Internalization of Exosomes through Receptor-Mediated Endocytosis

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

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Extracellular vesicles: Exosomes, microvesicles, and friends

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Molecular Biology of the Cell

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Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids

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Tumour exosome integrins determine organotropic metastasis

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Regulated portals of entry into the cell

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Extracellular vesicles: biology and emerging therapeutic opportunities

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Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

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Routes and mechanisms of extracellular vesicle uptake

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Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

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Double-stranded DNA in exosomes: a novel biomarker in cancer detection

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Proteomic Analysis of Dendritic Cell-Derived Exosomes: A Secreted Subcellular Compartment Distinct from Apoptotic Vesicles

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Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

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Heparan Sulfate ProteoglycansPreprint

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Activated Platelets Release Two Types of Membrane Vesicles: Microvesicles by Surface Shedding and Exosomes Derived From Exocytosis of Multivesicular Bodies and -Granules

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The LDL Receptor

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Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes.

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Identification of Tim4 as a phosphatidylserine receptor

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Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells

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Tissue-factor–bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation

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Lipids in exosomes: current knowledge and the way forward

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Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

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Cellular Internalization of Exosomes Occurs Through Phagocytosis

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Microvesicles: mediators of extracellular communication during cancer progression

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Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

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Phagocytosis: An Immunobiologic Process

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Exosomes as new vesicular lipid transporters involved in cell–cell communication and various pathophysiologies

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Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

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Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

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Sorting it out: Regulation of exosome loading

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Exosome uptake through clathrin-mediated endocytosis and macropinocytosis and mediating miR-21 delivery

Tian, T., Zhu, Y.-L., Zhou, Y.-Y., Liang, G.-F., Wang, Y.-Y., Hu, F.-H., & Xiao, Z.-D. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.588046 · Cited by 726 · see citing works

Exosome-delivered microRNAs modulate the inflammatory response to endotoxin

Alexander, M., Hu, R., Runtsch, M. C., Kagele, D. A., Mosbruger, T. L., Tolmachova, T., Seabra, M. C., Round, J. L., Ward, D. M., & O’Connell, R. M. (2015) · Nature Communications · doi:10.1038/ncomms8321 · Cited by 707 · see citing works

Macropinocytosis: an endocytic pathway for internalising large gulps

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Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E

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Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

Svensson, K. J., Christianson, H. C., Wittrup, A., Bourseau-Guilmain, E., Lindqvist, E., Svensson, L. M., Mörgelin, M., & Belting, M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.445403 · Cited by 690 · see citing works

TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.

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Cell Surface Tetraspanin Tspan8 Contributes to Molecular Pathways of Exosome-Induced Endothelial Cell Activation

Nazarenko, I. A., Rana, S., Baumann, A., McAlear, J., Hellwig, A., Trendelenburg, M. F., Lochnit, G., Preissner, K. T., & Zöller, M. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2470 · Cited by 686 · see citing works

Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR

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Interaction and uptake of exosomes by ovarian cancer cells

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Molecular cell biology 3.0

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TCR Activation of Human T Cells Induces the Production of Exosomes Bearing the TCR/CD3/ζ Complex

Blanchard, N., Lankar, D., Faure, F., Regnault, A., Dumont, C., Raposo, G., & Hivroz, C. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3235 · Cited by 660 · see citing works

Molecular Biology of the Cell

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Protein Corona of Nanoparticles: Distinct Proteins Regulate the Cellular Uptake

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Emerging Roles of Exosomes in Normal and Pathological Conditions: New Insights for Diagnosis and Therapeutic Applications

Toro, J. D., Herschlik, L., Waldner, C., & Mongini, C. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00203 · Cited by 616 · see citing works

Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells

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TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity

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Exosomes and their roles in immune regulation and cancer

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Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain

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MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells

Okoye, I., Coomes, S. M., Pelly, V. S., Czieso, S., Papayannopoulos, V., Tolmachova, T., Seabra, M. C., & Wilson, M. S. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.019 · Cited by 604 · see citing works

Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor inhibiting HIF-1

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Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

Yuyama, K., Sun, H., Mitsutake, S., & Igarashi, Y. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.324616 · Cited by 591 · see citing works

Lipid rafts and membrane dynamics

Rajendran, L., & Simons, K. (2005) · Journal of Cell Science · doi:10.1242/jcs.01681 · Cited by 590 · see citing works

Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes

Park, J. E., Tan, H. S., Datta, A., Lai, R. C., Zhang, H., Meng, W., Lim, S. K., & Sze, S. K. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900381-mcp200 · Cited by 582 · see citing works

Exosomes and tumor-mediated immune suppression

Whiteside, T. L. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81136 · Cited by 570 · see citing works

Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells

Safaei, R., Larson, B. J., Cheng, T., Gibson, M. A., Otani, S., Naerdemann, W., & Howell, S. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0102 · Cited by 563 · see citing works

Cellular uptake of extracellular vesicles is mediated by clathrin-independent endocytosis and macropinocytosis

Verdera, H. C., Gitz-Francois, J. J., Schiffelers, R. M., & Vader, P. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.09.019 · Cited by 557 · see citing works

Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry

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Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells

van Balkom, B. W. M., de Jong, O. G., Smits, M., Brummelman, J., den Ouden, K., de Bree, P., van Eijndhoven, M. A. J., Pegtel, D. M., Stoorvogel, W., Wurdinger, T. D., et al. (2013) · Blood · doi:10.1182/blood-2013-02-478925 · Cited by 514 · see citing works

Proteomic Analysis of Exosomes from Mutant KRAS Colon Cancer Cells Identifies Intercellular Transfer of Mutant KRAS

Beckler, M. D., Higginbotham, J. N., Franklin, J. L., Ham, A. L., Halvey, P. J., Imasuen, I., Whitwell, C. A., Li, M., Liebler, D. C., & Coffey, R. J. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.022806 · Cited by 514 · see citing works

Two Distinct Populations of Exosomes Are Released from LIM1863 Colon Carcinoma Cell-derived Organoids

Tauro, B. J., Greening, D. W., Mathias, R. A., Mathivanan, S., Ji, H. L., & Simpson, R. J. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.021303 · Cited by 446 · see citing works

Activated T cells recruit exosomes secreted by dendritic cells via LFA-1

Hoen, E. N. M. N., Buschow, S. I., Anderton, S. M., Stoorvogel, W., & Wauben, M. H. M. (2008) · Blood · doi:10.1182/blood-2008-08-174094 · Cited by 436 · see citing works

Heparan sulfate proteoglycan as a cell-surface endocytosis receptor

Christianson, H. C., & Belting, M. (2014) · Matrix Biology · doi:10.1016/j.matbio.2013.10.004 · Cited by 429 · see citing works

Display of GPI‐anchored anti‐EGFR nanobodies on extracellular vesicles promotes tumour cell targeting

Kooijmans, S. A. A., Gomez‐Aleza, C., Roffler, S. R., van Solinge, W. W., Vader, P., & Schiffelers, R. M. (2016) · Journal of Extracellular Vesicles · doi:10.3402/jev.v5.31053 · Cited by 429 · see citing works

Exosome removal as a therapeutic adjuvant in cancer

Marleau, A. M., Chen, C.-S., Joyce, J. A., & Tullis, R. H. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-134 · Cited by 412 · see citing works

Exosome-mediated transfer of miR-10b promotes cell invasion in breast cancer

Singh, R., Pochampally, R. R., Watabe, K., Lü, Z., & Mo, Y. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-256 · Cited by 403 · see citing works

CD169 mediates the capture of exosomes in spleen and lymph node

Saunderson, S. C., Dunn, A. C., Crocker, P. R., & McLellan, A. D. (2013) · Blood · doi:10.1182/blood-2013-03-489732 · Cited by 396 · see citing works

Immune modulation of T-cell and NK (natural killer) cell activities by TEXs (tumour-derived exosomes)

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Efficient production and enhanced tumor delivery of engineered extracellular vesicles

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Exosomes Derived from Epstein-Barr Virus-Infected Cells Are Internalized via Caveola-Dependent Endocytosis and Promote Phenotypic Modulation in Target Cells

Nanbo, A., Kawanishi, E., Yoshida, R., & Yoshiyama, H. (2013) · Journal of Virology · doi:10.1128/jvi.01310-13 · Cited by 356 · see citing works

Adhesion and signaling by B cell‐derived exosomes: the role of integrins

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Tumor cell-derived exosomes: A message in a bottle

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Plasma-Derived Exosomal Survivin, a Plausible Biomarker for Early Detection of Prostate Cancer

Khan, S., Jutzy, J. M. S., Valenzuela, M. M. A., Turay, D., Aspe, J. R., Ashok, A., Mirshahidi, S., Mercola, D., Lilly, M. B., & Wall, N. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046737 · Cited by 331 · see citing works

Reticulocyte maturation and exosome release: transferrin receptor containing exosomes shows multiple plasma membrane functions

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Fibroblast-Derived Exosomes Contribute to Chemoresistance through Priming Cancer Stem Cells in Colorectal Cancer

Hu, Y.-B., Yan, C., Mu, L., Huang, K., Li, X.-L., Tao, D., Wu, Y.-Q., & Qin, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125625 · Cited by 328 · see citing works

Galectin-3 drives glycosphingolipid-dependent biogenesis of clathrin-independent carriers

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Endocytosis of gene delivery vectors: from clathrin-dependent to lipid raft-mediated endocytosis.

El-Sayed, A., & Harashima, H. (2013) · Molecular Therapy · doi:10.1038/mt.2013.54 · Cited by 319 · see citing works

Heparan sulfate proteoglycan as a plasma membrane carrier

Belting, M. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00031-8 · Cited by 312 · see citing works

Heparanase activates the syndecan-syntenin-ALIX exosome pathway

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Characterization and proteomic analysis of ovarian cancer-derived exosomes

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Exosomes secreted by cortical neurons upon glutamatergic synapse activation specifically interact with neurons

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Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions

Purushothaman, A., Bandari, S., Liu, J., Mobley, J. A., Brown, E. E., & Sanderson, R. D. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.686295 · Cited by 304 · see citing works

Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes

Nakase, I., & Futaki, S. (2015) · Scientific Reports · doi:10.1038/srep10112 · Cited by 297 · see citing works

Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages

Barrès, C., Blanc, L., Bette‐Bobillo, P., André, S., Mamoun, R. Z., Gabius, H., & Vidal, M. (2009) · Blood · doi:10.1182/blood-2009-07-231449 · Cited by 295 · see citing works

Galectin expression in cancer diagnosis and prognosis: A systematic review

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CD8+ Dendritic Cells Use LFA-1 to Capture MHC-Peptide Complexes from Exosomes In Vivo

Segura, É., Guérin, C. L., Hogg, N., Amigorena, S., & Théry, C. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.3.1489 · Cited by 278 · see citing works

Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomes

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Exosomes released by EBV-infected nasopharyngeal carcinoma cells convey the viral Latent Membrane Protein 1 and the immunomodulatory protein galectin 9

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