Atrial Remodeling and Atrial Fibrillation: Mechanisms and Implications

Atrial Fibrillation Begets Atrial Fibrillation

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Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study

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New ideas about atrial fibrillation 50 years on

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Promotion of Atrial Fibrillation by Heart Failure in Dogs

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Signal Transduction by the TGF-β Superfamily

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Atrial Fibrosis: Mechanisms and Clinical Relevance in Atrial Fibrillation

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Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation.

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Arrhythmogenic Ion-Channel Remodeling in the Heart: Heart Failure, Myocardial Infarction, and Atrial Fibrillation

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Prevention of Atrial Fibrillation With Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers

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Effects of Angiotensin-Converting Enzyme Inhibition on the Development of the Atrial Fibrillation Substrate in Dogs With Ventricular Tachypacing–Induced Congestive Heart Failure

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Body Mass Index and Body Fat Distribution and New-Onset Atrial Fibrillation. Sub study of The European Prospective Investigation Into Cancer and Nutrition in Norfolk (EPIC-Norfolk) Study

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Serine-threonine protein phosphatase regulation of Cx43 dephosphorylation in arrhythmogenic disorders

Ai, X., Yan, J., & Pogwizd, S. M. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110070 · Cited by 24

H2S inhibits atrial fibrillation-induced atrial fibrosis through miR-133a/CTGF axis

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Left Atrial Strain: Clinical Use and Future Applications—A Focused Review Article

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Review on Compressive Sensing Algorithms for ECG Signal for IoT Based Deep Learning Framework

Kumar, S. S., & Ramachandran, P. (2022) · Applied Sciences · doi:10.3390/app12168368 · Cited by 25

Atrial Fibrillation: Recent Advances in Understanding the Role of MicroRNAs in Atrial Remodeling with an Electrophysiological Overview

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Looking into a Conceptual Framework of ROS–miRNA–Atrial Fibrillation

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Usefulness of a Combination of Interatrial Block and a High CHADS2 Score to Predict New Onset Atrial Fibrillation

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Atrial Fibrillation: The Science behind Its Defiance

Czick, M. E., Shapter, C., & Silverman, D. I. (2016) · Aging and Disease · doi:10.14336/ad.2016.0211 · Cited by 26

Left atrial sphericity as a marker of atrial remodeling: Comparison of atrial fibrillation patients and controls

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Abnormal Ca2+ homeostasis, atrial arrhythmogenesis, and sinus node dysfunction in murine hearts modeling RyR2 modification

Zhang, Y., Matthews, G. D. K., Lei, M., & Huang, C. L.-H. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00150 · Cited by 23

Myocyte Remodeling Due to Fibro-Fatty Infiltrations Influences Arrhythmogenicity

Coster, T. D., Claus, P., Seemann, G., Willems, R., Sipido, K. R., & Panfilov, A. V. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01381 · Cited by 22

Atrial arrhythmias in chronic lung disease‐associated pulmonary hypertension

Vahdatpour, C., Luebbert, J. J., & Palevsky, H. I. (2020) · Pulmonary Circulation · doi:10.1177/2045894020910685 · Cited by 22

Mechanisms underlying pathological Ca2+ handling in diseases of the heart

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Left Atrial Wall Stress and the Long-Term Outcome of Catheter Ablation of Atrial Fibrillation: An Artificial Intelligence-Based Prediction of Atrial Wall Stress

Lee, J.-H., Kwon, O., Shim, J., Lee, J., Han, H.-J., Yu, H. T., Kim, T., Uhm, J., Joung, B., Lee, M., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.686507 · Cited by 22

A novel tsRNA-5008a promotes ferroptosis in cardiomyocytes that causes atrial structural remodeling predisposed to atrial fibrillation

Xie, L., Zhao, Z., Xia, H., Su, S., He, L., Huang, Z., Li, Y., Gao, M., Chen, J., Peng, J., et al. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.113923 · Cited by 22

Slow blood-flow in the left atrial appendage is associated with stroke in atrial fibrillation patients

Paliwal, N., Park, H.-C., Mao, Y., Hong, S. J., Lee, Y., SPRAGG, D. D., Calkins, H. G., & Trayanova, N. A. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e26858 · Cited by 22

Impact of race and gender on clinical outcomes of catheter ablation in patients with atrial fibrillation

Bukari, A., Nayak, H. M., Aziz, Z. A., Deshmukh, A., Tung, R. H., & Özcan, C. (2017) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.13165 · Cited by 21

miR-1231 exacerbates arrhythmia by targeting calciumchannel gene CACNA2D2 in myocardial infarction.

Zhang, J., Wu, L., Li, Z., & Fu, G. (2017) · PubMed Central · Cited by 22

The Relationship Between Atrial Fibrillation and Chronic Kidney Disease : Epidemiologic and Pathophysiologic Considerations for a Dual Epidemic.

McManus, D. D., Saczynski, J. S., Ward, J. A., Jaggi, K., Bourell, P., Darling, C. E., & Goldberg, R. J. (2012) · Europe PMC (PubMed Central) · doi:10.4022/jafib.442 · Cited by 26

Atrial Fibrillation-Associated Remodeling Does Not Promote Atrial Thrombus Formation in Canine Models

Nishida, K., Chiba, K., Iwasaki, Y., Katsouras, G., Shi, Y., Blostein, M. D., Khairy, P., Guerra, P. G., Dubuc, M., Tardif, J., et al. (2012) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.112.974410 · Cited by 22

Glucagon-like Peptide-1 Receptor Activation Reduces Pulmonary Vein Arrhythmogenesis and Regulates Calcium Homeostasis

Chan, C., Lin, F.-J., Chen, Y., Lin, Y., Higa, S., Chen, S.-A., & Chen, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713100 · Cited by 21

Prolonged atrial refractoriness predicts the onset of atrial fibrillation: A 12-year follow-up study

Lee, J., Lee, H., Janardhan, A. H., Park, J., Joung, B., Pak, H., Lee, M., Kim, S. S., & Hwang, H. J. (2016) · Heart Rhythm · doi:10.1016/j.hrthm.2016.03.037 · Cited by 21

PU.1 inhibition attenuates atrial fibrosis and atrial fibrillation vulnerability induced by angiotensin‐II by reducing TGF‐β1/Smads pathway activation

Hu, J., Zhang, J., Li, L., Wang, S., Yang, H., Fan, X., Zhang, L., Hu, G., Fu, H., Song, W., et al. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16678 · Cited by 20

Left atrial strain is associated with arrhythmia recurrence after atrial fibrillation ablation: Cardiac magnetic resonance rapid strain vs. feature tracking strain

Hopman, L. H. G. A., Mulder, M. J., van der Laan, A. M., Bhagirath, P., Demirkıran, A., von Bartheld, M. B., Kemme, M. J. B., van Rossum, A. C., Allaart, C. P., & Götte, M. (2023) · International Journal of Cardiology · doi:10.1016/j.ijcard.2023.02.019 · Cited by 22

Angiotensin II in atrial structural remodeling: the role of Ang II/JAK/STAT3 signaling pathway.

Zheng, L., Jia, X., Zhang, C., Wang, D., Cao, Z., Wang, J., & Du, X. (2015) · PubMed Central · Cited by 21

High-rate pacing-induced atrial fibrillation effectively reveals properties of spontaneously occurring paroxysmal atrial fibrillation in humans

Calvo, D., Atienza, F., Jalife, J., Martínez‐Alzamora, N., Bravo, L., Almendral, J. M., González‐Torrecilla, E., Arenal, Á., Bermejo, J., Fernández‐Avilés, F., et al. (2012) · EP Europace · doi:10.1093/europace/eus180 · Cited by 21

Prognostic value of new onset atrial fibrillation after transcatheter aortic valve implantation: A FRANCE 2 registry substudy

Furuta, A., Lellouche, N., Mouillet, G., Dhanjal, T., Gilard, M., Laskar, M., Eltchaninoff, H., Fajadet, J. C., Iung, B., Donzeau‐Gouge, P., et al. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.02.073 · Cited by 21

Calcium Handling Abnormalities as a Target for Atrial Fibrillation Therapeutics

Heijman, J., Voigt, N., Ghezelbash, S., Schirmer, I., & Dobrev, D. (2015) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000253 · Cited by 21

Predictors of early and late left atrial tachycardia and left atrial flutter after catheter ablation of atrial fibrillation: Long-term follow-up

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Impact of Atrial Fibrillation Duration on the Success of First-Time Concomitant Cox Maze Procedures

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Optimisation of a Generic Ionic Model of Cardiac Myocyte Electrical Activity

Guo, T., Abed, A. A., Lovell, N. H., & Dokos, S. (2013) · Computational and Mathematical Methods in Medicine · doi:10.1155/2013/706195 · Cited by 20

Effective suppression of atrial fibrillation by ivabradine: Novel target for an established drug?

Frommeyer, G., Sterneberg, M., Dechering, D. G., Ellermann, C., Bögeholz, N., Kochhäuser, S., Pott, C., Fehr, M., & Eckardt, L. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.02.055 · Cited by 21

Effects of selective mineralocorticoid receptor antagonism on atrial ion currents and early ionic tachycardia-induced electrical remodelling in rabbits

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The diagnosis and management of atrial fibrillation in the horse

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Effects of acute autonomic modulation on atrial conduction delay and local electrograms duration in paroxysmal atrial fibrillation

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The Use of Gene Therapy for Ablation of Atrial Fibrillation

Liu, Z., & Donahue, J. K. (2014) · Arrhythmia & Electrophysiology Review · doi:10.15420/aer.2014.3.3.139 · Cited by 20

Reduction of atrial fibrillation by Tanshinone IIA in chronic heart failure

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Multi‐parametric system for risk stratification in mitral regurgitation: A multi‐task Gaussian prediction approach

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Toward a hierarchy of mechanisms in CaMKII-mediated arrhythmia

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Ablation of the Androgen Receptor Gene Modulates Atrial Electrophysiology and Arrhythmogenesis With Calcium Protein Dysregulation

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New-onset Atrial Fibrillation is Associated With Polycystic Kidney Disease

Yu, T., Chuang, Y., Yu, M., Huang, S., Chou, C., Lin, C., Chiu, C., & Kao, C. (2016) · Medicine · doi:10.1097/md.0000000000002623 · Cited by 20

Atrial fibrillation in chronic kidney disease

Voroneanu, L. E., Ortíz, A., Nistor, I., & Covic, A. C. (2016) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2016.04.007 · Cited by 20

Characterization of the Genetic Program Linked to the Development of Atrial Fibrillation in CREM-IbΔC-X Mice

Seidl, M. D., Stein, J., Hamer, S., Pluteanu, F., Scholz, B., Wardelmann, E., Huge, A., Witten, A., Stoll, M., Hammer, E., et al. (2017) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.117.005075 · Cited by 20

Relationship Between Left Atrial Strain and Atrial Fibrillation: The Role of Stress Echocardiography

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Programmed cell death-1 deficiency results in atrial remodeling in C57BL/6 mice

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Rotor Termination Is Critically Dependent on Kinetic Properties of IKur Inhibitors in an In Silico Model of Chronic Atrial Fibrillation

Scholz, E. P., Carrillo-Bustamante, P., Fischer, F., Wilhelms, M., Zitron, E., Dössel, O., Katus, H. A., & Seemann, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083179 · Cited by 19

Ablation in selective patients with long-standing persistent atrial fibrillation: medium-term results of the Dallas lesion set

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Increased Preoperative Serum Apoptosis Marker Fas Ligand Correlates With Histopathology and New‐Onset of Atrial Fibrillation in Patients After Cardiac Surgery

Müller, P., Deneke, T., Schiedat, F., Bösche, L., Strauch, J., Dietrich, J. W., Vogt, M., Tannapfel, A., Stiegler, H., Mügge, A., et al. (2013) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12191 · Cited by 19

Biologic drugs and arrhythmic risk in chronic inflammatory arthritis: the good and the bad

Lazzerini, P. E., Capecchi, P. L., Galeazzi, M., & Pasini, F. L. (2016) · Immunologic Research · doi:10.1007/s12026-016-8833-7 · Cited by 19

Hyperuricemia as a Risk Factor for Atrial Fibrillation Due to Soluble and Crystalized Uric Acid

Taufiq, F., Li, P., Miake, J., & Hisatome, I. (2019) · Circulation Reports · doi:10.1253/circrep.cr-19-0088 · Cited by 20

Longer diagnosis‐to‐ablation time is associated with recurrence of atrial fibrillation after catheter ablation—Systematic review and meta‐analysis

Pranata, R., Chintya, V., Raharjo, S. B., Yamin, M., & Yuniadi, Y. (2019) · Journal of Arrhythmia · doi:10.1002/joa3.12294 · Cited by 19

Toward Mechanism-Directed Electrophenotype-Based Treatments for Atrial Fibrillation

Ng, F. S., Handa, B. S., Li, X., & Peters, N. S. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00987 · Cited by 18

Fragmented sinoatrial dynamics in the prediction of atrial fibrillation: the Multi-Ethnic Study of Atherosclerosis

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Voltage-Clamp-Based Methods for the Detection of Constitutively Active Acetylcholine-Gated IK,ACh Channels in the Diseased Heart

Voigt, N., Makary, S., Nattel, S., & Dobrev, D. (2010) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-381298-8.00032-0 · Cited by 19

Noninvasive determination of atrial fibrillation cycle length by atrial colour tissue D oppler imaging in horses

Decloedt, A., Clercq, D. D., Vekens, N. V. D., Verheyen, T., & van Loon, G. (2013) · Equine Veterinary Journal · doi:10.1111/evj.12108 · Cited by 19

Association of Aldosterone Synthase Polymorphism (CYP11B2 -344T>C) and Genetic Ancestry with Atrial Fibrillation and Serum Aldosterone in African Americans with Heart Failure

Bress, A. P., Han, J., Patel, S., Desai, A. A., Mansour, I. N., Groo, V. L., Progar, K., Shah‐Williams, E., Stamos, T. D., Wing, C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071268 · Cited by 20

A monounsaturated fatty acid (oleic acid) modulates electrical activity in atrial myocytes with calcium and sodium dysregulation

Lin, Y., Chen, Y., Kao, Y., Tsai, C.-F., Yeh, Y., Huang, J., Cheng, C., Chen, S.-A., & Chen, Y. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.07.004 · Cited by 21

Long-Term Overexpression of Hsp70 Does Not Protect against Cardiac Dysfunction and Adverse Remodeling in a MURC Transgenic Mouse Model with Chronic Heart Failure and Atrial Fibrillation

Bernardo, B. C., Sapra, G., Patterson, N. L., Cemerlang, N., Kiriazis, H., Ueyama, T., Febbraio, M. A., & McMullen, J. R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145173 · Cited by 19

Left atrial volume index and left ventricular global longitudinal strain predict new-onset atrial fibrillation in patients with transient ischemic attack

Pedersen, K. B., Madsen, C., Sandgaard, N. C. F., Hey, T. M., Diederichsen, A. C. P., Bak, S., & Brandes, A. (2019) · International journal of cardiac imaging · doi:10.1007/s10554-019-01586-w · Cited by 19

Mechanisms and Prediction of Ischemic Stroke in Atrial Fibrillation Patients

Aarnink, E. W., Zabern, M., Boersma, L. V. A., & Glikson, M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12206491 · Cited by 20

Senescent CD8+ T cells: a novel risk factor in atrial fibrillation

Li, X., Bao, Y., Zhang, N., Lin, C., Xie, Y., Wei, Y. Z., Luo, Q., Liu, J., Sha, Z., Wu, G., et al. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae222 · Cited by 18

A Computational Study of the Electrophysiological Substrate in Patients Suffering From Atrial Fibrillation

Pagani, S., Dede’, L., Frontera, A., Salvador, M., Limite, L. R., Manzoni, A., Lipartiti, F., Tsitsinakis, G., Hadjis, A. E., Bella, P. E. D., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.673612 · Cited by 18

Cardioversion in patients with newly diagnosed non-valvular atrial fibrillation: observational study using prospectively collected registry data

Pope, M. K., Hall, T. S., Schirripa, V., Radić, P., Virdone, S., Pieper, K. S., Heuzey, J. L., Janský, P., Fitzmaurice, D. A., Cappato, R., et al. (2021) · BMJ · doi:10.1136/bmj-2021-066450 · Cited by 17

Artificial Intelligence-Driven Algorithm for Drug Effect Prediction on Atrial Fibrillation: An in silico Population of Models Approach

Nava, A., Arenal, Á., Fernández‐Avilés, F., & Atienza, F. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.768468 · Cited by 18

Mechanism and Prevention of Atrial Remodeling and Their Related Genes in Cardiovascular Disorders

Sandeep, B., Ding, W., Huang, X., Liu, C., Wu, Q., Su, X., Gao, K., & Xiao, Z. (2022) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2022.101414 · Cited by 18

Impact of right atrial enlargement on clinical outcome in patients with atrial fibrillation

Ko, K., Jang, J.-H., Choi, S., Baek, Y., Kwon, S. W., Park, S., Woo, S., Kim, D., & Shin, S. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.989012 · Cited by 19

Integrative human atrial modelling unravels interactive protein kinase A and Ca2+/calmodulin-dependent protein kinase II signalling as key determinants of atrial arrhythmogenesis

Ni, H., Morotti, S., Zhang, X., Dobrev, D., & Grandi, E. (2022) · bioRxiv · doi:10.1093/cvr/cvad118 · Cited by 15

Electrophysiological effects of stretch‐activated ion channels: a systematic computational characterization

Buonocunto, M., Lyon, A., Delhaas, T., Heijman, J., & Lumens, J. (2023) · The Journal of Physiology · doi:10.1113/jp284439 · Cited by 18

Functional and structural impact of pirfenidone on the alterations of cardiac disease and diabetes mellitus

Ávila, G., Osornio-Garduño, D. S., Pérez, E. B. R., & Ramos‐Mondragón, R. (2014) · Cell Calcium · doi:10.1016/j.ceca.2014.07.008 · Cited by 19

The β3 Adrenergic Receptor Agonist BRL37344 Exacerbates Atrial Structural Remodeling Through iNOS Uncoupling in Canine Models of Atrial Fibrillation

Wang, X., Wang, R., Liu, G., Dong, J., Zhao, G., Tian, J., Sun, J., Jia, X.-Y., Wei, L., Wang, Y., et al. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000438647 · Cited by 18

The Stress-Response MAP Kinase Signaling in Cardiac Arrhythmias

Ai, X., Yan, J., Carrillo, E., & Ding, W. (2016) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2016_8 · Cited by 18

Canonical transient receptor potential 3 channels in atrial fibrillation

Han, L., & Li, J. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.08.030 · Cited by 18

Entropy Mapping Approach for Functional Reentry Detection in Atrial Fibrillation: An In-Silico Study

Ugarte, J. P., Tobón, C., & Orozco‐Duque, A. (2019) · Entropy · doi:10.3390/e21020194 · Cited by 19

Human Heart Cardiomyocytes in Drug Discovery and Research: New Opportunities in Translational Sciences

Abi‐Gerges, N., Miller, P. E., & Ghetti, A. (2019) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201021666191210142023 · Cited by 18

The Therapeutic Potential of MicroRNAs in Atrial Fibrillation

Xu, X., Zhao, Z., & Li, G. (2020) · Mediators of Inflammation · doi:10.1155/2020/3053520 · Cited by 18

Insulin Treatment Reduces Susceptibility to Atrial Fibrillation in Type 1 Diabetic Mice

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Influence of left ventricular remodeling on atrial fibrillation recurrence and cardiovascular hospitalizations in patients undergoing rhythm-control therapy

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