Cited by 1,411Lipoproteins and Cardiovascular HealthLipid metabolism and disordersDiabetes, Cardiovascular Risks, and Lipoproteins

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Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk

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Austin, M A, King, M C, Vranizan, K M, Krauss, R M·1990·Circulation

DOI 10.1161/01.cir.82.2.495

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Abstract

In a community-based study of 301 subjects from 61 nuclear families, two distinct phenotypes (denoted A and B) were identified by nondenaturing gradient gel electrophoretic analysis of low density lipoprotein (LDL) subclasses. Phenotype A was characterized by predominance of large, buoyant LDL particles, and phenotype B consisted of a major peak of small, dense LDL particles. Previous analysis of the family data by complex segregation analysis demonstrated that these phenotypes appear to be inherited as a single-gene trait. In the present study, the phenotypes were found to be closely associated with variations in plasma levels of other lipid, lipoprotein, and apolipoprotein measurements. Specifically, phenotype B was associated with increases in plasma levels of triglyceride and apolipoprotein B, with mass of very low and intermediate density lipoproteins, and with decreases in high density lipoprotein (HDL) cholesterol, HDL2 mass, and plasma levels of apolipoprotein A-I. Thus, the proposed genetic locus responsible for LDL subclass phenotypes also results in an atherogenic lipoprotein phenotype.

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Authors: Austin, M. A., King, M. C., Vranizan, K. M., & Krauss, R. M.
Affiliations: University of California, Berkeley (US)
ORCID: King, M C
Krauss, R M
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1990-08
Volume: 82
Issue: 2
Pages: 495-506
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.82.2.495
OpenAlex: W2089286420
Cited by: 1,411
References: 63
Citations by year: 2026: 11 · 2025: 15 · 2024: 17 · 2023: 39 · 2022: 20 · 2021: 26 · 2020: 25 · 2019: 27 · 2018: 17 · 2017: 21 · 2016: 27 · 2015: 42 · 2014: 38 · 2013: 46 · 2012: 39
FWCI: 47.63
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Energy (DE-AC03-?, AC03-76SF00098, DEAC03-76SF00098)
National Institutes of Health (7r29hl038760-03, 5p01hl018574-26, DE-AC03- 76SF00098)
National Heart, Lung, and Blood Institute (HL38760, HL-18574)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: atherogenic lipoprotein phenotype, LDL subclasses, low-density lipoprotein, coronary heart disease risk, genetic markers, single-gene inheritance, apolipoprotein B, apolipoprotein A-I, HDL cholesterol, HDL2, triglycerides, VLDL, intermediate density lipoprotein
MeSH terms: Adolescent, Adult, Aged, Arteriosclerosis, Child, Child, Preschool, Chromosome Mapping, Coronary Disease, Female, Genetic Markers, Humans, Lipids, Lipoproteins, Cholesterol, HDL, Male, Middle Aged, Phenotype, Risk Factors, Triglycerides, Multivariate Analysis

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Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk

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