Endothelial aging
Abstract
Aging is considered to be the major risk factor for the development of atherosclerosis and, therefore, for coronary artery disease. Apart from age-associated remodeling of the vascular wall, which includes luminal enlargement, intimal and medial thickening, and increased vascular stiffness, endothelial function declines with age. This is most obvious from the attenuation of endothelium-dependent dilator responses, which is a consequence of the alteration in the expression and/or activity of the endothelial NO synthase, upregulation of the inducible NO synthase, and increased formation of reactive oxygen species. Aging is also associated with a reduction in the regenerative capacity of the endothelium and endothelial senescence, which is characterized by an increased rate of endothelial cell apoptosis.
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The study used a well-established endothelial aging model by generating hiPSCs from five independent human donors and differentiating them into endothelial cells.
“we used a well-established model for endothelial aging57,58 by generating human induced pluripotent stem cells (hiPSCs) from fibroblasts obtained from five independent human donors59 and subsequently differentiated them into endothelial cells (hiPSC-ECs)60.”
From An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging (2021) · cites this paper as [58]
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Bochenek, M. L., Schütz, E., & Schäfer, K. (2016) · Thrombosis Research · doi:10.1016/j.thromres.2016.09.019 · Cited by 96 · see citing works
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- Authors
- BRANDES, R., FLEMING, I., & BUSSE, R.
- Affiliations
- Goethe University Frankfurt (DE)
- Corresponding author
- BRANDES, R
- ORCID
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-05-01
- Volume
- 66
- Issue
- 2
- Pages
- 286-294
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W4256530495
- Cited by
- 563
- References
- 0
- Citations by year
- 2026: 13 · 2025: 19 · 2024: 23 · 2023: 23 · 2022: 38 · 2021: 31 · 2020: 27 · 2019: 26 · 2018: 20 · 2017: 26 · 2016: 32 · 2015: 33 · 2014: 35 · 2013: 25 · 2012: 41
- FWCI
- 12.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cardiovascular Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- endothelial aging, endothelial function, atherosclerosis, coronary artery disease, nitric oxide synthase, inducible nitric oxide synthase, reactive oxygen species, endothelial cell senescence, endothelial cell apoptosis, vascular remodeling, vascular stiffness
- MeSH terms
- Aged, Aging, Coronary Disease, Endothelium, Vascular, Humans, Vasodilation, Cellular Senescence, Apoptosis, Reactive Oxygen Species, Oxidative Stress, Nitric Oxide Synthase, Nitric Oxide Synthase Type II, Nitric Oxide Synthase Type III
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