Cited by 2,048Angiogenesis and VEGF in CancerBarrier Structure and Function StudiesLymphatic System and Diseases

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Endothelial/Pericyte Interactions

Armulik, Annika, Abramsson, Alexandra, Betsholtz, Christer·2005·Circulation Research

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Abstract

Interactions between endothelial cells and mural cells (pericytes and vascular smooth muscle cells) in the blood vessel wall have recently come into focus as central processes in the regulation of vascular formation, stabilization, remodeling, and function. Failure of the interactions between the 2 cell types, as seen in numerous genetic mouse models, results in severe and often lethal cardiovascular defects. Abnormal interactions between the 2 cell types are also implicated in a number of human pathological conditions, including tumor angiogenesis, diabetic microangiopathy, ectopic tissue calcification, and stroke and dementia syndrome CADASIL. In the present review, we summarize current knowledge concerning the identity, characteristics, diversity, ontogeny, and plasticity of pericytes. We focus on the advancement in recent years of the understanding of intercellular communication between endothelial and mural cells with a focus on transforming growth factor β, angiopoietins, platelet-derived growth factor, spingosine-1-phosphate, and Notch ligands and their respective receptors. We finally highlight recent important data contributing to the understanding of the role of pericytes in tumor angiogenesis, diabetic retinopathy, and hereditary lymphedema.

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Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis
Suri, C., Jones, P. F., Patan, S., Bartunkova, S., Maisonpierre, P. C., Davis, S. H., Sato, T. N., & Yancopoulos, G. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81813-9 · Cited by 2,872
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Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
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Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
Hellström, M., Kalén, M., Lindahl, P., Abramsson, A., & Betsholtz, C. (1999) · Development · doi:10.1242/dev.126.14.3047 · Cited by 1,734
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McAllister, K. A., Grogg, K. M., Johnson, D. W., Gallione, C. J., Baldwin, M. A., Jackson, C. E., Helmbold, E. A., Markel, D. S., McKinnon, W. C., Murrel, J., et al. (1994) · Nature Genetics · doi:10.1038/ng1294-345 · Cited by 1,475
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Thurston, G., Suri, C., Smith, K., McClain, J., Sato, T. T., Yancopoulos, G. D., & McDonald, D. M. (1999) · Science · doi:10.1126/science.286.5449.2511 · Cited by 1,350

Show all 134 references

Research works printed but not linked: 5

10.1161/circ.105.1.112 · DOI
10.1161/res.80.4.444 · DOI
10.1161/circ.103.11.1522 · DOI
10.1172/JCI200318549 · DOI
10.1172/JCI200317929 · DOI

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Authors: Armulik, A., Abramsson, A., & Betsholtz, C.
Affiliations: Karolinska Institutet (SE)
Corresponding author: Betsholtz, Christer
ORCID: Abramsson, Alexandra
Betsholtz, Christer
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2005-09-16
Volume: 97
Issue: 6
Pages: 512-523
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/01.res.0000182903.16652.d7
OpenAlex: W2115390024
Cited by: 2,048
References: 134
Citations by year: 2026: 39 · 2025: 62 · 2024: 97 · 2023: 108 · 2022: 90 · 2021: 116 · 2020: 121 · 2019: 101 · 2018: 92 · 2017: 110 · 2016: 117 · 2015: 131 · 2014: 122 · 2013: 120 · 2012: 114
FWCI: 5.70
Type: journal article
Language: en
Open access: closed
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
Keywords: pericytes, endothelial cells, pericyte-endothelial interactions, vascular remodeling, intercellular communication, TGF-beta, angiopoietins, platelet-derived growth factor, sphingosine-1-phosphate, Notch signaling, tumor angiogenesis, diabetic retinopathy, hereditary lymphedema, CADASIL, vascular calcification, cardiovascular defects
MeSH terms: Becaplermin, Animals, Calcinosis, Cell Communication, Cell Differentiation, Humans, Lysophospholipids, Membrane Proteins, Muscle, Smooth, Vascular, Platelet-Derived Growth Factor, Sphingosine, Signal Transduction, Transforming Growth Factor beta, Pericytes, Proto-Oncogene Proteins c-sis, Receptor, Platelet-Derived Growth Factor beta, Angiopoietin-1, Endothelial Cells, Receptor, TIE-2, Receptors, Lysosphingolipid, Receptors, Notch

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