The DOI matches its Crossref record; 139 of the 140 references it cites were found in a registry or an index.
The Intersection Between Aging and Cardiovascular Disease
Open accessAbstract
The average lifespan of humans is increasing, and with it the percentage of people entering the 65 and older age group is growing rapidly and will continue to do so in the next 20 years. Within this age group, cardiovascular disease will remain the leading cause of death, and the cost associated with treatment will continue to increase. Aging is an inevitable part of life and unfortunately poses the largest risk factor for cardiovascular disease. Although numerous studies in the cardiovascular field have considered both young and aged humans, there are still many unanswered questions as to how the genetic pathways that regulate aging in model organisms influence cardiovascular aging. Likewise, in the molecular biology of aging field, few studies fully assess the role of these aging pathways in cardiovascular health. Fortunately, this gap is beginning to close, and these two fields are merging together. We provide an overview of some of the key genes involved in regulating lifespan and health span, including sirtuins, AMP-activated protein kinase, mammalian target of rapamycin, and insulin-like growth factor 1 and their roles regulating cardiovascular health. We then discuss a series of review articles that will appear in succession and provide a more comprehensive analysis of studies carried out linking genes of aging and cardiovascular health, and perspectives of future directions of these two intimately linked fields.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Lung cancer mortality was improving across these recent cohorts and taken in tandem with trends for obesity-related cancers indicates a declining role of cigarette smoking and an increasing role of diet and obesity in shaping young adulthood mortality patterns (39).”
From Insights into US life expectancy stagnation from birth cohort mortality dynamics (2026) · cites this paper as [39]
Experimental — accuracy not yet measuredIn the citing paper
“A strong suspect for the central upstream source of inflammatory factors is ageing, being the strongest independent risk factor for cardiovascular disease (CVD).6”
From Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis (2020) · cites this paper as [6]
In the citing paper
“Aging is the major risk factor for cardiovascular diseases (CVD).”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [137]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
Self-citationLagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670
A C. elegans mutant that lives twice as long as wild type
Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300
Heidenreich, P. A., Trogdon, J. G., Khavjou, O. A., Butler, J., Dracup, K., Ezekowitz, M. D., Finkelstein, E. A., Hong, Y., Johnston, S. C., Khera, A., et al. (2011) · Circulation · doi:10.1161/cir.0b013e31820a55f5 · Cited by 3,208
Cited by
Sorted by citations
Items 501–600 of 1,000
Palacios-Valladares, J. R., Martinez-Jimenez, Y. I., Morillon-Torres, V., Rivera-Maya, O. B., Gómez, R., & Calderon-Aranda, E. S. (2024) · Antioxidants · doi:10.3390/antiox13121468 · Cited by 20
Angiotensin II and Cardiovascular Disease: Balancing Pathogenic and Protective Pathways
Bayraktutan, U. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47070501 · Cited by 22
Evans, J. R., Torres-Pérez, J. V., Petrazzini, M. E. M., Riley, R. J., & Brennan, C. H. (2021) · Scientific Reports · doi:10.1038/s41598-020-79615-1 · Cited by 22
Laic, R. A. G., Sloten, J. V., & Depreitere, B. (2022) · Acta Neurochirurgica · doi:10.1007/s00701-022-05159-0 · Cited by 19
The Effect of Walking Exercise on Blood Pressure and Blood Glucose in the Elderly
Rizka, M., Ambardini, R. L., Virama, L. O. A., & Yudhistira, D. (2022) · International Journal of Kinesiology and Sports Science · doi:10.7575/aiac.ijkss.v.10n.1p.30 · Cited by 19
Menopause, androgens, and cardiovascular ageing: a narrative review
Armeni, E., & Lambrinoudaki, I. V. (2022) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188221129946 · Cited by 20
Rumbo-Rodríguez, L., Zaragoza-Martí, A., Sánchez‐SanSegundo, M., Ferrer‐Cascales, R., Laguna-Pérez, A., & Sánchez, J. A. H. (2022) · Nutrients · doi:10.3390/nu14224762 · Cited by 19
Booth, L. K., Redgrave, R. E., Tual‐Chalot, S., Spyridopoulos, I., Phillips, H. M., & Richardson, G. D. (2023) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-26576-1_4 · Cited by 20
Möhl, A., Behrens, S., Flaßkamp, F., Obi, N., Kreienbrinck, A., Holleczek, B., Gali, K., Chang-Claude, J. C., & Becher, H. (2023) · Breast Cancer Research · doi:10.1186/s13058-023-01680-x · Cited by 19
Giuliani, M. E., Bigossi, G., Lai, G., Marcozzi, S., Brunetti, D., & Malavolta, M. (2024) · Marine Drugs · doi:10.3390/md22050210 · Cited by 21
Ye, Z., Lang, H., Xie, Z., Duan, S., Peng, B., Chen, X., Fang, Y., & Xin, J. (2024) · BMC Medicine · doi:10.1186/s12916-024-03640-4 · Cited by 20
Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence
Gonzalez-Valdes, I. B., Hidalgo, I., Bujarrabal-Dueso, A., Lara‐Pezzi, E., Padrón-Barthe, L., García‐Pavía, P., Arco, P. G., Redondo, J. M., Ruı́z-Cabello, J., Jiménez‐Borreguero, L. J., et al. (2015) · Nature Communications · doi:10.1038/ncomms7473 · Cited by 19
RetractedChen, F., Song, F., Chen, Y., Wang, Z., Li, Y., Liu, M., Li, Y., Song, M., Zhang, W., Zhao, J., et al. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.01.029 · Cited by 19
Aging-Related Molecular Pathways in Chronic Cholestatic Conditions
Pinto, C., Ninfole, E., Benedetti, A., Maroni, L., & Marzioni, M. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2019.00332 · Cited by 18
Characterization of mechanical properties of lamellar structure of the aortic wall: Effect of aging
Taghizadeh, H., & Tafazzoli‐Shadpour, M. (2016) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2016.08.011 · Cited by 19
Advances in Nanotherapy for Targeting Senescent Cells
Shi, Y., Zhang, Y., Zhang, Y., Yao, J., Guo, J., Xu, X., & Wang, L. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s469110 · Cited by 20
Wang, S., Gao, L., Wang, C., Bai, J., Shen, M., Zhao, X., & Lin, M. F. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1433558 · Cited by 22
The Immune System and Cellular Senescence: A Complex Interplay in Aging and Disease
Ayoub, M., Jaoude, C. A., Ayoub, M., Hamadé, A., & Rima, M. (2025) · Immunology · doi:10.1111/imm.70036 · Cited by 25
Tan, M., Jiang, Z.-N., Li, Y. C., Li, Z., & Niu, B. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02940-0 · Cited by 19
Lacroix, S., Lauria, M., Scott‐Boyer, M., Marchetti, L., Priami, C., & Caberlotto, L. (2015) · Genes & Nutrition · doi:10.1007/s12263-015-0508-9 · Cited by 19
Platelet-derived β2m regulates age related monocyte/macrophage functions
Hilt, Z. T., Ture, S. K., Mohan, A. M., Arne, A., & Morrell, C. N. (2019) · Aging · doi:10.18632/aging.102520 · Cited by 19
Angiotensin-(1-7) Improves Integrated Cardiometabolic Function in Aged Mice
Miller, A. J., Bingaman, S. S., Mehay, D., Medina, D., & Arnold, A. C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145131 · Cited by 18
Sánchez‐Díaz, M., Salvador‐Rodríguez, L., Montero‐Vílchez, T., Martínez‐López, A., Arias‐Santiago, S., & Molina‐Leyva, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10225222 · Cited by 19
Role of Autophagy in Cardiovascular Disease and Aging
Koutouroushis, C., & Sarkar, O. (2021) · Cureus · doi:10.7759/cureus.20042 · Cited by 18
Jansen, S. A., Huiskens, B., Trompet, S., Jukema, J., Mooijaart, S. P., van Dijk, K. W., van Heemst, D., & Noordam, R. (2021) · GeroScience · doi:10.1007/s11357-021-00498-9 · Cited by 17
Tucci, M., Marino, M., Martini, D., Porrini, M., Riso, P., & Bo’, C. D. (2022) · Nutrients · doi:10.3390/nu14132615 · Cited by 20
Mechanisms of mitochondrial microRNA regulation in cardiovascular diseases
Roiz‐Valle, D., Caravia, X. M., & López-Otı́n, C. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111822 · Cited by 19
Kalash, A., Abdelrahman, A., Al-Zakwani, I., & Suleimani, Y. A. (2023) · Drugs - Real World Outcomes · doi:10.1007/s40801-023-00373-3 · Cited by 14
MiR ‐203 improves cardiac dysfunction by targeting PARP1‐NAD + axis in aging murine
Zhao, L., Tang, P., Lin, Y., Du, M., Li, H., Jiang, L., Xu, H., Sun, H., Han, J., Sun, Z., et al. (2023) · Aging Cell · doi:10.1111/acel.14063 · Cited by 17
Development of a portable wireless system for bipolar concentric ECG recording
Prats-Boluda, G., Ye-Lin, Y., Bueno-Barrachina, J.-M., Senent, E. G., de Sanabria, R. R., & Garcia‐Casado, J. (2015) · Measurement Science and Technology · doi:10.1088/0957-0233/26/7/075102 · Cited by 18
Drechsler, S., Lynch, M. A., Novella, S., Navarro, H. G., Hecimovic, S. K., Barini, E., Tucci, V., Castro, R. E., Vandenbroucke, R. E., Osuchowski, M. F., et al. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.07.005 · Cited by 20
Understanding lamin proteins and their roles in aging and cardiovascular diseases
Jiang, Y., & Ji, J. Y. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.09.026 · Cited by 18
Rozanski, A., Arnson, Y., Gransar, H., Hayes, S. W., Friedman, J. D., Thomson, L., Dey, D., & Berman, D. S. (2020) · Mayo Clinic Proceedings Innovations Quality & Outcomes · doi:10.1016/j.mayocpiqo.2020.02.005 · Cited by 17
Role of circulating factors in cardiac aging
Cannata, A. N., Marcon, G., Cimmino, G., Camparini, L., Ciucci, G., Sinagra, G., & Loffredo, F. S. (2017) · Journal of Thoracic Disease · doi:10.21037/jtd.2017.03.95 · Cited by 20
Biomarkers of Airway Type-2 Inflammation and Integrating Complex Phenotypes to Endotypes in Asthma
Peters, M. C., Nguyen, M. T., & Dunican, E. M. (2016) · Current Allergy and Asthma Reports · doi:10.1007/s11882-016-0651-4 · Cited by 18
Predictors of statin use among older adults: A nationwide cross-sectional study
Ofori‐Asenso, R., Ilomäki, J., TACEY, M. A., Zomer, E., Curtis, A. J., Bell, J. S., Zoungas, S., & Liew, D. (2018) · Journal of clinical lipidology · doi:10.1016/j.jacl.2018.10.002 · Cited by 17
Soluble Epoxide Hydrolase in Aged Female Mice and Human Explanted Hearts Following Ischemic Injury
Jamieson, K. L., Darwesh, A. M., Sosnowski, D. K., Zhang, H., Shah, S., Zhabyeyev, P., Yang, J., Hammock, B. D., Edin, M. L., Zeldin, D. C., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041691 · Cited by 17
Castro‐Diehl, C., Ehrbar, R. Q., Obas, V., Oh, A., Vasan, R. S., & Xanthakis, V. (2021) · PLoS ONE · doi:10.1371/journal.pone.0251308 · Cited by 17
Atherosclerosis and Cardiovascular Diseases in Progeroid Syndromes
Kato, H., & Maezawa, Y. (2021) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.rv17061 · Cited by 17
Clonal hematopoiesis of indeterminate potential and cardiovascular disease
Saadatagah, S., & Ballantyne, C. M. (2022) · Translational research · doi:10.1016/j.trsl.2022.08.013 · Cited by 17
Drosophila exercise, an emerging model bridging the fields of exercise and aging in human
Ding, M., Li, H., & Zheng, L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.966531 · Cited by 19
RNA modifications in aging-associated cardiovascular diseases
Yang, X., Gokulnath, P., Lehmann, H. I., Hou, Z., Yang, S., You, L., Zhang, G., Xing, Y., Lei, J., Li, G., et al. (2022) · Aging · doi:10.18632/aging.204311 · Cited by 17
Klotho protects against aged myocardial cells by attenuating ferroptosis
Xiong, X., Wang, G., Wang, Y., Zhang, T., Bao, Y., Wang, K., Ainiwaer, D., & Sun, Z. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112157 · Cited by 17
Kim, H., & Kim, M. (2023) · Korean Circulation Journal · doi:10.4070/kcj.2023.0205 · Cited by 18
Prelamin A and ZMPSTE24 in premature and physiological aging
Worman, H. J., & Michaelis, S. (2023) · Nucleus · doi:10.1080/19491034.2023.2270345 · Cited by 18
Xu, C., Song, Z., Wang, J., & Li, C.-C. (2024) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2024.100323 · Cited by 18
Masterson, S., Teljeur, C., Cullinan, J., Murphy, A. W., Deasy, C., & Vellinga, A. (2018) · International Journal of Health Geographics · doi:10.1186/s12942-018-0126-z · Cited by 17
Borderline personality disorder traits associate with midlife cardiometabolic risk.
Barber, T. A., Ringwald, W. R., Wright, A. G. C., & Manuck, S. B. (2019) · Personality Disorders Theory Research and Treatment · doi:10.1037/per0000373 · Cited by 22
Effects of Aging and Diet on Cardioprotection and Cardiometabolic Risk Markers
Corina, A., Abrudan, M. B., Nikolic, D., Cătoi, A. F., Chianetta, R., Castellino, G., Citarrella, R., Stoian, A. P., Pérez‐Martínez, P., & Rizzo, M. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191105111232 · Cited by 19
Chronic Sildenafil Treatment Improves Vasomotor Function in a Mouse Model of Accelerated Aging
Golshiri, K., Ataabadi, E. A., Brandt, R. M. C., van der Pluijm, I., VRIES, R. D., Danser, A. H. J., & Roks, A. J. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134667 · Cited by 17
Mitochondrial Contact Sites in Inflammation-Induced Cardiovascular Disease
Liu, H., Liu, X., Zhuang, H., Fan, H., Zhu, D., Xu, Y., He, P., Liu, J., & Feng, D. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00692 · Cited by 18
Ke, S., Liu, D., Wu, L., Yu, X., Wang, M., Shi, G., Wen, R.-H., Zhou, B., Hao, B., Liu, Y., et al. (2020) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x20500676 · Cited by 17
Spartano, N. L., Davis‐Plourde, K. L., Himali, J. J., Murabito, J. M., Vasan, R. S., Beiser, A., & Seshadri, S. S. (2019) · Journal of Diabetes Research · doi:10.1155/2019/2718465 · Cited by 17
Collura, S., Morsiani, C., Vacirca, A., Fronterrè, S., Ciavarella, C., Vasuri, F., D’Errico, A., Franceschi, C., Pasquinelli, G., Gargiulo, M., et al. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101090 · Cited by 17
Pan, Y., Du, B., Feng, L., & Bi, J. (2025) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-025-01919-x · Cited by 18
Guerrero, F., Carmona, A., Jimenez, M. J., Obrero, T., Pulido-Escribano, V., Moreno, J. A., Soriano, S., Martín‐Malo, A., & Aljama, P. (2021) · Toxins · doi:10.3390/toxins13100738 · Cited by 17
Golf and Physical Health: A Systematic Review
Sorbie, G. G., Beaumont, A. J., Williams, A. K., & Lavallee, D. E. (2022) · Sports Medicine · doi:10.1007/s40279-022-01732-w · Cited by 16
Salis, F., & Mandas, A. (2023) · Medicina · doi:10.3390/medicina59050964 · Cited by 16
Salehi, N., Afrashteh, M. Y., Majzoobi, M. R., Ziapour, A., Janjani, P., & Karami, S. (2023) · BMC Geriatrics · doi:10.1186/s12877-023-04083-x · Cited by 17
Gonadal sex vs genetic sex in experimental atherosclerosis
Nour, J., Bonacina, F., & Norata, G. D. (2023) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2023.117277 · Cited by 17
Chen, Z., Li, X., Sun, X., Xiao, S., Chen, T., Ren, L., & Liu, N. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.06.010 · Cited by 17
Elstein, D., Belmatoug, N., Bembi, B., Deegan, P. B., Fernandez‐Sasso, D., Giraldo, P., Göker-Alpan, Ö., Hughes, D. A., Lau, H., Lukina, E., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13123588 · Cited by 16
PM2.5 Induces Cardiomyoblast Senescence via AhR-Mediated Oxidative Stress
Liu, T., Jiang, B., Fu, B., Shang, C., Feng, H., Chen, T., & Jiang, Y. T. (2024) · Antioxidants · doi:10.3390/antiox13070786 · Cited by 17
Teliewubai, J., Ji, H., Lu, Y., Bai, B., Yu, S., Chen, C., Xu, Y., & Zhang, Y. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9467 · Cited by 16
Diagnosis and treatment of acquired arteriovenous fistula after lower extremity deep vein thrombosis
Yuan, H., Sun, J., Zhou, Z., Qi, H., Wang, M., Dong, D., & Wu, X. (2019) · International Angiology · doi:10.23736/s0392-9590.19.04063-x · Cited by 16
Hassen, H. Y., Bastiaens, H., Royen, K. V., & Abrams, S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0243422 · Cited by 16
Potential Role of Melatonin as an Adjuvant for Atherosclerotic Carotid Arterial Stenosis
Zhang, R., Ni, L., Di, X., Ma, B., Niu, S., Rong, Z., & Liu, C. (2021) · Molecules · doi:10.3390/molecules26040811 · Cited by 16
Sayed, R. K. A., Fernández‐Ortiz, M., Rahim, I., Fernández‐Martínez, J., Aranda‐Martínez, P., Rusanova, I., Martínez-Ruiz, L., Alsaadawy, R. M., Escames, G., & Acuña-Castroviejo, D. (2021) · Antioxidants · doi:10.3390/antiox10081269 · Cited by 17
The effect of camel milk curd masses on rats blood serum biochemical parameters: Preliminary study
Dikhanbayeva, F., Zhaxybayeva, E., Смаилова, Ж., Issimov, A., Dimitrov, Z., Наурзбаевна, К. У., & Bansal, N. (2021) · PLoS ONE · doi:10.1371/journal.pone.0256661 · Cited by 16
The Role of Energy Balance in Successful Aging Among Elderly Individuals
Tyrovolas, S., Haro, J. M., Mariolis, A. D., Piscopo, S., Valacchi, G., Makri, K., Zeimbekis, A., Tyrovola, D., Bountziouka, V., Gotsis, E., et al. (2015) · Journal of Aging and Health · doi:10.1177/0898264315583053 · Cited by 18
Huang, Y.-Y., Kung, P., Chiu, L.-T., & Tsai, W. (2014) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2014.10.019 · Cited by 16
Cardiac Aging – Benefits of Exercise, Nrf2 Activation and Antioxidant Signaling
Narasimhan, M., & Rajasekaran, N. S. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-4307-9_13 · Cited by 17
Neves, J. S., Guerreiro, V. A., Carvalho, D. M., Serrão, R., Sarmento, A., & Freitas, P. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00681 · Cited by 16
Zhao, C. X., Cao, Y., Zhang, Y., & Qiao, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030752 · Cited by 16
Lin, H., Ramesh, S., Chang, Y., Tsai, C., Tsai, C., Shibu, M. A., Tamilselvi, S., Mahalakshmi, B., Kuo, W., & Huang, C. (2020) · Environmental Toxicology · doi:10.1002/tox.23014 · Cited by 16
Endothelial dysfunction and vascular stiffness: molecular drivers of cardiovascular aging
Çelik, M. C., Kalçık, M., Bi̇rgün, A., Yetim, M., Bekar, L., & Karavelioğlu, Y. (2025) · Exploration of Cardiology · doi:10.37349/ec.2025.101279 · Cited by 17
Cardiometabolic Modification of Amyloid Beta in Alzheimer’s Disease Pathology
Hefner, M., Baliga, V., Amphay, K., Ramos, D., & Hegde, V. K. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.721858 · Cited by 18
Dyball, D. M., Bennett, A. N., Schofield, S. J., Cullinan, P., Boos, C. J., Bull, A. M. J., Stevelink, S. A. M., & Fear, N. T. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.01.010 · Cited by 15
Acute myocardial infarction triggered by physical exertion: a systematic review and meta-analysis
Čulić, V., AlTurki, A., Vio, R., Proietti, R., & Jerončić, A. (2023) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwad045 · Cited by 15
Kang, S., Seo, S., Song, E. J., Kweon, O., Jo, A.-H., Park, S., Woo, T., Kim, B.-H., Oh, G. T., & Park, B.-J. (2023) · Cells · doi:10.3390/cells12091232 · Cited by 15
Hydrogen sulfide ameliorates endothelial dysfunction in aging arteries by regulating ferroptosis
Miao, Y., Zhang, S., Liang, Z., Wang, Y., Tian, D., Jin, S., Guo, Q., Xue, H., Teng, X., Xiao, L., et al. (2023) · Nitric Oxide · doi:10.1016/j.niox.2023.10.002 · Cited by 16
Pappritz, K., Puhl, S., Matz, I., Brauer, E., Shia, Y. X., El-Shafeey, M. E. A., Koch, S. E., Miteva, K., Mucha, C., Duda, G. N., et al. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1117419 · Cited by 15
Sarandy, M. M., Gonçalves, R. V., & Valacchi, G. (2024) · Biomedicines · doi:10.3390/biomedicines12020348 · Cited by 16
Singh, J., Jackson, K. L., Tang, F. S., Fu, T., Nowell, C. J., Salimova, E., Kiriazis, H., Ritchie, R. H., Head, G. A., Woodman, O. L., et al. (2024) · The FASEB Journal · doi:10.1096/fj.202301802r · Cited by 17
Kalies, K., Knöpp, K., Wurmbrand, L., Korte, L., Dutzmann, J., Pilowski, C., Koch, S., & Sedding, D. (2024) · Scientific Reports · doi:10.1038/s41598-024-54455-5 · Cited by 15
Fabre, L., & Rangel, É. B. (2024) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188241242947 · Cited by 15
Non‐coding RNAs to treat vascular smooth muscle cell dysfunction
Brown, S., Klimi, E., Bakker, W. A. M., Beqqali, A., & Baker, A. H. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16409 · Cited by 15
Wang, Y., Li, Q., Bi, L., Wang, B., Lv, T., & Zhang, P. (2025) · Tobacco Induced Diseases · doi:10.18332/tid/199931 · Cited by 14
Long-Term Lipid Lowering With Evolocumab in Older Individuals
Said, S. A., O’Donoghue, M. L., Ran, X., Murphy, S. A., Atar, D., KEECH, A. C., Flores‐Arredondo, J. H., Wang, B., Sabatine, M. S., & Giugliano, R. P. (2025) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.11.019 · Cited by 15
Hemodynamic Instability in Heart Failure Intensifies Age-Dependent Cognitive Decline
de la Torre, J. C. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200296 · Cited by 16
Dehbalaei, M. G., Ashtary‐Larky, D., Mesrkanlou, H. A., Talebi, S., & Asbaghi, O. (2020) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2020.10.021 · Cited by 15
Abooshahab, R., & Dass, C. R. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111478 · Cited by 15
Sanderson, J. E. (2016) · European Heart Journal - Quality of Care and Clinical Outcomes · doi:10.1093/ehjqcco/qcw026 · Cited by 15
Circadian system and aging: where both times interact
Cobarro, C., Soares, L. I., Kutsenko, Y., & Tomás‐Loba, A. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1646794 · Cited by 15
Huang, N., Zhuang, Z., Song, Z., Wang, W., Li, Y., Zhao, Y., Xiao, W., Dong, X. Y., Jia, J., Liu, Z., et al. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.026736 · Cited by 15
Magkoutas, K., Weisskopf, M., Falk, V., Emmert, M. Y., Meboldt, M., Cesarovic, N., & Daners, M. S. (2023) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2022.12.008 · Cited by 16
Magyar-Stang, R., István, L., Pál, H., Csányi, B., Gaál, A., Mihály, Z., Czinege, Z., Sótonyi, P., Horváth, T., Koller, Á., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0291521 · Cited by 14
PARP-2 mediates cardiomyocyte aging and damage induced by doxorubicin through SIRT1 Inhibition
Huang, C., Zhang, X., Wang, S., Shen, A., Xu, T., Hou, Y., Gao, S., Xie, Y., Zeng, Y., Chen, J., et al. (2024) · APOPTOSIS · doi:10.1007/s10495-023-01929-y · Cited by 14
Oh, J., Hong, S., Ko, S., & Kim, H. (2024) · Antioxidants · doi:10.3390/antiox13020241 · Cited by 14
New Insights into IGF-1 Signaling in the Heart
Lee, W. S., Abel, E. D., & Kim, J. (2024) · Physiology · doi:10.1152/physiol.00003.2024 · Cited by 14
Metadata
- Authors
- North, B. J., & Sinclair, D. A.
- Affiliations
- Harvard University (US)
- Venue
- Circulation Research
- Published
- 2012-04-13
- Volume
- 110
- Issue
- 8
- Pages
- 1097-1108
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC3366686
- OpenAlex
- W2142194547
- Cited by
- 1,585
- References
- 140
- Citations by year
- 2026: 144 · 2025: 217 · 2024: 204 · 2023: 205 · 2022: 163 · 2021: 144 · 2020: 122 · 2019: 95 · 2018: 66 · 2017: 54 · 2016: 48 · 2015: 51 · 2014: 40 · 2013: 24 · 2012: 5
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Glenn Foundation for Medical Research
- Beth Israel Deaconess Medical Center
- Fondation pour la Recherche Médicale
- National Institutes of Health
- National Institute on Aging (R37AG028730, R01AG028730, R01AG019719, T32AG023480)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Keywords
- aging, cardiovascular disease, cardiovascular aging, lifespan regulation, healthspan, sirtuins, AMPK, mTOR, insulin-like growth factor I, longevity genes, aged population
- MeSH terms
- Age Factors, Aged, Aging, Animals, Cardiovascular Diseases, Cardiovascular System, Gene Expression Regulation, Humans, Longevity, Prognosis, Risk Factors, Risk Assessment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review