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Cited by 377

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Anabolic Deficiency in Men With Chronic Heart Failure: Prevalence and Detrimental Impact on Survival

Open access
Jankowska, Ewa A., Biel, Bartosz, Majda, Jacek, Szklarska, Alicja, Lopuszanska, Monika, Medras, Marek, Anker, Stefan D., Banasiak, Waldemar, Poole-Wilson, Philip A., Ponikowski, Piotr·2006·Circulation
DOI 10.1161/circulationaha.106.649426
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Abstract

Background— The age-related decline of circulating anabolic hormones in men is associated with increased morbidity and mortality. We studied the prevalence and prognostic consequences of deficiencies in circulating total testosterone (TT) and free testosterone, dehydroepiandrosterone sulfate (DHEAS), and insulin-like growth factor-1 (IGF-1) in men with chronic heart failure (CHF). Methods and Results— Serum levels of TT, DHEAS, and IGF-1 were measured with immunoassays in 208 men with CHF (median age 63 years; median left ventricular ejection fraction 33%; New York Heart Association class I/II/III/IV, 19/102/70/17) and in 366 healthy men. Serum levels of free testosterone were estimated (eFT) from levels of TT and sex hormone binding globulin. Deficiencies in DHEAS, TT, eFT, and IGF-1, defined as serum levels at or below the 10th percentile of healthy peers, were seen across all age categories in men with CHF. DHEAS, TT, and eFT were inversely related to New York Heart Association class irrespective of cause (all P <0.01). DHEAS correlated positively with left ventricular ejection fraction and inversely with N-terminal pro-brain natriuretic peptide (both P <0.01). Circulating TT, eFT, DHEAS, and IGF-1 levels were prognostic markers in multivariable models when adjusted for established prognostic factors (all P <0.05). Men with CHF and normal levels of all anabolic hormones had the best 3-year survival rate (83%, 95% CI 67% to 98%) compared with those with deficiencies in 1 (74% survival rate, 95% CI 65% to 84%), 2 (55% survival rate, 95% CI 45% to 66%), or all 3 (27% survival rate, 95% CI 5% to 49%) anabolic endocrine axes ( P <0.0001). Conclusions— In male CHF patients, anabolic hormone depletion is common, and a deficiency of each anabolic hormone is an independent marker of poor prognosis. Deficiency of >1 anabolic hormone identifies groups with a higher mortality.

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Show all 7 references

Research works printed but not linked: 26

  1. 10.1016/S0735-1097(97)00262-3 · DOI
  2. 10.1161/circ.96.2.526 · DOI
  3. 10.1016/S0735-1097(01)01385-7 · DOI
  4. 10.1016/S0735-1097(98)00226-5 · DOI
  5. 10.1097/01.mco.0000134374.24181.5b · DOI
  6. 10.1152/ajpcell.00114.2003 · DOI
  7. 10.1067/mhj.2001.119124 · DOI
  8. Moriyama Y, Yasue H, Yoshimura M, Mizuno Y, Nishiyama K, Tsunoda R, Kawano H, Kugiyama K, Ogawa H, Saito Y, Nakao K. The plasma levels of dehydroepiandrosterone sulfate are decreased in patients with chronic heart failure in proportion to the severity. J Clin Endocrinol Metab. 2000; 85: 1834–1840.
  9. 10.1210/jcem-73-5-1016 · DOI · Paper page
  10. 10.1126/science.278.5337.419 · DOI · Paper page
  11. 10.1016/j.amjmed.2003.05.001 · DOI · Paper page
  12. 10.7326/0003-4819-139-8-200310210-00007 · DOI · Paper page
  13. 10.1053/euhj.2001.2783 · DOI · Paper page
  14. Jankowska EA, Szklarska A, Lopuszanska M, Medras M. Are age and educational level the determinants of hormonal parameters considered as indices of andropause [in Polish]? Pol Merkuriusz Lek. 2004; 16: 323–327.
  15. 10.1111/j.1365-2265.2004.02174.x · DOI
  16. Elmlinger MW, Kuhnel W, Ranke MB. Reference ranges for serum concentrations of lutropin (LH), follitropin (FSH), estradiol (E2), prolactin, progesterone, sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), cortisol and ferritin in neonates, children and young adults. Clin Chem Lab Med. 2002; 40: 1151–1160.
  17. 10.1053/meta.2002.31975 · DOI · Paper page
  18. 10.1159/000180580 · DOI · Paper page
  19. 10.1111/j.1365-2265.2004.02002.x · DOI
  20. 10.1046/j.1365-2265.2000.01131.x · DOI
  21. 10.1093/eurheartj/ehi443 · DOI · Paper page
  22. 10.1016/S0531-5565(01)00122-X · DOI
  23. 10.1016/S0165-0378(02)00020-7 · DOI · Paper page
  24. 10.1016/S0735-1097(97)00185-X · DOI · Paper page
  25. 10.1111/j.1749-6632.1995.tb17373.x · DOI
  26. Thijssen JHH. Laboratory tests in the endocrine evaluation of aging males. In: Lunenfeld B Gooren L eds. Textbook of Men’s Health. New York NY: Parthenon Publishing Group; 2002: 44–50.

Cited by

Metadata

Authors
Jankowska, E. A., Biel, B., Majda, J., Szklarska, A., Lopuszanska, M., Medras, M., Anker, S. D., Banasiak, W., Poole-Wilson, P. A., & Ponikowski, P.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2006-10-24
Volume
114
Issue
17
Pages
1829-1837
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/circulationaha.106.649426
OpenAlex
W2165196113
Cited by
377
References
7
FWCI
10.49
Type
journal article
Language
en
Open access
bronze

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