The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Pericardial Fat Is Associated With Prevalent Atrial Fibrillation: The Framingham Heart Study
Open accessAbstract
Background—: Obesity represents an important risk factor for atrial fibrillation (AF). We tested the hypothesis that pericardial fat, a unique fat deposit in close anatomic proximity to cardiac structures and autonomic fibers, is associated with prevalent AF. Methods and Results—: Participants from the Framingham Heart Study underwent multidetector computed tomography from 2002 to 2005. We estimated the association between quantitative pericardial, intrathoracic and visceral adipose tissue volumes (per standard deviation of volume) with prevalent AF adjusting for established AF risk factors (age, sex, systolic blood pressure, blood pressure treatment, PR interval, and clinically significant valvular disease). Of the 3217 eligible participants (mean age, 50.6±10.1 years; 48% women), 54 had a confirmed diagnosis of AF. Pericardial fat but not intrathoracic or visceral abdominal fat was associated with prevalent AF in multivariable-adjusted models (odds ratio per standard deviation of pericardial fat volume, 1.28; 95% confidence intervals, 1.03 to 1.58). Further adjustments for body mass index, heart failure, myocardial infarction, and intrathoracic fat volume did not materially change the association between pericardial fat and AF. Conclusions—: Pericardial fat was associated with prevalent AF even after adjustment for AF risk factors, including body mass index. If this association is replicated, further investigations into the mechanisms linking pericardial fat to AF are merited.
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Fox, C. S., Massaro, J. M., Hoffmann, U., Pou, K. M., Maurovich-Horvat, P., Liu, C.-Y., Vasan, R. S., Murabito, J. M., Meigs, J. B., Cupples, L. A., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.675355 · Cited by 2,882
Self-citationMiyasaka, Y., Barnes, M. E., Gersh, B. J., Cha, S. S., Bailey, K. R., Abhayaratna, W. P., Seward, J. B., & Tsang, T. S. M. (2006) · Circulation · doi:10.1161/circulationaha.105.595140 · Cited by 2,564
Human epicardial adipose tissue is a source of inflammatory mediators
Mazurek, T., Zhang, L., Zalewski, A., Mannion, J. D., Diehl, J. T., Arafat, H., Sarov-Blat, L., O’Brien, S., Keiper, E. A., Johnson, A. G., et al. (2003) · Circulation · doi:10.1161/01.cir.0000099542.57313.c5 · Cited by 1,966
Obesity and the risk of new-onset atrial fibrillation
Wang, T. J. (2004) · JAMA · doi:10.1001/jama.292.20.2471 · Cited by 1,427
Self-citationSchnabel, R. B., Sullivan, L. M., Levy, D., Pencina, M. J., Massaro, J. M., D'Agostino, R. B., Newton-Cheh, C., Yamamoto, J. F., Magnani, J. W., Tadros, T. M., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60443-8 · Cited by 1,041
Self-citationRosito, G. A., Massaro, J. M., Hoffmann, U., Ruberg, F. L., Mahabadi, A. A., Vasan, R. S., O’Donnell, C. J., & Fox, C. S. (2008) · Circulation · doi:10.1161/circulationaha.107.743062 · Cited by 1,017
Self-citationEpicardial adipose tissue: Anatomic, biomolecular and clinical relationships with the heart
Iacobellis, G., Corradi, D., & Sharma, A. M. (2005) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0319 · Cited by 1,015
Human epicardial adipose tissue: A review
Sacks, H. S., & Fain, J. N. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.03.019 · Cited by 969
Splansky, G. L., Corey, D., Yang, Q., Atwood, L. D., Cupples, L. A., Benjamin, E. J., D'Agostino, R. B., Fox, C. S., Larson, M. G., Murabito, J. M., et al. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm021 · Cited by 860
Self-citationIacobellis, G., Ribaudo, M. C., Assael, F., Vecci, E., Tiberti, C., Zappaterreno, A., Di Mario, U., & Leonetti, F. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030698 · Cited by 842
Cited by
Atrial Fibrillation: Epidemiology, Pathophysiology, and Clinical Outcomes
Staerk, L., Sherer, J. A., Ko, D., Benjamin, E. J., & Helm, R. H. (2017) · Circulation Research · doi:10.1161/circresaha.117.309732 · Cited by 1,201
Self-citationObesity, Adipose Tissue and Vascular Dysfunction
Koenen, M., Hill, M. A., Cohen, P., & Sowers, J. R. (2021) · Circulation Research · doi:10.1161/circresaha.121.318093 · Cited by 904
Epicardial adipose tissue in contemporary cardiology
Iacobellis, G. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00679-9 · Cited by 797
Local and systemic effects of the multifaceted epicardial adipose tissue depot
Iacobellis, G. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.58 · Cited by 605
Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features
Iacobellis, G., & Bianco, A. C. (2011) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.07.003 · Cited by 599
Metadata
- Authors
- Thanassoulis, G., Massaro, J. M., O'Donnell, C. J., Hoffmann, U., Levy, D., Ellinor, P. T., Wang, T. J., Schnabel, R. B., Vasan, R. S., Fox, C. S., & Benjamin, E. J.
- Venue
- Circulation: Arrhythmia and Electrophysiology
- Published
- 2010-08
- Volume
- 3
- Issue
- 4
- Pages
- 345-350
- ISSN
- 1941-3084 (ISSN-L)
- 1941-3149
- OpenAlex
- W1994291717
- Cited by
- 457
- References
- 40
- FWCI
- 11.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Thanassoulis, G., Massaro, J. M., O'Donnell, C. J., Hoffmann, U., Levy, D., Ellinor, P. T., Wang, T. J., Schnabel, R. B., Vasan, R. S., Fox, C. S., & Benjamin, E. J. (2010). Pericardial Fat Is Associated With Prevalent Atrial Fibrillation: The Framingham Heart Study. Circulation: Arrhythmia and Electrophysiology. https://doi.org/10.1161/circep.109.912055
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
