 2026: 2 · 2025: 4 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 5 · 2014: 5 · 2013: 13 · 2012: 8
FWCI: 15.24
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Arteriosclerosis and Thrombosis A Journal of Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (7r29hl038760-03)
National Heart, Lung, and Blood Institute (HL38760, P01HL030086, HL3-0086)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: plasma triglycerides, coronary artery disease, cardiovascular risk factors, hypertriglyceridemia, familial hypertriglyceridemia, small dense LDL, HDL cholesterol, genetic susceptibility, primary prevention, lipid-lowering intervention
MeSH terms: Coronary Disease, Female, Humans, Male, Pedigree, Triglycerides, Multivariate Analysis

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