Physiology and Pathophysiology of Vascular Signaling Controlled by Cyclic Guanosine 3′,5′-Cyclic Monophosphate–Dependent Protein Kinase

Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress

Cai, H., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.87.10.840 · Cited by 3,839

Rapid Measurement of B-Type Natriuretic Peptide in the Emergency Diagnosis of Heart Failure

Maisel, A. S., Krishnaswamy, P., Nowak, R. M., McCord, J., Hollander, J. E., Duc, P., Omland, T., Storrow, A. B., Abraham, W. T., Wu, A. H. B., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020233 · Cited by 3,346

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

Uehata, M., Ishizaki, T., Satoh, H., Ono, T., Kawahara, T., Morishita, T., Tamakawa, H., Yamagami, K., Inui, J., Maekawa, M., et al. (1997) · Nature · doi:10.1038/40187 · Cited by 2,862

A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

Molkentin, J. D., Lu, J., Antos, C. L., Markham, B. E., Richardson, J. A., Robbins, J. M., Grant, S. R., & Olson, E. N. (1998) · Cell · doi:10.1016/s0092-8674(00)81573-1 · Cited by 2,566

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

Rajagopalan, S., Kurz, S. D., Münzel, T. F., Tarpey, M. M., Freeman, B. Α., Griendling, K. K., & Harrison, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118623 · Cited by 2,467

Endothelial Dysfunction, Oxidative Stress, and Risk of Cardiovascular Events in Patients With Coronary Artery Disease

Heitzer, T., Schlinzig, T., Krohn, K., Meinertz, T., & Münzel, T. (2001) · Circulation · doi:10.1161/hc4601.099485 · Cited by 1,961

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

Beavo, J. A. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.4.725 · Cited by 1,788

Hypercholesterolemia increases endothelial superoxide anion production.

Ohara, Y., Peterson, T. E., & Harrison, D. G. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116491 · Cited by 1,765

Intravenous Nesiritide, a Natriuretic Peptide, in the Treatment of Decompensated Congestive Heart Failure

Colucci, W. S., Elkayam, U., Horton, D. P., Abraham, W. T., Bourge, R. C., Johnson, A. D., Wagoner, L. E., Givertz, M. M., Liang, C., Neibaur, M., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007273430403 · Cited by 907

Role of Superoxide in Angiotensin II–Induced but Not Catecholamine-Induced Hypertension

Laursen, J. B., Rajagopalan, S., Galis, Z. S., Tarpey, M. M., Freeman, B. Α., & Harrison, D. G. (1997) · Circulation · doi:10.1161/01.cir.95.3.588 · Cited by 820

Phosphorylation of Thr 495 Regulates Ca 2+ /Calmodulin-Dependent Endothelial Nitric Oxide Synthase Activity

Fleming, I., Fisslthaler, B., Dimmeler, S., Kemp, B. E., & Busse, R. (2001) · Circulation Research · doi:10.1161/hh1101.092677 · Cited by 770

Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions

Soderling, S. H., & Beavo, J. A. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)00073-3 · Cited by 737

Endothelial Regulation of Vasomotion in ApoE-Deficient Mice: Implications for Interactions Between Peroxynitrite and Tetrahydrobiopterin

Laursen, J. B., Somers, M., Kurz, S., McCann, L., Warnholtz, A., Freeman, B. A., Tarpey, M., Fukai, T., & Harrison, D. G. (2001) · Circulation · doi:10.1161/01.cir.103.9.1282 · Cited by 721

Effects of Angiotensin II Infusion on the Expression and Function of NAD(P)H Oxidase and Components of Nitric Oxide/cGMP Signaling

Mollnau, H., Wendt, M., Szöcs, K., Lassègue, B., Schulz, E., Oelze, M., Li, H., Bodenschatz, M., August, M., Kleschyov, A. L., et al. (2002) · Circulation Research · doi:10.1161/01.res.0000012569.55432.02 · Cited by 676

Increased NADH-Oxidase–Mediated Superoxide Production in the Early Stages of Atherosclerosis

Warnholtz, A., Nickenig, G., Schulz, E., Macharzina, R. R., Bräsen, J. H., Skatchkov, M. P., Heitzer, T. A., Stasch, J. P., Griendling, K. K., Harrison, D. G., et al. (1999) · Circulation · doi:10.1161/01.cir.99.15.2027 · Cited by 676

Cardiac fibrosis in mice lacking brain natriuretic peptide

Tamura, N., Ogawa, Y., Chusho, H., Nakamura, K., Nakao, K., Suda, M., Kasahara, M., Hashimoto, R., Katsuura, G., Mukoyama, M., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.070371497 · Cited by 617

Novel Competitive Inhibitor of NAD(P)H Oxidase Assembly Attenuates Vascular O2−and Systolic Blood Pressure in Mice

Rey, F. E., Cifuentes-Pagano, E., Kiarash, A., Quinn, M. T., & Pagano, P. J. (2001) · Circulation Research · doi:10.1161/hh1701.096037 · Cited by 613

Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle

Sauzeau, V., Le Jeune, H., Cario-Toumaniantz, C., Smolenski, A., Lohmann, S. M., Bertoglio, J., Chardin, P., Pacaud, P., & Loirand, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000753200 · Cited by 602

Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.

Stroes, E. S. G., Kastelein, J. J. P., Cosentino, F., Erkelens, W. D., Wever, R. M. F., Koomans, H. A., Lüscher, T. F., & Rabelink, T. J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119131 · Cited by 588

Regulation of Myosin Phosphatase by a Specific Interaction with cGMP- Dependent Protein Kinase Iα

Surks, H. K., Mochizuki, N., Kasai, Y., Georgescu, S. P., Tang, K. M., Ito, M., Lincoln, T., & Mendelsohn, M. E. (1999) · Science · doi:10.1126/science.286.5444.1583 · Cited by 527

Invited Review: cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene expression

Lincoln, T., Dey, N. B., & Sellak, H. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.3.1421 · Cited by 512

Chronic Phospholamban–Sarcoplasmic Reticulum Calcium ATPase Interaction Is the Critical Calcium Cycling Defect in Dilated Cardiomyopathy

Minamisawa, S., Hoshijima, M., Chu, G., Ward, C. A., Frank, K. F., Gu, Y., Martone, M. E., Wang, Y., ROSS, J. R., Kranias, E. G., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81662-1 · Cited by 505

Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro

Wallis, R. M., Corbin, J. D., Francis, S. H., & Ellis, P. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00042-9 · Cited by 503

Defective smooth muscle regulation in cGMP kinase I‐deficient mice

Pfeifer, A., Klatt, P., Massberg, S., Ny, L., Sausbier, M., Hirneiß, C., Wang, G., Korth, M., Aszódi, A., Andersson, K., et al. (1998) · The EMBO Journal · doi:10.1093/emboj/17.11.3045 · Cited by 499

Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite

Zou, M.-H., Shi, C., & Cohen, R. A. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214442 · Cited by 494

Nitric oxide, atrial natriuretic peptide, and cyclic GMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts.

Calderone, A., Thaik, C. M., Takahashi, N., Chang, D. L. F., & Colucci, W. S. (1998) · Journal of Clinical Investigation · doi:10.1172/jci119883 · Cited by 489

Ca2+ current is regulated by cyclic GMP-dependent protein kinase in mammalian cardiac myocytes.

Méry, P., Lohmann, S. M., Walter, U., & Fischmeister, R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.4.1197 · Cited by 478

Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Iβ

Schlossmann, J., Ammendola, A., Ashman, K., Zong, X., Huber, A., Neubauer, G., Wang, G., Allescher, H., Korth, M., Wilm, M. S., et al. (2000) · Nature · doi:10.1038/35004606 · Cited by 455

Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP

Cornwell, T. L., Arnold, E., Boerth, N. J., & Lincoln, T. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.267.5.c1405 · Cited by 455

Tetrahydrobiopterin Improves Endothelium-Dependent Vasodilation in Chronic Smokers

Heitzer, T. A., Brockhoff, C. J., Mayer, B., Warnholtz, A., Mollnau, H., Henne, S., Meinertz, T., & Münzel, T. F. (2000) · Circulation Research · doi:10.1161/01.res.86.2.e36 · Cited by 449

Shear Stress Stimulates Phosphorylation of Endothelial Nitric-oxide Synthase at Ser1179 by Akt-independent Mechanisms

Boo, Y. C., Sorescu, G. P., Boyd, N. L., Shiojima, I., Walsh, K., Du, J., & Jo, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108789200 · Cited by 447

The Multidrug Resistance Protein 5 Functions as an ATP-dependent Export Pump for Cyclic Nucleotides

Jedlitschky, G., Burchell, B., & KEPPLER, D. O. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005463200 · Cited by 442

Scientific and therapeutic advances in antiplatelet therapy

Bhatt, D. L., & Topol, E. J. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd985 · Cited by 409

Intestinal Secretory Defects and Dwarfism in Mice Lacking cGMP-Dependent Protein Kinase II

Pfeifer, A., Aszódi, A., Seidler, U. E., Ruth, P., Hofmann, F. B., & Fässler, R. (1996) · Science · doi:10.1126/science.274.5295.2082 · Cited by 403

Distinct and specific functions of cGMP-dependent protein kinases

Lohmann, S. M., Vaandrager, A. B., Smolenski, A., Walter, U., & de Jonge, H. R. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(97)01086-4 · Cited by 383

Rising behind NO: cGMP-dependent protein kinases

Hofmann, F. B., Ammendola, A., & Schlossmann, J. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.10.1671 · Cited by 340

Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A

Holtwick, R., van Eickels, M., Skryabin, B. V., Baba, H. A., Bubikat, A., Begrow, F., Schneider, M. D., Garbers, D. L., & Kühn, M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17061 · Cited by 340

Analysis and Regulation of Vasodilator-stimulated Phosphoprotein Serine 239 Phosphorylation in Vitro and in Intact Cells Using a Phosphospecific Monoclonal Antibody

Smolenski, A., Bachmann, C., Reinhard, K., Hönig‐Liedl, P., Jarchau, T., Hoschuetzky, H., & Walter, U. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20029 · Cited by 332

Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure

Holtwick, R., Gotthardt, M., Skryabin, B. V., Steinmetz, M., Potthast, R., Zetsche, B., Hammer, R. E., Herz, J., & Kühn, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102650499 · Cited by 332

Taming platelets with cyclic nucleotides11Abbreviations: ABP, actin binding protein; AC, adenylyl cyclase; cAMP, cyclic AMP; cAMP-PK, cAMP-dependent protein kinase; cGMP, cyclic GMP; cGMP-PK, cGMP-dependent protein kinase; DAG, 1,2-diacylglycerol; EDRF, endothelium-derived relaxing factor; GC, guanylyl cyclase; GP, glycoprotein; Hsp27, heat shock protein 27; IP3, inositol 1,4,5- trisphosphate; IRAG, IP3 receptor-associated cGMP-PK substrate; MAPK, mitogen-activated protein kinase; MAPKAPK-2, MAPK-activated protein kinase-2; MARCKS, myristoylated alanine-rich C kinase substrate; MLC, myosin light chain; MLCK, myosin light chain kinase; PDE, phosphodiesterase; PG-E1, prostaglandin E1; PG-I2, prostacyclin; PIP2, phosphatidylinositol 4,5-bisphosphate; PKC, protein kinase C; PLC, phospholipase C; TxA2, thromboxane A2, and VASP, vasodilator-stimulated phosphoprotein.

Schwarz, U. R., Walter, U., & Eigenthaler, M. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00760-2 · Cited by 329

Invited Review: Regulation of myosin phosphorylation in smooth muscle

Pfitzer, G. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.1.497 · Cited by 318

Regulation of Intracellular Ca2+ Levels in Cultured Vascular Smooth Muscle Cells

Cornwell, T. L., & Lincoln, T. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85065-2 · Cited by 314

NO‐ and haem‐independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle

Stasch, J., Schmidt, P. M., Alonso‐Alija, C., Apeler, H., Dembowsky, K., Haerter, M., Heil, M., Minuth, T., Perzborn, E., Pleiß, U., et al. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704778 · Cited by 313

Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug.

Münzel, T. F., Kurz, S. D., Rajagopalan, S., Thoenes, M., Berrington, W. R., Thompson, J. A., Freeman, B. Α., & Harrison, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118935 · Cited by 313

Potential Antiatherogenic Mechanisms of Ascorbate (Vitamin C) and α-Tocopherol (Vitamin E)

Carr, A. C., Zhu, B., & Frei, B. B. (2000) · Circulation Research · doi:10.1161/01.res.87.5.349 · Cited by 305

Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A–deficient mice

Knowles, J. W., Esposito, G., Mao, L., Hagaman, J. R., Fox, J. E., Smithies, O., Rockman, H. A., & Maeda, N. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11273 · Cited by 302

Endothelial Nitric-oxide Synthase (Type III) Is Activated and Becomes Calcium Independent upon Phosphorylation by Cyclic Nucleotide-dependent Protein Kinases

Butt, E., Bernhardt, M., Smolenski, A., Kotsonis, P., Fröhlich, L. G., Sickmann, A., Meyer, H. E., Lohmann, S. M., & Schmidt, H. H. H. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.7.5179 · Cited by 284

Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3

Biel, M., Seeliger, M. W., Pfeifer, A., Köhler, K., Gerstner, A., Ludwig, A., Jaissle, G. B., Fauser, S., Zrenner, E., & Hofmann, F. B. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7553 · Cited by 280

Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes

Fiedler, B., Lohmann, S. M., Smolenski, A., Linnemüller, S., Pieske, B. M., Schröder, F., Molkentin, J. D., Drexler, H., & Wollert, K. C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162100799 · Cited by 276

Phosphorylation of the Vasodilator-stimulated Phosphoprotein Regulates Its Interaction with Actin

Harbeck, B., Hüttelmaier, S., Schlüter, K., Jockusch, B. M., & Illenberger, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005066200 · Cited by 255

Vasodilator-Stimulated Phosphoprotein Serine 239 Phosphorylation as a Sensitive Monitor of Defective Nitric Oxide/cGMP Signaling and Endothelial Dysfunction

Oelze, M. W., Mollnau, H., Hoffmann, N., Warnholtz, A., Bodenschatz, M., Smolenski, A., Walter, U., Skatchkov, M. P., Meinertz, T., & Münzel, T. F. (2000) · Circulation Research · doi:10.1161/01.res.87.11.999 · Cited by 253

Mechanisms of NO/cGMP-Dependent Vasorelaxation

Sausbier, M., Schubert, R., Voigt, V., Hirneiß, C., Pfeifer, A., Korth, M., Kleppisch, T., Ruth, P., & Hofmann, F. B. (2000) · Circulation Research · doi:10.1161/01.res.87.9.825 · Cited by 244

Shear stress stimulates phosphorylation of eNOS at Ser635by a protein kinase A-dependent mechanism

Boo, Y. C., Hwang, J., Sykes, M. C., Michell, B. J., Kemp, B. E., Lum, H., & Jo, H. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00214.2002 · Cited by 240

Effects of Long-Term Nitroglycerin Treatment on Endothelial Nitric Oxide Synthase (NOS III) Gene Expression, NOS III–Mediated Superoxide Production, and Vascular NO Bioavailability

Münzel, T. F., Li, H., Mollnau, H., Hink, U., Matheis, E., Hartmann, M., Oelze, M., Skatchkov, M. P., Warnholtz, A., Duncker, L., et al. (2000) · Circulation Research · doi:10.1161/01.res.86.1.e7 · Cited by 234

Cyclic GMP-dependent protein kinase phosphorylates phospholamban in isolated sarcoplasmic reticulum from cardiac and smooth muscle

Raeymaekers, L., Hofmann, F. B., & Casteels, R. (1988) · Biochemical Journal · doi:10.1042/bj2520269 · Cited by 226

Increased Adhesion and Aggregation of Platelets Lacking Cyclic Guanosine 3′,5′-Monophosphate Kinase I

Maßberg, S., Sausbier, M., Klatt, P., Bauer, M., Pfeifer, A., Siess, W., Fässler, R., Ruth, P., Krombach, F., & Hofmann, F. B. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.8.1255 · Cited by 224

Regulation of cGMP-specific Phosphodiesterase (PDE5) Phosphorylation in Smooth Muscle Cells

Rybalkin, S. D., Rybalkina, I. G., Feil, R., Hofmann, F. B., & Beavo, J. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106562200 · Cited by 219

Targeted Overexpression of the Sarcoplasmic Reticulum Ca 2+ -ATPase Increases Cardiac Contractility in Transgenic Mouse Hearts

Baker, D. L., 橋本, 克., Grupp, I. L., Ji, Y. H., Reed, T., Loukianov, E. V., Grupp, G., Bhagwhat, A., Hoit, B. D., Walsh, R. A., et al. (1998) · Circulation Research · doi:10.1161/01.res.83.12.1205 · Cited by 213

Role for G 12 /G 13 in Agonist-Induced Vascular Smooth Muscle Cell Contraction

Gohla, A., Schultz, G., & Offermanns, S. (2000) · Circulation Research · doi:10.1161/01.res.87.3.221 · Cited by 211

Downregulation of Soluble Guanylyl Cyclase in Young and Aging Spontaneously Hypertensive Rats

Ruetten, H., Zabel, U., Linz, W., & Schmidt, H. H. H. W. (1999) · Circulation Research · doi:10.1161/01.res.85.6.534 · Cited by 209

Actin-based motility: stop and go with Ena/VASP proteins

Reinhard, M., Jarchau, T., & Walter, U. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01785-0 · Cited by 207

Structure and function of cGMP-dependent protein kinases

Pfeifer, A., Ruth, P., Dostmann, W. R., Sausbier, M., Klatt, P., & Hofmann, F. B. (2005) · Springer eBooks · doi:10.1007/bfb0033671 · Cited by 204

Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice

Hedlund, P., Aszódi, A., Pfeifer, A., Alm, P., Hofmann, F. B., Ahmad, M., Fässler, R., & Andersson, K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.030419997 · Cited by 198

Upregulation of Phosphodiesterase 1A1 Expression Is Associated With the Development of Nitrate Tolerance

Kim, D., Rybalkin, S. D., Pi, X., Wang, Y., Zhang, C., Münzel, T. F., Beavo, J. A., Berk, B. C., & Chen, Y. (2001) · Circulation · doi:10.1161/hc4401.098432 · Cited by 196

Inhibition of Rho-Associated Kinase Results in Suppression of Neointimal Formation of Balloon-Injured Arteries

Sawada, N., Itoh, H., Ueyama, K., Yamashita, J. K., Doi, K., Chun, T., Inoue, M., Masatsugu, K., Saito, T., Fukunaga, Y., et al. (2000) · Circulation · doi:10.1161/01.cir.101.17.2030 · Cited by 195

Folic Acid Prevents Nitroglycerin-Induced Nitric Oxide Synthase Dysfunction and Nitrate Tolerance: A Human In Vivo Study

Gori, T., Burstein, J. M., Ahmed, S., Miner, S. E. S., Al-Hesayen, A., Kelly, S., & Parker, J. D. (2001) · Circulation · doi:10.1161/hc3501.095358 · Cited by 178

Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance.

Münzel, T. F., Giaid, A., Kurz, S. D., Stewart, D. J., & Harrison, D. G. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.5244 · Cited by 176

Vasodilator dysfunction in aged spontaneously hypertensive rats: changes in NO synthase III and soluble guanylyl cyclase expression, and in superoxide anion production

Bauersachs, J. K., Bouloumié, A., Mülsch, A., Wiemer, G., Fleming, I., & Busse, R. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00250-2 · Cited by 170

cGMP-Dependent Protein Kinase I Mediates the Negative Inotropic Effect of cGMP in the Murine Myocardium

Wegener, J. W., Nawrath, H., Wolfsgruber, W., Kühbandner, S., Werner, C. G., Hofmann, F. B., & Feil, R. (2002) · Circulation Research · doi:10.1161/hh0102.103222 · Cited by 170

Muscarinic and β-adrenergic regulation of heart rate, force of contraction and calcium current is preserved in mice lacking endothelial nitric oxide synthase

Vandecasteele, G., Eschenhagen, T., Scholz, H., Stein, B., Verde, I., & Fischmeister, R. (1999) · Nature Medicine · doi:10.1038/6553 · Cited by 169

Functional and Biochemical Analysis of Endothelial (Dys)function and NO/cGMP Signaling in Human Blood Vessels With and Without Nitroglycerin Pretreatment

Schulz, E., Tsilimingas, N., Rinze, R., Reiter, B., Wendt, M., Oelze, M., Woelken-Weckmüller, S., Walter, U., Reichenspurner, H. C., Meinertz, T., et al. (2002) · Circulation · doi:10.1161/hc1002.105186 · Cited by 166

Adenovirus-mediated Gene Transfer of cGMP-dependent Protein Kinase Increases the Sensitivity of Cultured Vascular Smooth Muscle Cells to the Antiproliferative and Pro-apoptotic Effects of Nitric Oxide/cGMP

Chiche, J., Schlutsmeyer, S. M., Bloch, D. B., de la Monte, S. M., Roberts, J. D., Filippov, G., Janssens, S. P., Rosenzweig, A., & Bloch, K. D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.34263 · Cited by 161

Active Rho Kinase (ROK-α) Associates with Insulin Receptor Substrate-1 and Inhibits Insulin Signaling in Vascular Smooth Muscle Cells

Begum, N., Sandu, O. A., Ito, M., Lohmann, S. M., & Smolenski, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110508200 · Cited by 159

Direct activation of PDE5 by cGMP

Müllershausen, F., Friebe, A., Feil, R., Thompson, W. J., Hofmann, F. B., & Koesling, D. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211041 · Cited by 156

Nebivolol Prevents Vascular NOS III Uncoupling in Experimental Hyperlipidemia and Inhibits NADPH Oxidase Activity in Inflammatory Cells

Mollnau, H., Schulz, E., Daiber, A., Baldus, S. E., Oelze, M. W., August, M., Wendt, M., Walter, U., Geiger, C., Agrawal, R., et al. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000065234.70518.26 · Cited by 152

Cyclic GMP regulation of the L‐type Ca2+ channel current in human atrial myocytes

Vandecasteele, G., Verde, I., Rücker‐Martin, C., Donzeau‐Gouge, P., & Fischmeister, R. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0329a.x · Cited by 151

Muscarinic cholinergic regulation of cardiac myocyte I Ca-L is absent in mice with targeted disruption of endothelial nitric oxide synthase

Han, X., Kubota, I., Féron, O., Opel, D. J., Arstall, M. A., Zhao, Y., Huang, P. L., Fishman, M. C., Michel, T. M., & Kelly, R. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6510 · Cited by 146

Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP

Butt, E., Nolte, C., Schulz, S., Beltman, J., Beavo, J. A., Jastorff, B., & Walter, U. (1992) · Biochemical Pharmacology · doi:10.1016/0006-2952(92)90148-c · Cited by 141

Differential role of cyclic GMP–dependent protein kinase II in ion transport in murine small intestine and colon

Vaandrager, A. B., Bot, A. G. M., Ruth, P., Pfeifer, A., Hofmann, F. B., & de Jonge, H. R. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70419-7 · Cited by 139

Dietary supplement with vitamin C prevents nitrate tolerance

Bassenge, E., Fink, N., Skatchkov, M., & Fink, B. (1998) · Journal of Clinical Investigation · doi:10.1172/jci977 · Cited by 138

Gene Transfer of cGMP-Dependent Protein Kinase I Enhances the Antihypertrophic Effects of Nitric Oxide in Cardiomyocytes

Wollert, K. C., Fiedler, B., Gambaryan, S. P., Smolenski, A., Heineke, J., Butt, E., Trautwein, C., Lohmann, S. M., & Drexler, H. (2002) · Hypertension · doi:10.1161/hy1201.097292 · Cited by 135

Prospects for Cardiovascular Research

Lefkowitz, R. J. (2001) · JAMA · doi:10.1001/jama.285.5.581 · Cited by 134

Effects of In Vivo Nitroglycerin Treatment on Activity and Expression of the Guanylyl Cyclase and cGMP-Dependent Protein Kinase and Their Downstream Target Vasodilator-Stimulated Phosphoprotein in Aorta

Mülsch, A., Oelze, M. W., Klöss, S., Mollnau, H., Töpfer, A., Smolenski, A., Walter, U., Stasch, J., Warnholtz, A., Hink, U., et al. (2001) · Circulation · doi:10.1161/01.cir.103.17.2188 · Cited by 133

Regulation of Human Endothelial Cell Focal Adhesion Sites and Migration by cGMP-dependent Protein Kinase I

Smolenski, A., Poller, W. C., Walter, U., & Lohmann, S. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909632199 · Cited by 132

B-Type Natriuretic Peptide — A Window to the Heart

Baughman, K. L. (2002) · New England Journal of Medicine · doi:10.1056/nejmp020057 · Cited by 132

Enhanced in vivo platelet adhesion in vasodilator-stimulated phosphoprotein (VASP)–deficient mice

Maßberg, S., Grüner, S., Konrad, I., García-Arguinzonis, M., Eigenthaler, M., Hemler, K., Kersting, J., Schulz, C., Müller, I. I., Besta, F., et al. (2003) · Blood · doi:10.1182/blood-2002-11-3417 · Cited by 132

Effect of In Vivo Nitroglycerin Therapy on Endothelium-Dependent and Independent Vascular Relaxation and Cyclic GMP Accumulation in Rat Aorta

Molina, C. R., Andresen, J. W., Rapoport, R. M., Waldman, S. A., & Murad, F. (1987) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-198710000-00001 · Cited by 128

The Guanylyl Cyclase Family at Y2K

Wedel, B. J., & Garbers, D. L. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.215 · Cited by 128

Detection of cGMP dependent protein kinase isozymes by specific antibodies

Keilbach, A., Ruth, P., & Hofmann, F. B. (1992) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1992.tb17209.x · Cited by 125

Cyclic Nucleotide Phosphodiesterase 1C Promotes Human Arterial Smooth Muscle Cell Proliferation

Rybalkin, S. D., Rybalkina, I. G., Beavo, J. A., & Bornfeldt, K. (2002) · Circulation Research · doi:10.1161/hh0202.104108 · Cited by 123

KT5823 Inhibits cGMP-dependent Protein Kinase Activity in Vitro but Not in Intact Human Platelets and Rat Mesangial Cells

Burkhardt, M., Glazova, M. V., Gambaryan, S. P., Vollkommer, T., Butt, E., Bader, B., Heermeier, K., Lincoln, T., Walter, U., & Palmetshofer, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005670200 · Cited by 122

Inotropic response to β‐adrenergic receptor stimulation and anti‐adrenergic effect of ACh in endothelial NO synthase‐deficient mouse hearts

Gödecke, A., Heinicke, T., Kamkin, A., Kiseleva, I. S., Strasser, R. H., Decking, U. K. M., Stumpe, T., Isenberg, G., & Schrader, J. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0195g.x · Cited by 121

Cardiovascular actions of a novel NO‐independent guanylyl cyclase stimulator, BAY 41‐8543: in vivo studies

Stasch, J., Dembowsky, K., Perzborn, E., Stahl, E., & Schramm, M. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704483 · Cited by 120

Dipyridamole Enhances NO/cGMP-Mediated Vasodilator-Stimulated Phosphoprotein Phosphorylation and Signaling in Human Platelets

Aktas, B., Utz, A. L., Hönig‐Liedl, P., Walter, U., & Geiger, J. (2003) · Stroke · doi:10.1161/01.str.0000056527.34434.59 · Cited by 116

Expression of cGMP-Dependent Protein Kinase I and Phosphorylation of Its Substrate, Vasodilator-Stimulated Phosphoprotein, in Human Endothelial Cells of Different Origin

Draijer, R., Vaandrager, A. B., Nolte, C., de Jonge, H. R., Walter, U., & van Hinsbergh, V. W. M. (1995) · Circulation Research · doi:10.1161/01.res.77.5.897 · Cited by 116

Smooth muscle cell expression of type I cyclic GMP-dependent protein kinase is suppressed by continuous exposure to nitrovasodilators, theophylline, cyclic GMP, and cyclic AMP.

Soff, G. A., Cornwell, T. L., Cundiff, D. L., Gately, S. T., & Lincoln, T. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119801 · Cited by 109

Actin Binding of Human LIM and SH3 Protein Is Regulated by cGMP- and cAMP-dependent Protein Kinase Phosphorylation on Serine 146

Butt, E., Gambaryan, S. P., Göttfert, N., Galler, A. B., Marcus, K., & Meyer, H. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209009200 · Cited by 107

Functional Reconstitution of Vascular Smooth Muscle Cells With cGMP-Dependent Protein Kinase I Isoforms

Feil, R., Gappa, R. N., Rutz, M., Schlossmann, J., Rose, C. R., Konnerth, A., Brummer, S., Kühbandner, S., & Hofmann, F. B. (2002) · Circulation Research · doi:10.1161/01.res.0000019586.95768.40 · Cited by 107

Targeted Deletion of a Cyclic Nucleotide-Gated Channel Subunit (OCNC1): Biochemical and Morphological Consequences in Adult Mice

Baker, H. A., Cummings, D. M., Munger, S. D., Margolis, J. W., Franzen, L., Reed, R. R., & Margolis, F. L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09313.1999 · Cited by 105

Cardiorenal and Humoral Properties of a Novel Direct Soluble Guanylate Cyclase Stimulator BAY 41-2272 in Experimental Congestive Heart Failure

Boerrigter, G., Costello‐Boerrigter, L. C., Cataliotti, A., Tsuruda, T., Harty, G. J., Lapp, H., Stasch, J., & Burnett, J. C. J. (2003) · Circulation · doi:10.1161/01.cir.0000055737.15443.f8 · Cited by 103

Randomized, Double-Blind, Placebo-Controlled Study of Supplemental Vitamin E on Attenuation of the Development of Nitrate Tolerance

Watanabe, H., Kakihana, M., Ohtsuka, S., & Sugishita, Y. (1997) · Circulation · doi:10.1161/01.cir.96.8.2545 · Cited by 99

Nitric Oxide Activation of p38 Mitogen-activated Protein Kinase in 293T Fibroblasts Requires cGMP-dependent Protein Kinase

Browning, D. D., McShane, M. P., Marty, C., & Ye, R. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2811 · Cited by 98

cGMP Signaling through cAMP- and cGMP-Dependent Protein Kinases

Lincoln, T., Komalavilas, P., Boerth, N. J., MacMillan-Crow, L. A., & Cornwell, T. L. (1995) · Advances in pharmacology · doi:10.1016/s1054-3589(08)61094-7 · Cited by 96

Relaxation of pig coronary arteries by new and potent cGMP analogs that selectively activate type I alpha, compared with type I beta, cGMP-dependent protein kinase.

Sekhar, K. R., Hatchett, R. J., Shabb, J. B., Wolfe, L., Francis, S. H., Wells, J. N., Jastorff, B., Butt, E., Chakinala, M. M., & Corbin, J. D. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08837-6 · Cited by 96

Role of cGMP-kinase II in the control of renin secretion and renin expression.

Wagner, C., Pfeifer, A., Ruth, P., Hofmann, F. B., & Kurtz, A. (1998) · Journal of Clinical Investigation · doi:10.1172/jci4044 · Cited by 90

cGMP Stimulation of Cystic Fibrosis Transmembrane Conductance Regulator Cl− Channels Co-expressed with cGMP-dependent Protein Kinase Type II but Not Type Iβ

Vaandrager, A. B., Tilly, B. C., Smolenski, A., Schneider-Rasp, S., Bot, A. G. M., Edixhoven, M., Scholte, B. J., Jarchau, T., Walter, U., Lohmann, S. M., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.7.4195 · Cited by 90

Nitric Oxide Increases p21Waf1/Cip1 Expression by a cGMP-dependent Pathway That Includes Activation of Extracellular Signal-regulated Kinase and p70 S6k *

Gu, M.-F., Lynch, J. A., & Brecher, P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.15.11389 · Cited by 87

Activation of cGMP-dependent Protein Kinase Iβ Inhibits Interleukin 2 Release and Proliferation of T Cell Receptor-stimulated Human Peripheral T Cells

Fischer, T. A., Palmetshofer, A., Gambaryan, S. P., Butt, E., Jassoy, C., Walter, U., Sopper, S., & Lohmann, S. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009781200 · Cited by 85

Sildenafil citrate: A therapeutic update

Boyce, E. G. (2001) · Clinical Therapeutics · doi:10.1016/s0149-2918(01)80027-8 · Cited by 85

Cloning and characterization of two splice variants of human phosphodiesterase 11A

Hetman, J., Robas, N. M., Baxendale, R. W., Fidock, M. D., Phillips, S. C., Soderling, S. H., & Beavo, J. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200355397 · Cited by 84

Protein Kinase G Activates the JNK1 Pathway via Phosphorylation of MEKK1

Soh, J., Mao, Y., Liu, L., Thompson, W. J., Pamukcu, R., & Weinstein, I. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100079200 · Cited by 82

Alteration of the Soluble Guanylate Cyclase System in the Vascular Wall of Lead-Induced Hypertension in Rats

Marqués, M., Millás, I., Jiménez, A., García-Colis, E., Rodríguez-Feo, J. A., Velasco, S., Barrientos, A., Casado, S., & López-Farré, A. J. (2001) · Journal of the American Society of Nephrology · doi:10.1681/asn.v12122594 · Cited by 82

Expression of type II cGMP-dependent protein kinase in rat kidney is regulated by dehydration and correlated with renin gene expression.

Gambaryan, S. P., Häusler, C., Markert, T., Pöhler, D., Jarchau, T., Walter, U., Haase, W., Kurtz, A., & Lohmann, S. M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118837 · Cited by 81

Defective nitrovasodilator-stimulated protein phosphorylation and calcium regulation in cGMP-dependent protein kinase-deficient human platelets of chronic myelocytic leukemia

Eigenthaler, M., Ullrich, H., Geiger, J., Horstrup, K., Hönig‐Liedl, P., Wiebecke, D., & Walter, U. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38681-8 · Cited by 80

NO upregulation of a cyclic nucleotide-gated channel contributes to calcium elevation in endothelial cells

Zhang, J., Xia, S., Block, E. R., & Patel, J. M. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00048.2002 · Cited by 78

A Novel Interaction of cGMP-dependent Protein Kinase I with Troponin T

Yuasa, K., Michibata, H., Omori, K., & Yanaka, N. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.37429 · Cited by 76

Endogenous or overexpressed cGMP-dependent protein kinases inhibit cAMP-dependent renin release from rat isolated perfused kidney, microdissected glomeruli, and isolated juxtaglomerular cells

Gambaryan, S. P., Wagner, C., Smolenski, A., Walter, U., Poller, W. C., Haase, W., Kurtz, A., & Lohmann, S. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.9003 · Cited by 76

Regression of Atherosclerosis in Monkeys Reduces Vascular Superoxide Levels

Hathaway, C. A., Heistad, D. D., Piegors, D. J., & Miller, F. J. (2002) · Circulation Research · doi:10.1161/hh0302.104724 · Cited by 76

Signal transduction by cGMP-dependent protein kinases and their emerging roles in the regulation of cell adhesion and gene expression

Eigenthaler, M., Lohmann, S. M., Walter, U., & Pilz, R. B. (2005) · Springer eBooks · doi:10.1007/bfb0033673 · Cited by 72

Upregulation of Vascular NAD(P)H Oxidase Subunit gp91phox and Impairment of the Nitric Oxide Signal Transduction Pathway in Hypertension

Morawietz, H., Weber, M., Rueckschloss, U., Lauer, N., Hacker, A., & Kojda, G. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5312 · Cited by 69

Overexpression of a Constitutively Active Protein Kinase G Mutant Reduces Neointima Formation and In-Stent Restenosis

Sinnaeve, P., Chiche, J., Gillijns, H., Pelt, N. V., Wirthlin, D. J., de Werf, F. V., Collen, D., Bloch, K. D., & Janssens, S. P. (2002) · Circulation · doi:10.1161/01.cir.0000018169.59205.ca · Cited by 66

Antimitogenic Actions of Organic Nitrates Are Potentiated by Sildenafil and Mediated Via Activation of Protein Kinase A

Osinski, M. T., Rauch, B. H., & Schrör, K. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.5.1044 · Cited by 66

Impaired relaxation of stomach smooth muscle in mice lacking cyclic GMP‐dependent protein kinase I

Ny, L., Pfeifer, A., Aszódi, A., Ahmad, M., Alm, P., Hedlund, P., Fässler, R., & Andersson, K. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703061 · Cited by 61

Ca 2+ Signaling in Cardiac Myocytes Overexpressing the α 1 Subunit of L-Type Ca 2+ Channel

Song, L., Guia, A., Muth, J. N., Rubio, M., Wang, S., Xiao, R.-P., Josephson, I. R., Lakatta, E. G., Schwartz, A., & Cheng, H. (2002) · Circulation Research · doi:10.1161/hh0202.103230 · Cited by 61

Effects of C‐type natriuretic peptide on rat cardiac contractility

Brusq, J.-M. G., Mayoux, E., Guigui, L., & Kirilovsky, J. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702766 · Cited by 60

Insulin inhibits PDGF-directed VSMC migration via NO/ cGMP increase of MKP-1 and its inactivation of MAPKs

Jacob, A., Molkentin, J. D., Smolenski, A., Lohmann, S. M., & Begum, N. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00110.2002 · Cited by 60

Therapeutic Potential of Nitric Oxide Synthase Gene Manipulation

von der Leyen, H. E., & Dzau, V. J. (2001) · Circulation · doi:10.1161/01.cir.103.22.2760 · Cited by 55

Cardiac natriuretic peptides - hope or hype?

Venugopal, J. (2001) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1046/j.1365-2710.2001.00322.x · Cited by 50

Atherogenesis and the arginine hypothesis

Cooke, J. P., & Oka, R. K. (2001) · Current Atherosclerosis Reports · doi:10.1007/s11883-001-0068-x · Cited by 50

Tetrahydrobiopterin improves endothelium-dependent vasodilation in nitroglycerin-tolerant rats

Gruhn, N., Aldershvile, J., & Boesgaard, S. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00879-2 · Cited by 46

Effects of Nitroglycerin on Soluble Guanylate Cyclase

Artz, J. D., Schmidt, B., McCracken, J., & Marletta, M. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200170200 · Cited by 40

Synergistic phosphorylation of the focal adhesion-associated vasodilator-stimulated phosphoprotein in intact human platelets in response to cGMP- and cAMP-elevating platelet inhibitors

Nolte, C., Eigenthaler, M., Horstrup, K., Hönig‐Liedl, P., & Walter, U. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)90201-1 · Cited by 37

Phosphorylation of smg p21B/rap1B p21 by cyclic GMP‐dependent protein kinase

Miura, Y., Kaibuchi, K., Itoh, T., Corbin, J. D., Francis, S. H., & Takai, Y. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80353-i · Cited by 35

Effect of Hypercholesterolemia on Expression and Function of Vascular Soluble Guanylyl Cyclase

Laber, U., Kober, T., Schmitz, V., Schrammel, A., Meyer, W., Mayer, B., Weber, M., & Kojda, G. (2002) · Circulation · doi:10.1161/hc0702.103975 · Cited by 34

The Vasodilator-Stimulated Phosphoprotein (VASP): Target of YC-1 and Nitric Oxide Effects in Human and Rat Platelets

Becker, E. M., Schmidt, P. M., Schramm, M., Schröder, H., Walter, U., Hoenicka, M., Gerzer, R., & Stasch, J. (2000) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200003000-00007 · Cited by 34

Hydralazine prevents endothelial dysfunction, but not the increase in superoxide production in nitric oxide-deficient hypertension

Bauersachs, J. K., Bouloumié, A., Fraccarollo, D., Hu, K., Busse, R., & Ertl, G. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00763-8 · Cited by 31

Serine 19 of Human 6-Pyruvoyltetrahydropterin Synthase Is Phosphorylated by cGMP Protein Kinase II

Oppliger, T., Leimbacher, W., Blau, N., & Thöny, B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.44.31341 · Cited by 31

− OONO

Beckman, J. S. (2001) · Circulation Research · doi:10.1161/res.89.4.295 · Cited by 30

Expression of cGMP‐dependent protein kinase I and its substrate VASP in neointimal cells of the injured rat carotid artery

Mönks, D., Lange, V., Silber, R., Markert, T., Walter, U., & Nehls, V. (1998) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1998.00308.x · Cited by 26

A cGMP-Dependent Protein Kinase Assay for High Throughput Screening Based on Time-Resolved Fluorescence Resonance Energy Transfer

Bader, B., Butt, E., Palmetshofer, A., Walter, U., Jarchau, T., & Drueckesl, P. (2001) · SLAS DISCOVERY · doi:10.1177/108705710100600407 · Cited by 21

Inhibition of platelet P2Y12 and α2A receptor signaling by cGMP-dependent protein kinase

Aktas, B., Hönig‐Liedl, P., Walter, U., & Geiger, J. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01113-9 · Cited by 13

Cyclic GMP Dependent Protein Kinase ( c GK , PKG )

Smolenski, A., & Lohmann, S. M. (2002) · Wiley Encyclopedia of Molecular Medicine · doi:10.1002/0471203076.emm0423 · Cited by 2

Erectile dysfunction

Shamloul, R., & Ghanem, H. (2013) · The Lancet · doi:10.1016/s0140-6736(12)60520-0 · Cited by 1,091

cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action

Francis, S. H., Busch, J. L., & Corbin, J. D. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002907 · Cited by 1,059

Nitric oxide signalling in cardiovascular health and disease

Farah, C., Michel, L. Y. M., & Balligand, J.-L. (2018) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.224 · Cited by 779

Adhesion Mechanisms in Platelet Function

Ruggeri, Z. M., & Mendolicchio, G. L. (2007) · Circulation Research · doi:10.1161/01.res.0000267878.97021.ab · Cited by 759

Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications

Andrabi, S. M., Sharma, N. S., Karan, A., Shahriar, S. M. S., Cordon, B., Ma, B., & Xie, J. (2023) · Advanced Science · doi:10.1002/advs.202303259 · Cited by 688

QUARTERLY Review

Birschmann, I., & Walter, U. (2004)

[Nitric Oxide Signaling Pathway and Vascular Activity].

Gao, Y. (2017) · PubMed

Physiology and pathophysiology of vascular signaling controlled by guanosine 3',5'-cyclic monophosphate-dependent protein kinase.

Birschmann, I., & Walter, U. (2004) · Acta Biochimica Polonica · doi:10.18388/abp.2004_3579 · Cited by 115

Pharmacologic Modulators of Soluble Guanylate Cyclase/Cyclic Guanosine Monophosphate in the Vascular System - From Bench Top to Bedside

Jackson, E. B., Mukhopadhyay, S., & Tulis, D. A. (2007) · Current Vascular Pharmacology · doi:10.2174/1570161110705010001 · Cited by 17

Cyclic GMP as a Second Messenger in the Cardiovascular System.

Imai, S. (1995) · Japanese Heart Journal · doi:10.1536/ihj.36.127 · Cited by 10