Long-term neuroblast migration along blood vessels in an area with transient angiogenesis and increased vascularization after stroke
Abstract
Background and Purpose— Stroke induced by middle cerebral artery occlusion (MCAO) causes long-term formation of new striatal neurons from stem/progenitor cells in the subventricular zone (SVZ). We explored whether MCAO leads to hypoxia, changes in vessel density, and angiogenesis in the ipsilateral SVZ and adjacent striatum, and determined the relation between the migrating neuroblasts and the vasculature. Methods— Adult rats were subjected to 2 hours of MCAO. Hypoxia was studied by injecting Hypoxyprobe-1 during MCAO or 6 weeks later. Vessel density and length was estimated using stereology. New cells were labeled with 5′-bromo-2′deoxyuridine (BrdU) during weeks 1 and 2 or 7 and 8 after MCAO, and angiogenesis was assessed immunohistochemically with antibodies against BrdU and endothelial cell markers. Distance from neuroblasts to nearest vessel was measured using confocal microscopy. Results— The ischemic insult caused transient hypoxia and early, low-grade angiogenesis, but no damage or increase of vascular density in the SVZ. Angiogenesis was detected during the first 2 weeks in the dorsomedial striatum adjacent to the SVZ, which also showed long-lasting increase of vascularization. At 2, 6, and 16 weeks after MCAO, the majority of neuroblasts migrated through this area toward the damage, closely associated with blood vessels. Conclusions— The vasculature plays an important role for long-term striatal neurogenesis after stroke. During several months, neuroblasts migrate close to blood vessels through an area exhibiting early vascular remodeling and persistently increased vessel density. Optimizing vascularization should be an important strategy to promote neurogenesis and repair after stroke.
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The finding that neural precursor cells prevent ischaemic injury and promote neurological recovery could be attributed to bystander effects from interaction of neuroblasts with microvasculature near the lesion, creating an environment that promotes brain remodelling.
“The finding that neural precursor cells prevent ischaemic injury and promote neurological recovery could be attributed to bystander effects related to the interaction of neuroblasts with the microvasculature in the vicinity of the ischaemic lesion, which creates an environment that promotes brain remodelling (figure 2).14,15,37,45”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [37]
After stroke, neural precursor cells proliferate and migrate toward the ischaemic lesion, propagating in chains along blood vessels.
“When a stroke occurs, these cells proliferate and migrate in the direction of the ischaemic lesion, propagating in chains along blood vessels.37,38”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [37]
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- Authors
- Thored, P., Wood, J., Arvidsson, A., Cammenga, J., Kokaia, Z., & Lindvall, O.
- Affiliations
- From Laboratory of Neurogenesis and Cell Therapy (P.T., J.W., A.A., O.L.), Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden; Laboratory of Gene Therapy and Molecular Medicine (J.C.), Wallenberg Neuroscience Center, University Hospital, Lund, Sweden; Laboratory of Neural Stem Cell Biology (Z.K.), Section of Restorative Neurology, University Hospital, Lund, Sweden; Lund Strategic Research Center for Stem Cell Biology and Cell Therapy (P.T., J.W., A.A....
- Lund University (SE)
- Venue
- Stroke
- Published
- 2007-11
- Volume
- 38
- Issue
- 11
- Pages
- 3032-3039
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2134717451
- Cited by
- 421
- References
- 34
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 14 · 2023: 13 · 2022: 13 · 2021: 22 · 2020: 16 · 2019: 22 · 2018: 23 · 2017: 31 · 2016: 23 · 2015: 24 · 2014: 32 · 2013: 30 · 2012: 40
- FWCI
- 7.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Stiftelsen för Strategisk Forskning
- Vetenskapsrådet
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- neuroblast migration, angiogenesis, subventricular zone, striatal neurogenesis, middle cerebral artery occlusion, hypoxia, vascular remodeling, vessel density
- MeSH terms
- Animals, Cell Count, Cell Differentiation, Cell Movement, Cells, Cultured, Hypoxia, Brain, Cerebral Arteries, Corpus Striatum, Disease Models, Animal, Male, Nerve Regeneration, Neuronal Plasticity, Neurons, Stem Cells, Telencephalon, Time Factors, Rats, Wistar, Disease Progression, Neovascularization, Physiologic, Recovery of Function, Infarction, Middle Cerebral Artery, Stroke, Lateral Ventricles, Cell Proliferation, Rats
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