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Cited by 194Ovarian function and disordersAcupuncture Treatment Research StudiesCardiovascular and exercise physiology

Low-frequency electroacupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome

Stener-Victorin, Elisabet, Jedel, Elizabeth, Janson, Per Olof, Sverrisdottir, Yrsa Bergmann·2009·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
DOI 10.1152/ajpregu.00197.2009
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Abstract

We have recently shown that polycystic ovary syndrome (PCOS) is associated with high muscle sympathetic nerve activity (MSNA). Animal studies support the concept that low-frequency electroacupuncture (EA) and physical exercise, via stimulation of ergoreceptors and somatic afferents in the muscles, may modulate the activity of the sympathetic nervous system. The aim of the present study was to investigate the effect of these interventions on sympathetic nerve activity in women with PCOS. In a randomized controlled trial, 20 women with PCOS were randomly allocated to one of three groups: low-frequency EA ( n = 9), physical exercise ( n = 5), or untreated control ( n = 6) during 16 wk. Direct recordings of multiunit efferent postganglionic MSNA in a muscle fascicle of the peroneal nerve before and following 16 wk of treatment. Biometric, hemodynamic, endocrine, and metabolic parameters were measured. Low-frequency EA ( P = 0.036) and physical exercise ( P = 0.030) decreased MSNA burst frequency compared with the untreated control group. The low-frequency EA group reduced sagittal diameter ( P = 0.001), while the physical exercise group reduced body weight ( P = 0.004) and body mass index ( P = 0.004) compared with the untreated control group. Sagittal diameter was related to MSNA burst frequency ( Rs = 0.58, P < 0.005) in the EA group. No correlation was found for body mass index and MSNA in the exercise group. There were no differences between the groups in hemodynamic, endocrine, and metabolic variables. For the first time we demonstrate that low-frequency EA and physical exercise lowers high sympathetic nerve activity in women with PCOS. Thus, treatment with low-frequency EA or physical exercise with the aim to reduce MSNA may be of importance for women with PCOS.

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Crossref · 10.1152/ajpregu.00197.2009

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  • All included trials reported baseline and immediately post-intervention data; only one trial completed follow-up beyond the end of the intervention.

    “All included trials reported baseline and immediately post-intervention data; only one trial [111] completed follow-up beyond the end of the intervention.”

    From Exercise, or exercise and diet for the management of polycystic ovary syndrome: a systematic review and meta-analysis (2019) · cites this paper as [111]

  • In one trial reporting data from a post-intervention 16-week follow-up [111], a 12% increase in VO2 max (4.11 ± 5.20 ml/kg/min; p = .001) from baseline was still evident in the exercise group.

    “In one trial reporting data from a post-intervention 16-week follow-up [111], a 12% increase in VO2 max (4.11 ± 5.20 ml/kg/min; p = .001) from baseline was still evident in the exercise group.”

    From Exercise, or exercise and diet for the management of polycystic ovary syndrome: a systematic review and meta-analysis (2019) · cites this paper as [111]

  • Data from two trials [111, 118] were pooled in the analysis of waist-to-hip ratio (WHR); there was no effect in either change from baseline or post-intervention values analyses.

    “Data from two trials [111, 118] were pooled in the analysis of waist-to-hip ratio (WHR); there was no effect in either change from baseline or post-intervention values analyses.”

    From Exercise, or exercise and diet for the management of polycystic ovary syndrome: a systematic review and meta-analysis (2019) · cites this paper as [111]

  • Follow-up reporting (16-weeks post-intervention) of BMI from one trial [111] showed no statistically significant within-group changes or between-group differences in either exercise or control arms.

    “Follow-up reporting (16-weeks post-intervention) of BMI from one trial [111] showed no statistically significant within-group changes or between-group differences in either exercise or control arms.”

    From Exercise, or exercise and diet for the management of polycystic ovary syndrome: a systematic review and meta-analysis (2019) · cites this paper as [111]

  • When the greatest outliers were removed from the social functioning [119] and mental health [111] domains, both I2 values were reduced to 0%, but the effect only remained in the mental health domain (MD 17.84, 95% CI 7.33 to 28.36).

    “When the greatest outliers were removed from the social functioning [119] and mental health [111] domains, both I2 values were reduced to 0%, but the effect only remained in the mental health domain (MD 17.84, 95% CI 7.33 to 28.36).”

    From Exercise, or exercise and diet for the management of polycystic ovary syndrome: a systematic review and meta-analysis (2019) · cites this paper as [111]

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Authors
Stener-Victorin, E., Jedel, E., Janson, P. O., & Sverrisdottir, Y. B.
Venue
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher
American Physiological Society
Published
2009-08
Volume
297
Issue
2
Pages
R387-R395
ISSN
  • 0363-6119 (ISSN-L)
  • 1522-1490
DOI
10.1152/ajpregu.00197.2009
OpenAlex
W1977287851
Semantic Scholar
0f85744933b0896c9d1ce4764706b369f8c8d6aa
Cited by
194
References
86
Citations by year
2026: 13 · 2025: 10 · 2024: 10 · 2023: 12 · 2022: 11 · 2021: 8 · 2020: 8 · 2019: 14 · 2018: 12 · 2017: 9 · 2016: 12 · 2015: 11 · 2014: 14 · 2013: 18 · 2012: 12
FWCI
12.17
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Complementary and alternative medicine › Acupuncture Treatment Research Studies
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
polycystic ovary syndrome, low-frequency electroacupuncture, physical activity, muscle sympathetic nerve activity, sympathetic nervous system, peroneal nerve, somatic afferents, body mass index, sagittal diameter, weight loss
MeSH terms
Action Potentials, Adult, Amenorrhea, Body Weight, Body Weights and Measures, Female, Humans, Muscle, Smooth, Oligomenorrhea, Peroneal Nerve, Polycystic Ovary Syndrome, Sympathetic Nervous System, Testosterone, Exercise, Electroacupuncture, Body Mass Index, Young Adult

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