The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Vascular endothelium responds to fluid shear stress gradients.
Open accessAbstract
In vitro investigations of the responses of vascular endothelium to fluid shear stress have typically been conducted under conditions where the time-mean shear stress is uniform. In contrast, the in vitro experiments reported here have re-created the large gradients in surface fluid shear stress found near arterial branches in vivo; specifically, we have produced a disturbed-flow region that includes both flow separation and reattachment. Near reattachment regions, shear stress is small but its gradient is large. Cells migrate away from this region, predominantly in the downstream direction. Those that remain divide at a rate that is high compared with that of cells subjected to uniform shear. We speculate that large shear stress gradients can induce morphological and functional changes in the endothelium in regions of disturbed flow in vivo and thus may contribute to the formation of atherosclerotic lesions.
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Cites
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Endothelial Expression of a Mononuclear Leukocyte Adhesion Molecule During Atherogenesis
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Self-citationFlow Effects on Prostacyclin Production by Cultured Human Endothelial Cells
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The Dynamic Response of Vascular Endothelial Cells to Fluid Shear Stress
Dewey, C. F., Bussolari, S. R., Gimbrone, M. A., & Davies, P. F. (1981) · Journal of Biomechanical Engineering · doi:10.1115/1.3138276 · Cited by 1,136
Self-citationHaemodynamic shear stress activates a K+ current in vascular endothelial cells
Olesen, S.-P., Claphamt, D., & Davies, P. (1988) · Nature · doi:10.1038/331168a0 · Cited by 1,001
Self-citationTurbulent fluid shear stress induces vascular endothelial cell turnover in vitro.
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Self-citationThe Elongation and Orientation of Cultured Endothelial Cells in Response to Shear Stress
Levesque, M. J., & Nerem, R. M. (1985) · Journal of Biomechanical Engineering · doi:10.1115/1.3138567 · Cited by 723
Induction of human vascular endothelial stress fibres by fluid shear stress
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Fluid Flow Stimulates Tissue Plasminogen Activator Secretion by Cultured Human Endothelial Cells
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Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells
Shen, J., Luscinskas, F. W., Connolly, A., Dewey, C. F., & Gimbrone, M. A. (1992) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1992.262.2.c384 · Cited by 346
Self-citation
Cited by
Hemodynamic shear stress and its role in atherosclerosis
Malek, A. M. (1999) · JAMA · doi:10.1001/jama.282.21.2035 · Cited by 3,650
Flow-mediated endothelial mechanotransduction
Davies, P. F. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.519 · Cited by 2,802
Self-citationChiu, J.-J., & Chien, S. (2011) · Physiological Reviews · doi:10.1152/physrev.00047.2009 · Cited by 2,280
The Response-to-Retention Hypothesis of Early Atherogenesis
Williams, K. J., & Tabas, I. (1995) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.15.5.551 · Cited by 1,413
Laminar Shear Stress: Mechanisms by Which Endothelial Cells Transduce an Atheroprotective Force
Traub, O., & Berk, B. C. (1998) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.18.5.677 · Cited by 1,085
Metadata
- Authors
- DePaola, N., Gimbrone, M. A., Davies, P. F., & Dewey, C. F.
- Venue
- Arteriosclerosis and Thrombosis: A Journal of Vascular Biology
- Published
- 1992-11
- Volume
- 12
- Issue
- 11
- Pages
- 1254-1257
- ISSN
- 1049-8834 (ISSN-L)
- OpenAlex
- W2113357422
- Cited by
- 493
- References
- 18
- FWCI
- 2.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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- DePaola, N., Gimbrone, M. A., Davies, P. F., & Dewey, C. F. (1992). Vascular endothelium responds to fluid shear stress gradients. Arteriosclerosis and Thrombosis: A Journal of Vascular Biology. https://doi.org/10.1161/01.atv.12.11.1254
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
