Dehydroepiandrosterone and Erectile Function: A Review
Open accessAbstract
To review the contemporary knowledge regarding the dehydroepiandrosterone and erectile function. Medline was reviewed for English-language journal articles spanning the time between January 1990 and December 2017, using the terms 'erectile function', 'dehydroepiandrosterone'. We used Journal Articles and review articles that found to be relevant to the purpose of this review. Criteria included all pertinent review articles, randomized controlled trials with tight methodological design, cohort studies and retrospective analyses. We also manually revised references from selected articles. Several interesting studies have addressed the age-related decline in dehydroepiandrosterone levels with many age-related phenomena or deterioration in various physiological functions. Particularly, aging; neurological functions including decreased well-being, cognition, and memory; increased depression, decreased bone mineral density, obesity, diabetes, increased cardiovascular morbidity, erectile dysfunction (ED), and decreased libido. Supporting this result, some trials of dehydroepiandrosterone supplementation in healthy, middle-aged, and elderly subjects have reported improvements in different aspects of well-being. Several studies had demonstrated that dehydroepiandrosterone level is declined as a part of aging. Large-scale well-designed prospective studies are warranted to better define indications and therapeutic implications of dehydroepiandrosterone in men with ED.
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DHEA supplementation does not improve erectile function.
“Additionally, studies have shown that DHEA supplementation does not improve erectile function (39).”
From Non-testosterone management of male hypogonadism: an examination of the existing literature (2020) · cites this paper as [39]
The ‘Dehydroepiandrosterone and Erectile Dysfunction’ section reports a trial in 79 men that found no significant difference in sexual-performance outcomes between DHEA and placebo. But the review also reports studies finding improved erectile-function scores or erection maintenance with DHEA, and its Conclusions call for further research. The categorical claim that supplementation does not improve erectile function overstates this mixed evidence. Page numbers are unavailable in our copy. (LLM, conf=0.88)
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Alkhazraji, A. K. (2026) · European Journal of Medical and Health Research · doi:10.59324/ejmhr.2026.4(3).34
- Authors
- El-Sakka, A. I.
- Affiliations
- Department of Urology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
- ORCID
- El-Sakka, Ahmed I.
- Venue
- The World Journal of Men's Health
- Publisher
- XMLink
- Published
- 2018
- Volume
- 36
- Issue
- 3
- Pages
- 183
- ISSN
- 2287-4208 (ISSN-L)
- 2287-4690
- PMC
- PMC6119841
- OpenAlex
- W2802388173
- Cited by
- 20
- References
- 72
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 1 · 2023: 3 · 2022: 4 · 2020: 3 · 2019: 2
- FWCI
- 0.19
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- The World Journal of Men s Health (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- dehydroepiandrosterone, erectile dysfunction, DHEA supplementation, aging, sexual desire, cognitive function, bone mineral density, depression, obesity, cardiovascular morbidity, men's health
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