Cited by 86Sulfur Compounds in BiologyNitric Oxide and Endothelin EffectsHeme Oxygenase-1 and Carbon Monoxide

Hydrogen Sulfide and Endothelial Dysfunction: Relationship with Nitric Oxide

Open access
Altaany, Zaid, Moccia, Francesco, Munaron, Luca, Mancardi, Daniele, Wang, Rui·2014·Current Medicinal Chemistry

Abstract

The endothelium is a cellular monolayer that lines the inner surface of blood vessels and plays a central role in the maintenance of cardiovascular homeostasis by controlling platelet aggregation, vascular tone, blood fluidity and fibrinolysis, adhesion and transmigration of inflammatory cells, and angiogenesis. Endothelial dysfunctions are associated with various cardiovascular diseases, including atherosclerosis, hypertension, myocardial infarction, and cardiovascular complications of diabetes. Numerous studies have established the anti-inflammatory, anti-apoptotic, and anti-oxidant effects of hydrogen sulfide (H2S), the latest member to join the gasotransmitter family along with nitric oxide and carbon monoxide, on vascular endothelium. In addition, H2S may prime endothelial cells (ECs) toward angiogenesis and contribute to wound healing, besides to its well-known ability to relax vascular smooth muscle cells (VSMCs), and thereby reducing blood pressure. Finally, H2S may inhibit VSMC proliferation and platelet aggregation. Consistently, a deficit in H2S homeostasis is involved in the pathogenesis of atherosclerosis and of hyperglycaemic endothelial injury. Therefore, the application of H2S-releasing drugs or using gene therapy to increase endogenous H2S level may help restore endothelial function and antagonize the progression of cardiovascular diseases. The present article reviews recent studies on the role of H2S in endothelial homeostasis, under both physiological and pathological conditions, and its putative therapeutic applications.

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Crossref · 10.2174/0929867321666140706142930

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  • H2S has been implicated as a regulator of both nitric oxide and eicosanoid synthesis.

    “H2S has been implicated as a regulator of both nitric oxide and eicosanoid ynthesis [28], [34], [60].”

    From Cytoprotective Effects of Hydrogen Sulfide in Novel Rat Models of Non-Erosive Esophagitis (2014) · cites this paper as [60]

    Section 6.5 (page unavailable) reports H₂S-induced NO release, supporting its implication in NO regulation. Section 1.0 lists eicosanoids alongside H₂S as endothelial products, but does not say H₂S regulates their synthesis; searches for eicosanoid synthesis and related compounds found no such passage. (LLM, conf=0.85)

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Research works printed but not linked: 2

  1. Kimura Y, K.H., Hydrogen sulfide protect neurons from oxidative stress. FASEB J, 2004, 18, 1165-1167.
  2. Fiorio Pla, A.; Avanzato, D.; Munaron, L.; Ambudkar, I.S., Ion channels and transporters in cancer. 6. Vascularizing the tumor: TRP channels as molecular targets. American Journal of Physiology -Cell Physiology, 2012, 302, (1), C9-15.

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Authors
Altaany, Z., Moccia, F., Munaron, L., Mancardi, D., & Wang, R.
Affiliations
  • Lakehead University (CA)
  • Bentham Science Publishers (United Arab Emirates) (AE)
  • University of Turin (IT)
Venue
Current Medicinal Chemistry
Published
2014-07-06
Volume
21
Issue
32
Pages
3646-3661
ISSN
0929-8673 (ISSN-L)
OpenAlex
W2122874855
Cited by
86
References
191
Citations by year
2026: 1 · 2025: 5 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 7 · 2020: 12 · 2019: 8 · 2018: 10 · 2017: 9 · 2016: 4 · 2015: 10 · 2014: 4
FWCI
3.99
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Current Medicinal Chemistry (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
  • Archivio Istituzionale della Ricerca - Università degli Studi del Molise (submittedVersion)
Funders
  • Ministero dell’Istruzione, dell’Università e della Ricerca
  • Canadian Institutes of Health Research
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
Keywords
hydrogen sulfide, endothelial dysfunction, nitric oxide, gasotransmitters, cardiovascular disease, atherosclerosis, angiogenesis, vascular smooth muscle cells, platelet aggregation, gene therapy, endothelial homeostasis
MeSH terms
Animals, Endothelium, Vascular, Hydrogen Sulfide, Nitric Oxide, Signal Transduction, Mice, Knockout, Hyperhomocysteinemia, Mice, Nitric Oxide Synthase Type III

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