Quantitative studies of transfer in vivo of low density, Sf 12-60, and Sf 60-400 lipoproteins between plasma and arterial intima in humans.
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To assess the potential of various plasma lipoprotein classes to contribute to the lipid content of the arterial intima, influx and efflux of these plasma lipoprotein fractions into and from the intima of human carotid arteries were measured in vivo. While low density lipoprotein (LDL) is known to transfer from plasma into the arterial wall, there is less information on the atherogenic potential of lipoproteins of intermediate density (Sf 12-60) or of very low density (Sf 60-400). Aliquots of the same lipoprotein (LDL, Sf 12-60 lipoprotein particles, or Sf 60-400 lipoprotein particles) iodinated with iodine-125 and iodine-131 were injected intravenously 18-29 hours and 3-6 hours, respectively, before elective surgical removal of atheromatous arterial tissue, and the intimal clearance of lipoproteins, lipoprotein influx, and fractional loss of newly entered lipoproteins were calculated. Intimal clearance of Sf 60-400 particles was not detectable (less than 0.3 microliter x hr-1 x cm-2), whereas the average value for both LDL and Sf 12-60 lipoprotein particles was 0.9 microliter x hr-1 x cm-2. Since the fractional loss of newly entered LDL and Sf 12-60 lipoprotein particles was also similar, the results suggest similar modes of entry and exit for these two particles. However, due to lower plasma concentrations of Sf 12-60 lipoproteins as compared with LDL, the mass influx of cholesterol in the Sf 12-60 particles was on the order of one 10th of that in LDL, and that of apolipoprotein B was about one 20th.(ABSTRACT TRUNCATED AT 250 WORDS)
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Lipoproteins smaller than 70 nm in diameter can pass the endothelial barrier and enter the arterial intima.
“Lipoproteins <70 nm in diameter (that is, all HDL, LDL and intermediate-density lipoprotein (IDL) particles, most VLDL remnants and the smallest chylo-micron remnants) can pass the endothelial barrier and enter the arterial intima from the circulation41,42.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [42]
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- Authors
- Shaikh, M., Wootton, R., Nordestgaard, B. G., Baskerville, P., Lumley, J. S., La Ville, A. E., Quiney, J., & Lewis, B.
- Affiliations
- Guy's Hospital (GB)
- Department of Chemical Pathology and Metabolic Disorders, United Medical School, Guys Hospital, London, U.K.
- Venue
- Arteriosclerosis and Thrombosis: A Journal of Vascular Biology
- Published
- 1991-05
- Volume
- 11
- Issue
- 3
- Pages
- 569-577
- ISSN
- 1049-8834 (ISSN-L)
- OpenAlex
- W2171921241
- Cited by
- 206
- References
- 28
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 9 · 2023: 11 · 2022: 12 · 2021: 11 · 2020: 18 · 2019: 9 · 2018: 10 · 2017: 8 · 2016: 12 · 2015: 6 · 2014: 10 · 2013: 3 · 2012: 3
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Arteriosclerosis and Thrombosis A Journal of Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hjerteforeningen
- Sundhed og Sygdom, Det Frie Forskningsråd
- Medical Research Council
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- arterial intima, low-density lipoprotein, intermediate density lipoprotein, VLDL, carotid artery, atherogenesis, apolipoprotein B, cholesterol transport
- MeSH terms
- Apolipoproteins B, Arteriosclerosis, Biological Transport, Carotid Arteries, Cholesterol, Endarterectomy, Humans, Iodine Radioisotopes, Kinetics, Lipoproteins, LDL
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