Endothelial Function and Dysfunction: Testing and Clinical Relevance

Atherosclerosis--an inflammatory disease

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The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

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The pathogenesis of atherosclerosis: a perspective for the 1990s

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Biochemistry and molecular cell biology of diabetic complications

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Inflammation, Atherosclerosis, and Coronary Artery Disease

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Isolation of Putative Progenitor Endothelial Cells for Angiogenesis

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Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis

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Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery

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Missing Pieces in the NF-κB Puzzle

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Circulating endothelial progenitor cells, vascular function, and cardiovascular risk

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In vivo correlates of altered blood rheology

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Preeclampsia in healthy women and endothelial dysfunction 10 years later

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Reproducibility of Non-Invasive Assessment of Skin Endothelial Function Using Laser Doppler Flowmetry and Laser Speckle Contrast Imaging

Puissant, C., Abraham, P., Durand, S., Humeau‐Heurtier, A., Faure, S., Lefthériotis, G., Rousseau, P., & Mahé, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061320 · Cited by 74

Dengue Therapeutics, Chemoprophylaxis, and Allied Tools: State of the Art and Future Directions

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Diabetes Mellitus, ArterialWall, and Cardiovascular Risk Assessment

Kozàkovà, M., & Palombo, C. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13020201 · Cited by 74

Dickkopf1 destabilizes atherosclerotic plaques and promotes plaque formation by inducing apoptosis of endothelial cells through activation of ER stress

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Green Tea Catechins Improve Human Forearm Endothelial Dysfunction and Have Antiatherosclerotic Effects in Smokers

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Reduced number and function of endothelial progenitor cells in patients with aortic valve stenosis: a novel concept for valvular endothelial cell repair

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Endothelial Dysfunction in Primary Aldosteronism

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Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering

Khanna, A., Zamani, M., & Huang, N. F. (2021) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd8110137 · Cited by 80

End-organ dysfunction and cardiovascular outcomes: the role of the microcirculation

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Randomized clinical trial on the efficacy of hesperidin 2S on validated cardiovascular biomarkers in healthy overweight individuals

Salden, B. N., Troost, F. J., de Groot, E., Stevens, Y., Garcés‐Rimón, M., Possemiers, S., Winkens, B., & Masclee, A. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.136960 · Cited by 73

Ferulic acid inhibits advanced glycation end products (AGEs) formation and mitigates the AGEs-induced inflammatory response in HUVEC cells

Liu, J., He, Y., Wang, S., He, Y., Wang, W., Li, Q., & Cao, X. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.06.024 · Cited by 73

How do Uremic Toxins Affect the Endothelium?

da Cunha, R. S., Santos, A. F., Barreto, F. C., & Stinghen, A. E. M. (2020) · Toxins · doi:10.3390/toxins12060412 · Cited by 77

Stress-induced RNA–chromatin interactions promote endothelial dysfunction

Calandrelli, R., Xu, L., Luo, Y., Wu, W., Fan, X., Nguyen, T. C., Chen, C.-J., Sriram, K., Tang, X., Burns, A. B., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18957-w · Cited by 75

Environmental Factors in the Relapse and Recurrence of Inflammatory Bowel Disease: A Review of the Literature

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Blood Flow Restricted Exercise and Vascular Function

Horiuchi, M., & Okita, K. (2012) · International Journal of Vascular Medicine · doi:10.1155/2012/543218 · Cited by 75

Heme oxygenase-1 ameliorates oxidative stress-induced endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling

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Polyphenolic Composition of Rosa canina, Rosa sempervivens and Pyrocantha coccinea Extracts and Assessment of Their Antioxidant Activity in Human Endothelial Cells

Kerasioti, E., Apostolou, A., Kafantaris, I., Chronis, K., Kokka, E., Dimitriadou, C., Tzanetou, E. N., Priftis, A., Koulocheri, S. D., Haroutounian, S. A., et al. (2019) · Antioxidants · doi:10.3390/antiox8040092 · Cited by 71

Defining therapeutic targets for renal fibrosis: Exploiting the biology of pathogenesis

Yan, H., Xu, J., Xu, Z., Yang, B., Luo, P., & He, Q. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112115 · Cited by 73

Endothelin-1 plasma levels and vascular endothelial dysfunction in primary open angle glaucoma

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Endothelial Jag1-RBPJ signalling promotes inflammatory leucocyte recruitment and atherosclerosis

Nus, M., Martı́nez-Poveda, B., MacGrogan, D., Chevre, R., D’Amato, G., Sbroggió, M., Rodrı́guez, C., Martínez‐González, J., Andrés, V., Hidalgo, A., et al. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw193 · Cited by 71

Adipokines and the cardiovascular system: mechanisms mediating health and disease

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Classical and non-classical proangiogenic factors as a target of antiangiogenic therapy in tumor microenvironment

Marech, I., Leporini, C., Ammendola, M., Porcelli, M., Gadaleta, C. D., Russo, E., Sarro, G. D., & Ranieri, G. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.07.028 · Cited by 73

Risk Factors Associated with Developing Branch Retinal Vein Occlusion Among Enrollees in a United States Managed Care Plan

Newman-Casey, P. A., Stem, M. S., Talwar, N., Musch, D. C., Besirli, C. G., & Stein, J. D. (2014) · Ophthalmology · doi:10.1016/j.ophtha.2014.04.045 · Cited by 70

Selective PKC Beta Inhibition with Ruboxistaurin and Endothelial Function in Type-2 Diabetes Mellitus

Mehta, N. N., Sheetz, M. J., Price, K., Comiskey, L., Amrutia, S., Iqbal, N., Mohler, E. R., & Reilly, M. P. (2008) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-008-6144-5 · Cited by 70

Preeclampsia and Extracellular Vesicles

Gilani, S. I., Weissgerber, T. L., Garovic, V. D., & Jayachandran, M. (2016) · Current Hypertension Reports · doi:10.1007/s11906-016-0678-x · Cited by 67

Flow-mediated dilation stimulated by sustained increases in shear stress: A useful tool for assessing endothelial function in humans?

Tremblay, J. C., & Pyke, K. E. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00534.2017 · Cited by 70

Endothelial function and insulin resistance in polycystic ovary syndrome: The effects of medical therapy

Teede, H. J., Meyer, C., Hutchison, S. K., Zoungas, S., McGrath, B. P., & Moran, L. J. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.09.034 · Cited by 68

Luteolinidin Protects the Postischemic Heart through CD38 Inhibition with Preservation of NAD(P)(H)

Boslett, J., Hemann, C., Zhao, Y. J., Lee, H.-C., & Zweier, J. L. (2017) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.239459 · Cited by 69

Phthalate exposure increases subclinical atherosclerosis in young population

Su, T., Hwang, J.-S., Torng, P., Wu, C. W., Lin, C., & Sung, F. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.04.006 · Cited by 69

Endothelial Cell–Specific Liver Kinase B1 Deletion Causes Endothelial Dysfunction and Hypertension in Mice In Vivo

Zhang, W., Wang, Q., Wu, Y., Moriasi, C. M., Liu, Z., Dai, X., Wang, Q., Liu, W., Yuan, Z., & Zou, M. (2014) · Circulation · doi:10.1161/circulationaha.113.004146 · Cited by 69

Cardiovascular Comorbidities of Type 2 Diabetes Mellitus: Defining the Potential of Glucagonlike peptide–1-Based Therapies

CHILTON, R. J., Wyatt, J., Nandish, S., OLIVEROS, R. A., & Lujan, M. (2010) · The American Journal of Medicine · doi:10.1016/j.amjmed.2010.11.004 · Cited by 68

Endothelial function testing and cardiovascular disease: focus on peripheral arterial tonometry

Ghiadoni, L., Bruno, R. M., & Gori, T. (2014) · Vascular Health and Risk Management · doi:10.2147/vhrm.s44471 · Cited by 69

Rapamycin: A Bacteria-Derived Immunosuppressant That Has Anti-atherosclerotic Effects and Its Clinical Application

Liu, Y., Yang, F., Zou, S., & Qu, L. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01520 · Cited by 69

Inorganic nitrite supplementation for healthy arterial aging

Sindler, A. L., DeVan, A. E., Fleenor, B. S., & Seals, D. R. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01100.2013 · Cited by 68

Endothelial contribution to COVID-19: an update on mechanisms and therapeutic implications

Ma, Z., Yang, Y., Huang, Y., & Lui, K. O. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.11.010 · Cited by 70

Significance and assessment of coronary microvascular dysfunction

Leung, D. Y., & Leung, M. (2011) · Heart · doi:10.1136/hrt.2009.183327 · Cited by 68

Polyphenolic composition of grape stem extracts affects antioxidant activity in endothelial and muscle cells

Goutzourelas, N., Stagos, D., Spanidis, Y., LIOSI, M., Apostolou, A., Priftis, A., Haroutounian, S., Spandidos, D. A., Tsatsakis, A. M., & Kouretas, D. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4216 · Cited by 68

Endothelin-1 and F2-isoprostane relate to and predict renal dysfunction in hypertensive patients

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Short-term treatment with L-arginine prevents the smoking-induced impairment of endothelial function and vascular elastic properties in young individuals

Siasos, G., Tousoulis, D., Vlachopoulos, C. V., Antoniades, C. A., Stefanadi, E., Ioakeimidis, N., Andreou, I., Zisimos, K., Papavassiliou, A. G., & Stefanadis, C. (2007) · International Journal of Cardiology · doi:10.1016/j.ijcard.2007.04.057 · Cited by 68

Effects of a lifestyle intervention on endothelial function in men on long-term androgen deprivation therapy for prostate cancer

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Endothelial damage is aggravated in acute GvHD and could predict its development

Mir, E., Palomo, M., Rovira, M., Pereira, A., Escolar, G., Penack, O., Holler, E., Carreras, E., & Díaz‐Ricart, M. (2017) · Bone Marrow Transplantation · doi:10.1038/bmt.2017.121 · Cited by 68

Uric acid: from a biological advantage to a potential danger. A focus on cardiovascular effects

Cortese, F., Giordano, P., Scicchitano, P., Faienza, M. F., Pergola, G. D., Calculli, G., Meliota, G., & Ciccone, M. M. (2019) · Vascular Pharmacology · doi:10.1016/j.vph.2019.106565 · Cited by 67

Endothelial TRPV1 as an Emerging Molecular Target to Promote Therapeutic Angiogenesis

Negri, S., Faris, P. S., Rosti, V., Antognazza, M. R., Lodola, F., & Moccia, F. D. (2020) · Cells · doi:10.3390/cells9061341 · Cited by 67

The Role of Vascular Cells in Pancreatic Beta-Cell Function

Burganova, G., Bridges, C. A., Thorn, P., & Landsman, L. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.667170 · Cited by 70

Obesity-associated cardiovascular risk in women: hypertension and heart failure

Faulkner, J. (2021) · Clinical Science · doi:10.1042/cs20210384 · Cited by 71

NAD+ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension

Qiu, Y., Xu, S., Chen, X., Wu, X., Zhou, Z., Zhang, J., Tu, Q., Dong, B., Liu, Z., He, J., et al. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01577-3 · Cited by 70

Albumin infusion improves renal blood flow autoregulation in patients with acute decompensation of cirrhosis and acute kidney injury

García‐Martínez, R., Noiret, L., Sen, S., Mookerjee, R. P., & Jalan, R. (2014) · Liver International · doi:10.1111/liv.12528 · Cited by 67

Fetoplacental Vascular Endothelial Dysfunction as an Early Phenomenon in the Programming of Human Adult Diseases in Subjects Born from Gestational Diabetes Mellitus or Obesity in Pregnancy

Leiva, A., Pardo, F., Ramírez, M. A., Farías, M., Casanello, P. C., & Sobrevía, L. (2011) · Experimental Diabetes Research · doi:10.1155/2011/349286 · Cited by 68

HDL and atherosclerosis: Insights from inherited HDL disorders

Calabresi, L., Gomaraschi, M., Simonelli, S., Bernini, F., & Franceschini, G. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.07.015 · Cited by 67

A Parallel-Plate Flow Chamber for Mechanical Characterization of Endothelial Cells Exposed to Laminar Shear Stress

Wong, A. K., Llanos, P., Boroda, N., Rosenberg, S. R., & Rabbany, S. Y. (2015) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-015-0424-5 · Cited by 67

Subclinical Atherosclerosis in Systemic Lupus Erythematosus and Antiphospholipid Syndrome

Conti, F., Spinelli, F. R., Alessandri, C., Pacelli, M., Ceccarelli, F., Marocchi, E., Montali, A., Capozzi, A., Buttari, B., Profumo, E., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.302680 · Cited by 67

Methotrexate and anti-tumor necrosis factor treatment improves endothelial function in patients with inflammatory arthritis

Deyab, G., Hokstad, I., Whist, J. E., Småstuen, M. C., Agewall, S., Lyberg, T., Ronda, N., Mikkelsen, K., Hjeltnes, G., & Hollan, I. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-017-1439-1 · Cited by 67

Endothelial dysfunction and arterial abnormalities in childhood obesity

Skilton, M. R., & Celermajer, D. S. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803397 · Cited by 66

Modulation of Endothelial Function by TMAO, a Gut Microbiota-Derived Metabolite

Querio, G., Antoniotti, S., Geddo, F., Levi, R. C., & Gallo, M. P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065806 · Cited by 70

Cardiovascular Complications of Energy Drinks

Higgins, J. P., Yarlagadda, S., & Yang, B. K. (2015) · Beverages · doi:10.3390/beverages1020104 · Cited by 74

Nifedipine Improves Endothelial Function

Sugiura, T., Kondo, T., Kureishi-Bando, Y., Numaguchi, Y., Yoshida, O., Dohi, Y., Kimura, G., Ueda, R., Rabelink, T. J., & Murohara, T. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.111914 · Cited by 65

Acute effects of ingestion of a novel whey-derived extract on vascular endothelial function in overweight, middle-aged men and women

Ballard, K. D., Kupchak, B. R., Volk, B. M., Mah, E., Shkreta, A., Liptak, C., Ptolemy, A. S., Kellogg, M. D., Bruno, R. S., Seip, R. L., et al. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512002061 · Cited by 66

Endothelial Dysfunction Is Related to Aldosterone Excess and Raised Blood Pressure

Tsuchiya, K., Yoshimoto, T., & Hirata, Y. (2009) · Endocrine Journal · doi:10.1507/endocrj.k09e-014 · Cited by 66

Endothelial dysfunction but not increased carotid intima-media thickness in young European women with endometriosis

Santoro, L., D'Onofrio, F., Campo, S., Ferraro, P. M., Tondi, P., Campo, V., Flex, A., Gasbarrini, A., & Santoliquido, A. (2012) · Human Reproduction · doi:10.1093/humrep/des062 · Cited by 66

Cardiovascular effects of arsenic: clinical and epidemiological findings

Stea, F., Bianchi, F., Cori, L., & Sicari, R. (2013) · Environmental Science and Pollution Research · doi:10.1007/s11356-013-2113-z · Cited by 66

Regulation of Foam Cells by Adenosine

Reiss, A. B., & Cronstein, B. N. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.226878 · Cited by 65

The Activation Function-1 of Estrogen Receptor Alpha Prevents Arterial Neointima Development Through a Direct Effect on Smooth Muscle Cells

Smirnova, N. F., Fontaine, C., Buscato, M., Lupieri, A., Vinel, A., Valera, M., Guillaume, M., Malet, N., Foidart, J., Raymond‐Letron, I., et al. (2015) · Circulation Research · doi:10.1161/circresaha.115.306416 · Cited by 65

Skin vasomotion investigation: A useful tool for clinical evaluation of microvascular endothelial function?

Rossi, M., Carpi, A., Galetta, F., Franzoni, F., & Santoro, G. (2008) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2008.07.085 · Cited by 65

Exercise effects on perivascular adipose tissue: endocrine and paracrine determinants of vascular function

Boa, B. C. S., Yudkin, J. S., van Hinsbergh, V. W. M., Bouskela, E., & Eringa, E. C. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13732 · Cited by 65

Covid‐19 and Liver Injury: Role of Inflammatory Endotheliopathy, Platelet Dysfunction, and Thrombosis

McConnell, M. J., Kondo, R., Kawaguchi, N., & Iwakiri, Y. (2021) · Hepatology Communications · doi:10.1002/hep4.1843 · Cited by 68

Endothelial Cell Dysfunction: Onset, Progression, and Consequences

Naderi‐Meshkin, H., & Setyaningsih, W. A. W. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2906223 · Cited by 78

Serum Oxidative Stress-Induced Repression of Nrf2 and GSH Depletion: A Mechanism Potentially Involved in Endothelial Dysfunction of Young Smokers

Pasini, A. F., Albiero, A., Stranieri, C., Cominacini, M., Pasini, A., Mozzini, C., Vallerio, P., Cominacini, L., & Garbin, U. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030291 · Cited by 64

Combination therapy for treatment or prevention of atherosclerosis: Focus on the lipid-RAAS interaction

Koh, K. K., Han, S. H., Oh, P. C., Shin, E. K., & Quon, M. J. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.09.007 · Cited by 64

Association of Testosterone Levels With Endothelial Function in Men

Empen, K., Lorbeer, R., Dörr, M., Haring, R., Nauck, M. A., Gläser, S., Krebs, A., Reffelmann, T., Ewert, R., Völzke, H., et al. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.232876 · Cited by 64

Mechanisms behind the atherothrombotic effects of acrolein, a review

Zirak, M. R., Mehri, S., Karimani, A., Zeinali, M., Hayes, A. W., & Karimi, G. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.04.034 · Cited by 65

GDF15 secreted by senescent endothelial cells improves vascular progenitor cell functions

Ha, G., Torres, F. D., Arouche, N., Benzoubir, N., Ferratge, S., Hatem, E., Anginot, A., & Uzan, G. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216602 · Cited by 64

Matrix density drives 3D organotypic lymphatic vessel activation in a microfluidic model of the breast tumor microenvironment

Lugo-Cintrón, K. M., Ayuso, J. M., White, B. R., Harari, P. M., Ponik, S. M., Beebe, D. J., Gong, M. M., & Virumbrales-Muñoz, M. (2020) · Lab on a Chip · doi:10.1039/d0lc00099j · Cited by 64

Effect of different walking break strategies on superficial femoral artery endothelial function

Carter, S. E., Draijer, R., Holder, S. M., Brown, L., Thijssen, D. H. J., & Hopkins, N. D. (2019) · Physiological Reports · doi:10.14814/phy2.14190 · Cited by 63

Exploring the evolution of tissue engineering strategies over the past decade: From cell-based strategies to gene-activated matrix

Esmaeili, Y., Bidram, E., Bigham, A., Atari, M., Azadani, R. N., Tavakoli, M., Salehi, S., Mirhaj, M., Basiri, A., Mirzavandi, Z., et al. (2023) · Alexandria Engineering Journal · doi:10.1016/j.aej.2023.08.080 · Cited by 67

Effect of Polyelectrolyte Film Stiffness on Endothelial Cells During Endothelial-to-Mesenchymal Transition

Zhang, H., Chang, H., Wang, L., Ren, K., Martins, M. C. L., Barbosa, M. A., & Ji, J. (2015) · Biomacromolecules · doi:10.1021/acs.biomac.5b01057 · Cited by 63

Impaired vascular function in patients with Fontan circulation

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Visceral adiposopathy: a vascular perspective

Farb, M. G., & Gokce, N. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2014-0047 · Cited by 66

Acute effects of various fast-food meals on vascular function and cardiovascular disease risk markers: the Hamburg Burger Trial

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Rosuvastatin use improves measures of coagulation in patients with venous thrombosis

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