Endothelial/Pericyte Interactions

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., et al. (1997) · Science · doi:10.1126/science.277.5322.55 · Cited by 3,570

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

Suri, C., Jones, P. F., Patan, S., Bartunkova, S., Maisonpierre, P. C., Davis, S. H., Sato, T. N., & Yancopoulos, G. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81813-9 · Cited by 2,872

Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice

Lindahl, P., Johansson, B. R., Levéen, P., & Betsholtz, C. (1997) · Science · doi:10.1126/science.277.5323.242 · Cited by 2,226

Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia

Joutel, A., Corpechot, C., Ducros, A., Vahedi, K., Chabriat, H., Mouton, P., Alamowitch, S., Domenga, V., Cécillion, M., Maréchal, E., et al. (1996) · Nature · doi:10.1038/383707a0 · Cited by 2,068

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

Davis, S., Aldrich, T. H., Jones, P. F., Acheson, A., Compton, D. L., Jain, V., Ryan, T. E., Bruno, J., Radziejewski, C., Maisonpierre, P. C., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81812-7 · Cited by 1,989

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

Sato, T. N., Tozawa, Y., Deutsch, U., Wolburg‐Buchholz, K., Fujiwara, Y., Gendron‐Maguire, M., Gridley, T., Wolburg, H., Risau, W., & Qin, Y. (1995) · Nature · doi:10.1038/376070a0 · Cited by 1,821

Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse

Hellström, M., Kalén, M., Lindahl, P., Abramsson, A., & Betsholtz, C. (1999) · Development · doi:10.1242/dev.126.14.3047 · Cited by 1,734

Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

McAllister, K. A., Grogg, K. M., Johnson, D. W., Gallione, C. J., Baldwin, M. A., Jackson, C. E., Helmbold, E. A., Markel, D. S., McKinnon, W. C., Murrel, J., et al. (1994) · Nature Genetics · doi:10.1038/ng1294-345 · Cited by 1,475

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

Bergers, G., Song, S., Meyer-Morse, N., Bergsland, E. K., & Hanahan, D. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17929 · Cited by 1,361

Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1

Thurston, G., Suri, C., Smith, K., McClain, J., Sato, T. T., Yancopoulos, G. D., & McDonald, D. M. (1999) · Science · doi:10.1126/science.286.5449.2511 · Cited by 1,350

Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

Liu, Y., Wada, R., Yamashita, T., Mi, Y., Deng, C., Hobson, J. P., Rosenfeldt, H. M., Nava, V. E., Chae, S.-S., Lee, M.-J., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10905 · Cited by 1,165

Lack of Pericytes Leads to Endothelial Hyperplasia and Abnormal Vascular Morphogenesis

Hellström, M., Gerhardt, H., Kalén, M., Li, X., Eriksson, U., Wolburg, H., & Betsholtz, C. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.3.543 · Cited by 1,132

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.Preprint

Levéen, P., Pekny, M., Gebré‐Medhin, S., Swolin, B., Larsson, E., & Betsholtz, C. (1994) · Genes & Development · doi:10.1101/gad.8.16.1875 · Cited by 1,130

Balancing the activation state of the endothelium via two distinct TGF‐β type I receptors

Goumans, M., Valdimarsdóttir, G., Itoh, S., Rosendahl, A., Sideras, P., & ten Dijke, P. (2002) · The EMBO Journal · doi:10.1093/emboj/21.7.1743 · Cited by 1,127

Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2

Johnson, D. W., Berg, J. N., Baldwin, M. A., Gallione, C. J., Marondel, I., Yoon, S.-H., Stenzel, T. T., Speer, M. C., Pericak‐Vance, M. A., Diamond, A. G., et al. (1996) · Nature Genetics · doi:10.1038/ng0696-189 · Cited by 1,113

Endothelial-pericyte interactions in angiogenesis

Gerhardt, H., & Betsholtz, C. (2003) · Cell and Tissue Research · doi:10.1007/s00441-003-0745-x · Cited by 1,086

Bone Formation and Inflammation in Cardiac Valves

Mohler, E. R., Gannon, F. H., Reynolds, C. A., Zimmerman, R. A., Keane, M. G., & Kaplan, F. S. (2001) · Circulation · doi:10.1161/01.cir.103.11.1522 · Cited by 1,067

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

Dickson, M. C., Martin, J. S., Cousins, F. M., Kulkarni, A. B., Karlsson, S., & Akhurst, R. J. (1995) · Development · doi:10.1242/dev.121.6.1845 · Cited by 1,029

Angiopoietin-2 Is Required for Postnatal Angiogenesis and Lymphatic Patterning, and Only the Latter Role Is Rescued by Angiopoietin-1

Gale, N. W., Thurston, G., Hackett, S. F., Renard, R. A., Wang, Q., McClain, J., Martin, C., Witte, C. L., Witte, M. H., Jackson, D. G., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00217-4 · Cited by 1,017

Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate

Lee, M.-J., Thangada, S., Claffey, K. P., Ancellin, N., Liu, C. H., Kluk, M., Volpi, M., Sha'afi, R. I., & Hla, T. (1999) · Cell · doi:10.1016/s0092-8674(00)81661-x · Cited by 1,003

Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.Preprint

Soriano, P. M. (1994) · Genes & Development · doi:10.1101/gad.8.16.1888 · Cited by 988

Abnormalities in Pericytes on Blood Vessels and Endothelial Sprouts in Tumors

Morikawa, S., Bałuk, P., Kaidoh, T., Haskell, A., Jain, R. K., & McDonald, D. M. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64920-6 · Cited by 987

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.

Dumont, D. J., Gradwohl, G., Fong, G. H., Puri, M. C., Gertsenstein, M., Auerbach, A., & Breitman, M. L. (1994) · Genes & Development · doi:10.1101/gad.8.16.1897 · Cited by 985

Notch signaling is required for arterial-venous differentiation during embryonic vascular development

Lawson, N. D., Scheer, N., Pham, V. N., Kim, C., Chitnis, A. B., Campos‐Ortega, J. A., & Weinstein, B. M. (2001) · Development · doi:10.1242/dev.128.19.3675 · Cited by 923

Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis

Oh, S. P., Seki, T., Goss, K. A., Imamura, T., Yi, Y., Donahoe, P. K., Li, L., Miyazono, K., ten Dijke, P., Kim, S., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.6.2626 · Cited by 872

Defective Angiogenesis in Mice Lacking Endoglin

Li, D. Y., Sorensen, L. K., Brooke, B. S., Urness, L. D., Davis, E. C., Taylor, D. G., Boak, B. B., & Wendel, D. P. (1999) · Science · doi:10.1126/science.284.5419.1534 · Cited by 853

Increased Vascularization in Mice Overexpressing Angiopoietin-1

Suri, C., McClain, J., Thurston, G., McDonald, D. M., Zhou, H., Oldmixon, E. H., Sato, T. N., & Yancopoulos, G. D. (1998) · Science · doi:10.1126/science.282.5388.468 · Cited by 818

Vascular Dysmorphogenesis Caused by an Activating Mutation in the Receptor Tyrosine Kinase TIE2

Vikkula, M., Boon, L. M., Carraway, K. L., Calvert, J. T., Diamonti, A. J., Goumnerov, B. C., Pasyk, K. A., Marchuk, D. A., Warman, M. L., Cantley, L. C., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81814-0 · Cited by 797

PDGF, TGF-β, and Heterotypic Cell–Cell Interactions Mediate Endothelial Cell–induced Recruitment of 10T1/2 Cells and Their Differentiation to a Smooth Muscle Fate

Hirschi, K. K., Rohovsky, S. A., & D'Amore, P. A. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.3.805 · Cited by 796

Cellular abnormalities of blood vessels as targets in cancer

Bałuk, P., Hashizume, H., & McDonald, D. M. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.12.005 · Cited by 782

An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes.

Orlidge, A., Saunders, K. B., Smith, S. R., & D'Amore, P. A. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.12.4544 · Cited by 752

The Tie-2 ligand Angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies

Fiedler, U., Scharpfenecker, M., Koidl, S., Hegen, A., Grunow, V., Schmidt, J. M., Kriz, W., Thurston, G., & Augustin, H. G. (2004) · Blood · doi:10.1182/blood-2003-10-3685 · Cited by 742

Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity

You, L., Lin, F., Lee, C. T., DeMayo, F. J., Tsai, M., & Tsai, S. Y. (2005) · Nature · doi:10.1038/nature03511 · Cited by 674

Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wallPreprint

Lindblom, P., Gerhardt, H., Liebner, S., Abramsson, A., Enge, M., Hellström, M., Bäckström, G., Fredriksson, S., Landegren, U. D., Nyström, H. C., et al. (2003) · Genes & Development · doi:10.1101/gad.266803 · Cited by 674

Role of tissue factor in embryonic blood vessel development

Carmeliet, P., Mackman, N., Moons, L., Luther, T., Gressèns, P., Vlaenderen, L. V., Demunck, H., Kasper, M. E., Breier, G., Evrard, P., et al. (1996) · Nature · doi:10.1038/383073a0 · Cited by 669

Pericytes and the Pathogenesis of Diabetic Retinopathy

Hammes, H., Lin, J., Renner, O., Shani, M., Lundqvist, A., Betsholtz, C., Brownlee, M., & Deutsch, U. (2002) · Diabetes · doi:10.2337/diabetes.51.10.3107 · Cited by 669

The Notch target genes Hey1 and Hey2 are required for embryonic vascular developmentPreprint

Fischer, A., Schumacher, N., Maier, M., Sendtner, M., & Gessler, M. (2004) · Genes & Development · doi:10.1101/gad.291004 · Cited by 669

The cephalic neural crest provides pericytes and smooth muscle cells to all blood vessels of the face and forebrain

Etchevers, H. C., Vincent, C., Douarin, N. M. L., & F. Couly, G. (2001) · Development · doi:10.1242/dev.128.7.1059 · Cited by 657

Endoglin promotes endothelial cell proliferation and TGF‐β/ALK1 signal transduction

Lebrin, F., Goumans, M., Jonker, L., Carvalho, R. L. C., Valdimarsdóttir, G., Thorikay, M., Mummery, C. L., Arthur, H. M., & ten Dijke, P. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600386 · Cited by 653

Pericyte physiology

Sheṕro, D., & Morel-Laurens, N. (1993) · The FASEB Journal · doi:10.1096/fasebj.7.11.8370472 · Cited by 652

TGF-β Receptor Type II Deficiency Results in Defects of Yolk Sac Hematopoiesis and Vasculogenesis

Oshima, M., Oshima, H., & Taketo, M. M. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0259 · Cited by 651

Extensive Vasculogenesis, Angiogenesis, and Organogenesis Precede Lethality in Mice Lacking All αv Integrins

Bader, B., Rayburn, H., Crowley, D. G., & Hynes, R. O. (1998) · Cell · doi:10.1016/s0092-8674(00)81618-9 · Cited by 649

The pericyte—A review

Sims, D. (1986) · Tissue and Cell · doi:10.1016/0040-8166(86)90026-1 · Cited by 602

Roles of PDGF in animal development

Hoch, R. V., & Soriano, P. M. (2003) · Development · doi:10.1242/dev.00721 · Cited by 593

Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis

Petrova, T. V., Kärpänen, T., Norrmén, C., Mellor, R. H., Tamakoshi, T., Finegold, D. N., Ferrell, R. E., Kerjaschki, D., Mortimer, P. S., Ylä‐Herttuala, S., et al. (2004) · Nature Medicine · doi:10.1038/nm1094 · Cited by 587

Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

Abramsson, A., Lindblom, P., & Betsholtz, C. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18549 · Cited by 578

Vascular Pericytes Express Osteogenic Potential In Vitro and In Vivo

Doherty, M. J., Ashton, B. A., Walsh, S., Beresford, J. N., Grant, M. E., & Canfield, A. E. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.5.828 · Cited by 566

Abnormal angiogenesis but intact hematopoietic potential in TGF‐β type I receptor‐deficient mice

Larsson, J., Goumans, M., Sjöstrand, L. J., van Rooijen, M. A., Ward, D., Levéen, P., Xu, X., ten Dijke, P., Mummery, C. L., & Karlsson, S. (2001) · The EMBO Journal · doi:10.1093/emboj/20.7.1663 · Cited by 563

Notch3 is required for arterial identity and maturation of vascular smooth muscle cellsPreprint

Domenga, V., Fardoux, P., Lacombe, P., Monet, M., Maciazek, J., Krebs, L. T., Klonjkowski, B., Berrou, E., Mericskay, M., Li, Z., et al. (2004) · Genes & Development · doi:10.1101/gad.308904 · Cited by 555

Cell Type-Specific Expression of Angiopoietin-1 and Angiopoietin-2 Suggests a Role in Glioblastoma Angiogenesis

Stratmann, A., Risau, W., & Plate, K. H. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65733-1 · Cited by 485

A murine model of hereditary hemorrhagic telangiectasia

Bourdeau, A., Dumont, D., & Letarte, M. (1999) · Journal of Clinical Investigation · doi:10.1172/jci8088 · Cited by 471

Chondrogenic and Adipogenic Potential of Microvascular Pericytes

Farrington, C., Crofts, N. J., Doherty, M. J., Ashton, B. A., Griffin-Jones, C., & Canfield, A. E. (2004) · Circulation · doi:10.1161/01.cir.0000144457.55518.e5 · Cited by 470

Arteriovenous malformations in mice lacking activin receptor-like kinase-1

Urness, L. D., Sorensen, L. K., & Li, D. Y. (2000) · Nature Genetics · doi:10.1038/81634 · Cited by 454

Pericytes: Cell Biology and Pathology

Allt, G., & Lawrenson, J. G. (2001) · Cells Tissues Organs · doi:10.1159/000047855 · Cited by 451

Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors.

Pietras, K., Östman, A., SJÖQUIST, M., Buchdunger, E., Reed, R. K., Heldin, C., & Rubin, K. (2001) · PubMed · Cited by 449

Endoglin, an Ancillary TGFβ Receptor, Is Required for Extraembryonic Angiogenesis and Plays a Key Role in Heart Development

Arthur, H. M., Ure, J. M., Smith, A. J. H., Renforth, G. L., Wilson, D. I., Torsney, E., Charlton, R., Parums, D. V., Jowett, T., Marchuk, D. A., et al. (2000) · Developmental Biology · doi:10.1006/dbio.1999.9534 · Cited by 448

Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system.

Sato, Y., Tsuboi, R., Lyons, R., Moses, H., & Rifkin, D. B. (1990) · The Journal of cell biology · doi:10.1083/jcb.111.2.757 · Cited by 444

Insight into the physiological functions of PDGF through genetic studies in mice

Betsholtz, C. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2004.03.005 · Cited by 437

Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects

Chang, H., Huylebroeck, D., Verschueren, K., Guo, Q., Matzuk, M. M., & Zwijsen, A. (1999) · Development · doi:10.1242/dev.126.8.1631 · Cited by 435

Chemotactic Properties of Angiopoietin-1 and -2, Ligands for the Endothelial-specific Receptor Tyrosine Kinase Tie2

Witzenbichler, B., Maisonpierre, P. C., Jones, P. F., Yancopoulos, G. D., & Isner, J. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18514 · Cited by 433

Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy.

Pietras, K., Rubin, K., Sjöblom, T., Buchdunger, E., Sjöquist, M., Heldin, C., & Östman, A. (2002) · PubMed · Cited by 430

The Sphingosine-1-phosphate Receptors S1P1, S1P2, and S1P3 Function Coordinately during Embryonic Angiogenesis

Kono, M., Mi, Y., Liu, Y., Sasaki, T., Allende, M. L., Wu, Y., Yamashita, T., & Proia, R. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403937200 · Cited by 423

Endothelium‐specific platelet‐derived growth factor‐B ablation mimics diabetic retinopathy

Enge, M., Bjarnegård, M., Gerhardt, H., Gustafsson, E., Kalén, M., Asker, N., Hammes, H., Shani, M., Fässler, R., & Betsholtz, C. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf418 · Cited by 409

Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells

Rajantie, I., Ilmonen, M., Alminaite, A., Özerdem, U., Alitalo, K. K., & Salvén, P. (2004) · Blood · doi:10.1182/blood-2004-01-0336 · Cited by 390

G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation

Allende, M. L., Yamashita, T., & Proia, R. L. (2003) · Blood · doi:10.1182/blood-2003-02-0460 · Cited by 388

Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5

Yang, X. Y., Castilla, L. H., Xu, X., Li, C., Gotay, J., Weinstein, M. B., Liu, P. P., & Deng, C. (1999) · Development · doi:10.1242/dev.126.8.1571 · Cited by 387

The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesisPreprint

Kuo, C. T., Veselits, M., Barton, K., Lu, M. M., Clendenin, C., & Leiden, J. M. (1997) · Genes & Development · doi:10.1101/gad.11.22.2996 · Cited by 371

Fli-1 Is Required for Murine Vascular and Megakaryocytic Development and Is Hemizygously Deleted in Patients with Thrombocytopenia

Hart, A., Melet, F., Grossfeld, P., Chien, K., Jones, C., Tunnacliffe, A., Favier, R., & Bernstein, A. (2000) · Immunity · doi:10.1016/s1074-7613(00)00017-0 · Cited by 369

Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities

Bjarnegård, M., Enge, M., Norlin, J., Gustafsdottir, S., Fredriksson, S., Abramsson, A., Takemoto, M., Gustafsson, E., Fässler, R., & Betsholtz, C. (2004) · Development · doi:10.1242/dev.01080 · Cited by 368

Brain pericytes contribute to the induction and up-regulation of blood–brain barrier functions through transforming growth factor-β production

Dohgu, S., Takata, F., Yamauchi, A., Nakagawa, S., Egawa, T., Naito, M., Tsuruo, T., Sawada, Y., Niwa, M., & Kataoka, Y. (2005) · Brain Research · doi:10.1016/j.brainres.2005.01.027 · Cited by 350

Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function

Iwamoto, R., Yamazaki, S., Asakura, M., Takashima, S., Hasuwa, H., Miyado, K., Adachi, S., Kitakaze, M., Hashimoto, K., Raab, G., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0537588100 · Cited by 347

Angiopoietin-2 Causes Pericyte Dropout in the Normal Retina

Hammes, H., Lin, J., Wagner, P., Feng, Y., Hagen, F. V., Krzizok, T. H., Renner, O., Breier, G., Brownlee, M., & Deutsch, U. (2004) · Diabetes · doi:10.2337/diabetes.53.4.1104 · Cited by 347

A pericyte‐derived angiopoietin‐1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie‐2 activation in vitro

Hori, S., Ohtsuki, S., Hosoya, K., Nakashima, E., & Terasaki, T. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02343.x · Cited by 341

Embryonic Endothelial Cells Transdifferentiate Into Mesenchymal Cells Expressing Smooth Muscle Actins In Vivo and In Vitro

DeRuiter, M. C., Poelmann, R. E., van Munsteren, J. C., Mironov, V., Markwald, R. R., & Groot, A. C. G. (1997) · Circulation Research · doi:10.1161/01.res.80.4.444 · Cited by 332

Requirement of the MADS-box transcription factor MEF2C for vascular development

Lin, Q., Lu, J., Yanagisawa, H., Webb, R. C., Lyons, G. E., Richardson, J. A., & Olson, E. N. (1998) · Development · doi:10.1242/dev.125.22.4565 · Cited by 311

Role of the CNS microvascular pericyte in the blood-brain barrier

Balabanov, R. D., & Dore‐Duffy, P. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19980915)53:6 · Cited by 309

Developmental Biology of the Vascular Smooth Muscle Cell: Building a Multilayered Vessel Wall

Hungerford, J. E., & Little, C. (1999) · Journal of Vascular Research · doi:10.1159/000025622 · Cited by 291

Akt-Mediated Phosphorylation of the G Protein-Coupled Receptor EDG-1 Is Required for Endothelial Cell Chemotaxis

Lee, M.-J., Thangada, S., Paik, J.-H., Sapkota, G. P., Ancellin, N., Chae, S.-S., Wu, M.-T., Morales‐Ruiz, M., Sessa, W. C., Alessi, D. R., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00324-0 · Cited by 288

Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilizationPreprint

Paik, J., Skoura, A., Chae, S., Cowan, A. E., Han, D. K. M., Proia, R. L., & Hla, T. (2004) · Genes & Development · doi:10.1101/gad.1227804 · Cited by 283

Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells

Uemura, A., Ogawa, M., Hirashima, M., Fujiwara, T., Koyama, S., Takagi, H., Honda, Y., Wiegand, S. J., Yancopoulos, G. D., & Nishikawa, S.-I. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15621 · Cited by 282

Ultrastructure and Three-Dimensional Organization of the Telangiectases of Hereditary Hemorrhagic Telangiectasia

Braverman, I. M., Keh, A., & Jacobson, B. S. (1990) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12555569 · Cited by 279

Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis.

Sjöblom, T., Shimizu, A., O'Brien, K. P., Pietras, K., Cin, P. D., Buchdunger, E., Dumanski, J. P., Östman, A., & Heldin, C. (2001) · PubMed · Cited by 279

β8 integrins are required for vascular morphogenesis in mouse embryos

Zhu, J., Motejlek, K., Wang, D., Zang, K., Schmidt, A., & Reichardt, L. F. (2002) · Development · doi:10.1242/dev.129.12.2891 · Cited by 274

Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in ovarian cancer.

Zhang, L., Yang, N., Park, J.-W., Katsaros, D., Fracchioli, S., Cao, G., O’Brien-Jenkins, A., Randall, T. C., Rubin, S. C., & Coukos, G. (2003) · PubMed · Cited by 263

Angiogenesis and Pericytes in the Initiation of Ectopic Calcification

Collett, G. D. M., & Canfield, A. E. (2005) · Circulation Research · doi:10.1161/01.res.0000163634.51301.0d · Cited by 260

Stable Expression of Angiopoietin-1 and Other Markers by Cultured Pericytes: Phenotypic Similarities to a Subpopulation of Cells in Maturing Vessels During Later Stages of Angiogenesis In Vivo

Sundberg, C., Kowanetz, M., Brown, L. F., Detmar, M. J., & Dvorak, H. F. (2002) · Laboratory Investigation · doi:10.1038/labinvest.3780433 · Cited by 253

Pericytes and the Pathogenesis of Diabetic Retinopathy

Hammes, H. (2005) · Hormone and Metabolic Research · doi:10.1055/s-2005-861361 · Cited by 246

Smooth muscle cells and fibroblasts of the coronary arteries derive from epithelial-mesenchymal transformation of the epicardium

Peeters, M.-P. F. M. V., Groot, A. C. G., Mentink, M. M. T., & Poelmann, R. E. (1999) · Anatomy and Embryology · doi:10.1007/s004290050235 · Cited by 242

Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells

Uemura, A., Ogawa, M., Hirashima, M., Fujiwara, T., Koyama, S., Takagi, H., Honda, Y., Wiegand, S. J., Yancopoulos, G. D., & Nishikawa, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215621 · Cited by 226

Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization

Berger, M., Bergers, G., Arnold, B., Hämmerling, G. J., & Ganß, R. (2005) · Blood · doi:10.1182/blood-2004-06-2315 · Cited by 220

Cellular mechanisms of CNS pericytes

Rucker, H. K., Wynder, H. J., & Thomas, W. E. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00260-9 · Cited by 220

The versatility of microvascular pericytes: from mesenchyme to smooth muscle?

Nehls, V., & Drenckhahn, D. (1993) · Histochemistry · doi:10.1007/bf00268014 · Cited by 216

Integrin α4β1–VCAM-1–mediated adhesion between endothelial and mural cells is required for blood vessel maturation

Garmy-Susini, B. H., Jin, H., Zhu, Y., Sung, R.-J., Hwang, R. F., & Varner, J. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23445 · Cited by 216

Notch function in the vasculature: insights from zebrafish, mouse and man

Shawber, C. J., & Kitajewski, J. (2004) · BioEssays · doi:10.1002/bies.20004 · Cited by 214

Transforming growth factor-β1 signaling contributes to development of smooth muscle cells from embryonic stem cells

Sinha, S., Hoofnagle, M. H., Kingston, P. A., McCanna, M. E., & Owens, G. K. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00221.2004 · Cited by 203

Characterization of Smooth Muscle Cell and Pericyte Differentiation in the Rat Retina In Vivo

Hughes, S., & Chan‐Ling, T. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-1312 · Cited by 203

Additive Effects of PDGF Receptor β Signaling Pathways in Vascular Smooth Muscle Cell Development

Tallquist, M. D., French, W. J., & Soriano, P. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000052 · Cited by 192

Platelet-derived growth factor β receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3′ kinase signaling

Heuchel, R. L., Berg, A., Tallquist, M. D., Åhlén, K., Reed, R. K., Rubin, K., Claesson, L., Heldin, C., & Soriano, P. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11410 · Cited by 188

N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis

Luo, Y., & Radice, G. L. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200411127 · Cited by 187

Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1–derived O-glycans

Xia, L., Ju, T., Westmuckett, A. D., An, G., Ivanciu, L., McDaniel, J. M., Lupu, F., Cummings, R. D., & McEver, R. P. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200311112 · Cited by 186

Analysis of Mural Cell Recruitment to Tumor Vessels

Abramsson, A., Berlin, O., Papayan, H., Paulin, D., Shani, M., & Betsholtz, C. (2002) · Circulation · doi:10.1161/hc0102.101437 · Cited by 178

Gap Junction Communication Mediates Transforming Growth Factor-β Activation and Endothelial-Induced Mural Cell Differentiation

Hirschi, K. K., Burt, J. M., Hirschi, K. D., & Dai, C. (2003) · Circulation Research · doi:10.1161/01.res.0000091259.84556.d5 · Cited by 176

Continuous subendothelial network formed by pericyte-like cells in human vascular bed

Andreeva, E. R., Pugach, I. M., Gordon, D., & Orekhov, A. N. (1998) · Tissue and Cell · doi:10.1016/s0040-8166(98)80014-1 · Cited by 164

The basic helix-loop-helix transcription factor, dHAND, is required for vascular development

Yamagishi, H., Olson, E. N., & Srivastava, D. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8856 · Cited by 162

Pericytes as collagen-producing cells in excessive dermal scarring.

Sundberg, C., Ivarsson, M., Gerdin, B., & Rubin, K. (1996) · PubMed · Cited by 161

Sphingosine 1-Phosphate-induced Mobilization of Intracellular Ca2+ Mediates Rac Activation and Adherens Junction Assembly in Endothelial Cells

Mehta, D., Konstantoulaki, M., Ahmmed, G. U., & Malik, A. B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411674200 · Cited by 160

Defective paracrine signalling by TGFβ in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia

Carvalho, R. L. C., Jonker, L., Goumans, M., Larsson, J. T., Bouwman, P., Karlsson, S., ten Dijke, P., Arthur, H. M., & Mummery, C. L. (2004) · Development · doi:10.1242/dev.01529 · Cited by 159

Pericyte endothelial gap junctions in human cerebral capillaries

Cuevas, P., Gutiérrez-Díaz, J. A., Reimers, D., Dujovny, M., Diaz, F. G., & Ausman, J. I. (1984) · Anatomy and Embryology · doi:10.1007/bf00319000 · Cited by 157

Retinoic acid regulates endothelial cell proliferation during vasculogenesis

Lai, L., Bohnsack, B. L., Niederreither, K., & Hirschi, K. K. (2003) · Development · doi:10.1242/dev.00887 · Cited by 154

Sphingosine-1-phosphate receptors and the development of the vascular system

Allende, M. C. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(02)00175-0 · Cited by 153

Fibronectin in the microvasculature: localization in the pericyte-endothelial interstitium

Courtoy, P. J., & Boyles, J. K. (1983) · Journal of Ultrastructure Research · doi:10.1016/s0022-5320(83)90133-8 · Cited by 151

Integrin αvβ8-Mediated Activation of Transforming Growth Factor-β by Perivascular Astrocytes: An Angiogenic Control Switch

Cambier, S., Gline, S. E., Mu, D., Collins, R., Araya, J., Dolganov, G., Einheber, S., Boudreau, N., & Nishimura, S. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62497-2 · Cited by 147

Pericyte-endothelial relationships in cardiac and skeletal muscle capillaries

Tilton, R. G., Kilo, C., & Williamson, J. R. (1979) · Microvascular Research · doi:10.1016/0026-2862(79)90041-4 · Cited by 146

Inactivation of TGFβ signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndromePreprint

Wurdak, H., Ittner, L. M., Lang, K. S., Levéen, P., Suter, U., Fischer, J. A., Karlsson, S., Born, W., & Sommer, L. (2005) · Genes & Development · doi:10.1101/gad.317405 · Cited by 141

Angiopoietin‐regulated recruitment of vascular smooth muscle cells by endothelial‐derived heparin binding EGF‐like growth factor

Iivanainen, E., Nelimarkka, L. O., Elenius, V., Heikkinen, S.-M., Junttila, T. T., Sihombing, L., Sundvall, M., Määttä, J. A., Laine, V. J. O., Ylä‐Herttuala, S., et al. (2003) · The FASEB Journal · doi:10.1096/fj.02-0939com · Cited by 125

An MT1-MMP-PDGF receptor-β axis regulates mural cell investment of the microvasculaturePreprint

Lehti, K., Allen, E. D., Birkedal‐Hansen, H., Holmbeck, K., Miyake, Y., Chun, T., & Weiss, S. J. (2005) · Genes & Development · doi:10.1101/gad.1294605 · Cited by 123

Mouse Model for Hereditary Hemorrhagic Telangiectasia Has a Generalized Vascular Abnormality

Torsney, E., Charlton, R., Diamond, A. G., Burn, J., Soames, J. V., & Arthur, H. M. (2003) · Circulation · doi:10.1161/01.cir.0000058170.92267.00 · Cited by 120

The enigmatic role of angiopoietin-1 in tumor angiogenesis

Metheny‐Barlow, L. J., & Lu Yuan, L. I. (2003) · Cell Research · doi:10.1038/sj.cr.7290176 · Cited by 114

Chimaeric analysis reveals role of Pdgf receptors in all muscle lineages

Crosby, J. R., Seifert, R. A., Soriano, P. M., & Bowen‐Pope, D. F. (1998) · Nature Genetics · doi:10.1038/ng0498-385 · Cited by 111

Extra-embryonic vasculature development is regulated by the transcription factor HAND1

Morikawa, Y., & Cserjesi, P. (2004) · Development · doi:10.1242/dev.01091 · Cited by 86

Desmin Ensheathment Ratio as an Indicator of Vessel Stability

Chan‐Ling, T., Page, M. P., Gardiner, T. A., Baxter, L., Rosinova, E., & Hughes, S. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63389-5 · Cited by 82

Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF β-receptor null mice

Kaminski, W. E., Lindahl, P., Lin, N. L., Broudy, V. C., Crosby, J. R., Hellström, M., Swolin, B., Bowen-Pope, D. F., Martin, P. J., Ross, R., et al. (2001) · Blood · doi:10.1182/blood.v97.7.1990 · Cited by 77

Retention of PDGFR-β function in mice in the absence of phosphatidylinositol 3′-kinase and phospholipase Cγ signaling pathwaysPreprint

Tallquist, M. D., Klinghoffer, R. A., Heuchel, R. L., Mueting-Nelsen, P. F., Corrin, P. D., Heldin, C., Johnson, R. J., & Soriano, P. M. (2000) · Genes & Development · doi:10.1101/gad.844700 · Cited by 77

Rat aorta-derived mural precursor cells express the Tie2 receptor and respond directly to stimulation by angiopoietins

Iurlaro, M., Scatena, M., Zhu, W., Fogel, E., Wieting, S. L., & Nicosia, R. F. (2003) · Journal of Cell Science · doi:10.1242/jcs.00629 · Cited by 74

Abnormal pericyte recruitment as a cause for pulmonary hypertension in Adams–Oliver syndrome

Patel, M. S., Taylor, G. P., Bharya, S., Al-Sannaa, N. A., Adatia, I., Chitayat, D. A., Lewis, M. E. S., & Human, D. G. (2004) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.30221 · Cited by 72

Stromal cells of fibrodysplasia ossificans progressiva lesions express smooth muscle lineage markers and the osteogenic transcription factor Runx2/Cbfa‐1: clues to a vascular origin of heterotopic ossification?

Hegyi, L., Gannon, F. H., Glaser, D. L., Shore, E. M., Kaplan, F. S., & Shanahan, C. M. (2003) · The Journal of Pathology · doi:10.1002/path.1413 · Cited by 58

Mouse Notch 3 Expression in the Pre- and Postnatal Brain: Relationship to the Stroke and Dementia Syndrome CADASIL

Prakash, N., Hansson, E. M., Betsholtz, C., Mitsiadis, T. A., & Lendahl, U. (2002) · Experimental Cell Research · doi:10.1006/excr.2002.5544 · Cited by 52

Prediction of Cell Type-Specific Gene Modules: Identification and Initial Characterization of a Core Set of Smooth Muscle-Specific GenesPreprint

Nelander, S., Mostad, P., & Lindahl, P. (2003) · Genome Research · doi:10.1101/gr.1197303 · Cited by 38

Neuron-Specific Ablation of PDGF-B Is Compatible with Normal Central Nervous System Development and Astroglial Response to Injury

Enge, M., Wilhelmsson, U., Abramsson, A., Stakeberg, J., Kühn, R., Betsholtz, C., & Pekny, M. (2003) · Neurochemical Research · doi:10.1023/a:1022421001288 · Cited by 38

Requisite Role of p38 MAPK in Mural Cell Recruitment during Angiogenesis in the Rat Aorta Model

Zhu, W.-H., Han, J., & Nicosia, R. F. (2003) · Journal of Vascular Research · doi:10.1159/000070711 · Cited by 29

The CNS pericyte response to low oxygen: early synthesis of cyclopentenone prostaglandins of the J-series

Dore‐Duffy, P., Balabanov, R. D., Beaumont, T., & Katar, M. (2005) · Microvascular Research · doi:10.1016/j.mvr.2004.11.004 · Cited by 23

Platelet-Derived Growth Factor B-Chain of Hematopoietic Origin Is Not Necessary for Granulation Tissue Formation and Its Absence Enhances Vascularization

Buetow, B. S., Crosby, J. R., Kaminski, W. E., Ramachandran, R. K., Lindahl, P., Martin, P. J., Betsholtz, C., Seifert, R. A., Raines, E. W., & Bowen‐Pope, D. F. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63033-7 · Cited by 22

Expression of chicken slug and snail in mesenchymal components of the developing central nervous system

Marı́n, F., & Nieto, M. A. (2004) · Developmental Dynamics · doi:10.1002/dvdy.20027 · Cited by 22

Untitled work

(2000) · doi:10.1002/1097-0177(200007)218:3

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.022 · Cited by 4,632

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

Armulik, A., Genové, G., & Betsholtz, C. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.07.001 · Cited by 2,653

Role of platelet-derived growth factors in physiology and medicinePreprint

Andræ, J., Gallini, R., & Betsholtz, C. (2008) · Genes & Development · doi:10.1101/gad.1653708 · Cited by 2,534

Blood-Brain Barrier: From Physiology to Disease and Back

Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,312

Pericytes, the Mural Cells of the Microvascular System

Bergers, G. (2008) · Springer eBooks · doi:10.1007/978-0-387-71518-6_4 · Cited by 3

ATVB In Focus Developmental Biology in the Vasculature Series Editor: Mark Majesky, PhD Endothelial-Mural Cell Signaling in Vascular Development

Angiogenesis, Gaengel, K., Armulik, A., & Betsholtz, C. (2016)

BEYOND THE ENDOTHELIUM: THE ROLE OF MURAL CELLS IN VASCULAR BIOLOGY: In vitro systems to study endothelial/pericyte cell interactions

Warren, E., & Gerecht, S. (2023) · Vascular Biology · doi:10.1530/vb-22-0021 · Cited by 27

Endothelial-pericyte interactions in angiogenesis

Gerhardt, H., & Betsholtz, C. (2003) · Cell and Tissue Research · doi:10.1007/s00441-003-0745-x · Cited by 1,086

Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis

KonstantinGaengel, GuillemGenové, AnnikaArmulik, & ChristerBetsholtz (2009) · Arteriosclerosis Thrombosis and Vascular Biology