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Cited by 131Cardiovascular and exercise physiologyDiabetes, Cardiovascular Risks, and LipoproteinsBlood Pressure and Hypertension Studies

Suppression of insulin-induced sympathetic activation and vasodilation by dexamethasone in humans.

Scherrer, U, Vollenweider, P, Randin, D, Jéquier, E, Nicod, P, Tappy, L·1993·Circulation
DOI 10.1161/01.cir.88.2.388
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Abstract

Background Physiological hyperinsulinemia in lean human subjects stimulates sympathetic nerve activity and blood flow in skeletal muscle, but the underlying mechanism is unknown. Potential mechanisms include central neural or peripheral actions of insulin. Glucocorticoids may potentially interfere with both such actions and thereby may attenuate sympathoexcitatory and vasodilatory effects of insulin in skeletal muscle. Methods and results To determine whether insulin-induced sympathetic activation and vasodilation are attenuated by dexamethasone, we measured muscle sympathetic nerve activity and muscle blood flow during euglycemic hyperinsulinemia before and after short-term administration of this pharmacological agent. Insulin concentrations, which normally doubled sympathetic activity and markedly increased blood flow, had no such stimulatory effect after short-term dexamethasone administration. In contrast, responses to two noninsulin sympathetic stimuli, the Valsalva maneuver and immersion of the hand in ice water, and the vasodilatory response to calf vascular occlusion were not altered by dexamethasone. Conclusions These results demonstrate a dramatic impairment of insulin-induced sympathetic activation and vasodilation by dexamethasone in lean, healthy humans. This study suggests that dexamethasone administration to lean subjects may offer an experimental model to examine underlying mechanisms that regulate the interplay between cardiovascular, sympathetic, and metabol…

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Crossref · 10.1161/01.cir.88.2.388

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  • In lean subjects, sympathetic activation evoked by acute elevation of plasma insulin to high physiological concentrations does not raise blood pressure.

    “In lean subjects, sympathetic activation evoked by acute elevation of plasma insulin to high physiological concentrations does not raise blood pressure (12–14)”

    From Impaired insulin-induced sympathetic neural activation and vasodilation in skeletal muscle in obese humans. (1994) · cites this paper as [13]

  • In lean healthy subjects, insulin-induced stimulation of muscle blood flow is consistently accompanied by a marked stimulation of sympathetic neural outflow to the same vascular bed.

    “In lean healthy subjects, insulin-induced stimulation of muscle blood flow consistently is accompanied by a marked stimulation of sympathetic neural outflow to the same vascular bed (12-14).”

    From Impaired insulin-induced sympathetic neural activation and vasodilation in skeletal muscle in obese humans. (1994) · cites this paper as [13]

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Authors
Scherrer, U., Vollenweider, P., Randin, D., Jéquier, E., Nicod, P., & Tappy, L.
Affiliations
Centre Hospitalier Universitaire Vaudois (CH)
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1993-08
Volume
88
Issue
2
Pages
388-394
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.88.2.388
OpenAlex
W2026983353
Cited by
131
References
42
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2019: 4 · 2018: 3 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 2
FWCI
16.23
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS (submittedVersion)
  • SERVAL (Université de Lausanne) (submittedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
insulin, dexamethasone, glucocorticoids, sympathetic activity, muscle blood flow, euglycemic hyperinsulinemia, vasodilation, skeletal muscle, Valsalva maneuver, cold pressor response, vascular occlusion, sympathoexcitation
MeSH terms
Adult, Dexamethasone, Electrophysiology, Glucose, Humans, Insulin, Insulin Antagonists, Leg, Muscles, Plethysmography, Regional Blood Flow, Sympathetic Nervous System, Vascular Resistance, Vasodilation, Glucose Clamp Technique

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