Atrial Remodeling and Atrial Fibrillation: Mechanisms and Implications

Atrial Fibrillation Begets Atrial Fibrillation

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Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study

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New ideas about atrial fibrillation 50 years on

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Promotion of Atrial Fibrillation by Heart Failure in Dogs

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Signal Transduction by the TGF-β Superfamily

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Atrial Fibrosis: Mechanisms and Clinical Relevance in Atrial Fibrillation

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Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation.

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Arrhythmogenic Ion-Channel Remodeling in the Heart: Heart Failure, Myocardial Infarction, and Atrial Fibrillation

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Prevention of Atrial Fibrillation With Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers

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Effects of Angiotensin-Converting Enzyme Inhibition on the Development of the Atrial Fibrillation Substrate in Dogs With Ventricular Tachypacing–Induced Congestive Heart Failure

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A proposal for new clinical concepts in the management of atrial fibrillation

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Advanced interatrial block predicts clinical recurrence of atrial fibrillation after catheter ablation

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Combined Analysis of Human and Experimental Murine Samples Identified Novel Circulating MicroRNAs as Biomarkers for Atrial Fibrillation

Natsume, Y., Oaku, K., Takahashi, K., Nakamura, W., Oono, A., Hamada, S., Yamazoe, M., Ihara, K., Sasaki, T., Goya, M., et al. (2018) · Circulation Journal · doi:10.1253/circj.cj-17-1194 · Cited by 50

The imminent epidemic of atrial fibrillation and its concomitant diseases – Myocardial infarction and heart failure - A cause for concern

Börschel, C. S., & Schnabel, R. B. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.11.123 · Cited by 52

Revisiting Antiarrhythmic Drug Therapy for Atrial Fibrillation: Reviewing Lessons Learned and Redefining Therapeutic Paradigms

Geng, M., Lin, A., & Nguyen, T. P. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.581837 · Cited by 54

Calmodulin Kinase II, Sarcoplasmic Reticulum Ca2+ Leak, and Atrial Fibrillation

Dobrev, D., & Wehrens, X. H. T. (2010) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2010.03.004 · Cited by 49

Calcium signalling microdomains and the t-tubular system in atrial mycoytes: potential roles in cardiac disease and arrhythmias

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Phosphatase-1 inhibitor-1 in physiological and pathological -adrenoceptor signalling

Wittköpper, K., Dobrev, D., Eschenhagen, T., & El‐Armouche, A. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr058 · Cited by 50

Cardiac MRI assessment of atrial fibrosis in atrial fibrillation: implications for diagnosis and therapy

Higuchi, K., Akkaya, M., AKOUM, N. W., & MARROUCHE, N. F. (2013) · Heart · doi:10.1136/heartjnl-2013-303884 · Cited by 49

Antiarrhythmic therapy in atrial fibrillation

Ravens, U. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.06.004 · Cited by 48

Stretch of Atrial Myocytes Stimulates Recruitment of Macrophages via ATP Released Through Gap-Junction Channels

Oishi, S., Sasano, T., Tateishi, Y., Tamura, N., Isobe, M., & Furukawa, T. (2012) · Journal of Pharmacological Sciences · doi:10.1254/jphs.12202fp · Cited by 47

Sex Differences in the Electrophysiological Characteristics of Pulmonary Veins and Left Atrium and Their Clinical Implication in Atrial Fibrillation

Tsai, W.-C., Chen, Y.-C., Lin, Y.-K., Chen, S.-A., & Chen, Y.-J. (2011) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.111.961995 · Cited by 49

Regulation of cardiac CACNB2 by microRNA-499: Potential role in atrial fibrillation

Ling, T.-Y., Wang, X.-L., Chai, Q., Lü, T., Stulak, J. M., Joyce, L. D., Daly, R. C., Greason, K. L., Wu, L.-Q., Shen, W.-K., et al. (2017) · BBA Clinical · doi:10.1016/j.bbacli.2017.02.002 · Cited by 49

The Role of Epicardial Adipose Tissue in the Development of Atrial Fibrillation, Coronary Artery Disease and Chronic Heart Failure in the Context of Obesity and Type 2 Diabetes Mellitus: A Narrative Review

Krishnan, A., Sharma, H., Yuan, D., Trollope, A. F., & Chilton, L. (2022) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd9070217 · Cited by 51

Atrial fibrillation and left atrial size and function: a Mendelian randomization study

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Right atrial function and fibrosis in relation to successful atrial fibrillation ablation

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Heart Failure and Atrial Fibrillation: From Basic Science to Clinical Practice

Ferreira, J. P., & Santos, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16023133 · Cited by 47

Cardiac expression and atrial fibrillation-associated remodeling of K2P2.1 (TREK-1) K+ channels in a porcine model

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Cloning, functional characterization, and remodeling of K2P3.1 (TASK-1) potassium channels in a porcine model of atrial fibrillation and heart failure

Schmidt, C., Wiedmann, F., Langer, C., Tristram, F., Anand, P., Wenzel, W., Lugenbiel, P., Schweizer, P. A., Katus, H. A., & Thomas, D. (2014) · Heart Rhythm · doi:10.1016/j.hrthm.2014.06.020 · Cited by 47

Counteracting Protein Kinase Activity in the Heart: The Multiple Roles of Protein Phosphatases

Weber, S., Meyer-Roxlau, S., Wagner, M., Dobrev, D., & El‐Armouche, A. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00270 · Cited by 50

Keeping up the balance: role of HDACs in cardiac proteostasis and therapeutic implications for atrial fibrillation

Zhang, D., Hu, X., Henning, R. H., & Brundel, B. J. J. M. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv265 · Cited by 50

Possible role of rivaroxaban in attenuating pressure-overload-induced atrial fibrosis and fibrillation

Kondo, H., Abe, I., Fukui, A., Saito, S., Miyoshi, M., Aoki, K., Shinohara, T., Teshima, Y., Yufu, K., & Takahashi, N. (2017) · Journal of Cardiology · doi:10.1016/j.jjcc.2017.08.007 · Cited by 47

The Fibrotic Substrate in Persistent Atrial Fibrillation Patients: Comparison Between Predictions From Computational Modeling and Measurements From Focal Impulse and Rotor Mapping

Boyle, P. M., Hakim, J. B., Zahid, S., Franceschi, W. H., Murphy, M. J., Prakosa, A., Aronis, K. N., Zghaib, T., Balouch, M., İpek, E. G., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01151 · Cited by 47

Comparing Reentrant Drivers Predicted by Image-Based Computational Modeling and Mapped by Electrocardiographic Imaging in Persistent Atrial Fibrillation

Boyle, P. M., Hakim, J. B., Zahid, S., Franceschi, W. H., Murphy, M. J., Vigmond, E. J., Dubois, R., Haı̈ssaguerre, M., Hocini, M., Jaı̈s, P., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00414 · Cited by 46

Stachydrine Ameliorates Cardiac Fibrosis Through Inhibition of Angiotensin II/Transformation Growth Factor β1 Fibrogenic Axis

Liu, X., Shan, X., Chen, H., Li, Z., Zhao, P., Zhang, C., Guo, W., Xu, M. G., & Lü, R. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00538 · Cited by 46

Heterogeneous Effects of Fibroblast-Myocyte Coupling in Different Regions of the Human Atria Under Conditions of Atrial Fibrillation

Sánchez, J., Gómez, J. F., Martínez-Mateu, L., Romero, L., Sáiz, J., & Trénor, B. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00847 · Cited by 46

Role of mineralocorticoid receptor on atrial structural remodeling and inducibility of atrial fibrillation in hypertensive rats

Kimura, S., 伊藤, 正., Tomita, M., Hoyano, M., Obata, H., Ding, L., Chinushi, M., Hanawa, H., Kodama, M., & Aizawa, Y. (2011) · Hypertension Research · doi:10.1038/hr.2010.277 · Cited by 46

Atrial cellular electrophysiological changes in patients with ventricular dysfunction may predispose to AF

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Disrupted Calcium Release as a Mechanism for Atrial Alternans Associated with Human Atrial Fibrillation

Chang, K. C., Bayer, J. D., & Trayanova, N. A. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004011 · Cited by 45

Ablation of sarcolipin results in atrial remodeling

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Carvedilol targets human K2P3.1 (TASK1) K+leak channels

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Attraction of Rotors to the Pulmonary Veins in Paroxysmal Atrial Fibrillation: A Modeling Study

Calvo, C. J., Deo, M., Zlochiver, S., Millet, J., & Berenfeld, O. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2014.02.030 · Cited by 44

Long-term modulation of Na+ and K+ channels by TGF-β1 in neonatal rat cardiac myocytes

Ramos‐Mondragón, R., Vega, A. V., & Ávila, G. (2011) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0912-3 · Cited by 44

Surgical treatment of atrial fibrillation: an updated review

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Acute atrial arrhythmogenicity and altered Ca2+ homeostasis in murine RyR2-P2328S hearts

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Relationship between local production of microRNA-328 and atrial substrate remodeling in atrial fibrillation

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Numerical Study of Atrial Fibrillation Effects on Flow Distribution in Aortic Circulation

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PAGln, an Atrial Fibrillation-Linked Gut Microbial Metabolite, Acts as a Promoter of Atrial Myocyte Injury

Chen, F., Zuo, K., Jiao, K., Zhu, X., Fu, Y., Zhong, J., Xu, L., & Yang, X. (2022) · Biomolecules · doi:10.3390/biom12081120 · Cited by 44

Cardiac ion channels and mechanisms for protection against atrial fibrillation.

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JCS / JHRS 2020 Guideline on Pharmacotherapy of Cardiac Arrhythmias

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The role of multi-modality imaging for the assessment of left atrium and left atrial appendage: a clinical consensus statement of the European Association of Cardiovascular Imaging (EACVI), European Heart Rhythm Association (EHRA) of the European Society of Cardiology (ESC)

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Atrial Ca2+ signaling in atrial fibrillation as an antiarrhythmic drug target

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Facilitatory and inhibitory effects of SCN5A mutations on atrial fibrillation in Brugada syndrome

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Underexpression of CACNA1C Caused by Overexpression of microRNA-29a Underlies the Pathogenesis of Atrial Fibrillation

Zhao, Y., Yuan, Y., & Qiu, C. (2016) · Medical Science Monitor · doi:10.12659/msm.896191 · Cited by 43

Left atrium: the last bulwark before overt heart failure

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The burden of proof: The current state of atrial fibrillation prevention and treatment trials

Zakeri, R., Wagoner, D. R. V., Calkins, H. G., Wong, T., Ross, H., Heist, E. K., Meyer, T. E., Kowey, P. R., Mentz, R. J., Cleland, J. G. F., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.01.032 · Cited by 42

Left Atrial Myopathy in Atrial Fibrillation and Heart Failure: Clinical Implications, Mechanisms, and Therapeutic Targets

Peigh, G., Shah, S. J., & Patel, R. B. (2021) · Current Heart Failure Reports · doi:10.1007/s11897-021-00510-5 · Cited by 45

Comparative Effectiveness of Early Rhythm Control Versus Rate Control for Cardiovascular Outcomes in Patients With Atrial Fibrillation

Kim, D., Yang, P., You, S. C., Jang, E., Yu, H. T., Kim, T., Pak, H., Lee, M., Lip, G. Y. H., Sung, J., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.023055 · Cited by 44

Involvement of Src in L-type Ca2+ channel depression induced by macrophage migration inhibitory factor in atrial myocytes

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The counterintuitive role of exercise in the prevention and cause of atrial fibrillation

Buckley, B. J. R., Lip, G. Y. H., & Thijssen, D. H. J. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00509.2020 · Cited by 43

Sinoatrial node electrical activity modulates pulmonary vein arrhythmogenesis

Chen, Y., Lu, Y., Cheng, C., Lin, Y., Chen, S., & Chen, Y. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.03.009 · Cited by 42

Different structural remodelling in atrial fibrillation with different types of mitral valvular diseases

Qian, Y., Meng, J., Tang, H., Yang, B., Deng, Y., Wei, D., Xiang, B., & Xiao, X. (2010) · EP Europace · doi:10.1093/europace/eup438 · Cited by 42

Insights into sick sinus syndrome from an inducible mouse model

Herrmann, S., Fabritz, L., Layh, B., Kirchhof, P. F., & Ludwig, A. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq390 · Cited by 42

The clinical significance of endocardial endothelial dysfunction

Smiljić, S. (2017) · Medicina · doi:10.1016/j.medici.2017.08.003 · Cited by 42

Atrial fibrillation in horses part 1: Pathophysiology

Decloedt, A., Steenkiste, G. V., Vera, L., Buhl, R., & van Loon, G. (2020) · The Veterinary Journal · doi:10.1016/j.tvjl.2020.105521 · Cited by 42

Hyperleptinemia Exacerbates High‐Fat Diet‐Mediated Atrial Fibrosis and Fibrillation

Fukui, A., Ikebe, Y., Kondo, H., Saito, S., Aoki, K., Fukunaga, N., Shinohara, T., Masaki, T., Teshima, Y., & TAKAHASHI, N. (2017) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13200 · Cited by 43

Oxidative stress and atrial fibrillation

Pfenniger, A., Yoo, S., & Arora, R. (2024) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2024.09.011 · Cited by 49

Effect of Spironolactone on Patients With Atrial Fibrillation and Structural Heart Disease

Williams, R. S., deLemos, J. A., Dimas, V., REISCH, J. S., Hill, J. A., & Naseem, R. H. (2011) · Clinical Cardiology · doi:10.1002/clc.20914 · Cited by 40

Association between serum uric acid and atrial fibrillation: a cross-sectional community-based study in China

Chen, Y., Xia, Y., Han, X., Yang, Y., Yin, X., Qiu, J., Liu, H., Zhou, Y., & Liu, Y. (2017) · BMJ Open · doi:10.1136/bmjopen-2017-019037 · Cited by 41

Gut Microbiota Dysbiosis Induced by a High-Fat Diet Increases Susceptibility to Atrial Fibrillation

Kong, B., Fu, H., Xiao, Z., Zhou, Y., Shuai, W., & Huang, H. (2022) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2022.08.231 · Cited by 41

Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation

Glasscock, E., Voigt, N., McCauley, M. D., Sun, Q., Li, N., Chiang, D. Y.-E., Zhou, X.-B., Molina, C. E., Thomas, D., Schmidt, C., et al. (2015) · Basic Research in Cardiology · doi:10.1007/s00395-015-0505-6 · Cited by 41

LncRNA H19 Drives Proliferation of Cardiac Fibroblasts and Collagen Production via Suppression of the miR-29a-3p/miR-29b-3p-VEGFA/TGF-β Axis

Guo, F., Tang, C., Huang, B., Gu, L., Zhou, J., Mo, Z., Liu, C., & Liu, Y. (2021) · Molecules and Cells · doi:10.14348/molcells.2021.0066 · Cited by 40

Reverse atrial electrical remodeling: A systematic review

Pang, H., Ronderos, R., Pérez‐Riera, A. R., Femenía, F., & Baranchuk, A. M. (2011) · Cardiology Journal · doi:10.5603/cj.2011.0025 · Cited by 40

Post-operative atrial fibrillation is associated with a pre-existing structural and electrical substrate in human right atrial myocardium

Zaman, J. A. B., Harling, L., Ashrafian, H., Darzi, A. W., Gooderham, N. J., Athanasiou, T., & Peters, N. S. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.06.249 · Cited by 40

Uric Acid Level and Prevalence of Atrial Fibrillation in a Japanese General Population of 285,882

Kawasoe, S., Kubozono, T., Yoshifuku, S., Ojima, S., Oketani, N., Miyata, M., Miyahara, H., Maenohara, S., & Ohishi, M. (2016) · Circulation Journal · doi:10.1253/circj.cj-16-0766 · Cited by 40

Pathophysiology, incidence, management, and consequences of cardiac arrhythmia in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension

Cirulis, M. M., Ryan, J. J., & Archer, S. L. (2019) · Pulmonary Circulation · doi:10.1177/2045894019834890 · Cited by 40

Presence of Left Atrial Fibrosis May Contribute to Aberrant Hemodynamics and Increased Risk of Stroke in Atrial Fibrillation Patients

Paliwal, N., Ali, R. L., Salvador, M., O’Hara, R., Yu, R. A., Daimee, U. A., Akhtar, T., Pandey, P., SPRAGG, D. D., Calkins, H. G., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.657452 · Cited by 40

Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation

Künzel, S. R., Hoffmann, M., Weber, S., Künzel, K., Kämmerer, S., Günscht, M., Klapproth, E., Rausch, J. S. E., Sadek, M. S., Kolanowski, T. J., et al. (2021) · Circulation Research · doi:10.1161/circresaha.121.319425 · Cited by 41

Importance of pericardial fat in the formation of complex fractionated atrial electrogram region in atrial fibrillation

Kanazawa, H., Yamabe, H., Enomoto, K., Koyama, J., Morihisa, K., Hoshiyama, T., Matsui, K., & Ogawa, H. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.04.135 · Cited by 40

Inhibition of aldosterone synthase (CYP11B2) by torasemide prevents atrial fibrosis and atrial fibrillation in mice

Adam, O., Zimmer, C., Hanke, N., Hartmann, R. W., Klemmer, B., Böhm, M., & Laufs, U. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.05.019 · Cited by 39

Exploring susceptibility to atrial and ventricular arrhythmias resulting from remodeling of the passive electrical properties in the heart: a simulation approach

Trayanova, N. A., Boyle, P. M., Arevalo, H., & Zahid, S. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00435 · Cited by 39

New-onset atrial fibrillation after anatomic lung resection: predictive factors, treatment and follow-up in a UK thoracic centre

Garner, M., Routledge, T., King, J. E., Pilling, J. E., Veres, L., Harrison‐Phipps, K., Billè, A., & Harling, L. (2016) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1093/icvts/ivw348 · Cited by 39

Converse role of class I and class IIa HDACs in the progression of atrial fibrillation

Zhang, D., Hu, X., Li, J., Hoogstra‐Berends, F., Zhuang, Q., Esteban, M. A., de Groot, N. M. S., Henning, R. H., & Brundel, B. J. J. M. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.09.010 · Cited by 39

Cardiac Biomarkers and Risk of Atrial Fibrillation in Chronic Kidney Disease: The CRIC Study

Lamprea-Montealegre, J. A., Zelnick, L. R., Shlipak, M. G., Floyd, J. S., Anderson, A. H., He, J., Christenson, R. H., Seliger, S. L., Soliman, E. Z., Deo, R., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.012200 · Cited by 38

AMPKα1 deletion in myofibroblasts exacerbates post-myocardial infarction fibrosis by a connexin 43 mechanism

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Effect of Sinus Rhythm Restoration After Electrical Cardioversion on Apelin and Brain Natriuretic Peptide Prohormone Levels in Patients With Persistent Atrial Fibrillation

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Atrial-selective sodium channel block for the treatment of atrial fibrillation

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Patient-Specific TBX5-G125R Variant Induces Profound Transcriptional Deregulation and Atrial Dysfunction

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Ion Channels in the Heart

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The more effective treatment of atrial fibrillation applying the natural compounds; as NADPH oxidase and ion channel inhibitors

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Cardiac Sympathetic Denervation Suppresses Atrial Fibrillation and Blood Pressure in a Chronic Intermittent Hypoxia Rat Model of Obstructive Sleep Apnea

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Attenuation of Oxidative Injury With Targeted Expression of NADPH Oxidase 2 Short Hairpin RNA Prevents Onset and Maintenance of Electrical Remodeling in the Canine Atrium

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LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation

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Diffuse Ventricular Fibrosis Measured by T 1 Mapping on Cardiac MRI Predicts Success of Catheter Ablation for Atrial Fibrillation

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The Role of MicroRNAs in Antiarrhythmic Therapy for Atrial Fibrillation

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Serine/Threonine Phosphatases in Atrial Fibrillation

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Atrial Fibrillation Dynamics and Ionic Block Effects in Six Heterogeneous Human 3D Virtual Atria with Distinct Repolarization Dynamics

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Calcium handling and atrial fibrillation

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Atrial Cardiomyopathy in Valvular Heart Disease: From Molecular Biology to Clinical Perspectives

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Incidence and predictors of atrial fibrillation and its impact on long-term survival in patients with supraventricular arrhythmias

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Atrial arrhythmia prevalence and characteristics for human immunodeficiency virus-infected persons and matched uninfected controls

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Atrial Fibrillation: Current Evidence and Management Strategies During the Perioperative Period

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Myofibroblast-Derived Exosomes Contribute to Development of a Susceptible Substrate for Atrial Fibrillation

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Inositol Trisphosphate Receptors and Nuclear Calcium in Atrial Fibrillation

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Molecular remodeling of ion channels, exchangers and pumps in atrial and ventricular myocytes in ischemic cardiomyopathy

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Class I/B antiarrhythmic property of ranolazine, a novel antianginal agent, in dog and human cardiac preparations

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Comparison of Pro-Atrial Natriuretic Peptide and Atrial Remodeling in Marathon Versus Non-Marathon Runners

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Left Atrial Anatomic Remodeling in Atrial Fibrillation

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Atrial Remodeling And Atrial Fibrillation: Mechanistic Interactions And Clinical Implications

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Exercise Capacity and Atrial Remodeling in Atrial Fibrillation

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Electrophysiologic Remodeling of the Atrium in Patients With Atrial Fibrillation

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Atrial Remodeling Induced by Exercise: a Model(s) for Atrial Fibrillation

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