Cited by 66Cardiovascular Health and Disease PreventionObesity, Physical Activity, DietCardiovascular Function and Risk Factors

Endothelial dysfunction and arterial abnormalities in childhood obesity

Skilton, M R, Celermajer, D S·2006·International Journal of Obesity

Abstract

Rates of overweight and obesity in both adults and children have risen sharply during the past 20 years. The reasons for this escalation in obesity are not fully determined, however, sedentary lifestyle and dietary changes in combination with genetic predisposition are probably involved. Clinical cardiovascular disease, including myocardial infarction and stroke, are usually only manifest in the fifth decade of life or beyond. However, the earliest physical signs of atherosclerosis, the underlying disease process that leads to these events, may be present from early childhood. There are now a variety of noninvasive tests used to assess both the structural and functional properties of the vasculature and in vivo changes suggestive of 'early atherosclerosis' have now been characterised. These have allowed not only an increased understanding of the atherosclerotic changes to the vasculature that accompany overweight and obesity in children, but have also allowed serial study of the effects of diet and exercise interventions on early atherosclerosis changes, in childhood obesity.

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Registry

Crossref · 10.1038/sj.ijo.0803397

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110 of 110 references verified0 citation errors · 0 not checkable

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  • Endothelial dysfunction is widely present in obesity and the metabolic syndrome.

    “In addition, endothelial dysfunction is widely present in obesity and the metabolic syndrome (84, 325, 358).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [325]

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Authors
Skilton, M. R., & Celermajer, D. S.
Affiliations
Royal Prince Alfred Hospital (AU)
Corresponding author
Celermajer, D S
Venue
International Journal of Obesity
Published
2006-06-27
Volume
30
Issue
7
Pages
1041-1049
ISSN
  • 0307-0565 (ISSN-L)
  • 1476-5497
OpenAlex
W2080609471
Cited by
66
References
110
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 6
FWCI
0.61
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Obesity (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
childhood obesity, endothelial dysfunction, early atherosclerosis, cardiovascular risk, noninvasive vascular testing, diet and exercise intervention, sedentary lifestyle
MeSH terms
Cardiovascular Diseases, Child, Diet, Reducing, Endothelium, Vascular, Humans, Obesity, Risk Factors, Exercise, Atherosclerosis

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