The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Influence of Leptin on Arterial Distensibility: A Novel Link Between Obesity and Cardiovascular Disease?
Abstract
Background— The mechanisms by which obesity increases the risk of atherosclerotic cardiovascular disease (CVD) are poorly understood. In experimental models, leptin, a hormone produced by adipose tissue, has been shown adversely to affect vascular health. Therefore, we tested the hypothesis that high leptin concentrations are associated with lower arterial distensibility, an index of circulatory function relevant to the atherosclerotic process. Methods and Results— Noninvasive, high-resolution, vascular ultrasound was used to measure brachial artery distensibility in 294 healthy adolescents (aged 13 to 16 years) who had a broad range of body mass indexes. Fat mass was measured by bioelectric impedance analysis; fasting serum leptin concentration by radioimmunoassay; and lipid profile, fasting insulin, glucose, and C-reactive protein concentrations by standard laboratory techniques. Higher leptin concentrations were associated with impaired arterial distensibility (regression coefficient, −1.3% change in arterial distension per 10% increase in leptin; 95% CI, −1.9% to −0.8%; P <0.001). This association was independent of fat mass, blood pressure, and C-reactive protein, fasting insulin, or LDL cholesterol concentrations. Conclusions— Elevation in leptin was associated with impaired vascular function, independent of the metabolic and inflammatory disturbances associated with obesity. Our observations are consistent with data from experimental models and suggest that high leptin concentration is an important mechanism for the adverse influence of body fatness on CVD.
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Cites
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Cited by
Fox, C. S., Massaro, J. M., Hoffmann, U., Pou, K. M., Maurovich-Horvat, P., Liu, C.-Y., Vasan, R. S., Murabito, J. M., Meigs, J. B., Cupples, L. A., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.675355 · Cited by 2,882
Mechanisms linking obesity with cardiovascular disease
Van Gaal, L. F., Mertens, I. L., & De Block, C. E. (2006) · Nature · doi:10.1038/nature05487 · Cited by 2,814
Urbina, E. M., Williams, R. V., Alpert, B. S., Collins, R. T., Daniels, S. R., Hayman, L., Jacobson, M., Mahoney, L., Mietus-Snyder, M., Rocchini, A., et al. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.192639 · Cited by 641
Koerner, A., Kratzsch, J., & Kiess, W. (2005) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2005.07.008 · Cited by 471
Measures of Obesity Are Associated With Vascular Stiffness in Young and Older Adults
Wildman, R. P., Mackey, R. H., Bostom, A., Thompson, T., & Sutton-Tyrrell, K. (2003) · Hypertension · doi:10.1161/01.hyp.0000090360.78539.cd · Cited by 441
Metadata
- Authors
- Singhal, A., Farooqi, I. S., Cole, T. J., O’Rahilly, S., Fewtrell, M., Kattenhorn, M., Lucas, A., & Deanfield, J.
- Venue
- Circulation
- Published
- 2002-10-08
- Volume
- 106
- Issue
- 15
- Pages
- 1919-1924
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2168105134
- Cited by
- 363
- References
- 33
- FWCI
- 13.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Influence of Leptin on Arterial Distensibility: A Novel Link Between Obesity and Cardiovascular Disease? https://app.cochat.ai/papers/10.1161/01.cir.0000033219.24717.52
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- Singhal, A., Farooqi, I. S., Cole, T. J., O’Rahilly, S., Fewtrell, M., Kattenhorn, M., Lucas, A., & Deanfield, J. (2002). Influence of Leptin on Arterial Distensibility: A Novel Link Between Obesity and Cardiovascular Disease? Circulation. https://doi.org/10.1161/01.cir.0000033219.24717.52
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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