Cited by 309Angiogenesis and VEGF in CancerAdipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and Adiposity

The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.

Angiogenic Role of LYVE-1–Positive Macrophages in Adipose Tissue

Open access

Cho, Chung-Hyun, Jun Koh, Young, Han, Jinah, Sung, Hoon-Ki, Jong Lee, Hyuek, Morisada, Tohru, Schwendener, Reto A., Brekken, Rolf A., Kang, Guson, Oike, Yuichi, Choi, Tae-Saeng, Suda, Toshio, Yoo, Ook-Joon, Koh, Gou Young·2007·Circulation Research

DOI 10.1161/01.res.0000259564.92792.93

Open this paper in CoChat — free account Open PDF

Abstract

Here we report the discovery of a characteristic dense vascular network (DVN) in the tip portion of epididymal adipose tissue in adult mice. The DVN is formed by angiogenesis rather than by vasculogenesis, and has functional blood circulation. This DVN and its subsequent branching may provide a new functional route for adipogenesis. The recruitment, infiltration, and accumulation of bone marrow-derived LYVE-1 + macrophages in the tip region are crucial for the formation of the DVN. Matrix metalloproteinases (MMPs) and the VEGF-VEGFR2 system are responsible not only for the formation of the DVN, but also for the recruitment and infiltration of LYVE-1 + macrophages into the epididymal adipose tissue tip region. SDF-1, but not the MCP-1-CCR2 system, is a critical factor in recruitment and ongoing retention of macrophages in this area. We also demonstrate that the tip region of epididymal adipose tissue is highly hypoxic, and thus provides a microenvironment conducive to the high expression and enhanced activities of VEGF, VEGFR2, MMPs, and SDF-1 in autocrine and paracrine manners, to create an ideal niche for the recruitment, retention, and angiogenic action of macrophages. These findings shed light on the complex interplay between macrophage infiltration, angiogenesis, and adipogenesis in the tip region of adult epididymal adipose tissue, and provide novel insight into the regulation of alternative outgrowth of adipose tissue.

Integrity signals

Registry

Crossref · 10.1161/01.res.0000259564.92792.93

Cites

64 of 64 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
The biology of VEGF and its receptors
Ferrara, N., Gerber, H.-P., & LeCouter, J. (2003) · Nature Medicine · doi:10.1038/nm0603-669 · Cited by 9,591
Human Adipose Tissue Is a Source of Multipotent Stem Cells
Zuk, P. A., Zhu, M., Ashjian, P. H., Ugarte, D. A. D., Huang, J. I., Mizuno, H., Alfonso, Z. C., Fraser, J. K., Benhaim, P., & Hedrick, M. H. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-02-0105 · Cited by 6,762
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Mechanisms of angiogenesis
Risau, W. (1997) · Nature · doi:10.1038/386671a0 · Cited by 5,727
Angiogenesis in life, disease and medicine
Carmeliet, P. (2005) · Nature · doi:10.1038/nature04478 · Cited by 3,551
Tumour-educated macrophages promote tumour progression and metastasis
Pollard, J. W. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1256 · Cited by 3,414
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302047 · Cited by 2,894
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
Bergers, G., Brekken, R., McMahon, G., Vu, T. H., Itoh, T., Tamaki, K., Tanzawa, K., Thorpe, P., Itohara, S., Werb, Z., et al. (2000) · Nature Cell Biology · doi:10.1038/35036374 · Cited by 2,797
Self-citation
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
Kanda, H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26498 · Cited by 2,682

Show all 64 references

Research works printed but not linked: 2

10.1172/JCI20514 · DOI · Paper page
10.1093/ansci/82.3.925 · DOI

Sorted by citations

Items 101–200 of 308

Therapeutic Lymphangiogenesis With Implantation of Adipose‐Derived Regenerative Cells
Shimizu, Y., Shibata, R., Shintani, S., Ishii, M., & Murohara, T. (2012) · Journal of the American Heart Association · doi:10.1161/jaha.112.000877 · Cited by 73
Shear stress: An essential driver of endothelial progenitor cells
Кутихин, А. Г., Sinitsky, M. Y., Yuzhalin, A. E., & Velikanova, E. A. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.03.007 · Cited by 72
Lymphatic development in mouse small intestine
Kim, K. E., Sung, H., & Koh, G. Y. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21200 · Cited by 71
Self-citation
Deciphering the Dynamic Transcriptional and Post-transcriptional Networks of Macrophages in the Healthy Heart and after Myocardial Injury
Walter, W., Alonso-Herranz, L., Trappetti, V., Crespo, I., Ibberson, M. R., Cedenilla, M., Karaszewska, A., Núñez, V., Xénarios, I., Arroyo, A. G., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.029 · Cited by 71
Emerging role of estrogen in the control of cardiometabolic disease
Cignarella, A., Kratz, M., & Bolego, C. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.01.001 · Cited by 74
IL-10 Indirectly Regulates Corneal Lymphangiogenesis and Resolution of Inflammation via Macrophages
Hos, D., Bucher, F., Regenfuß, B., Dreisow, M.-L., Bock, F., Heindl, L. M., Eming, S. A., & Cursiefen, C. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.09.012 · Cited by 70
Intravital two-photon microscopy of lymphatic vessel development and function using a transgenic Prox1 promoter-directed mOrange2 reporter mouse
Hägerling, R., Pollmann, C., Kremer, L., Andresen, V., & Kiefer, F. (2011) · Biochemical Society Transactions · doi:10.1042/bst20110722 · Cited by 69
Vascular Endothelial Growth Factor–D (VEGF-D) Overexpression and Lymphatic Expansion in Murine Adipose Tissue Improves Metabolism in Obesity
Chakraborty, A., Barajas, S., Lammoglia, G. M., Reyna, A. J., Morley, T. S., Johnson, J. A., Scherer, P. E., & Rutkowski, J. M. (2019) · American Journal Of Pathology · doi:10.1016/j.ajpath.2018.12.008 · Cited by 64
Imaging White Adipose Tissue with Confocal Microscopy
Martinez-Santibañez, G., Cho, K. W., & Lumeng, C. N. (2014) · Methods in Enzymology · doi:10.1016/b978-0-12-411619-1.00002-1 · Cited by 64
Angiogenic Deficiency and Adipose Tissue Dysfunction Are Associated with Macrophage Malfunction in SIRT1−/− Mice
Xu, F. L., Burk, D. H., Gao, Z., Yin, J., Zhang, X., Weng, J., & Ye, J. (2012) · Endocrinology · doi:10.1210/en.2011-1667 · Cited by 67
Inflammation: a way to understanding the evolution of portal hypertension
Aller, M., Arias, J.-L., Cruz, A., & Árias, J. (2007) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-4-44 · Cited by 63
Neuropilin-1 expression in adipose tissue macrophages protects against obesity and metabolic syndrome
Wilson, A. M., Shao, Z., Grenier, V., Mawambo, G., Daudelin, J., Dejda, A., Pilon, F., Popović, N., Boulet, S., Parinot, C., et al. (2018) · Science Immunology · doi:10.1126/sciimmunol.aan4626 · Cited by 65
Obesity, Adipose Tissue, and Inflammation Answered in Questions
Guerreiro, V. A., Carvalho, D. M., & Freitas, P. (2022) · Journal of Obesity · doi:10.1155/2022/2252516 · Cited by 73
LYVE-1 + Macrophages Form a Collaborative CCR5-Dependent Perivascular Niche That Influences Chemotherapy Responses in Cancer
Anstee, J. E., Feehan, K. T., Opzoomer, J. W., Dean, I., Muller, H. P., Bahri, M., Cheung, T. S., Liakath‐Ali, K., Liu, Z., Choy, D., et al. (2022) · Developmental Cell · doi:10.1016/j.devcel.2023.06.006 · Cited by 67
Blood Vessel Formation and Bone Regeneration Potential of the Stromal Vascular Fraction Seeded on a Calcium Phosphate Scaffold in the Human Maxillary Sinus Floor Elevation Model
Farré-Guasch, E., Bravenboer, N., Helder, M. N., Schulten, E. A. J. M., Bruggenkate, C. M. T., & Klein‐Nulend, J. (2018) · Materials · doi:10.3390/ma11010161 · Cited by 64
Functional analyses reveal the greater potency of preadipocytes compared with adipocytes as endothelial cell activator under normoxia, hypoxia, and TNFα exposure
Mack, I., BelAiba, R. S., Djordjevic, T., Görlach, A., Hauner, H., & Bader, B. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90851.2008 · Cited by 63
Isolation of Murine Adipose Tissue-derived Microvascular Fragments as Vascularization Units for Tissue Engineering
Frueh, F. S., Später, T., Scheuer, C., Menger, M. D., & Laschke, M. W. (2017) · Journal of Visualized Experiments · doi:10.3791/55721 · Cited by 60
Activation of PPARγ induces profound multilocularization of adipocytes in adult mouse white adipose tissues
Koh, Y. J., Park, B., Park, J., Han, J., Lee, I., Park, J., & Koh, G. Y. (2009) · Experimental & Molecular Medicine · doi:10.3858/emm.2009.41.12.094 · Cited by 63
Self-citation
Adipose Tissue Lymphocytes and Macrophages in Obesity and Insulin Resistance: Makers or Markers, and Which Comes First?
Bouloumié, A., Casteilla, L., & Lafontan, M. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.168229 · Cited by 57
The Evolving Roles of Cardiac Macrophages in Homeostasis, Regeneration, and Repair
Alvarez‐Argote, S., & O'Meara, C. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157923 · Cited by 57
Macrophage depletion induces edema through release of matrix-degrading proteases and proteoglycan deposition
Bissinger, S., Hage, C., Wagner, V., Maser, I.-P., Brand, V. B., Schmittnaegel, M., Jegg, A.-M., Cannarile, M. A., Watson, C., Klaman, I., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abd4550 · Cited by 56
Control of Adipose Tissue Expandability in Response to High Fat Diet by the Insulin-like Growth Factor-binding Protein-4
Gealekman, O., Gurav, K., Chouinard, M., Straubhaar, J., Thompson, M. J., Malkani, S., Hartigan, C., & Corvera, S. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.545798 · Cited by 55
VISTA Targeting of T-cell Quiescence and Myeloid Suppression Overcomes Adaptive Resistance
Schaafsma, E., Croteau, W., ElTanbouly, M. A., Nowak, E. C., Smits, N. C., Deng, J., Sarde, A., Webber, C. A., Rabadi, D., Cheng, C., et al. (2022) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-22-0116 · Cited by 52
Blocking high-fat diet-induced obesity, insulin resistance and fatty liver by overexpression of Il-13 gene in mice
Darkhal, P., Gao, M., Ma, Y., & Liu, D. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.52 · Cited by 53
Hypertrophied human adipocyte spheroids as in vitro model of weight gain and adipose tissue dysfunction
Ioannidou, A., Alatar, S., Schipper, R., Baganha, F., Åhlander, M., Hornell, A., Fisher, R. M., & Hagberg, C. E. (2021) · The Journal of Physiology · doi:10.1113/jp281445 · Cited by 58
Adipose tissue plasticity and the pleiotropic roles of BMP signaling
Qian, S., Tang, Y., & Tang, Q. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100678 · Cited by 56
Macrophage-Mediated Tissue Vascularization: Similarities and Differences Between Cornea and Skin
Hadrian, K., Willenborg, S., Bock, F., Cursiefen, C., Eming, S., & Hos, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.667830 · Cited by 44
The relationship between inflammatory markers, angiogenesis, and obesity.
Tahergorabi, Z., & Khazaei, M. (2013) · Europe PMC (PubMed Central) · Cited by 46
Link between Adipose Tissue Angiogenesis and Fat Accumulation in Severely Obese Subjects
Lemoine, A. Y., Ledoux, S., Quéguiner, I., Caldérari, S., Mechler, C., Msika, S., Corvol, P. L., & Larger, É. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2649 · Cited by 47
Lymphatic Vascularisation and Involvement of Lyve-1+ Macrophages in the Human Onchocerca Nodule
Attout, T., Hoerauf, A. M., Dénécé, G., Debrah, A. Y., Marfo‐Debrekyei, Y., Boussinesq, M., Wanji, S., Martinez, V., Mand, S., Adjei, O., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008234 · Cited by 46
Signaling of Prostaglandin E Receptors, EP3 and EP4 Facilitates Wound Healing and Lymphangiogenesis with Enhanced Recruitment of M2 Macrophages in Mice
Hosono, K., Isonaka, R., Kawakami, T., Narumiya, S., & Majima, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162532 · Cited by 46
An overview of lymphatic vessels and their emerging role in cardiovascular disease
Jones, D., & Wang, M. (2011) · Journal of Cardiovascular Disease Research · doi:10.4103/0975-3583.85260 · Cited by 46
Therapeutic Assessment of Cytochrome C for the Prevention of Obesity Through Endothelial Cell-targeted Nanoparticulate System
Hossen, M. N., Kajimoto, K., Akita, H., Hyodo, M., Ishitsuka, T., & Harashima, H. (2013) · Molecular Therapy · doi:10.1038/mt.2012.256 · Cited by 44
Anticancer effects of metformin on neuroendocrine tumor cells in vitro
Vlotides, G., Tanyeri, A., Spampatti, M. P., Zitzmann, K., Chourdakis, M., Spöttl, G., Maurer, J., Nölting, S., Göke, B., & Auernhammer, C. J. (2014) · HORMONES · doi:10.14310/horm.2002.1517 · Cited by 47
Cellular and molecular mechanisms in vascular repair after traumatic brain injury: a narrative review
Zhao, Z., Yan, L., Wen, J., Satyanarayanan, S. K., Feng, Y., Lu, J., Liu, Y., & Su, H. (2023) · Burns & Trauma · doi:10.1093/burnst/tkad033 · Cited by 45
Single‐cell RNA sequencing reveals the induction of novel myeloid and myeloid‐associated cell populations in visceral fat with long‐term obesity
Harasymowicz, N. S., Rashidi, N., Savadipour, A., Wu, C., Tang, R., Bramley, J. C., Buchser, W., & Guilak, F. (2021) · The FASEB Journal · doi:10.1096/fj.202001970r · Cited by 41
Increased Expression of miR-483-3p Impairs the Vascular Response to Injury in Type 2 Diabetes
Kuschnerus, K., Strässler, E. T., Müller, M. F., Lüscher, T. F., Landmesser, U., & Kränkel, N. (2018) · Diabetes · doi:10.2337/db18-0084 · Cited by 42
Endothelial cell crosstalk improves browning but hinders white adipocyte maturation in 3D engineered adipose tissue
Hammel, J. H., & Bellas, E. (2020) · Integrative Biology · doi:10.1093/intbio/zyaa006 · Cited by 41
Bonghan System as Mesenchymal Stem Cell Niches and Pathways of Macrophages in Adipose Tissues
Lee, B.-C., Bae, K.-H., Jhon, G., & Soh, K. (2009) · Journal of Acupuncture and Meridian Studies · doi:10.1016/s2005-2901(09)60020-0 · Cited by 40
Increased adipose tissue hypoxia and capacity for angiogenesis and inflammation in young diet-sensitive C57 mice compared with diet-resistant FVB mice
Kim, D.-H., Gutiérrez‐Aguilar, R., Kim, H.-J., Woods, S. C., & Seeley, R. J. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.141 · Cited by 42
Pro-inflammatory macrophages coupled with glycolysis remodel adipose vasculature by producing platelet-derived growth factor-B in obesity
Onogi, Y., Wada, T., Okekawa, A., Matsuzawa, T., Watanabe, E., Ikeda, K., Nakano, M., Kitada, M., Koya, D., Tsuneki, H., et al. (2020) · Scientific Reports · doi:10.1038/s41598-019-57368-w · Cited by 39
Isolation and culture of microvascular endothelial cells from murine inguinal and epididymal adipose tissues
Kajimoto, K., Hossen, M. N., Hida, K., Ohga, N., Akita, H., Hyodo, M., Hida, Y., & Harashima, H. (2010) · Journal of Immunological Methods · doi:10.1016/j.jim.2010.03.011 · Cited by 37
Immunohistochemical Examination on the Distribution of Cells Expressed Lymphatic Endothelial Marker Podoplanin and LYVE-1 in the Mouse Tongue Tissue
Noda, Y., Amano, I., Hata, M., Kojima, H., & Sawa, Y. (2010) · ACTA HISTOCHEMICA ET CYTOCHEMICA · doi:10.1267/ahc.10008 · Cited by 37
Vascular endothelial growth factors signalling in normal human dental pulp: a study of gene and protein expression
Virtej, A., Løes, S., Iden, O., Bletsa, A., & Berggreen, E. (2013) · European Journal Of Oral Sciences · doi:10.1111/eos.12019 · Cited by 37
Identification of Lyve‐1 positive macrophages as resident cells in meninges of rats
Brezováková, V., & Jadhav, S. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.24870 · Cited by 36
Role of lymphatic endothelial cells in the tumor microenvironment—a narrative review of recent advances
He, M., He, Q., Cai, X., Chen, Z., Lao, S., Deng, H., Liu, X., Zheng, Y., Liu, X., Liu, J., et al. (2021) · Translational Lung Cancer Research · doi:10.21037/tlcr-21-40 · Cited by 37
Kinetics of LYVE-1-positive M2-like macrophages in developing and repairing dental pulp in vivo and their pro-angiogenic activity in vitro
Kieu, T. Q., Tazawa, K., Kawashima, N., Noda, S., Fujii, M., Nara, K., Hashimoto, K., Han, P., & Okiji, T. (2022) · Scientific Reports · doi:10.1038/s41598-022-08987-3 · Cited by 40
Potential functions of embryonic cardiac macrophages in angiogenesis, lymphangiogenesis and extracellular matrix remodeling
Gula, G., Rumiński, S., Niderla‐Bielińska, J., Jasińska-Nowacka, A., Kiernozek, E., Jankowska-Steifer, E. A., Flaht‐Zabost, A., & Ratajska, A. (2020) · Histochemistry and Cell Biology · doi:10.1007/s00418-020-01934-1 · Cited by 36
Septal LYVE1 + macrophages control adipocyte stem cell adipogenic potential
Yu, X., Hu, Y., Lim, H. Y., Li, Z., Jaitin, D. A., Yang, K. L., Kong, W. T., Xu, J., Bejarano, D. A., Bied, M., et al. (2025) · Science · doi:10.1126/science.adg1128 · Cited by 35
TM4SF19-mediated control of lysosomal activity in macrophages contributes to obesity-induced inflammation and metabolic dysfunction
Choi, C., Jeong, Y. L., Park, K.-M., Kim, M., Kim, S., Jo, H., Lee, S., Kim, H., Choi, G., Choi, Y. H., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47108-8 · Cited by 37
The Advanced Glycation End-Products (AGE)–Receptor for AGE System (RAGE): An Inflammatory Pathway Linking Obesity and Cardiovascular Diseases
Vianello, E., Beltrami, A. P., Aleksova, A., Janjusevic, M., Fluca, A. L., Romanelli, M. M. C., Sala, L. L., & Dozio, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083707 · Cited by 43
Myeloid Heme Oxygenase-1 Haploinsufficiency Reduces High Fat Diet-Induced Insulin Resistance by Affecting Adipose Macrophage Infiltration in Mice
Huang, J., Chiang, M., Yet, S., & Chau, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038626 · Cited by 33
Peritumoral adipose tissue as a source of inflammatory and angiogenic factors in colorectal cancer
Amor, S., de la Cruz, M. D. C. I., Ferrero, E., García-Villar, O., Barrios, V., Fernández, N., Monge, L., Garcı́a-Villalón, Á. L., & Granado, M. (2015) · International Journal of Colorectal Disease · doi:10.1007/s00384-015-2420-6 · Cited by 31
Intramuscular VEGF activates an SDF1-dependent progenitor cell cascade and an SDF1-independent muscle paracrine cascade for cardiac repair
Zisa, D. C., Shabbir, A., Mastri, M., Taylor, T., Aleksić, I., McDaniel, M., Suzuki, G., & Lee, T. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00343.2011 · Cited by 33
Effects of the roughage/concentrate ratio on the expression of angiogenic growth factors in adipose tissue of fattening Wagyu steers
Yamada, T., & Nakanishi, N. (2011) · Meat Science · doi:10.1016/j.meatsci.2011.11.019 · Cited by 32
VEGFR2 signaling drives meningeal vascular regeneration upon head injury
Koh, B. I., Lee, H. J., Kwak, P. A., Yang, M. J., Kim, J., Kim, H.-S., Koh, G. Y., & Kim, I. (2020) · Nature Communications · doi:10.1038/s41467-020-17545-2 · Cited by 30
Self-citation
Regulation of systemic metabolism by tissue-resident immune cell circuits
Li, J. H., Hepworth, M. R., & O’Sullivan, T. E. (2023) · Immunity · doi:10.1016/j.immuni.2023.05.001 · Cited by 36
Inhibition of tumor formation and metastasis by a monoclonal antibody against lymphatic vessel endothelial hyaluronan receptor 1
Hara, Y., Torii, R., Ueda, S., Kurimoto, E., Ueda, E., Okura, H., Tatano, Y., Yagi, H., Ohno, Y., Tanaka, T. T., et al. (2018) · Cancer Science · doi:10.1111/cas.13755 · Cited by 31
Effect of soluble Jagged1-mediated inhibition of Notch signaling on proliferation and differentiation of an adipocyte progenitor cell model
Urs, S., Turner, B., Tang, Y., Rostama, B., Small, D. J., & Liaw, L. (2012) · Adipocyte · doi:10.4161/adip.19186 · Cited by 31
Adipose Tissue Angiogenesis Assay
Rojas-Rodriguez, R., Gealekman, O., Kruse, M. E., Rosenthal, B., Rao, K., Min, S., Bellve, K. D., Lifshitz, L. M., & Corvera, S. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-411619-1.00005-7 · Cited by 31
Immunosuppressive Tumor Microenvironment of Osteosarcoma
Taylor, A. M., Sheng, J., Ng, P. K. S., Harder, J. M., Kumar, P., Ahn, J. Y., Cao, Y., Dzis, A. M., Jillette, N., Goodspeed, A. E., et al. (2025) · Cancers · doi:10.3390/cancers17132117 · Cited by 38
Blockade of Lymphangiogenesis Shapes Tumor-Promoting Adipose Tissue Inflammation
Wagner, M., Steinskog, E. S. S., & Wiig, H. (2019) · American Journal Of Pathology · doi:10.1016/j.ajpath.2019.06.010 · Cited by 27
Role of innate immune cells in metabolism: from physiology to type 2 diabetes
Dalmas, É. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00736-5 · Cited by 28
Fat Depot-Specific Differences in Angiogenic Growth Factor Gene Expression and Its Relation to Adipocyte Size in Cattle
Yamada, T., KAWAKAMI, S.-I., & NAKANISHI, N. (2010) · Journal of Veterinary Medical Science · doi:10.1292/jvms.10-0031 · Cited by 27
Transplantation of Normal Adipose Tissue Improves Blood Flow and Reduces Inflammation in High Fat Fed Mice With Hindlimb Ischemia
Chen, L., Wang, L., Li, Y., Wuang, L., Liu, Y., Pang, N., Luo, Y., He, J., Zhang, L., Chen, N., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00197 · Cited by 26
Characterization of the dental lymphatic system and identification of cells immunopositive to specific lymphatic markers
Berggreen, E., Haug, S. R., Mkonyi, L. E., & Bletsa, A. (2009) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.2008.00592.x · Cited by 26
Lymphatic Endothelial Cell Progenitors in the Tumor Microenvironment
Ran, S., & Volk-Draper, L. D. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-37184-5_7 · Cited by 27
Cellular phenotypes and spatio‐temporal patterns of lymphatic vessel development in embryonic mouse hearts
Flaht‐Zabost, A., Jankowska-Steifer, E. A., Radomska-Leśniewska, D. M., Madej, M., Gula, G., Kujawa, M., & Ratajska, A. (2012) · Developmental Dynamics · doi:10.1002/dvdy.23827 · Cited by 25
Macrophages in Atheromatous Plaque Developmental Stages
von Ehr, A., Bode, C., & Hilgendorf, I. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.865367 · Cited by 24
Obesity and dysregulated central and peripheral macrophage–neuron cross‐talk
Boura‐Halfon, S., Pecht, T., Jung, S., & Rudich, A. (2018) · European Journal of Immunology · doi:10.1002/eji.201747389 · Cited by 24
MRC1 and LYVE1 expressing macrophages in vascular beds of GNAQ p.R183Q driven capillary malformations in Sturge Weber syndrome
Nasim, S., Bichsel, C. A., Dayneka, S., Mannix, R. J., Holm, A., Vivero, M. P., Alexandrescu, S., Pinto, A., Greene, A. K., Ingber, D. E., et al. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01757-4 · Cited by 23
Exercise training regulates angiogenic gene expression in white adipose tissue
Lee, H. J. (2018) · Journal of Exercise Rehabilitation · doi:10.12965/jer.1836010.005 · Cited by 22
Endothelial cell-derived stem cell factor promotes lipid accumulation through c-Kit-mediated increase of lipogenic enzymes in brown adipocytes
Lee, H. J., Lee, J., Yang, M. J., Kim, Y. C., Hong, S. P., Kim, J. M., Hwang, G., & Koh, G. Y. (2023) · Nature Communications · doi:10.1038/s41467-023-38433-5 · Cited by 23
Self-citation
Functional improvement of an IRQ-PEG-MEND for delivering genes to the lung
Ishitsuka, T., Akita, H., & Harashima, H. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.05.012 · Cited by 23
Lipedema: A Disease Triggered by M2 Polarized Macrophages?
Grewal, T., Kempa, S., & Buechler, C. (2025) · Biomedicines · doi:10.3390/biomedicines13030561 · Cited by 22
CX3CR1hi macrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue
Zhou, Z., Zhang, H., Tao, Y., Jie, H., Zhao, J., Zang, J., Li, H., Wang, Y., Wang, T., Zhao, H., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112424 · Cited by 24
Emerging Advancements in Metabolic Properties of Macrophages within Disease Microenvironment for Immune Therapy
Zhao, F., Yue, Z., Zhang, L., Qi, Y., Sun, Y., Wang, S., & Tian, Q. (2025) · Journal of Innate Immunity · doi:10.1159/000546476 · Cited by 23
Macrophage mediators and mechanisms in cardiovascular disease
Schelemei, P., Wagner, E., Picard, F. S. R., & Winkels, H. (2024) · The FASEB Journal · doi:10.1096/fj.202302001r · Cited by 23
Expression of Lymphatic Markers in the Adult Rat Spinal Cord
Kaser-Eichberger, A., Schroedl, F., Bieler, L., Trost, A., Bogner, B., Runge, C., Tempfer, H., Zaunmair, P., Kreutzer, C., Traweger, A., et al. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00023 · Cited by 20
Lesson on obesity and anatomy of adipose tissue: new models of study in the era of clinical and translational research
Luca, T., Pezzino, S., Puleo, S., & Castorina, S. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05547-3 · Cited by 19
Interactions of monocytes and platelets implication for life
Reuter, S. (2014) · Frontiers in Bioscience-Scholar · doi:10.2741/s416 · Cited by 19
Adipocyte-endothelial cell interplay in adipose tissue physiology
Chaurasiya, V., Haridas, P. A. N., & Olkkonen, V. M. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116081 · Cited by 20
Characterizing Lymphangiogenesis and Concurrent Inflammation in Adipose Tissue in Response to VEGF-D
Chakraborty, A., Scogin, C., Rizwan, K., Morley, T. S., & Rutkowski, J. M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00363 · Cited by 18
Phytochemicals as Modulators of PPARs and RXRs
Ko, J. K.-S., Lee, S. S., & Martin, H. (2010) · PPAR Research · doi:10.1155/2010/407650 · Cited by 20
Visualization of 3D White Adipose Tissue Structure Using Whole-mount Staining
Jiang, Y., Yeung, J., Lee, J. H., An, J., Steadman, P. E., Kim, J., & Sung, H. (2018) · Journal of Visualized Experiments · doi:10.3791/58683 · Cited by 17
Self-citation
Understanding the heterogeneity and functions of metabolic tissue macrophages
Grosjean, A., Venteclef, N., & Dalmas, É. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.09.002 · Cited by 18
Physiological Perspective on Therapies of Lymphatic Vessels
Kilarski, W. W. (2018) · Advances in Wound Care · doi:10.1089/wound.2017.0768 · Cited by 19
Life span of monocytes and platelets: importance of interactions
Reuter, S. (2009) · Frontiers in bioscience · doi:10.2741/3388 · Cited by 17
Capturing the multifaceted function of adipose tissue macrophages
Matz, A. J., Qu, L., Karlinsey, K., Vella, A. T., & Zhou, B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1148188 · Cited by 16
3-D reconstruction and multiple marker analysis of mouse proepicardial endothelial cell population
Niderla‐Bielińska, J., Gula, G., Flaht‐Zabost, A., Jankowska-Steifer, E. A., Czarnowska, E., Radomska-Leśniewska, D. M., Ciszek, B., & Ratajska, A. (2015) · Microvascular Research · doi:10.1016/j.mvr.2015.08.007 · Cited by 15
Fat and inflammation: adipocyte-myeloid cell crosstalk in atherosclerosis
Mazitova, A., Márquez-Sánchez, A. C., & Koltsova, E. K. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1238664 · Cited by 17
Lymphangiogenesis, myeloid cells and inflammation
Xing, L., & Ji, R.-C. (2008) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.4.5.599 · Cited by 14
Endothelial-specific depletion of TGF-β signaling affects lymphatic function
Fukasawa, K., Hanada, K., Ichikawa, K., Hirashima, M., Takagi, T., Itoh, S., Watabe, T., & Itoh, F. (2021) · Inflammation and Regeneration · doi:10.1186/s41232-021-00185-4 · Cited by 15
Role of Distinct Fat Depots in Metabolic Regulation and Pathological Implications
Sahu, B., Tikoo, O., Pati, B., Senapati, U., & Bal, N. C. (2022) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2022_73 · Cited by 15
Systems Biology Will Direct Vascular-Targeted Therapy for Obesity
Fang, Y., Kaszuba, T., & Imoukhuede, P. I. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00831 · Cited by 13
Ablation of 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) in Vascular Endothelial Cells Enhances Insulin Sensitivity by Reducing Visceral Fat and Suppressing Angiogenesis
Tawaramoto, K., Kotani, K., Hashiramoto, M., Kanda, Y., Nagare, T., Sakaue, H., Ogawa, W., Emoto, N., Yanagisawa, M., Noda, T., et al. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0412 · Cited by 14
Role of Epicardial Adipose Tissue Secretome on Cardiovascular Diseases
Leo, S., Tremoli, E., Ferroni, L., & Zavan, B. (2023) · Biomedicines · doi:10.3390/biomedicines11061653 · Cited by 15
Dynamic Roles and Expanding Diversity of Adipose Tissue Macrophages in Obesity
Soedono, S., Julietta, V., Nawaz, H., & Cho, K. W. (2024) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes24030 · Cited by 16
Lymphatic markers in the human optic nerve
Trost, A., Runge, C., Bruckner, D., Kaser-Eichberger, A., Bogner, B., Strohmaier, C., Reitsamer, H. A., & Schroedl, F. (2018) · Experimental Eye Research · doi:10.1016/j.exer.2018.05.001 · Cited by 13
Obesity, Diabetes and Metabolic Syndrome Impact on Tumor Angiogenesis
Incio, J., & Soares, R. (2013) · CRC Press eBooks · doi:10.1201/b14842-13 · Cited by 13

Authors: Cho, C.-H., Jun Koh, Y., Han, J., Sung, H.-K., Jong Lee, H., Morisada, T., Schwendener, R. A., Brekken, R. A., Kang, G., Oike, Y., Choi, T.-S., Suda, T., Yoo, O.-J., & Koh, G. Y.
Affiliations: Korea Advanced Institute of Science and Technology (KR)
From the National Research Laboratory of Vascular Biology and Department of Biological Sciences (C-H.C., Y.J.K., J.H., H-K. S., H.J.L., O-J.Y., G.Y.K.), Korea Advanced Institute of Science and Technology, Daejeon, Korea; Department of Cell Differentiation (T.M.,Y.O., T.S.), The Sakaguchi Laboratory, Keio University Internal Medicine, Tokyo, Japan; Laboratory of Liposome Research (R.A.S.), Institute of Molecular Cancer Research, University of Zurich, Switzerland; Departments of Surgery and...
ORCID: Cho, Chung-Hyun
Sung, Hoon-Ki
Morisada, Tohru
Schwendener, Reto A.
Brekken, Rolf A.
Kang, Guson
Oike, Yuichi
Suda, Toshio
Koh, Gou Young
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2007-03-02
Volume: 100
Issue: 4
Pages: e47-57
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/01.res.0000259564.92792.93
OpenAlex: W2150586369
Cited by: 309
References: 64
Citations by year: 2026: 8 · 2025: 14 · 2024: 30 · 2023: 13 · 2022: 19 · 2021: 19 · 2020: 13 · 2019: 12 · 2018: 19 · 2017: 7 · 2016: 12 · 2015: 10 · 2014: 14 · 2013: 27 · 2012: 14
FWCI: 7.81
Type: journal article
Language: en
Open access: green
www.zora.uzh.ch
Licence: other-oa
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
Zurich Open Repository and Archive (University of Zurich)
Funders: Korea Advanced Institute of Science and Technology
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: adipose tissue angiogenesis, epididymal adipose tissue, adipogenesis, macrophage recruitment, CXCL12, VEGF/VEGFR2 signaling, matrix metalloproteinases, hypoxia, bone marrow-derived macrophages
MeSH terms: Adipose Tissue, Animals, Cell Movement, Epididymis, Glycoproteins, Macrophages, Male, Mice, Inbred C57BL, Mice, Knockout, Gene Expression Regulation, Developmental, Neovascularization, Physiologic, Membrane Transport Proteins, Adipogenesis, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Angiogenic Role of LYVE-1–Positive Macrophages in Adipose Tissue

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks