The Intersection Between Aging and Cardiovascular Disease

The serial cultivation of human diploid cell strains

Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810

Resveratrol improves health and survival of mice on a high-calorie diet

Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670

A C. elegans mutant that lives twice as long as wild type

Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300

Forecasting the Future of Cardiovascular Disease in the United States: A Policy Statement From the American Heart Association

Heidenreich, P. A., Trogdon, J. G., Khavjou, O. A., Butler, J., Dracup, K., Ezekowitz, M. D., Finkelstein, E. A., Hong, Y., Johnston, S. C., Khera, A., et al. (2011) · Circulation · doi:10.1161/cir.0b013e31820a55f5 · Cited by 3,208

Lipocalin 2 as a link between ageing, risk factor conditions and age-related brain diseases

Dekens, D. W., Eisel, U. L. M., Gouweleeuw, L., Schoemaker, R. G., Deyn, P. P. D., & Naudé, P. J. W. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101414 · Cited by 93

Cardiovascular disease burden: Italian and global perspectives

Saglietto, A., Manfredi, R., Elia, E., D’Ascenzo, F., Ferrari, G. M. D., Biondi‐Zoccai, G., & Münzel, T. F. (2021) · Minerva Cardiology and Angiology · doi:10.23736/s2724-5683.21.05538-9 · Cited by 92

The NLRP3 Inflammasome as a Critical Actor in the Inflammaging Process

Sebastian-Valverde, M., & Pasinetti, G. M. (2020) · Cells · doi:10.3390/cells9061552 · Cited by 90

Pharmacological Strategies to Retard Cardiovascular Aging

Alfaras, I., Germanio, C. D., Bernier, M., Csiszár, A., Ungvari, Z. I., Lakatta, E. G., & de Cabo, R. (2016) · Circulation Research · doi:10.1161/circresaha.116.307475 · Cited by 87

Cardiovascular disease (CVD) and its associated risk factors among older adults in India: Evidence from LASI Wave 1

Kundu, J., & Kundu, S. (2021) · Clinical Epidemiology and Global Health · doi:10.1016/j.cegh.2021.100937 · Cited by 91

The Epigenetic Link between Polyphenols, Aging and Age-Related Diseases

Arora, I., Sharma, M., Sun, L. Y., & Tollefsbol, T. O. (2020) · Genes · doi:10.3390/genes11091094 · Cited by 86

Percutaneous coronary intervention in patients with cancer and readmissions within 90 days for acute myocardial infarction and bleeding in the USA

Kwok, C. S., Wong, C. W., Kontopantelis, E., Barac, A., Brown, S.-A. N., Velagapudi, P., Hilliard, A. A., Bharadwaj, A. S., Alraies, M. C., Mohamed, M., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa1032 · Cited by 87

Role of the cGAS-STING Pathway in Aging-related Endothelial Dysfunction

Yu, H., Liao, K., Hu, Y., Lv, D., Luo, M., Liu, Q., Huang, L., & Luo, S. (2022) · Aging and disease · doi:10.14336/ad.2022.0316 · Cited by 84

Nrf2 signaling and redox homeostasis in the aging heart: A potential target to prevent cardiovascular diseases?

Silva‐Palacios, A., Königsberg, M., & Zazueta, C. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.12.005 · Cited by 84

Elevated Sodium and Dehydration Stimulate Inflammatory Signaling in Endothelial Cells and Promote Atherosclerosis

Dmitrieva, N. I., & Burg, M. B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128870 · Cited by 85

Circulating Metabolites Originating from Gut Microbiota Control Endothelial Cell Function

Amedei, A., & Morbidelli, L. (2019) · Molecules · doi:10.3390/molecules24213992 · Cited by 84

TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2

Chang, K., Kang, P., Liu, Y., Huang, K., Miao, T., Sagona, A. P., Nezis, I. P., Bodmer, R., Ocorr, K., & Bai, H. (2020) · Autophagy · doi:10.1080/15548627.2019.1704117 · Cited by 73

Urgent needs of caregiving in ageing populations with Alzheimer’s disease and other chronic conditions: Support our loved ones

Culberson, J. W., Kopel, J. J., Sehar, U., & Reddy, P. H. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102001 · Cited by 95

Emerging roles of frailty and inflammaging in risk assessment of age-related chronic diseases in older adults: the intersection between aging biology and personalized medicine

Wu, I., Lin, C., & Hsiung, C. A. (2015) · Biomedicine · doi:10.7603/s40681-015-0001-1 · Cited by 83

Reactive Oxygen Species Induced Pathways in Heart Failure Pathogenesis and Potential Therapeutic Strategies

Mongirdienė, A., Skrodenis, L., Varoneckaitė, L., Mierkytė, G., & Gerulis, J. (2022) · Biomedicines · doi:10.3390/biomedicines10030602 · Cited by 86

Sirtuin 2 deficiency aggravates ageing-induced vascular remodelling in humans and mice

Zhang, Y., Wang, X., Li, X.-K., Lv, S., Wang, H., Liu, Y., Zhou, J., Gong, H., Chen, X.-F., Ren, S., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad381 · Cited by 84

Ryanodine Receptor Glycation Favors Mitochondrial Damage in the Senescent Heart

Ruiz‐Meana, M., Minguet, M., Bou‐Teen, D., Miró‐Casas, E., Castans, C., Castellano, J., Bonzón‐Kulichenko, E., Igual, A., Rodríguez-Lecoq, R., Vázquez, J., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.035869 · Cited by 80

Prenatal Hypoxia Causes Long-Term Alterations in Vascular Endothelin-1 Function in Aged Male, but Not Female, Offspring

Bourque, S. L., Gragasin, F. S., Quon, A., Mansour, Y., Morton, J. S., & Davidge, S. T. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01516 · Cited by 80

The Effect of Aging on Relationships between Lean Body Mass and VO2max in Rowers

Kim, C., Wheatley, C. M., Behnia, M. M., & Johnson, B. D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160275 · Cited by 80

Targeting Cell Senescence and Senolytics: Novel Interventions for Age-Related Endocrine Dysfunction

Suda, M., Paul, K. H., Tripathi, U., Minamino, T., Tchkonia, T., & Kirkland, J. L. (2024) · Endocrine Reviews · doi:10.1210/endrev/bnae010 · Cited by 83

Estimated glucose disposal rate outperforms other insulin resistance surrogates in predicting incident cardiovascular diseases in cardiovascular-kidney-metabolic syndrome stages 0–3 and the development of a machine learning prediction model: a nationwide prospective cohort study

Dong, B., Chen, Y., Yang, X., Chen, Z., Zhang, H., Gao, Y., Zhao, E., & Zhang, C. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02729-1 · Cited by 98

The Effect of Ageing on Vascular Smooth Muscle Cell Behaviour - A Mini-Review

Monk, B. A., & George, S. J. (2014) · Gerontology · doi:10.1159/000368576 · Cited by 79

Ageing, the autonomic nervous system and arrhythmia: From brain to heart

Chadda, K. R., Ajijola, O. A., Vaseghi, M., Shivkumar, K., Huang, C. L.-H., & Jeevaratnam, K. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.09.005 · Cited by 77

Nutrition and Healthy Aging: Prevention and Treatment of Gastrointestinal Diseases

Cristina, N. M., & D’Alba, L. (2021) · Nutrients · doi:10.3390/nu13124337 · Cited by 90

Flavonoids: Potential therapeutic agents for cardiovascular disease

Liu, Y., Luo, J., Peng, L., Zhang, Q., Rong, X., Luo, Y., & Li, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32563 · Cited by 82

Melatonin: Protection against age-related cardiac pathology

Favero, G., Franceschetti, L., Buffoli, B., Moghadasian, M. H., Reiter, R. J., Rodella, L. F., & Rezzani, R. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.11.007 · Cited by 78

Mechanical, hormonal and metabolic influences on blood vessels, blood flow and bone

Prisby, R. D. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0666 · Cited by 76

Myocardial fibrosis in athletes—Current perspective

Małek, Ł. A., & Bucciarelli‐Ducci, C. (2020) · Clinical Cardiology · doi:10.1002/clc.23360 · Cited by 84

Effect of Cellular and ECM Aging on Human iPSC-derived Cardiomyocyte Performance, Maturity and Senescence

Ozcebe, S. G., Bahçecioğlu, G., Yue, X. S., & Zorlutuna, P. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120554 · Cited by 75

Melatonin as an Anti-Aging Therapy for Age-Related Cardiovascular and Neurodegenerative Diseases

Giménez, V. M. M., Heras, N. D. L., Lahera, V., Tresguerres, J. A. F., Reiter, R. J., & Manucha, W. A. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.888292 · Cited by 75

Statins for extension of disability-free survival and primary prevention of cardiovascular events among older people: protocol for a randomised controlled trial in primary care (STAREE trial)

Zoungas, S., Curtis, A. J., Spark, S., Wolfe, R. S., McNeil, J. J., Beilin, L. J., Chong, T. T. ‐., CLOUD, G. C., Hopper, I., Kost, A., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2022-069915 · Cited by 80

The Role of Intestinal Dysbacteriosis Induced Arachidonic Acid Metabolism Disorder in Inflammaging in Atherosclerosis

Sun, Y., Wu, D., Zeng, W., Chen, Y., Guo, M., Lü, B., Li, H., Sun, C. X., Yang, L., Jiang, X., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.618265 · Cited by 72

SIRT3 as a potential therapeutic target for heart failure

Chen, J., Chen, S., Zhang, B., & Liu, J. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105432 · Cited by 74

Mitochondrial Dysfunction: The Hidden Player in the Pathogenesis of Atherosclerosis?

Ciccarelli, G., Conte, S., Cimmino, G., Maiorano, P., Morrione, A., & Giordano, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021086 · Cited by 75

Insulin resistance: a risk marker for disease and disability in the older person

Krentz, A. J., Viljoen, A., & Sinclair, A. J. (2012) · Diabetic Medicine · doi:10.1111/dme.12063 · Cited by 75

Therapeutic Potential of Senolytics in Cardiovascular Disease

Dookun, E., Passos, J. F., Arthur, H. M., & Richardson, G. D. (2022) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-07075-w · Cited by 69

Cellular cross-talks in the diseased and aging heart

Wagner, J. U. G., & Dimmeler, S. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.11.152 · Cited by 77

Aging Fits the Disease Criteria of the International Classification of Diseases

Khaltourina, D. A., Matveyev, Y., Alekseev, A., Cortese, F., & Ioviţă, A. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111230 · Cited by 78

The role of interleukin-10 family members in cardiovascular diseases

Xu, S., Zhang, J., Liu, J., Ye, J., Xu, Y. Q., Wang, Z., Yu, J., Ye, D., Zhao, M., Feng, Y., et al. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107475 · Cited by 75

Age-dependent sex differences in cardiometabolic risk factors

Zhernakova, D. V., Sinha, T., Andreu‐Sánchez, S., Prins, J. R., Kurilshikov, A., Balder, J.-W., Sanna, S., Study, L. C., Franke, L., Kuivenhoven, J. A., et al. (2022) · Nature Cardiovascular Research · doi:10.1038/s44161-022-00131-8 · Cited by 79

Aging and cardiovascular diseases: the role of gene-diet interactions

Corella, D., & Ordovás, J. M. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.08.002 · Cited by 83

Cardiovascular disease-related miRNAs expression: potential role as biomarkers and effects of training exercise

Ultimo, S., Zauli, G., Martelli, A. M., Vitale, M., McCubrey, J. A., Capitani, S., & Neri, L. M. (2018) · Oncotarget · doi:10.18632/oncotarget.24428 · Cited by 72

A coronary artery disease-associated tRNAThr mutation altered mitochondrial function, apoptosis and angiogenesis

Jia, Z., Zhang, Y., Li, Q., Ye, Z., Liu, Y., Fu, C., Cang, X., Wang, M., & Guan, M. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1241 · Cited by 71

Prediction of vascular aging based on smartphone acquired PPG signals

Dall’Olio, L., Curti, N., Remondini, D., Harb, Y. S., Asselbergs, F. W., Castellani, G., & Uh, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-76816-6 · Cited by 70

Biological Aging and the Future of Geriatric Psychiatry

Rutherford, B. R., Taylor, W. D., Brown, P. J., Sneed, J. R., & Roose, S. P. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw241 · Cited by 75

Inorganic nitrite supplementation for healthy arterial aging

Sindler, A. L., DeVan, A. E., Fleenor, B. S., & Seals, D. R. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01100.2013 · Cited by 68

Are Endothelial Progenitor Cells the Real Solution for Cardiovascular Diseases? Focus on Controversies and Perspectives

Balistreri, C. R., Buffa, S., Pisano, C., Lio, D., Ruvolo, G., & Mazzesi, G. (2015) · BioMed Research International · doi:10.1155/2015/835934 · Cited by 76

Extracellular Matrix in Aging Aorta

Mammoto, A., Matus, K., & Mammoto, T. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.822561 · Cited by 68

Life in the cold: links between mammalian hibernation and longevity

Wu, C., & Storey, K. B. (2016) · BioMolecular Concepts · doi:10.1515/bmc-2015-0032 · Cited by 72

The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop

Budinger, G. R. S., Kohanski, R. A., Gan, W., Kobor, M. S., Amaral, L. A. N., Armanios, M. Y., Kelsey, K. T., Pardo, A., Tuder, R. M., Macián, F., et al. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx090 · Cited by 69

Exercise protects aged mice against coronary endothelial senescence via FUNDC1-dependent mitophagy

Ma, L., Li, K., Wei, W., Zhou, J., Li, Z., Zhang, T., Wangsun, Y., Tian, F., Dong, Q., Zhang, H., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102693 · Cited by 70

Resveratrol attenuates hydrogen peroxide-induced aging through upregulation of autophagy in human umbilical vein endothelial cells

Du, L., Chen, E., Wu, T., Ruan, Y., & Wu, S. (2019) · Drug Design Development and Therapy · doi:10.2147/dddt.s179894 · Cited by 67

NemaLife chip: a micropillar-based microfluidic culture device optimized for aging studies in crawling C. elegans

Rahman, M., Edwards, H., Birze, N., Gabrilska, R. A., Rumbaugh, K. P., Bławzdziewicz, J., Szewczyk, N. J., Driscoll, M., & Vanapalli, S. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-73002-6 · Cited by 75

Adhesive capsulitis: An age related symptom of metabolic syndrome and chronic low-grade inflammation?

Pietrzak, M. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2016.01.002 · Cited by 67

Multiple sclerosis and aging: comorbidity and treatment challenges

Ostolaza, A., Corroza, J., & Ayuso, T. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.102815 · Cited by 66

DNA repair as a shared hallmark in cancer and ageing

Clarke, T. L., & Mostoslavsky, R. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13285 · Cited by 74

Vascular Aging: Assessment and Intervention

Li, A., Yan, J., Ya, Z., Yu, Z., Tian, S., Khan, A. H., Zhu, Y., Wu, A., Zhang, C., & Tian, X. (2023) · Clinical Interventions in Aging · doi:10.2147/cia.s423373 · Cited by 70

Biological Age, Not Chronological Age, Is Associated with Late-Life Depression

Brown, P. J., Wall, M. M., Chen, C., Levine, M. E., Yaffe, K. S., Roose, S. P., & Rutherford, B. R. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx162 · Cited by 68

The multifaceted actions of the lncRNA H19 in cardiovascular biology and diseases

Busscher, D., Boon, R. A., & Juni, R. P. (2022) · Clinical Science · doi:10.1042/cs20210994 · Cited by 65

Longevity and anti-aging effects of curcumin supplementation

Izadi, M., Sadri, N., Abdi, A., Zadeh, M. M. R., Jalaei, D., Ghazimoradi, M. M., Shouri, S., & Tahmasebi, S. (2024) · GeroScience · doi:10.1007/s11357-024-01092-5 · Cited by 70

miR-29 family: A potential therapeutic target for cardiovascular disease

Liu, M., Luo, G., Gao, W., Yang, S., & Zhou, H. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105510 · Cited by 64

Effect of Physical Activity, Smoking, and Sleep on Telomere Length: A Systematic Review of Observational and Intervention Studies

Barragán, R., Ortega‐Azorín, C., Sorlí, J. V., Asensio, E. M., Coltell, Ó., St‐Onge, M., Portolés, O., & Corella, D. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm11010076 · Cited by 70

Regulation of cardiovascular health and disease by visceral adipose tissue‐derived metabolic hormones

Vasamsetti, S. B., Natarajan, N., Sadaf, S., Florentin, J., & Dutta, P. (2022) · The Journal of Physiology · doi:10.1113/jp282728 · Cited by 69

Glycosylation Biomarkers Associated with Age-Related Diseases and Current Methods for Glycan Analysis

Paton, B., Suárez, M., Herrero, P., & Canela-Canela, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115788 · Cited by 61

Aging Modulates the Substrate and Triggers Remodeling in Atrial Fibrillation

Lin, Y., Chen, Y.-A., Lee, T.-I., Chen, Y., Chen, S.-A., & Chen, Y. (2017) · Circulation Journal · doi:10.1253/circj.cj-17-0242 · Cited by 62

Excess ω-6 fatty acids influx in aging drives metabolic dysregulation, electrocardiographic alterations, and low-grade chronic inflammation

Kain, V., Ingle, K. A., Kachman, M. T., Baum, H., Shanmugam, G., Rajasekaran, N. S., Young, M. E., & Halade, G. V. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00297.2017 · Cited by 62

Regulation and roles of RNA modifications in aging‐related diseases

Jiapaer, Z., Su, D., Hua, L., Lehmann, H. I., Gokulnath, P., Vulugundam, G., Song, S., Zhang, L., Gong, Y., & Li, G. (2022) · Aging Cell · doi:10.1111/acel.13657 · Cited by 60

Geriatric Cardiology: Coming of Age

Goyal, P., Kwak, M. J., Malouf, C. A., Kumar, M., Rohant, N., Damluji, A. A., Denfeld, Q. E., Bircher, K. K., Krishnaswami, A., Alexander, K. P., et al. (2022) · JACC Advances · doi:10.1016/j.jacadv.2022.100070 · Cited by 64

Long non-coding RNAs in the failing heart and vasculature

Hermans-Beijnsberger, S., van Bilsen, M., & Schroen, B. L. M. (2018) · Non-coding RNA Research · doi:10.1016/j.ncrna.2018.04.002 · Cited by 63

Dietary Supplements and Natural Products: An Update on Their Clinical Effectiveness and Molecular Mechanisms of Action During Accelerated Biological Aging

Chen, Y., Hamidu, S., Yang, X., Yan, Y., Wang, Q., Li, L., Oduro, P. K., & Li, Y. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.880421 · Cited by 62

NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy

Yue, Z., Ma, Y., You, J., Li, Z., Ding, Y.-Q., He, P., Lu, X., Jiang, J., Chen, S., & Liu, P. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.07.006 · Cited by 59

Burden of cardiovascular disease attributed to air pollution: a systematic review

Khoshakhlagh, A. H., Mohammadzadeh, M., Gruszecka‐Kosowska, A., & Oikonomou, E. K. (2024) · Globalization and Health · doi:10.1186/s12992-024-01040-0 · Cited by 61

Extracellular matrix roles in cardiorenal fibrosis: Potential therapeutic targets for CVD and CKD in the elderly

Toba, H., & Lindsey, M. L. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.08.014 · Cited by 59

SIRT1: Role in cardiovascular biology

Ma, L., & Li, Y. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.10.036 · Cited by 59

Geriatric syndromes—vascular disorders?

Strandberg, T. E., Pitkälä, K. H., Tilvis, R. S., O’Neill, D. J., & Erkinjuntti, T. J. (2012) · Annals of Medicine · doi:10.3109/07853890.2012.727022 · Cited by 58

Cisd2 is essential to delaying cardiac aging and to maintaining heart functions

Yeh, C., Shen, Z., Hsiung, S.-Y., Wu, P.-C., Teng, Y., Chou, Y.-J., Fang, S.-W., Chen, C., Yan, Y.-T., Kao, L., et al. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000508 · Cited by 58

The Impact of Autophagy on Cardiovascular Senescence and Diseases

Sasaki, Y., Ikeda, Y., Iwabayashi, M., Akasaki, Y., & Ohishi, M. (2017) · International Heart Journal · doi:10.1536/ihj.17-246 · Cited by 60

Translational Aspects of 3D and 4D Printing and Bioprinting

Taylor, S., Mueller, E., Jones, L. R., Makela, A. V., & Ashammakhi, N. A. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400463 · Cited by 65

The Role of Essential Oils and Their Main Compounds in the Management of Cardiovascular Disease Risk Factors

Alves-Silva, J. M., Zuzarte, M., Girão, H., & Salgueiro, L. (2021) · Molecules · doi:10.3390/molecules26123506 · Cited by 57

Short‐Bowel Syndrome: Epidemiology, Hospitalization Trends, In‐Hospital Mortality, and Healthcare Utilization

Siddiqui, M. T., Al-Yaman, W. A., Singh, A., & Kirby, D. F. (2020) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.2051 · Cited by 55

A Machine-Generated View of the Role of Blood Glucose Levels in the Severity of COVID-19

Logette, E., Lorin, C., Favreau, C., Oshurko, E., Coggan, J. S., Casalegno, F., Sy, M. F., Monney, C., Bertschy, M., Delattre, É., et al. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.695139 · Cited by 58

Depression, cardiometabolic disease, and their co-occurrence after childhood maltreatment: an individual participant data meta-analysis including over 200,000 participants

Souama, C., Lamers, F., Milaneschi, Y., Vinkers, C. H., Defina, S., Garvert, L., Stein, F., Woofenden, T., Brosch, K., Dannlowski, U., et al. (2023) · BMC Medicine · doi:10.1186/s12916-023-02769-y · Cited by 58

Health Economic Research Assessing the Value of Early Detection of Cardiovascular Disease: A Systematic Review

Wolcherink, M. O. O., Behr, C., Pouwels, X., Doggen, C., & Koffijberg, H. (2023) · PharmacoEconomics (Auckland) · doi:10.1007/s40273-023-01287-2 · Cited by 54

G Protein-Coupled Receptor Systems and Their Role in Cellular Senescence

Santos‐Otte, P., Leysen, H., van Gastel, J., Hendrickx, J. O., Martin, B., & Maudsley, S. R. (2019) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2019.08.005 · Cited by 53

Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial

Katayoshi, T., Uehata, S., Nakashima, N., Nakajo, T., Kitajima, N., Kageyama, M., & Tsuji, K. (2023) · Scientific Reports · doi:10.1038/s41598-023-29787-3 · Cited by 54

Toll-like receptor-4 signaling pathway in aorta aging and diseases: “its double nature”

Balistreri, C. R., Ruvolo, G., Lio, D., & Madonna, R. (2017) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2017.06.011 · Cited by 55

A Glb1-2A-mCherry reporter monitors systemic aging and predicts lifespan in middle-aged mice

Sun, J., Wang, M., Zhong, Y., Ma, X., Sun, S., Xu, C., Peng, L., Li, G., Zhang, L., Liu, Z., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34801-9 · Cited by 52

Measurement of respiratory function in isolated cardiac mitochondria using Seahorse XFe24 Analyzer: applications for aging research

Sakamuri, S. S. V. P., Sperling, J. A., Sure, V. N. L. R., Dholakia, M. H., Peterson, N. R., Rutkai, I., Mahalingam, P. S., Satou, R., & Katakam, P. V. G. (2018) · GeroScience · doi:10.1007/s11357-018-0021-3 · Cited by 52

Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging

Jin, Y., Takeda, Y., Kondo, Y., Tripathi, L. P., Kang, S., Takeshita, H., Kuhara, H., Maeda, Y., Higashiguchi, M., Miyake, K., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-23338-x · Cited by 50

Estimating pulse wave velocity from the radial pressure wave using machine learning algorithms

Jin, W., Chowienczyk, P., & Alastruey, J. (2021) · PLoS ONE · doi:10.1371/journal.pone.0245026 · Cited by 55

Skeleton-secreted PDGF-BB mediates arterial stiffening

Santhanam, L., Liu, G., Jandu, S., Su, W., Wodu, B. P., Savage, W., Poe, A., Liu, X., Alexander, L. M., Cao, X., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci147116 · Cited by 51

Investigating genes associated with heart failure, atrial fibrillation, and other cardiovascular diseases, and predicting disease using machine learning techniques for translational research and precision medicine

Venkat, V., Abdelhalim, H., DeGroat, W., Zeeshan, S., & Ahmed, Z. (2023) · Genomics · doi:10.1016/j.ygeno.2023.110584 · Cited by 51

The Na+/K+-ATPase: A potential therapeutic target in cardiometabolic diseases

Obradovic, M. M., Sudar-Milovanovic, E. M., Gluvic, Z. M., Banjac, K., Rizzo, M., & Isenović, E. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1150171 · Cited by 56

Cellular and molecular biology of sirtuins in cardiovascular disease

Liu, Y., Wen, R., Liu, C., Zhang, T., & Yang, N. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114931 · Cited by 53

Cellular and molecular basis of the imbalance between vascular damage and repair in ageing and age-related diseases: As biomarkers and targets for new treatments

Madonna, R., Novo, G., & Balistreri, C. R. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.03.005 · Cited by 52

Estrogenic vascular effects are diminished by chronological aging

Nicholson, C., Sweeney, M., Robson, S. C., & Taggart, M. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-12153-5 · Cited by 51

Effect of a Walnut Diet on Office and 24-Hour Ambulatory Blood Pressure in Elderly Individuals

Doménech, M., Serra‐Mir, M., Roth, I., Freitas-Simoes, T. M., Valls‐Pedret, C., Cofán, M., López-Illamola, A., Sala‐Vila, A., Calvo, C., Rajaram, S., et al. (2019) · Hypertension · doi:10.1161/hypertensionaha.118.12766 · Cited by 56

Age-dependent association of gut bacteria with coronary atherosclerosis: Tampere Sudden Death Study

Tuomisto, S., Huhtala, H., Martiskainen, M., Goebeler, S., Lehtimäki, T. J., & Karhunen, P. J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0221345 · Cited by 51

Daily supplementation with aronia melanocarpa (chokeberry) reduces blood pressure and cholesterol: a meta analysis of controlled clinical trials

Hawkins, J., Hires, C., Baker, C., Keenan, L., & Bush, M. (2020) · Journal of Dietary Supplements · doi:10.1080/19390211.2020.1800887 · Cited by 51

Evaluation of Aspirin and Statin Therapy Use and Adherence in Patients With Premature Atherosclerotic Cardiovascular Disease

Mahtta, D., Ramsey, D. J., Rifai, M. A., Nasir, K., Samad, Z. Z., Aguilar, D. A., Jneid, H. M., Ballantyne, C. M., Petersen, L. A., & Virani, S. S. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.11051 · Cited by 50

Molecular Mechanisms of Cardiovascular Aging

Meiliana, A., & Wijaya, A. (2013) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v5i3.64 · Cited by 1

Role of lifespan-regulating genes in age-related cardiovascular disease

Puspitasari, Y. M., Schwarz, L., & Camici, G. G. (2021) · Cardiovascular Medicine · doi:10.4414/cvm.2022.02146 · Cited by 4

Genetic basis of cardiovascular aging is at the core of human longevity

Marian, A. J. (2022) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2022.06 · Cited by 6

Aging: Molecular Pathways and Implications on the Cardiovascular System

de Almeida, A. J. P. O., Ribeiro, T. P., & de Medeiros, I. A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7941563 · Cited by 120

Cardiovascular Aging and Longevity

Pietri, P. G., & Stefanadis, C. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.11.023 · Cited by 106