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The Intersection Between Aging and Cardiovascular Disease
Open accessAbstract
The average lifespan of humans is increasing, and with it the percentage of people entering the 65 and older age group is growing rapidly and will continue to do so in the next 20 years. Within this age group, cardiovascular disease will remain the leading cause of death, and the cost associated with treatment will continue to increase. Aging is an inevitable part of life and unfortunately poses the largest risk factor for cardiovascular disease. Although numerous studies in the cardiovascular field have considered both young and aged humans, there are still many unanswered questions as to how the genetic pathways that regulate aging in model organisms influence cardiovascular aging. Likewise, in the molecular biology of aging field, few studies fully assess the role of these aging pathways in cardiovascular health. Fortunately, this gap is beginning to close, and these two fields are merging together. We provide an overview of some of the key genes involved in regulating lifespan and health span, including sirtuins, AMP-activated protein kinase, mammalian target of rapamycin, and insulin-like growth factor 1 and their roles regulating cardiovascular health. We then discuss a series of review articles that will appear in succession and provide a more comprehensive analysis of studies carried out linking genes of aging and cardiovascular health, and perspectives of future directions of these two intimately linked fields.
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“Lung cancer mortality was improving across these recent cohorts and taken in tandem with trends for obesity-related cancers indicates a declining role of cigarette smoking and an increasing role of diet and obesity in shaping young adulthood mortality patterns (39).”
From Insights into US life expectancy stagnation from birth cohort mortality dynamics (2026) · cites this paper as [39]
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“A strong suspect for the central upstream source of inflammatory factors is ageing, being the strongest independent risk factor for cardiovascular disease (CVD).6”
From Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis (2020) · cites this paper as [6]
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“Aging is the major risk factor for cardiovascular diseases (CVD).”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [137]
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Sirtuin Activation by Small Molecules
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“Lung cancer mortality was improving across these recent cohorts and taken in tandem with trends for obesity - related cancers indicates a declining role of cigarette smoking and an increasing role of diet and obesity in shaping young adulthood mortality patterns (39).”
Metadata
- Authors
- North, B. J., & Sinclair, D. A.
- Affiliations
- Harvard University (US)
- Venue
- Circulation Research
- Published
- 2012-04-13
- Volume
- 110
- Issue
- 8
- Pages
- 1097-1108
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC3366686
- OpenAlex
- W2142194547
- Cited by
- 1,585
- References
- 140
- Citations by year
- 2026: 144 · 2025: 217 · 2024: 204 · 2023: 205 · 2022: 163 · 2021: 144 · 2020: 122 · 2019: 95 · 2018: 66 · 2017: 54 · 2016: 48 · 2015: 51 · 2014: 40 · 2013: 24 · 2012: 5
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Glenn Foundation for Medical Research
- Beth Israel Deaconess Medical Center
- Fondation pour la Recherche Médicale
- National Institutes of Health
- National Institute on Aging (R37AG028730, R01AG028730, R01AG019719, T32AG023480)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Keywords
- aging, cardiovascular disease, cardiovascular aging, lifespan regulation, healthspan, sirtuins, AMPK, mTOR, insulin-like growth factor I, longevity genes, aged population
- MeSH terms
- Age Factors, Aged, Aging, Animals, Cardiovascular Diseases, Cardiovascular System, Gene Expression Regulation, Humans, Longevity, Prognosis, Risk Factors, Risk Assessment
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