Cited by 2,465Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityLipoproteins and Cardiovascular Health

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating From Adipose Tissue?

Open access

Yudkin, John S., Stehouwer, C. D. A., Emeis, J. J., Coppack, S. W.·1999·Arteriosclerosis, Thrombosis, and Vascular Biology

DOI 10.1161/01.atv.19.4.972

Open this paper in CoChat — free account Open PDF

Abstract

Abstract —C-reactive protein, a hepatic acute phase protein largely regulated by circulating levels of interleukin-6, predicts coronary heart disease incidence in healthy subjects. We have shown that subcutaneous adipose tissue secretes interleukin-6 in vivo. In this study we have sought associations of levels of C-reactive protein and interleukin-6 with measures of obesity and of chronic infection as their putative determinants. We have also related levels of C-reactive protein and interleukin-6 to markers of the insulin resistance syndrome and of endothelial dysfunction. We performed a cross-sectional study in 107 nondiabetic subjects: (1) Levels of C-reactive protein, and concentrations of the proinflammatory cytokines interleukin-6 and tumor necrosis factor-α, were related to all measures of obesity, but titers of antibodies to Helicobacter pylori were only weakly and those of Chlamydia pneumoniae and cytomegalovirus were not significantly correlated with levels of these molecules. Levels of C-reactive protein were significantly related to those of interleukin-6 ( r =0.37, P <0.0005) and tumor necrosis factor-α ( r =0.46, P <0.0001). (2) Concentrations of C-reactive protein were related to insulin resistance as calculated from the homoeostasis model assessment model, blood pressure, HDL, and triglyceride, and to markers of endothelial dysfunction (plasma levels of von Willebrand factor, tissue plasminogen activator, and cellular fibronectin). A mean standard deviation score of levels of acute phase markers correlated closely with a similar score of insulin resistance syndrome variables ( r =0.59, P <0.00005), this relationship being weakened only marginally by removing measures of obesity from the insulin resistance score ( r =0.53, P <0.00005). These data suggest that adipose tissue is an important determinant of a low level, chronic inflammatory state as reflected by levels of interleukin-6, tumor necrosis factor-α, and C-reactive protein, and that infection with H pylori , C pneumoniae , and cytomegalovirus is not. Moreover, our data support the concept that such a low-level, chronic inflammatory state may induce insulin resistance and endothelial dysfunction and thus link the latter phenomena with obesity and cardiovascular disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/01.atv.19.4.972

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543
Interleukin-6 and the acute phase response
Heinrich, P. C., Castell, J. V., & Andus, T. (1990) · Biochemical Journal · doi:10.1042/bj2650621 · Cited by 2,734
IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance
Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630
Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1
Mohamed‐Ali, V., Goodrick, S., Rawesh, A., Katz, D. R., Miles, J. M., Yudkin, J. S., Klein, S., & Coppack, S. W. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4450 · Cited by 2,032
Self-citation
Interleukin-6: an overview
Van Snick, J. (1990) · Annual Review of Immunology · doi:10.1146/annurev.iy.08.040190.001345 · Cited by 1,890
Hemostatic Factors and the Risk of Myocardial Infarction or Sudden Death in Patients with Angina Pectoris
Thompson, S. G., Kienast, J., Pyke, S., Haverkate, F., & van de Loo, J. C. W. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321003 · Cited by 1,819

Show all 51 references

Research works printed but not linked: 12

1988, Lab Invest, 58, 249
10.1161/circ.94.5.874 · DOI
1997, J Clin Endocrinol Metab, 82, 4196
1995, J Clin Endocrinol, 9, 61
10.1161/circ.94.5.922 · DOI
10.1161/atvb.15.9.1330 · DOI
10.1161/atvb.16.3.450 · DOI
1989, J Lab Clin Med, 113, 586
10.1161/atvb.17.10.2167 · DOI
1982, Proc Natl Acad Sci U S A, 82, 912
1992, Cancer Res, 52, 4113
10.1161/atvb.15.1.52 · DOI

Sorted by citations

Items 801–900 of 1,003

Increased plasma N‐terminal pro‐B‐type natriuretic peptide and markers of inflammation related to atherosclerosis in patients with primary hyperparathyroidism
Øgard, C. G., Engelmann, M. D. M., Kistorp, C., Nielsen, S. L., & Vestergaard, H. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02363.x · Cited by 63
Sex differences in the relation of depressive symptoms, hostility, and anger expression to indices of glucose metabolism in nondiabetic adults.
Suarez, E. C. (2006) · Health Psychology · doi:10.1037/0278-6133.25.4.484 · Cited by 63
Steroidogenic versus Metabolic Programming of Reproductive Neuroendocrine, Ovarian and Metabolic Dysfunctions
Cardoso, R. C., Puttabyatappa, M., & Padmanabhan, V. (2015) · Neuroendocrinology · doi:10.1159/000381830 · Cited by 62
Obesity and brain illness: from cognitive and psychological evidences to obesity paradox
Monda, V., Marra, M. L., Perrella, R., Caviglia, G., Iavarone, A., Chieffi, S., Messina, G., Carotenuto, M., Monda, M., & Messina, A. (2017) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s148392 · Cited by 75
Comparison of arterial assessments in low and high vascular disease risk groups
Wilson, A. (2004) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2003.10.009 · Cited by 63
Initiation of insulin therapy reduces serum concentrations of high-sensitivity C-reactive protein in patients with type 2 diabetes
Takebayashi, K., Aso, Y., & Inukai, T. (2004) · Metabolism · doi:10.1016/j.metabol.2004.01.003 · Cited by 63
Effect of overweight on gastrointestinal microbiology and immunology: correlation with blood biomarkers
Tiihonen, K., Ouwehand, A. C., & Rautonen, N. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509992807 · Cited by 63
Relationship Between C-Reactive Protein and Progression of Early Carotid Atherosclerosis in Hypertensive Subjects
Hashimoto, H., Kitagawa, K., Hougaku, H., Etani, H., & Hori, M. (2004) · Stroke · doi:10.1161/01.str.0000130422.89335.81 · Cited by 63
A low level of C-reactive protein in Japanese adults and its association with cardiovascular risk factors: The Japan NCVC-Collaborative Inflammation Cohort (JNIC) Study
Saito, I., Sato, S., Nakamura, M., Kokubo, Y., Mannami, T., Adachi, H., Konishi, M., Okada, K., Iso, H., Kario, K., et al. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.07.032 · Cited by 62
Endothelial lipase is associated with inflammation in humans
Paradis, M., Badellino, K. O., Rader, D. J., Deshaies, Y., Couture, P., Archer, W. R., Bergeron, N., & Lamarche, B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.p600002-jlr200 · Cited by 62
Inflammatory Induction of Human Resistin Causes Insulin Resistance in Endotoxemic Mice
Park, H. K., Qatanani, M., Briggs, E. R., Ahima, R. S., & Lazar, M. A. (2011) · Diabetes · doi:10.2337/db10-1416 · Cited by 62
Correlation between metabolic syndrome and sleep apnea
Castaneda, A., Jauregui-Maldonado, E., Ratnani, I., Varón, J., & Surani, S. (2018) · World Journal of Diabetes · doi:10.4239/wjd.v9.i4.66 · Cited by 65
Sudden Cardiac Death (SCD) – risk stratification and prediction with molecular biomarkers
Osman, J., Tan, S. C., Lee, P. Y., Low, T. Y., & Jamal, R. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0535-8 · Cited by 62
Eradication of Helicobacter pylori infection induces an increase in body mass index
Azuma, T., Suto, H., Ito, Y., Muramatsu, A., Ohtani, M., Dojo, M., Yamazaki, Y., Kuriyama, M., & Kato, T. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.16.s2.31.x · Cited by 61
The relationship between blood glucose control and intolerance to enteral feeding during critical illness
Nguyen, N. Q., Ching, K. J., Fraser, R. J., Chapman, M. J., & Holloway, R. H. (2007) · Intensive Care Medicine · doi:10.1007/s00134-007-0869-7 · Cited by 60
The Risk of Developing Diabetes Mellitus in Patients with Psoriatic Arthritis: A Cohort Study
Eder, L., Chandran, V., Cook, R. J., & Gladman, D. D. (2017) · The Journal of Rheumatology · doi:10.3899/jrheum.160861 · Cited by 62
Associations Between C-Reactive Protein, Insulin Sensitivity, and Resting Metabolic Rate in Adults: A Mediator Analysis
Drabsch, T., Holzapfel, C., Stecher, L., Petzold, J., Skurk, T., & Hauner, H. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00556 · Cited by 61
Obesity, Fasting Plasma Insulin, and C‐Reactive Protein Levels in Healthy Children
Shea, S., Aymong, E. D., ZYBERT, P. A., Shamoon, H., Tracy, R. P., Deckelbaum, R. J., & Basch, C. E. (2003) · Obesity Research · doi:10.1038/oby.2003.15 · Cited by 61
CRP and Adiponectin and Its Oligomers in the Metabolic Syndrome
Devaraj, S., Swarbrick, M. M., Singh, U. S., ADAMS-HUET, B. A., Havel, P. J., & Jialal, I. (2008) · American Journal of Clinical Pathology · doi:10.1309/rn84k51b2jjy1y0b · Cited by 64
Fibrinogen and Fibrin Clot Structure in Diabetes
Dunn, E. J., & Ariëns, R. A. S. (2004) · Herz · doi:10.1007/s00059-004-2607-z · Cited by 61
Association of C-reactive protein with coronary heart disease risk factors in patients with type 2 diabetes mellitus
Mojiminiyi, O. A., Abdella, N., Moussa, M., Akanji, A. O., Mohammedi, H. A., & Zaki, M. (2002) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(02)00101-8 · Cited by 59
Elevated C-reactive protein levels and metabolic syndrome in the elderly: The role of central obesity
Zuliani, G., Volpato, S., Galvani, M., Blè, A., Bandinelli, S., Corsi, A. M., Lauretani, F., Maggio, M. G., Guralnik, J. M., Fellin, R., et al. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.07.038 · Cited by 62
Plasma and urine levels of resistin and adiponectin in chronic kidney disease
Yaturu, S., Dhanireddy, R., Rains, J., & Jain, S. K. (2007) · Cytokine · doi:10.1016/j.cyto.2007.02.003 · Cited by 60
Inflammation, insulin resistance, lipid disturbances, anthropometrics, and metabolic syndrome in morbidly obese patients: A case control study comparing laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy
Iannelli, A., Anty, R., Schneck, A. S., Tran, A., & Gugenheim, J. (2010) · Surgery · doi:10.1016/j.surg.2010.08.013 · Cited by 60
Unhealthy dietary patterns associated with inflammation and endothelial dysfunction in type 1 diabetes: The EURODIAB study
van Bussel, B. C. T., Soedamah‐Muthu, S. S., Henry, R. M. A., Schalkwijk, C., Ferreira, I., Chaturvedi, N., Toeller, M., Fuller, J., & Stehouwer, C. D. A. (2012) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2012.04.005 · Cited by 60
Self-citation
A Healthy Diet Is Associated with Less Endothelial Dysfunction and Less Low-Grade Inflammation over a 7-Year Period in Adults at Risk of Cardiovascular Disease1–3
van Bussel, B. C. T., Henry, R. M. A., Ferreira, I., van Greevenbroek, M. M. J., Kallen, C., Twisk, J. W. R., Feskens, E. J. M., Schalkwijk, C. G., & Stehouwer, C. D. A. (2015) · Journal of Nutrition · doi:10.3945/jn.114.201236 · Cited by 62
Self-citation
Plasma Inflammatory Markers and the Risk of Developing Hypertension in Men
Sesso, H. D., Jiménez, M. C., Wang, L., Ridker, P. M., Buring, J. E., & Gaziano, J. M. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.001802 · Cited by 60
C-reactive protein, insulin resistance and risk of cardiovascular disease: a population-based study
Jeppesen, J., Hansen, T. W., Olsen, M. H., Rasmussen, S. L., lbsen, H., Torp-Pedersen, C. T., Hildebrandt, P. R., & Madsbad, S. (2008) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e328308bb8b · Cited by 60
Canagliflozin protects against non-alcoholic steatohepatitis in type-2 diabetic rats through zinc alpha-2 glycoprotein up-regulation
Kabil, S. L., & Mahmoud, N. M. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.03.043 · Cited by 60
Heritability of C‐Reactive Protein and Association with Apolipoprotein E Genotypes in Japanese Americans
Austin, M. A., Zhang, C., Humphries, S. E., Chandler, W. L., Talmud, P. J., Edwards, K. L., Leonetti, D. L., McNeely, M. J., & Fujimoto, W. Y. (2004) · Annals of Human Genetics · doi:10.1046/j.1529-8817.2004.00078.x · Cited by 58
Vascular imaging and intervention in peripheral arteries in the diabetic patient
Dyet, J. F., Nicholson, A. A., & Ettles, D. F. (2000) · Diabetes/Metabolism Research and Reviews · doi:10.1002/1520-7560(200009/10)16:1+ · Cited by 43
Influence of Physical Activity and Nutrition on Obesity‐Related Immune Function
Huang, C., Zourdos, M. C., Jo, E., & Ormsbee, M. J. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/752071 · Cited by 60
Prospective Study of Surgical Treatment of Acromegaly: Effects on Ghrelin, Weight, Adiposity, and Markers of CV Risk
Reyes-Vidal, C. M., Fernandez, J. C., Bruce, J. N., Crisman, C., Conwell, I. M., Kostadinov, J., Geer, E. B., Post, K. D., & Freda, P. U. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2259 · Cited by 59
Corticosteroid-induced lipodystrophy is associated with features of the metabolic syndrome
Fardet, L., Cabane, J., Kettaneh, A., Lebbe, C., & Flahault, A. (2007) · Rheumatology · doi:10.1093/rheumatology/kem062 · Cited by 59
Chronic inflammation and risk of colorectal and other obesity‐related cancers: The health, aging and body composition study
Izano, M. A., Wei, E. K., Tai, C. G.-L., Swede, H., Gregorich, S. E., Harris, T. B., Klepin, H. D., Satterfield, S., Murphy, R. A., Newman, A. B., et al. (2015) · International Journal of Cancer · doi:10.1002/ijc.29868 · Cited by 57
Concentrations of leptin and C-reactive protein in serum and follicular fluid during assisted reproductive cycles
Wunder, D. M., Kretschmer, R., & Bersinger, N. A. (2005) · Human Reproduction · doi:10.1093/humrep/deh767 · Cited by 58
Elevation of Serum C-Reactive Protein Levels Is Associated with Obesity in Boys
Hiura, M., Kikuchi, T., Nagasaki, K., & Uchiyama, M. (2003) · Hypertension Research · doi:10.1291/hypres.26.541 · Cited by 59
Association of Serum C-Reactive Protein Level with Sex-Specific Type 2 Diabetes Risk: A Prospective Finnish Study
Hu, G., Jousilahti, P., Tuomilehto, J. O., Antikaínen, R., Sundvall, J., & Salomaa, V. V. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2260 · Cited by 59
Prevalence and correlates of metabolic syndrome (MS) in older adults
Cankurtaran, M., Halil, M. G., Doğu, B. B., Dağlı, N., Oyan, B., & Arıoğul, S. (2005) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2005.05.004 · Cited by 59
Serum C-Reactive Protein and Cognitive Function in Healthy Elderly Italian Community Dwellers
Ravaglia, G., Forti, P., Maioli, F., Brunetti, N., Martelli, M., Servadei, L., Bastagli, L., Bianchin, M., & Mariani, E. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.8.1017 · Cited by 62
The plasminogen activator inhibitor-1 −675 4G/5G genotype influences the risk of myocardial infarction associated with elevated plasma proinsulin and insulin concentrations in men from Europe: the HIFMECH Study
Juhan-Vague, I., Morange, P., Frère, C., Aillaud, M. F., Alessi, M., Hawe, E., Boquist, S., Tornvall, P., Yudkin, J. S., Tremoli, E., et al. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1046/j.1538-7836.2003.00458.x · Cited by 59
Self-citation
Why Do South Asians Have High Risk for CAD?
Nair, M., & Prabhakaran, D. (2012) · Global Heart · doi:10.1016/j.gheart.2012.09.001 · Cited by 58
IGF-1 levels across the spectrum of normal to elevated in acromegaly: relationship to insulin sensitivity, markers of cardiovascular risk and body composition
Reid, T. J., Jin, Z., Shen, W., Reyes-Vidal, C. M., Fernandez, J. C., Bruce, J. N., Kostadinov, J., Post, K. D., & Freda, P. U. (2015) · Pituitary · doi:10.1007/s11102-015-0657-2 · Cited by 58
Beneficial effects of cardiac rehabilitation and exercise after percutaneous coronary intervention on hsCRP and inflammatory cytokines in CAD patients
Kim, Y., Shin, Y., Bae, J.-S., Lee, J., Ham, J.-H., Son, Y., Kim, J.-K., Kim, C., Lee, B. K., Oh, J., et al. (2007) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-007-0356-6 · Cited by 58
Adipokines as Potential Biomarkers in Rheumatoid Arthritis
Prete, A. D., Salvi, V., & Sozzani, S. (2014) · Mediators of Inflammation · doi:10.1155/2014/425068 · Cited by 58
Effects of supplemental long-chain omega-3 fatty acids and erythrocyte membrane fatty acid content on circulating inflammatory markers in a randomized controlled trial of healthy adults
Flock, M. R., Skulas‐Ray, A. C., Harris, W. S., Gaugler, T. L., Fleming, J. A., & Kris‐Etherton, P. M. (2014) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2014.07.006 · Cited by 61
Metabolic Syndrome, a Cardiovascular Disease Risk Factor: Role of Adipocytokines and Impact of Diet and Physical Activity
Robinson, L. E., & Graham, T. E. (2004) · Canadian Journal of Applied Physiology · doi:10.1139/h04-053 · Cited by 57
Obesity and type 2 diabetes
Yaturu, S. (2011) · Journal of Diabetes Mellitus · doi:10.4236/jdm.2011.14012 · Cited by 64
High Dietary Fructose Intake on Cardiovascular Disease Related Parameters in Growing Rats
Yoo, S., Ahn, H., & Park, Y. K. (2016) · Nutrients · doi:10.3390/nu9010011 · Cited by 57
Trend in young coronary artery disease in China from 2010 to 2014: a retrospective study of young patients ≤ 45
Wang, X., Gao, M., Zhou, S., Wang, J., Liu, F., Tian, F., Jing, J., Ma, Q., Xue, X., Liu, J., et al. (2017) · BMC Cardiovascular Disorders · doi:10.1186/s12872-016-0458-1 · Cited by 58
Impact of systemic inflammation on the relationship between insulin resistance and all-cause and cancer-related mortality
Lee, W., Rhee, E., Chang, Y., Sohn, C. I., Shin, H. C., Ryu, S., & Lee, W. (2017) · Metabolism · doi:10.1016/j.metabol.2017.11.014 · Cited by 58
Distribution and metabolic syndrome correlates of plasma C-reactive protein in biracial (black-white) younger adults: the Bogalusa Heart Study
Patel, D. A., Srinivasan, S. R., Xu, J.-H., Li, S., Chen, W., & Berenson, G. S. (2006) · Metabolism · doi:10.1016/j.metabol.2005.07.015 · Cited by 58
Old and New Aspects of H. pylori-Associated Inflammation and Gastric Cancer
Dinca, A. L., Meliţ, L. E., & Mărginean, C. O. (2022) · Children · doi:10.3390/children9071083 · Cited by 64
Effect of weight loss after Roux-en-Y gastric bypass, on renal function and blood pressure in morbidly obese patients
Neto, A. S., Rossi, F. M. B., Amarante, R. D. M., Buriti, N. A., Saheb, G. C. B., & Rossi, M. (2009) · Journal of Nephrology · doi:10.1093/joneph/22.5.637 · Cited by 57
Polymorphisms in the IL6 gene in Asian Indian families with premature coronary artery disease – The Indian Atherosclerosis Research Study
Shanker, J., Dash, D., John, S., Sannappa, P. R., Rao, V. S., Ramanna, J. K., Kakkar, V. V., & Maitra, A. (2008) · Thrombosis and Haemostasis · doi:10.1160/th07-11-0686 · Cited by 57
The impact of physical activity and nutrition on inflammatory bowel disease: the potential role of cross talk between adipose tissue and skeletal muscle.
Bilski, J., Mazur-Biały, A. I., Wierdak, M., & Brzozowski, T. (2013) · PubMed · Cited by 55
Adipose tissue at the crossroads in the development of the metabolic syndrome, inflammation and atherosclerosis
WAJCHENBERG, B. L., Nery, M., Cunha, M. R., & da Silva, M. E. R. (2009) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302009000200005 · Cited by 57
The burden and extent of comorbid conditions in patients with erectile dysfunction
Hackett, G. I. (2009) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2009.02088.x · Cited by 57
Drug disease interactions: role of inflammatory mediators in disease and variability in drug response.
Kulmatycki, K. M., & Jamali, F. (2005) · PubMed · Cited by 58
Advanced Glycation End Products Induce Obesity and Hepatosteatosis in CD-1 Wild-Type Mice
Sayej, W. N., Knight, P. R., Guo, W. A., Mullan, B., Ohtake, P. J., Davidson, B. A., Khan, A. R., Baker, R. D., & Baker, S. S. (2016) · BioMed Research International · doi:10.1155/2016/7867852 · Cited by 58
Relations of Visceral and Abdominal Subcutaneous Adipose Tissue, Body Mass Index, and Waist Circumference to Serum Concentrations of Parameters of Chronic Inflammation
Schlecht, I., Fischer, B., Behrens, G., & Leitzmann, M. F. (2016) · Obesity Facts · doi:10.1159/000443691 · Cited by 57
Recapitulating T cell infiltration in 3D psoriatic skin models for patient-specific drug testing
Shin, J. U., Abaci, H. E., Herron, L. A., Guo, Z., Sallee, B. N., Pappalardo, A., Jackow, J., Wang, E. H. C., Doucet, Y., & Christiano, A. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-60275-0 · Cited by 59
White blood cell count as a risk factor for hypertension; a study of Japanese male office workers
Nakanishi, N., Sato, M., Shirai, K., Suzuki, K. S., & Tatara, K. (2002) · Journal of Hypertension · doi:10.1097/00004872-200205000-00018 · Cited by 57
C-reactive protein and tumor necrosis factor-α in gestational hyperglycemia
Bo, S., Signorile, A., Menato, G., Gambino, R., Bardelli, C., Gallo, M., Cassader, M., Massobrio, M., & Pagano, G. F. (2005) · Journal of Endocrinological Investigation · doi:10.1007/bf03347566 · Cited by 54
Levels of C3 in patients with severe, morbid and extreme obesity: its relationship to insulin resistance and different cardiovascular risk factors
Hernández‐Mijares, A., Jarabo-Bueno, M. M., López‐Ruiz, A., Solá-Izquierdo, E., Morillas, C., & Martínez-Triguero, M. L. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803543 · Cited by 56
Differential effects of dietary protein sources on postprandial low-grade inflammation after a single high fat meal in obese non-diabetic subjects
Holmer-Jensen, J., Karhu, T., Mortensen, L. S., Pedersen, S. B., Herzig, K., & Hermansen, K. (2011) · Nutrition Journal · doi:10.1186/1475-2891-10-115 · Cited by 56
Body fat and insulin resistance independently predict increased serum C-reactive protein in hyperandrogenic women with polycystic ovary syndrome
Tosi, F., Dorizzi, R. M., Castello, R., Maffeis, C., Spiazzi, G., Zoppini, G., Muggeo, M., & Moghetti, P. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0379 · Cited by 56
Effects of aerobic and resistance training on abdominal fat, apolipoproteins and high-sensitivity C-reactive protein in adolescents with obesity: the HEARTY randomized clinical trial
Alberga, A. S., Prud’homme, D., Kenny, G. P., Goldfield, G. S., Hadjiyannakis, S., Gougeon, R., Phillips, P., Malcolm, J., Wells, G. A., Doucette, S. P., et al. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.133 · Cited by 55
The relationship of high sensitivity C-reactive protein to percent body fat mass, body mass index, waist-to-hip ratio, and waist circumference in a Taiwanese population
Lin, C., Kardia, S. L. R., Li, C., Liu, C.-S., Lai, M.-M., Lin, C., Chang, P.-C., Lee, Y., Chen, C., Lin, C., et al. (2010) · BMC Public Health · doi:10.1186/1471-2458-10-579 · Cited by 55
Plasma ceruloplasmin as a biomarker for obesity: A proteomic approach
Kim, O. Y., Shin, M., Moon, J., & Chung, J. H. (2011) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2011.01.014 · Cited by 55
Effects of Auricular Acupuncture on Anthropometric, Lipid Profile, Inflammatory, and Immunologic Markers: A Randomized Controlled Trial Study
Abdi, H., Parizad, P. A., Zhao, B., Ghayour‐Mobarhan, M., Tavallaie, S., Rahsepar, A. A., Parizadeh, S. M. R., Safariyan, M., Nemati, M., Mohammadi, M., et al. (2012) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2011.0244 · Cited by 55
Development of coronary heart disease and ischemic stroke in relation to fasting and 2-hour plasma glucose levels in the normal range
Ning, F., Zhang, L., Dekker, J. M., Onat, A., Stehouwer, C. D. A., Yudkin, J. S., Laatikainen, T. K., Tuomilehto, J. O., Pyörälà, K., Qiao, Q., et al. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-76 · Cited by 56
Self-citation
Is early onset androgenic alopecia a marker of metabolic syndrome and carotid artery atherosclerosis in young Indian male patients?
Malhotra, S., Banger, H., Singh, S. P., & Mahajan, M. (2015) · International Journal of Trichology · doi:10.4103/0974-7753.171566 · Cited by 55
C-reactive protein and coronary heart disease in Western Turkey
Onat, A., Sansoy, V., Yıldırım, B., Keleş, İ., Uysal, Ö., & Hergenç, G. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)01799-4 · Cited by 55
Effect of obesity on inflammatory markers and renal functions
Cındık, N., Baskın, E., Ağras, P. I., Kınık, S. T., Turan, M., & Saatçi, U. (2005) · Acta Paediatrica · doi:10.1111/j.1651-2227.2005.tb01845.x · Cited by 55
The metabolic basis of atherogenic dyslipidemia
Vinik, A. I. (2005) · Clinical cornerstone · doi:10.1016/s1098-3597(05)80065-1 · Cited by 55
Insulin resistance and endothelial dysfunction in type 2 diabetes patients with or without microalbuminuria
Yu, Y., Suo, L., Yu, H., Wang, C., & Tang, H. (2004) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2004.01.006 · Cited by 54
C-reactive protein and microalbuminuria differ in their associations with various domains of vascular disease
Stuveling, E. M., Hillege, H. L., Bakker, S. J. L., Asselbergs, F. W., de Jong, P. E., Gans, R. O. B., & de Zeeuw, D. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00252-1 · Cited by 55
Effect of Fenofibrate on Serum Inflammatory Markers in Patients With High Triglyceride Values
Tsimihodimos, V., Kostoula, A., Kakafika, A. I., Bairaktari, E. T., Tselepis, A. D., Mikhailidis, D. P., & Elisaf, M. (2004) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/107424840400900i105 · Cited by 55
The association of body mass index with serum angiogenic markers in normal and abnormal pregnancies
Zera, C., Seely, E. W., Wilkins-Haug, L. E., Lim, K.-H., Parry, S. I., & McElrath, T. F. (2014) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2014.03.020 · Cited by 54
Insulin, Estrogen, Inflammatory Markers, and Risk of Benign Proliferative Breast Disease
Catsburg, C., Gunter, M. J., Chen, C., Coté, M. L., Kabat, G. C., Nassir, R., Tinker, L. F., Wactawski‐Wende, J., Page, D. L., & Rohan, T. E. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3514 · Cited by 54
Adipose-derived stromal/stem cells from different adipose depots in obesity development
Silva, K. R., & Baptista, L. S. (2019) · World Journal of Stem Cells · doi:10.4252/wjsc.v11.i3.147 · Cited by 62
Effect of insulin therapy on endothelium-dependent dilation in type 2 diabetes mellitus
Gaenzer, H., Neumayr, G., Marschang, P., Sturm, W., Lechleitner, M., Föger, B., Kirchmair, R., & Patsch, J. R. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)02266-4 · Cited by 52
Endothelial Dysfunction and Its Role in Diabetic Vascular Disease
Hartge, M., Kintscher, U., & Unger, T. (2006) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2006.06.006 · Cited by 54
Review article: the metabolic syndrome – a chronic cardiovascular inflammatory condition
Zambon, A., Pauletto, P., & Crepaldi, G. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02589.x · Cited by 54
Relation Between Soluble Adhesion Molecules and Insulin Sensitivity in Type 2 Diabetic Individuals
Targher, G., Bonadonna, R. C., Alberiche, M., Zenere, M. B., Muggeo, M., & Bonora, E. (2001) · Diabetes Care · doi:10.2337/diacare.24.11.1961 · Cited by 54
Elevated C-Reactive Protein Is Associated with an Increased Intima to Media Thickness of the Common Carotid Artery
Winbeck, K., Kukla, C., Poppert, H., Klingelhöfer, J., Conrad, B., & Sander, D. (2002) · Cerebrovascular Diseases · doi:10.1159/000047747 · Cited by 54
Decreasing levels of tumour necrosis factor α and interleukin 6 during lowering of body mass index with orlistat or placebo in obese subjects with cardiovascular risk factors
Samuelsson, L., Gottsäter, A., & Lindgärde, F. (2003) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2003.00264.x · Cited by 53
Insulin resistance, haemostatic and inflammatory markers and coronary heart disease risk factors in Type 2 diabetic men with and without coronary heart disease
Wannamethee, S. G., Lowe, G. D. O., Shaper, A. G., Rumley, A., LENNON, L. T., & Whincup, P. H. (2004) · Diabetologia · doi:10.1007/s00125-004-1491-7 · Cited by 54
Anti-inflammatory medications for the treatment of mental disorders: A scoping review
Fitton, R., Sweetman, J., Heseltine-Carp, W., & van der Feltz-Cornelis, C. (2022) · Brain, Behavior, & Immunity - Health · doi:10.1016/j.bbih.2022.100518 · Cited by 53
Alterations in Platelet Function and Cell-Derived Microvesicles in Recently Menopausal Women: Relationship to Metabolic Syndrome and Atherogenic Risk
Jayachandran, M., Litwiller, R. D., Lahr, B. D., Bailey, K. R., Owen, W. G., Mulvagh, S. L., Heit, J. A., Hodis, H. N., Harman, S. M., & Miller, V. M. (2011) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-011-9296-9 · Cited by 53
Association between plasma fatty acids and inflammatory markers in patients with and without insulin resistance and in secondary prevention of cardiovascular disease, a cross-sectional study
Bersch-Ferreira, Â. C., Sampaio, G. R., Gehringer, M. O., Torres, E. A. F. D. S., Ross-Fernandes, M. B., da Silva, J. T., Torreglosa, C. R., Kovacs, C., da Silva, R. A., Magnoni, D., et al. (2018) · Nutrition Journal · doi:10.1186/s12937-018-0342-1 · Cited by 53
Treatment with Metformin and Combination of Metformin Plus Pioglitazone on Serum Levels of IL-6 and IL-8 in Polycystic Ovary Syndrome: A Randomized Clinical Trial
Ali, D.-E.-S., Shah, M., Ali, A., Malik, M. O., Rehman, F., Badshah, H., Ehtesham, E., & Vitale, S. G. (2019) · Hormone and Metabolic Research · doi:10.1055/a-1018-9606 · Cited by 53
Relation of waist circumference and glycemic status to C-reactive protein in the Sandy Lake Oji-Cree
Connelly, P. W., Hanley, A. J., Harris, S. B., Hegele, R. A., & Zinman, B. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802239 · Cited by 53
Associations Between Dimensions of Job Stress and Biomarkers of Inflammation and Infection
Clays, E., Bacquer, D. D., Delanghe, J., Kittel, F., Renterghem, L. V., & Backer, G. D. (2005) · Journal of Occupational and Environmental Medicine · doi:10.1097/01.jom.0000171056.22917.ad · Cited by 55
C-Reactive Protein Causes Insulin Resistance in Mice Through Fcγ Receptor IIB–Mediated Inhibition of Skeletal Muscle Glucose Delivery
Tanigaki, K., Vongpatanasin, W., Barrera, J. A., Atochin, D. N., Huang, P. L., Bonvini, E., Shaul, P. W., & Mineo, C. (2012) · Diabetes · doi:10.2337/db12-0133 · Cited by 54
Physiopathological mechanisms related to inflammation in obesity and type 2 diabetes mellitus
Lempesis, I. G., & Georgakopoulou, V. (2023) · World Journal of Experimental Medicine · doi:10.5493/wjem.v13.i3.7 · Cited by 58
Weight Loss by Multidisciplinary Intervention Improves Endothelial and Sexual Function in Obese Fertile Women
Aversa, A., Bruzziches, R., Francomano, D., Greco, E. A., Violi, F., Lenzi, A., & Donini, L. M. (2013) · The Journal of Sexual Medicine · doi:10.1111/jsm.12069 · Cited by 53
Obesidade e adipocinas inflamatórias: implicações práticas para a prescrição de exercício
do Prado, W. L., Lofrano‐Prado, M. C., Oyama, L. M., & Dâmaso, A. R. (2009) · Revista Brasileira de Medicina do Esporte · doi:10.1590/s1517-86922009000600012 · Cited by 62
Chronic Obstructive Pulmonary Disease with Lung Cancer and/or Cardiovascular Disease
Rodriguez‐Roisin, R., & Soriano, J. B. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200807-075th · Cited by 54

Authors: Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W.
Affiliations: Whittington Hospital (GB)
ORCID: Yudkin, John S.
Stehouwer, C. D. A.
Venue: Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1999-04
Volume: 19
Issue: 4
Pages: 972-978
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/01.atv.19.4.972
OpenAlex: W2119316150
Cited by: 2,465
References: 51
Citations by year: 2026: 19 · 2025: 22 · 2024: 21 · 2023: 45 · 2022: 50 · 2021: 61 · 2020: 44 · 2019: 57 · 2018: 57 · 2017: 67 · 2016: 80 · 2015: 100 · 2014: 111 · 2013: 116 · 2012: 117
FWCI: 54.27
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
TNO Repository (submittedVersion)
Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: Wellcome Trust
British Heart Foundation
Diabetes Fonds
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords: C-reactive protein, interleukin-6, TNF-α, obesity, insulin resistance, endothelial dysfunction, adipose tissue, chronic inflammation, Helicobacter pylori, Chlamydia pneumoniae, cytomegalovirus, acute phase proteins, cardiovascular risk
MeSH terms: Adipose Tissue, Adult, Aged, C-Reactive Protein, Endothelium, Vascular, Female, Follow-Up Studies, United Kingdom, Humans, Insulin Resistance, Male, Middle Aged, Obesity, Random Allocation, Cytokines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating From Adipose Tissue?

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks