Cited by 1,585Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in MedicineTelomeres, Telomerase, and Senescence

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The Intersection Between Aging and Cardiovascular Disease

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North, Brian J., Sinclair, David A.·2012·Circulation Research

DOI 10.1161/circresaha.111.246876PMC PMC3366686

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Abstract

The average lifespan of humans is increasing, and with it the percentage of people entering the 65 and older age group is growing rapidly and will continue to do so in the next 20 years. Within this age group, cardiovascular disease will remain the leading cause of death, and the cost associated with treatment will continue to increase. Aging is an inevitable part of life and unfortunately poses the largest risk factor for cardiovascular disease. Although numerous studies in the cardiovascular field have considered both young and aged humans, there are still many unanswered questions as to how the genetic pathways that regulate aging in model organisms influence cardiovascular aging. Likewise, in the molecular biology of aging field, few studies fully assess the role of these aging pathways in cardiovascular health. Fortunately, this gap is beginning to close, and these two fields are merging together. We provide an overview of some of the key genes involved in regulating lifespan and health span, including sirtuins, AMP-activated protein kinase, mammalian target of rapamycin, and insulin-like growth factor 1 and their roles regulating cardiovascular health. We then discuss a series of review articles that will appear in succession and provide a more comprehensive analysis of studies carried out linking genes of aging and cardiovascular health, and perspectives of future directions of these two intimately linked fields.

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Authors: North, B. J., & Sinclair, D. A.
Affiliations: Harvard University (US)
ORCID: North, Brian J.
Sinclair, David A.
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2012-04-13
Volume: 110
Issue: 8
Pages: 1097-1108
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/circresaha.111.246876
PMC: PMC3366686
OpenAlex: W2142194547
Cited by: 1,585
References: 140
Citations by year: 2026: 144 · 2025: 217 · 2024: 204 · 2023: 205 · 2022: 163 · 2021: 144 · 2020: 122 · 2019: 95 · 2018: 66 · 2017: 54 · 2016: 48 · 2015: 51 · 2014: 40 · 2013: 24 · 2012: 5
FWCI: 3.87
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Glenn Foundation for Medical Research
Beth Israel Deaconess Medical Center
Fondation pour la Recherche Médicale
National Institutes of Health
National Institute on Aging (R37AG028730, R01AG028730, R01AG019719, T32AG023480)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Keywords: aging, cardiovascular disease, cardiovascular aging, lifespan regulation, healthspan, sirtuins, AMPK, mTOR, insulin-like growth factor I, longevity genes, aged population
MeSH terms: Age Factors, Aged, Aging, Animals, Cardiovascular Diseases, Cardiovascular System, Gene Expression Regulation, Humans, Longevity, Prognosis, Risk Factors, Risk Assessment

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