Endothelial dysfunction and arterial abnormalities in childhood obesity
Abstract
Rates of overweight and obesity in both adults and children have risen sharply during the past 20 years. The reasons for this escalation in obesity are not fully determined, however, sedentary lifestyle and dietary changes in combination with genetic predisposition are probably involved. Clinical cardiovascular disease, including myocardial infarction and stroke, are usually only manifest in the fifth decade of life or beyond. However, the earliest physical signs of atherosclerosis, the underlying disease process that leads to these events, may be present from early childhood. There are now a variety of noninvasive tests used to assess both the structural and functional properties of the vasculature and in vivo changes suggestive of 'early atherosclerosis' have now been characterised. These have allowed not only an increased understanding of the atherosclerotic changes to the vasculature that accompany overweight and obesity in children, but have also allowed serial study of the effects of diet and exercise interventions on early atherosclerosis changes, in childhood obesity.
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Endothelial dysfunction is widely present in obesity and the metabolic syndrome.
“In addition, endothelial dysfunction is widely present in obesity and the metabolic syndrome (84, 325, 358).”
From Cardiac remodeling in obesity (2008) · cites this paper as [325]
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PEDIATRIC HIGHLIGHT Correlates of changes in BMI of children from the Azores islands
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ИЗМЕНЕНИЯ ПСИХОЛОГИЧЕСКОГО СТАТУСА И ПИЩЕВОГО ПОВЕДЕНИЯ У ДЕТЕЙ С ОЖИРЕНИЕМ
Ergashevna, X. Z., & Nazhmitdinovna, K. G. (2022) · Международный журнал научной педиатрии · doi:10.56121/2181-2926-2022-3-35-39
- Authors
- Skilton, M. R., & Celermajer, D. S.
- Affiliations
- Royal Prince Alfred Hospital (AU)
- Corresponding author
- Celermajer, D S
- Venue
- International Journal of Obesity
- Published
- 2006-06-27
- Volume
- 30
- Issue
- 7
- Pages
- 1041-1049
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W2080609471
- Cited by
- 66
- References
- 110
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 6
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- childhood obesity, endothelial dysfunction, early atherosclerosis, cardiovascular risk, noninvasive vascular testing, diet and exercise intervention, sedentary lifestyle
- MeSH terms
- Cardiovascular Diseases, Child, Diet, Reducing, Endothelium, Vascular, Humans, Obesity, Risk Factors, Exercise, Atherosclerosis
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