Recovery recapitulates ontogeny
Abstract
Several studies support the hypothesis that after stroke, specific features of brain function revert to those seen at an early stage of development, with the subsequent process of recovery recapitulating ontogeny in many ways. Many clinical characteristics of stroke recovery resemble normal development, particularly in the motor system. Consistent with this, brain-mapping studies after an ischemic insult suggest re-emergence of childhood organizational patterns: recovery being associated with a return to adult patterns. Experimental animal studies demonstrate increased levels of developmental proteins, particularly in the area surrounding an infarct, suggesting an active process of reconditioning in response to cerebral ischemia. Understanding the patterns of similarity between normal development and stroke recovery might be of value in its treatment.
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The injured brain exhibits a re-emergence of childhood organisational patterns, reminiscent of an ontogenetic state.
“Thus, the injured brain exhibits a re-emergence of childhood organisational patterns, reminiscent of an ontogenetic state.5”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [5]
Neural surface receptors integrate signals with diverse functions, such as neuronal injury and repair, and depending on pathophysiological context could have Janus-like roles in the ischaemic brain.
“Neural surface receptors integrate signals with diverse functions, such as neuronal injury and repair,96 which depending on the pathophysiological context could have Janus-like roles in the ischaemic brain.5,100”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [5]
In view of the Janus-like role of brain-repair signals for neuronal injury, initiating neurorestorative therapies in the very acute phase of stroke would probably induce more undesirable effects than treatment in the very late (chronic) phase.
“In view of the Janus-like role of brain-repair signals for neuronal injury,5,100 the initiation of neurorestorative therapies in the very acute phase of stroke would probably induce more undesirable effects than would treatment in the very late (chronic) phase.”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [5]
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- Cramer, S. C., & Chopp, M.
- Affiliations
- University of Washington (US)
- Henry Ford Health (US)
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2000-06
- Volume
- 23
- Issue
- 6
- Pages
- 265-271
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2001908895
- Cited by
- 326
- References
- 86
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 8 · 2021: 7 · 2020: 9 · 2019: 14 · 2018: 8 · 2017: 9 · 2016: 12 · 2015: 13 · 2014: 20 · 2013: 14 · 2012: 22
- FWCI
- 3.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k08hd001213-05, 5r01ns033627-08)
- National Institute of Neurological Disorders and Stroke (P01NS23393, R01NS-33627, P01NS023393)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K08 HD1213)
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- stroke recovery, brain development, cerebral ischemia, motor recovery
- MeSH terms
- Stroke Rehabilitation, Adult, Animals, Brain, Child, Humans, Recovery of Function, Stroke
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