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Cited by 241Cardiovascular Function and Risk FactorsHemodynamic Monitoring and TherapyCardiac pacing and defibrillation studies

Systolic Time Intervals as Measures of the Contractile State of the Left Ventricular Myocardium in Man

AHMED, S. SULTAN, LEVINSON, GILBERT E., SCHWARTZ, CARL J., ETTINGER, PHILIP O.·1972·Circulation
DOI 10.1161/01.cir.46.3.559
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Abstract

Previous studies relating systolic time intervals and measures of cardiac performance have suggested that the time intervals may be useful indices of myocardial contractility. To explore this possibility, systolic times and left ventricular (LV) performance and contractility were measured nearly simultaneously in 14 normal subjects and 56 patients with cardiac disease. Preejection period (PEP) and the ratio of PEP to LV ejection time (LVET) changed significantly with acute inotropic influences (exercise and isoproterenol), were normal in patients with right or left ventricular overloads in whom cardiac index and ejection fraction were depressed but contractile element velocity at peak dP/dt and the Frank-Levinson contractility index were normal, and were significantly abnormal in patients with either clinically evident or occult LV decompensation in whom the measures of contractility were reduced. Correlations of PEP and PEP/LVET with measures of both performance and contractility were insignificant for patients with valvular disease, shunts, or cor pulmonale and significant but weak for the entire series. However, in subjects with either normal left ventricles or cardiac disease confined to the left ventricle, PEP and PEP/LVET exhibited good correlations with measures of pump function and excellent correlations with measures of contractility. These results indicate that the systolic times are a valid measure of contractility which should prove useful in comparing patients with cardiac pathology confined to the LV myocardium and in following patients with extramyocardial hemodynamic lesions of constant severity.

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Authors
AHMED, S. S., LEVINSON, G. E., SCHWARTZ, C. J., & ETTINGER, P. O.
Affiliations
Rutgers New Jersey Medical School (US)
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1972-09
Volume
46
Issue
3
Pages
559-571
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.46.3.559
OpenAlex
W2033498479
Cited by
241
References
39
Citations by year
2026: 1 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 4 · 2013: 1 · 2012: 2
FWCI
7.66
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Keywords
systolic time intervals, left ventricular contractility, pre-ejection period, left ventricular ejection time, left ventricular function, cardiac contractility, left ventricular decompensation, isoproterenol, physical activity, valvular heart disease, left ventricular overload, cor pulmonale, cardiac index, ejection fraction, dP/dt
MeSH terms
Biomechanical Phenomena, Blood Pressure, Cardiac Output, Cardiac Volume, Dye Dilution Technique, Electrocardiography, Physical Exertion, Cardiac Catheterization, Heart Diseases, Heart Function Tests, Heart Rate, Heart Valve Diseases, Humans, Isoproterenol, Pulse, Stimulation, Chemical, Time Factors

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