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Cited by 25Growth Hormone and Insulin-like Growth FactorsSleep and Wakefulness ResearchRegulation of Appetite and Obesity

Polysomnographic Sleep, Growth Hormone Insulin‐like Growth Factor‐I Axis, Leptin, and Weight Loss

Rasmussen, Michael H., Wildschiødtz, Gordon, Juul, Anders, Hilsted, Jannik·2008·Obesity
DOI 10.1038/oby.2008.249
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Abstract

Short sleep appears to be strongly associated with obesity and altered metabolic function, and sleep and growth hormone (GH) secretion seems interlinked. In obesity, both the GH‐insulin‐like‐growth‐factor‐I (GH‐IGF‐I) axis and sleep have been reported to be abnormal, however, no studies have investigated sleep in relation to the GH‐IGF‐I axis and weight loss in obese subjects. In this study polygraphic sleep recordings, 24‐h GH release, 24‐h leptin levels, free‐IGF‐I, total‐IGF‐I, IGF‐binding protein‐3 (IGFBP‐3), acid‐labile subunit (ALS), cortisol and insulin sensitivity were determined in six severely obese subjects (BMI: 41 ± 1 kg/m 2, 32 ± 2 years of age), cross‐sectional at baseline, and longitudinal after a dramatically diet‐induced weight loss (36 ± 7 kg). Ten age‐ and gender‐matched nonobese subjects served as controls. Sleep duration (360 ± 17 vs. 448 ± 15 min/night; P < 0.01), 24‐h GH (55 ± 9 vs. 344 ± 55 mU/l·24 h; P < 0.01), free‐IGF‐I (2.3 ± 0.42 vs. 5.7 ± 1.2 μg/l; P < 0.01), and total‐IGF‐I (186 ± 21 vs. 301 ± 18 μg/l; P < 0.01) were significantly decreased and 24‐h leptin levels were increased (35 ± 5 vs. 12 ± 3 μg/l; P < 0.01) in obese subjects at pre‐weight loss compared with nonobese subjects After diet‐induced weight loss the differences in GH, free IGF‐I, and leptin were no longer present between previously obese and nonobese subjects, whereas a significant difference in sleep duration and total IGF‐I levels persisted. Rapid eye movement (REM) sleep, non‐REM sleep, IGFBP‐3, ALS, and cortisol levels were similar in obese and nonobese subjects. Sleep duration, 24‐h GH, and IGF‐I levels were decreased and 24‐h leptin levels were increased in obese subjects. We conclude that hyposomatotropism and hyperleptinemia in obesity are transient phenomena reversible with weight loss, whereas short sleep seems to persist after weight has been reduced dramatically.

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Authors
Rasmussen, M. H., Wildschiødtz, G., Juul, A., & Hilsted, J.
Affiliations
University of Copenhagen (DK)
ORCID
Venue
Obesity
Publisher
Wiley
Published
2008-07
Volume
16
Issue
7
Pages
1516-1521
ISSN
  • 1930-7381 (ISSN-L)
  • 1930-739X
DOI
10.1038/oby.2008.249
OpenAlex
W2034159662
Cited by
25
References
48
Citations by year
2025: 2 · 2023: 2 · 2022: 1 · 2020: 3 · 2019: 3 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 4 · 2012: 3
FWCI
0.72
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1528 d)
Locations
  • Obesity (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
sleep duration, growth hormone, insulin-like growth factor I, leptin, weight loss, diet-induced weight loss, hyposomatotropism, hyperleptinemia, IGF binding protein-3, acid-labile subunit, cortisol, insulin sensitivity, REM sleep, NREM sleep, short sleep duration, metabolic function, growth hormone secretion
MeSH terms
Adult, Energy Intake, Carrier Proteins, Circadian Rhythm, Female, Glycoproteins, Humans, Hydrocortisone, Insulin, Insulin-Like Growth Factor I, Male, Obesity, Prospective Studies, Severity of Illness Index, Sleep, Sleep Wake Disorders, Sleep, REM, Weight Gain, Case-Control Studies, Treatment Outcome, Polysomnography, Insulin-Like Growth Factor Binding Proteins, Insulin-Like Growth Factor Binding Protein 3, Human Growth Hormone, Leptin

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