Cited by 2,465Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityLipoproteins and Cardiovascular Health

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating From Adipose Tissue?

Open access

Yudkin, John S., Stehouwer, C. D. A., Emeis, J. J., Coppack, S. W.·1999·Arteriosclerosis, Thrombosis, and Vascular Biology

DOI 10.1161/01.atv.19.4.972

Open this paper in CoChat — free account Open PDF

Abstract

Abstract —C-reactive protein, a hepatic acute phase protein largely regulated by circulating levels of interleukin-6, predicts coronary heart disease incidence in healthy subjects. We have shown that subcutaneous adipose tissue secretes interleukin-6 in vivo. In this study we have sought associations of levels of C-reactive protein and interleukin-6 with measures of obesity and of chronic infection as their putative determinants. We have also related levels of C-reactive protein and interleukin-6 to markers of the insulin resistance syndrome and of endothelial dysfunction. We performed a cross-sectional study in 107 nondiabetic subjects: (1) Levels of C-reactive protein, and concentrations of the proinflammatory cytokines interleukin-6 and tumor necrosis factor-α, were related to all measures of obesity, but titers of antibodies to Helicobacter pylori were only weakly and those of Chlamydia pneumoniae and cytomegalovirus were not significantly correlated with levels of these molecules. Levels of C-reactive protein were significantly related to those of interleukin-6 ( r =0.37, P <0.0005) and tumor necrosis factor-α ( r =0.46, P <0.0001). (2) Concentrations of C-reactive protein were related to insulin resistance as calculated from the homoeostasis model assessment model, blood pressure, HDL, and triglyceride, and to markers of endothelial dysfunction (plasma levels of von Willebrand factor, tissue plasminogen activator, and cellular fibronectin). A mean standard deviation score of levels of acute phase markers correlated closely with a similar score of insulin resistance syndrome variables ( r =0.59, P <0.00005), this relationship being weakened only marginally by removing measures of obesity from the insulin resistance score ( r =0.53, P <0.00005). These data suggest that adipose tissue is an important determinant of a low level, chronic inflammatory state as reflected by levels of interleukin-6, tumor necrosis factor-α, and C-reactive protein, and that infection with H pylori , C pneumoniae , and cytomegalovirus is not. Moreover, our data support the concept that such a low-level, chronic inflammatory state may induce insulin resistance and endothelial dysfunction and thus link the latter phenomena with obesity and cardiovascular disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/01.atv.19.4.972

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543
Interleukin-6 and the acute phase response
Heinrich, P. C., Castell, J. V., & Andus, T. (1990) · Biochemical Journal · doi:10.1042/bj2650621 · Cited by 2,734
IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance
Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630
Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1
Mohamed‐Ali, V., Goodrick, S., Rawesh, A., Katz, D. R., Miles, J. M., Yudkin, J. S., Klein, S., & Coppack, S. W. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4450 · Cited by 2,032
Self-citation
Interleukin-6: an overview
Van Snick, J. (1990) · Annual Review of Immunology · doi:10.1146/annurev.iy.08.040190.001345 · Cited by 1,890
Hemostatic Factors and the Risk of Myocardial Infarction or Sudden Death in Patients with Angina Pectoris
Thompson, S. G., Kienast, J., Pyke, S., Haverkate, F., & van de Loo, J. C. W. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321003 · Cited by 1,819

Flagged first, then by citations

Show all 51 references

Research works printed but not linked: 12

1988, Lab Invest, 58, 249
10.1161/circ.94.5.874 · DOI
1997, J Clin Endocrinol Metab, 82, 4196
1995, J Clin Endocrinol, 9, 61
10.1161/circ.94.5.922 · DOI
10.1161/atvb.15.9.1330 · DOI
10.1161/atvb.16.3.450 · DOI
1989, J Lab Clin Med, 113, 586
10.1161/atvb.17.10.2167 · DOI
1982, Proc Natl Acad Sci U S A, 82, 912
1992, Cancer Res, 52, 4113
10.1161/atvb.15.1.52 · DOI

Sorted by citations

Items 701–800 of 1,003

The Effects of Body Acupuncture on Obesity: Anthropometric Parameters, Lipid Profile, and Inflammatory and Immunologic Markers
Abdi, H., Zhao, B., Darbandi, M., Ghayour‐Mobarhan, M., Tavallaie, S., Rahsepar, A. A., Parizadeh, S. M. R., Safariyan, M., Nemati, M., Mohammadi, M., et al. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/603539 · Cited by 76
Obesity and stroke: Can we translate from rodents to patients?
Haley, M., & Lawrence, C. B. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16670411 · Cited by 79
Insulin resistance and the metabolic syndrome—or the pitfalls of epidemiology
Yudkin, J. S. (2007) · Diabetologia · doi:10.1007/s00125-007-0711-3 · Cited by 75
Self-citation
In vitro evidence that hyperglycemia stimulates tumor necrosis factor-α release in obese women with polycystic ovary syndrome
González, F., Rote, N. S., Minium, J., & Kirwan, J. P. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06579 · Cited by 76
The insulin resistance syndrome: implications for thrombosis and cardiovascular disease
Juhan-Vague, I., Morange, P., & Alessi, M. (2002) · Pathophysiology of Haemostasis and Thrombosis · doi:10.1159/000073579 · Cited by 75
Interpretation of circulating C-reactive protein levels in adults: Body Mass Index and gender are a must
Piéroni, L., Bastard, J., Piton, A., Khalil, L., Hainque, B., & Jardel, C. (2003) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70019-8 · Cited by 75
The potential role of peroxisome proliferator–activated receptors on inflammation in type 2 diabetes mellitus and atherosclerosis
Plutzky, J. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00614-3 · Cited by 75
Comparative effects of single-mode vs. duration-matched concurrent exercise training on body composition, low-grade inflammation, and glucose regulation in sedentary, overweight, middle-aged men
Donges, C. E., Duffield, R., Guelfi, K. J., Smith, G. C., Adams, D. R., & Edge, J. A. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2012-0443 · Cited by 74
Sedentary behaviour and physical activity are associated with biomarkers of endothelial dysfunction and low-grade inflammation—relevance for (pre)diabetes: The Maastricht Study
Vandercappellen, E. J., Koster, A., Savelberg, H. H. C. M., Eussen, S. J. P. M., Dagnelie, P. C., Schaper, N. C., Schram, M. T., Kallen, C., van Greevenbroek, M. M. J., Wesselius, A., et al. (2022) · Diabetologia · doi:10.1007/s00125-022-05651-3 · Cited by 76
Self-citation
Obesity and Low-Grade Inflammation among Young Finnish Men with Early-Onset Alopecia
Hirsso, P., Rajala, U., Hiltunen, L. A., Jokelainen, J. J., Keinanen-Kiukaanniemi, S. M., & Näyhä, S. (2007) · Dermatology · doi:10.1159/000098570 · Cited by 74
LPS induces interleukin-6 and interleukin-8 but not tumor necrosis factor-α in human adipocytes
Hoch, M., Eberlé, A. N., Peterli, R., Peters, T. T. A., Seboek, D., Keller, U. B., Müller-Stich, B. P., & Linscheid, P. (2007) · Cytokine · doi:10.1016/j.cyto.2007.10.008 · Cited by 74
Direct comparison of dietary portfolio vs statin on C-reactive protein
Jenkins, D. J. A., Kendall, C. W. C., Marchie, A., Faulkner, D. A., Josse, A. R., Wong, J. M., de Souza, R. J., Emam, A., Parker, T. L., Li, T. J., et al. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602152 · Cited by 74
Role of C Reactive Protein (CRP) in Leptin Resistance
Hribal, M. L., Fiorentino, T. V., & Sesti, G. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990016 · Cited by 75
Downregulation of zinc-α2-glycoprotein in adipose tissue and liver of obese ob/ob mice and by tumour necrosis factor-α in adipocytes
Mráček, T., Gao, D., Tzanavari, T., Bao, Y., Xiao, X., Stocker, C. J., Trayhurn, P., & Bing, C. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0299 · Cited by 74
Relationship between serum magnesium levels and C-reactive protein concentration, in non-diabetic, non-hypertensive obese subjects
Guerrero‐Romero, F., & Rodríguez‐Morán, M. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0801954 · Cited by 74
Association between C-reactive protein and hypertension in healthy middle-aged men and women
Bautista, L. E., Atwood, J. E., Pg, O., & Taylor, A. J. (2004) · Coronary Artery Disease · doi:10.1097/00019501-200409000-00006 · Cited by 74
Comparison of serum concentrations of C-reactive protein, TNF-α, and interleukin 6 between elderly Korean women with normal and impaired glucose tolerance
Choi, K. M., Lee, J., Lee, K. W., Seo, J. A., Oh, J.-H., Kim, S. G., Kim, N. H., Choi, D. S., & Baik, S. H. (2003) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2003.10.007 · Cited by 74
CRP reduction following gastric bypass surgery is most pronounced in insulin-sensitive subjects
Holdstock, C., Lind, L., Engstrom, B. E., Ohrvall, M., Sundbom, M., Larsson, A., & Karlsson, F. A. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803000 · Cited by 73
Adipose Tissue Interleukin‐18 mRNA and Plasma Interleukin‐18: Effect of Obesity and Exercise
Leick, L., Lindegaard, B., Stensvold, D., Plomgaard, P., Saltin, B., & Pilegaard, H. (2007) · Obesity · doi:10.1038/oby.2007.528 · Cited by 73
Association of High Sensitivity C-Reactive Protein With Coronary Heart Disease Prediction, but not With Carotid Atherosclerosis, in Patients With Hypertension
Choi, H.-A., Cho, D. H., Shin, H., & Park, J. B. (2004) · Circulation Journal · doi:10.1253/circj.68.297 · Cited by 73
Mechanisms of Adiponectin-Associated Perivascular Function in Vascular Disease
Withers, S., Bussey, C. E., Saxton, S. N., Melrose, H. M., Watkins, A., & Heagerty, A. M. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303031 · Cited by 73
Expression of the selenoprotein S (SELS) gene in subcutaneous adipose tissue and SELS genotype are associated with metabolic risk factors
Olsson, M. M., Olsson, B., Jacobson, P., Thelle, D. S., Björkegren, J., Walley, A. J., Froguel, P., Carlsson, L. M. S., & Sjöholm, K. (2010) · Metabolism · doi:10.1016/j.metabol.2010.05.011 · Cited by 72
Association of inflammation with worsening HOMA-insulin resistance
Park, K., Steffes, M., Lee, D.-H., Himes, J. H., & Jacobs, D. R. (2009) · Diabetologia · doi:10.1007/s00125-009-1486-5 · Cited by 72
C-reactive protein, depressed mood, and the prediction of coronary heart disease in initially healthy men: results from the MONICA–KORA Augsburg Cohort Study 1984–1998
Ladwig, K., Marten‐Mittag, B., Löwel, H., Döring, A., & Köenig, W. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi456 · Cited by 72
Fcγ Receptors and Ligands and Cardiovascular Disease
Tanigaki, K., Sundgren, N. C., Khera, A., Vongpatanasin, W., Mineo, C., & Shaul, P. W. (2015) · Circulation Research · doi:10.1161/circresaha.116.302795 · Cited by 73
Adiponectin and C-reactive protein in obesity, type 2 diabetes, and monodrug therapy
Putz, D., Goldner, W. S., Bar, R. S., Haynes, W. G., & Sivitz, W. I. (2004) · Metabolism · doi:10.1016/j.metabol.2004.06.013 · Cited by 72
Neutrophil Activation and C‐Reactive Protein Concentration in Preeclampsia
Belo, L., Santos‐Silva, A., CASLAKE, M. J., Cooney, J., Pereira‐Leite, L., Quintanilha, A. T., & Rebelo, I. (2003) · Hypertension in Pregnancy · doi:10.1081/prg-120021059 · Cited by 72
Adiponectin: a key fat-derived molecule regulating inflammation
Tilg, H., & Wolf, A. M. (2005) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.9.2.245 · Cited by 71
Physiological role of adiponectin in different tissues: a review
Esmaili, S., Hemmati, M., & Karamian, M. (2018) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2018.1493606 · Cited by 73
Obesity and Brain Function: The Brain–Body Crosstalk
Sui, S. X., & Pasco, J. A. (2020) · Medicina · doi:10.3390/medicina56100499 · Cited by 74
The relationship of inflammatory cytokines with asthma and obesity
Canãz, M., Erdenen, F., Uzun, H., MÜDERRİSOĞLU, C., & Aydın, S. (2008) · Clinical and investigative medicine · doi:10.25011/cim.v31i6.4924 · Cited by 72
High prevalence of metabolic syndrome and cardiovascular risk factors in men with ankylosing spondylitis on anti-TNFalpha treatment: correlation with disease activity.
Papadakis, J. A., Sidiropoulos, P. I., Karvounaris, S. A., Vrentzos, G. E., Spanakis, E. K., Ganotakis, E. S., Kritikos, H. D., Mikhailidis, D. P., & Boumpas, D. (2009) · PubMed · Cited by 71
Functional Polymorphism of IL-1 Alpha and Its Potential Role in Obesity in Humans and Mice
Um, J., Rim, H.-K., Kim, S., Kim, H., & Hong, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029524 · Cited by 71
Type 2 diabetes mellitus as inflammatory disease
Zozulińska‐Ziółkiewicz, D., & Wierusz‐Wysocka, B. (2006) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2006.06.007 · Cited by 70
Deficiency in Interferon-γ Results in Reduced Body Weight and Better Glucose Tolerance in Mice
Wong, N., Fam, B. C., Cempako, G. R., Steinberg, G. R., Walder, K. R., Kay, T. W. H., Proietto, J., & Andrikopoulos, S. (2011) · Endocrinology · doi:10.1210/en.2011-0288 · Cited by 70
Prevalence of Helicobacter pylori infection and its association with cardiovascular risk factors in Korean adults
Sung, K., Rhee, E., Ryu, S., & Beck, S. H. (2004) · International Journal of Cardiology · doi:10.1016/j.ijcard.2004.05.040 · Cited by 71
Pancreastatin-Dependent Inflammatory Signaling Mediates Obesity-Induced Insulin Resistance
Bandyopadhyay, G. K., Lu, M. L., Avolio, E., Siddiqui, J. A., Gayen, J. R., Wollam, J., Vu, C. U., Chi, N., O’Connor, D. T., & Mahata, S. K. (2014) · Diabetes · doi:10.2337/db13-1747 · Cited by 71
Serum procalcitonin and CRP levels in non-alcoholic fatty liver disease: a case control study
Oruç, N., Özütemız, Ö., Yüce, G., Akarca, U. S., Ersöz, G., Günşar, F., & Batur, Y. (2009) · BMC Gastroenterology · doi:10.1186/1471-230x-9-16 · Cited by 72
Relation Between Plasma Adiponectin, High-Sensitivity C-Reactive Protein, and Coronary Plaque Components in Patients With Acute Coronary Syndrome
Otake, H., Shite, J., Shinke, T., Watanabe, S., Tanino, Y., Ogasawara, D., Sawada, T., Hirata, K., & Yokoyama, M. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.07.041 · Cited by 71
Acute effects of periodontal therapy on bio‐markers of vascular health
D’Aiuto, F., Parkar, M. H., & Tonetti, M. S. (2007) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2006.01037.x · Cited by 71
C-reactive protein and the insulin-like growth factor (IGF)-system in relation to risk of cardiovascular disease in different ethnic groups
Heald, A. H., Anderson, S. G., Ivison, F., Laing, I., Gibson, M., & Cruickshank, K. J. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00235-1 · Cited by 71
Capacidade dos biomarcadores inflamatórios em predizer a síndrome metabólica: Inflammation biomarkers capacity in predicting the metabolic syndrome
Volp, A. C. P., Alfenas, R. D. C. G., Costa, N. M. B., Minim, V. P. R., Stringheta, P. C., & Bressan, J. (2008) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302008000300015 · Cited by 70
Diet and lifestyle are associated with serum C-reactive protein concentrations in a population-based study
Bertran, N., Camps, J., Fernandez-Ballart, J. D., Arija, V., Ferré, N., Tous, M., Simo, D., Murphy, M. M., Vilella, E., & Joven, J. (2005) · Journal of Laboratory and Clinical Medicine · doi:10.1016/j.lab.2004.11.002 · Cited by 68
Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese
Cheung, B. M. Y., Ong, K. L., Cheung, R. V., Wong, L. Y. F., Wat, N. M. S., Tam, S., Leung, G. M., Cheng, C. H., Woo, J., Janus, E. D., et al. (2008) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2008.111 · Cited by 70
Neutrophil to Lymphocyte Ratio is Related to Stent Thrombosis and High Mortality in Patients With Acute Myocardial Infarction
Ayça, B., Akın, F., Çelik, Ö., Şahin, İ., Yildiz, S. S., Avcı, İ. İ., Gülşen, K., Okuyan, E., & Dinçkal, M. H. (2014) · Angiology · doi:10.1177/0003319714542997 · Cited by 70
Serum leptin and C-reactive protein levels in the physiological spontaneous menstrual cycle in reproductive age women
Wunder, D. M., Yared, M. A., Bersinger, N. A., Widmer, D., Kretschmer, R., & Birkhäuser, M. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02178 · Cited by 71
Low‐grade systemic inflammation impairs arterial stiffness in newly diagnosed hypercholesterolaemia
Pirro, M., Schillaci, G., Savarese, G., Gemelli, F., Vaudo, G., Siepi, D., Bagaglia, F., & Mannarino, E. (2004) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2004.01345.x · Cited by 70
Effect of pioglitazone and rosiglitazone on mediators of endothelial dysfunction, markers of angiogenesis and inflammatory cytokines in type-2 diabetes
Vijay, S. K., Mishra, M., Kumar, H., & Tripathi, K. (2008) · Acta Diabetologica · doi:10.1007/s00592-008-0054-7 · Cited by 69
The Levels of Soluble CD40 Ligand and C-Reactive Protein in Normal Weight, Overweight and Obese People
Ünek, İ. T., Bayraktar, F., Solmaz, D., Ellıdokuz, H., Şişman, A. R., Yuksel, F., & Yeşil, S. (2010) · Clinical Medicine & Research · doi:10.3121/cmr.2010.889 · Cited by 69
Histidine supplementation alleviates inflammation in the adipose tissue of high-fat diet-induced obese rats via the NF-κB- and PPARγ-involved pathways
Sun, X., Feng, R., Li, Y., Lin, S., Zhang, W., Li, Y., Sun, C., & Li, S. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514001056 · Cited by 70
?717A>G polymorphism of human C-reactive protein gene associated with coronary heart disease in ethnic Han Chinese: the Beijing atherosclerosis study
Chen, J., Zhao, J., Huang, J., Su, S., Qiang, B., & Gu, D. (2004) · Journal of Molecular Medicine · doi:10.1007/s00109-004-0585-5 · Cited by 69
Impact of social integration on metabolic functions: evidence from a nationally representative longitudinal study of US older adults
Yang, Y. C., Li, T., & Ji, Y. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-1210 · Cited by 68
Exercise training is associated with improved levels of C-reactive protein and adiponectin in ZDF (type 2) diabetic rats.
Teixeira‐Lemos, E., Reis, F., Baptista, S., Pinto, R. M. A., Sepodes, B. M. N., Vala, H., Rocha‐Pereira, P., Santos‐Silva, A., & Teixeira, F. J. (2007) · PubMed · Cited by 68
Associations of visceral adiposity and exercise participation with C-reactive protein, insulin resistance, and endothelial dysfunction in Korean healthy adults
Kim, K., Valentine, R. J., Shin, Y.-J., & Gong, K. (2008) · Metabolism · doi:10.1016/j.metabol.2008.04.009 · Cited by 68
The Metabolic Syndrome: Definitions, Prevalence and Management
Levesque, J., & Lamarche, B. (2008) · Lifestyle Genomics · doi:10.1159/000112457 · Cited by 71
Fish Consumption in Healthy Adults Is Associated with Decreased Circulating Biomarkers of Endothelial Dysfunction and Inflammation during a 6-Year Follow-Up
van Bussel, B. C. T., Henry, R. M. A., Schalkwijk, C. G., Ferreira, I., Feskens, E. J. M., Streppel, M. T., Smulders, Y. M., Twisk, J. W. R., & Stehouwer, C. D. A. (2011) · Journal of Nutrition · doi:10.3945/jn.111.139733 · Cited by 67
Self-citation
Elevated Serum C-Reactive Protein and Free Fatty Acids Among Nondiabetic Carriers of Missense Mutations in the Gene Encoding Lamin A/C ( LMNA ) With Partial Lipodystrophy
Hegele, R. A., Kraw, M. E., Ban, M. R., Miskie, B. A., Huff, M. W., & Cao, H. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000047460.27435.b8 · Cited by 68
Relation of hypertriglyceridemia to plasma concentrations of biochemical markers of inflammation and endothelial activation (C-reactive protein, interleukin-6, soluble adhesion molecules, von Willebrand factor, and endothelin-1)
Lundman, P., Eriksson, M. J., Silveira, A. M. V., Hansson, L., Pernow, J., Ericsson, C.-G. Ö., Hamsten, A., & Tornvall, P. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00165-6 · Cited by 68
Gender Differences in C-Reactive Protein Concentrations - Confirmation with Two Sensitive Methods
McConnell, J. P., Branum, E. L., Ballman, K. V., Lagerstedt, S. A., Katzmann, J. A., & Jaffe, A. S. (2002) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2002.011 · Cited by 68
Cellular inflammatory responses: Novel insights for obesity and insulin resistance
Chen, H. (2006) · Pharmacological Research · doi:10.1016/j.phrs.2006.03.003 · Cited by 68
C-Reactive Protein Concentration is More Strongly Related to Metabolic Syndrome in Women Than in Men-The Minoh Study-
Nakanishi, N., SHIRAISHI, T., & Wada, M. (2005) · Circulation Journal · doi:10.1253/circj.69.386 · Cited by 68
Endothelial Dysfunction in Obesity and Therapeutic Targets
Engin, A. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-63657-8_17 · Cited by 78
Inflammation and insulin resistance are independently related to all-cause of death and cardiovascular events in Japanese patients with type 2 diabetes mellitus
Matsumoto, K., Sera, Y., Abe, Y., Ueki, Y., Tominaga, T., & Miyake, S. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00198-9 · Cited by 67
Inflammatory biomarkers in type 2 diabetic patients: effect of glycemic control and impact of ldl subfraction phenotype
Vinagre, I., Sánchez‐Quesada, J. L., Sánchez-Hernández, J. J., Santos, D., Ordóñez‐Llanos, J., de Leiva, A., & Pérez, A. (2014) · Cardiovascular Diabetology · doi:10.1186/1475-2840-13-34 · Cited by 67
Adipose expression of adipocytokines in women with polycystic ovary syndrome
Svendsen, P. F., Christiansen, M., Hedley, P. L., Nilas, L., Pedersen, S. B., & Madsbad, S. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.03.056 · Cited by 67
Cytokines and Chemokines as Biomarkers of Community-Acquired Bacterial Infection
Holub, M., Lawrence, D. A., Andersen, N. J., Davidová, A., Beran, O., Marešová, V., & Chalupa, P. (2013) · Mediators of Inflammation · doi:10.1155/2013/190145 · Cited by 67
Dietary determinants of subclinical inflammation, dyslipidemia and components of the metabolic syndrome in overweight children: a review
Zimmermann, M. B., & Herter‐Aeberli, I. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.202 · Cited by 67
Relationship between non-alcoholic fatty liver disease and inflammation in patients with non-alcoholic fatty liver
Foroughi, M., Maghsoudi, Z., Khayyatzadeh, S. S., Ghiasvand, R., Askari, G., & Iraj, B. (2016) · Advanced Biomedical Research · doi:10.4103/2277-9175.176368 · Cited by 70
The Impact of Microbiota-Gut-Brain Axis on Diabetic Cognition Impairment
Xu, Y., Zhou, H., & Zhu, Q. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00106 · Cited by 67
Systemic Inflammation as a Cardiovascular Disease Risk Factor and as a Potential Target for Drug Therapy
Kaplan, R. C., & Frishman, W. H. (2001) · Heart Disease · doi:10.1097/00132580-200109000-00009 · Cited by 67
Absence of Association Between Infectious Agents and Endothelial Function in Healthy Young Men
Khairy, P., Rinfret, S., Tardif, J., Marchand, R., Shapiro, S., Brophy, J. M., & Dupuis, J. (2003) · Circulation · doi:10.1161/01.cir.0000064895.89033.97 · Cited by 67
Lipaemia, Inflammation and Atherosclerosis
van Oostrom, A. J. H. H. M., van Wijk, J. P. H., & Cabezas, M. C. (2004) · Drugs · doi:10.2165/00003495-200464002-00004 · Cited by 67
Aldosterone Function in Diabetes Mellitus: Effects on Cardiovascular and Renal Disease
McFarlane, S. I., & Sowers, J. R. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021443 · Cited by 67
Cardiovascular Risks Associated With Obesity in Children and Adolescents
Ho, T. F. (2009) · Annals of the Academy of Medicine Singapore · doi:10.47102/annals-acadmedsg.v38n1p48 · Cited by 65
Plasma IL‐6 concentration is inversely related to insulin sensitivity, and acute‐phase proteins associate with glucose and lipid metabolism in healthy subjects
Heliövaara, M. K., Teppo, A. M., Karonen, S. ‐., Tuominen, J. A., & Ebeling, P. R. (2004) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2004.00463.x · Cited by 65
Overactive bladder: Is there a link to the metabolic syndrome in men?
Kirby, M. G., Wagg, A., Cardozo, L., Chapple, C. R., Castro-Diaz, D. M., Ridder, D. J. M. K. D., Espuña‐Pons, M., Haab, F., Kelleher, C. J., KÖLBL, H., et al. (2010) · Neurourology and Urodynamics · doi:10.1002/nau.20892 · Cited by 66
The Effect of Weight Loss on a Stable Biomarker of Inflammation, C-Reactive Protein
Dietrich, M., & Jialal, I. (2005) · Nutrition Reviews · doi:10.1111/j.1753-4887.2005.tb00107.x · Cited by 66
Cardiovascular disease prevention in patients with type 2 diabetes: the role of oral anti-diabetic agents
Ajjan, R., & Grant, P. J. (2006) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2006.023 · Cited by 64
Importance of metabolic changes induced by chemotherapy on prognosis of early‐stage breast cancer patients: a review of potential mechanisms
Gadéa, É., Thivat, É., Planchat, E., Morio, B., & Durando, X. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00957.x · Cited by 70
High-sensitivity C-reactive protein is associated with insulin resistance and cardiovascular autonomic dysfunction in type 2 diabetic patients
Anan, F., Takahashi, N., Nakagawa, M., Ooie, T., Saikawa, T., & Yoshimatsu, H. (2005) · Metabolism · doi:10.1016/j.metabol.2004.11.012 · Cited by 65
The anti-diabetic AMPK activator AICAR reduces IL-6 and IL-8 in human adipose tissue and skeletal muscle cells
Lihn, A. S., Pedersen, S. B., Lund, S. A., & Richelsen, B. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.06.004 · Cited by 65
Changes in inflammatory biomarkers after successful lifestyle intervention in obese children.
Garanty‐Bogacka, B., Syrenicz, M., Goral, J., Krupa, B., Syrenicz, J., Walczak, M., & Syrenicz, A. (2011) · PubMed · Cited by 65
Associations of Maternal Weight Status Before, During, and After Pregnancy with Inflammatory Markers in Breast Milk
Whitaker, K. M., Marino, R. C., Haapala, J. L., Foster, L., Smith, K. D., Teague, A. M., Jacobs, D. R., Fontaine, P. L., McGovern, P. M., Schoenfuss, T. C., et al. (2017) · Obesity · doi:10.1002/oby.22025 · Cited by 65
Plasma cytokines in obese women with polycystic ovary syndrome, before and after metformin treatment
Jakubowska, J., Bohdanowicz-Pawlak, A., Milewicz, A., Szymczak, J., Bednarek-Tupikowska, G., & Demissie, M. (2008) · Gynecological Endocrinology · doi:10.1080/09513590802128968 · Cited by 65
Zymosan-induced inflammation stimulates neo-adipogenesis
Thomas, G. P. L., Hemmrich, K., Abberton, K. M., McCombe, D., Penington, A., Thompson, E. W., & Morrison, W. A. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803702 · Cited by 65
Endothelial dysfunction in endocrine disease
Abdu, T. A. M. (2001) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(01)00425-8 · Cited by 64
PPARs and the orchestration of metabolic fuel selection
Sugden, M. C., Zariwala, M. G., & Holness, M. J. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.03.014 · Cited by 64
The metabolic syndrome and endothelial dysfunction: Common highway to type 2 diabetes and CVD?
Diamant, M., & Tushuizen, M. E. (2006) · Current Diabetes Reports · doi:10.1007/s11892-006-0061-4 · Cited by 64
Male pattern baldness and its association with coronary heart disease: a meta-analysis
Yamada, T., Hara, K., Umematsu, H., & Kadowaki, T. (2013) · BMJ Open · doi:10.1136/bmjopen-2012-002537 · Cited by 64
Aortic Stiffness: Epidemiology, Risk Factors, and Relevant Biomarkers
Angoff, R., Mosarla, R. C., & Tsao, C. W. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.709396 · Cited by 64
Type 2 diabetes and cardiovascular disease: getting to the fat of the matterThis paper is one of a selection of papers published in this Special Issue, entitled Young Investigators' Forum.
Goralski, K. B., & Sinal, C. J. (2007) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y06-092 · Cited by 66
Perivascular Fat and the Microcirculation: Relevance to Insulin Resistance, Diabetes, and Cardiovascular Disease
Houben, A. J. H. M., Eringa, E. C., Jonk, A. M., Serné, E. H., Smulders, Y. M., & Stehouwer, C. D. A. (2011) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-011-0214-0 · Cited by 62
Self-citation
Tissue Factor Is Induced by Resistin in Human Coronary Artery Endothelial Cells by the NF-ĸB-Dependent Pathway
Calabrò, P., Cirillo, P. L., Limongelli, G., Maddaloni, V., Riegler, L., Palmieri, R., Pacileo, G., Rosa, S. D., Pacileo, M., Palma, R. D., et al. (2010) · Journal of Vascular Research · doi:10.1159/000318775 · Cited by 64
High-density lipoproteins attenuate interleukin-6 production in endothelial cells exposed to pro-inflammatory stimuli
Gomaraschi, M., Basilico, N., Sisto, F., Taramelli, D., Eligini, S., Colli, S., Sirtori, C. R., Franceschini, G., & Calabresi, L. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.08.003 · Cited by 64
The role of lipoproteins and inflammation in cognitive decline: Do they interact?
van den Kommer, T. N., Dik, M. G., Comijs, H. C., Jonker, C., & Deeg, D. J. H. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.05.024 · Cited by 64
The levels of circulating markers of atherosclerosis and inflammation in subjects with different degrees of body mass index: Soluble CD40 ligand and high-sensitivity C-reactive protein
Güldiken, S., Demir, M., Arıkan, E., Turgut, B., Azcan, Ş., Gerenli, M., & Tuğrul, A. (2006) · Thrombosis Research · doi:10.1016/j.thromres.2005.12.019 · Cited by 64
Differences in atherosclerosis according to area level socioeconomic deprivation: cross sectional, population based study
Deans, K. A., Bezlyak, V., Ford, I., Batty, G. D., BURNS, H. J. G., Cavanagh, J., de Groot, E., McGinty, A., Millar, K., Shiels, P. G., et al. (2009) · BMJ · doi:10.1136/bmj.b4170 · Cited by 64
The metabolic syndrome and the risk of arterial and venous thrombosis
Franchini, M., Targher, G., Montagnana, M., & Lippi, G. (2007) · Thrombosis Research · doi:10.1016/j.thromres.2007.09.010 · Cited by 64
C-Reactive Protein, Fibrin D-Dimer, and Risk of Ischemic Heart Disease
Lowe, G. D. O., Sweetnam, P. M., YARNELL, J. W. G., Rumley, A., Rumley, C. N., Bainton, D., & Ben‐Shlomo, Y. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000141842.27810.a9 · Cited by 64
Exposure to the Saturated Free Fatty Acid Palmitate Alters BV-2 Microglia Inflammatory Response
Tracy, L. M., Bergqvist, F., Ivanova, E. V., Jacobsen, K. T., & Iverfeldt, K. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0068-7 · Cited by 63

Authors: Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W.
Affiliations: Whittington Hospital (GB)
ORCID: Yudkin, John S.
Stehouwer, C. D. A.
Venue: Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1999-04
Volume: 19
Issue: 4
Pages: 972-978
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/01.atv.19.4.972
OpenAlex: W2119316150
Cited by: 2,465
References: 51
Citations by year: 2026: 19 · 2025: 22 · 2024: 21 · 2023: 45 · 2022: 50 · 2021: 61 · 2020: 44 · 2019: 57 · 2018: 57 · 2017: 67 · 2016: 80 · 2015: 100 · 2014: 111 · 2013: 116 · 2012: 117
FWCI: 54.27
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
TNO Repository (submittedVersion)
Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: Wellcome Trust
British Heart Foundation
Diabetes Fonds
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords: C-reactive protein, interleukin-6, TNF-α, obesity, insulin resistance, endothelial dysfunction, adipose tissue, chronic inflammation, Helicobacter pylori, Chlamydia pneumoniae, cytomegalovirus, acute phase proteins, cardiovascular risk
MeSH terms: Adipose Tissue, Adult, Aged, C-Reactive Protein, Endothelium, Vascular, Female, Follow-Up Studies, United Kingdom, Humans, Insulin Resistance, Male, Middle Aged, Obesity, Random Allocation, Cytokines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating From Adipose Tissue?

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks